What is it about?
Designed cationic Ag complex shows the acid base cooperativity during cyclisation of alkynoic acid. Imidazole act as base and Silver as a Lewis acid. Base moiety helps in protonation and Ag increases the nucleophilicity of Alkyne. It is all about cooperative catalysis.
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Why is it important?
Designed cationic silver NHC complex employing imidazole at C5 position of rigid bicyclic NHC framework to give rigidity to the complex which prevent the interaction of imidazole nitrogen towards the silver metal centre. This employment of substituent at C5 position have functionality to give rigidness to the complex. In terms of concept, this is new.
Perspectives
My personal perspective is that the employment of substituent has changed the catalyst behaviour and further act as a acid base cooperative catalyst in the cyclization of alkynoic acid. This rigidy is new in terms of concept.
Vishal Kumar Rawat
Hokkaido Daigaku
Read the Original
This page is a summary of: Use of Imidazo[1,5‐
a
]pyridin‐3‐ylidene as a Platform for Metal‐Imidazole Cooperative Catalysis: Silver‐Catalyzed Cyclization of Alkyne‐Tethered Carboxylic Acids, Advanced Synthesis & Catalysis, February 2021, Wiley,
DOI: 10.1002/adsc.202001515.
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