What is it about?
We designed and demonstrated a hand held, low cost (<£1000) device for non-invasive magnetic particle retention and bubble activation.
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Why is it important?
The combined spatial targeting actions of aligned magnetic and ultrasonic fields is intended to improve drug delivery efficiency beyond what is already possible with microbubbles and separate field-generating external devices. The performance of this prototype system has been subsequently demonstrated (paper in progress) in a murine pancreatic cancer model. Ongoing design efforts are focused on a scaled-up device for length scales relevant to human applications.
Perspectives
Building on decades of magnetic microbubble targeting studies, this work took an important step towards clinical translation by building a compact and low cost device for multi-modal drug delivery.
Michael Gray
University of Oxford
Read the Original
This page is a summary of: A Combined Magnetic-Acoustic Device for Simultaneous, Coaligned Application of Magnetic and Ultrasonic Fields, Advanced Materials Technologies, June 2018, Wiley,
DOI: 10.1002/admt.201800081.
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