What is it about?
Photodynamic therapy (PDT) is a promising approach for the treatment of cancer tumors by combining photosensitizer (PS), oxygen molecule and light. But the selectivity of traditional PS is poor.In the treatment process,the first singlet excited state of molecular oxygen (singlet oxygen, 1O2) is important for PDT.So we present a summary of designing novel PS or controllable PDT by regulating singlet oxygen efficiency.
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Why is it important?
In this review, we have summarized the recent developments in controllable photodynamic therapy and some novel strategies of designing activatable PSs.We introduced various regulation methods to control the 1O2 production, such as PET,FRET, ICT, etc. Compared with traditional PDT reagents, which are untargetable, controllable PSs opens new avenue for PDT in clinical practice by selective control of photosensitization.
Perspectives
There are still some problems that have not been solved,sometimes ,controllable PDT and high 1O2 quantum yield cannot be achived simultaneously. Hence, it should be realized that even more wonderful strategies or PS should be designed to achieve more efficient and safer PDT. I hope that more people can pay attention to the field of photodynamic therapy through this article.and I hope you can get help from it.
Wenting Wu
China University of Petroleum Huadong
Read the Original
This page is a summary of: Controllable Photodynamic Therapy Implemented by Regulating Singlet Oxygen Efficiency, Advanced Science, June 2017, Wiley,
DOI: 10.1002/advs.201700113.
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