Realistic models for carry-over

What is it about?

The relationship between choice of model for carry-over and choice of efficient cross-over design is studied in particular with reference to two treatment designs in four periods and two sequences. The effect of model miss-specification is also examined. It is concluded that previous claims regarding efficient designs are not necessarily reasonable.

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Why is it important?

Explains that there are two types of design efficiency: type I you don't know the model when you design the trial but you will when you come to analyse it and type II where you won't know the right model either at analysis.