What is it about?

Outstanding review of the field of subunit vaccine development. Describes the current state of the art and future directions with a focus on adjuvants, delivery systems, particle size, dendritic cell targeting, and means to improve vaccine efficacy (e.g. promiscuous T helper epitopes) or steer immune responses towards desired responses.

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Why is it important?

Vaccines are one of the most effective means to prevent disease. We need new vaccines, with many diseases currently lacking marketed vaccines, and some vaccines requiring improvements. This review stimulates interest in the modern subunit vaccine development field.

Perspectives

This review provides many examples of important concepts for the development of subunit vaccines.

Dr Peter Michael Moyle
University of Queensland

Read the Original

This page is a summary of: Modern Subunit Vaccines: Development, Components, and Research Opportunities, ChemMedChem, January 2013, Wiley, DOI: 10.1002/cmdc.201200487.
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