What is it about?
Human subjects are ideal for studying joint disease mechanisms and testing drugs, which, however, should not be used because of ethical issues. Therefore, we used human cells to generate tissues of the knee joint and built a miniature joint model on a chip device, called miniJoint, for this purpose.
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Why is it important?
We found that the tissues could maintain their respective identities for at least four weeks in the miniJoint. Features of joint diseases could be modeled using the miniJoint platform, which also showed the ability to predict the efficacy of potential drugs targeting joint diseases.
Perspectives
We for the first time proved the feasibility of creating a four-tissue system that mimics key characteristics of healthy and diseased human synovial joints.
ZHONG Alan LI
University of Pittsburgh
Read the Original
This page is a summary of: Human Mesenchymal Stem Cell‐Derived Miniature Joint System for Disease Modeling and Drug Testing, Advanced Science, April 2022, Wiley,
DOI: 10.1002/advs.202105909.
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