Anatomical location in STN matters for DBS in Parkinson's
What is it about?
We provided a method to map continuous outcome measures for deep brain stimulation (DBS), like movement speed, onto a three-dimensional representation of brain anatomy, depending on the specific location in the brain where the electrical stimuli were applied. We supplied with it methods for mapping the expected change from stimulating a given point in the brain, based on our data, and a rigorous test for whether the place-outcome connection was statistically significant.
Why is it important?
Reliable statistical images of DBS's effects makes it possible to convincingly answer some of the most important open questions about DBS. Applying our new method to a reasonably large set of data from patients being treated with DBS for Parkinson disease provides evidence that some locations work better than others even for DBS aimed at the small subthalamic nucleus (STN). Our results also provide some of the most direct evidence that some parts of the STN are more likely than others to help anxiety in PD, or more likely to negatively affect a computerized measure of cognitive function.
The following have contributed to this page: Dr Kevin J. Black
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