All Stories

  1. Synthesis and Biological Evaluation of (E)-4-Hydroxy-3-methylbut-2-enyl Phosphate (HMBP) Aryloxy Triester Phosphoramidate Prodrugs as Activators of Vγ9/Vδ2 T-Cell Immune Responses

    Article • Journal of Medicinal Chemistry, February 2018, American Chemical Society (ACS)

    Dr Youcef Mehellou

  2. The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1

    Article • ChemBioChem, January 2018, Wiley

    Dr Youcef Mehellou

  3. WNK Signaling Inhibitors as Potential Antihypertensive Drugs

    Article • ChemMedChem, September 2017, Wiley

    Dr Youcef Mehellou

  4. BTN3A1 Discriminates γδ T Cell Phosphoantigens from Nonantigenic Small Molecules via a Conformational Sensor in Its B30.2 Domain

    Article • ACS Chemical Biology, September 2017, American Chemical Society (ACS)

    Dr Youcef Mehellou

  5. The ProTide Prodrug Technology: From the Concept to the Clinic

    Article • Journal of Medicinal Chemistry, August 2017, American Chemical Society (ACS)

    Dr Youcef Mehellou

  6. Rafoxanide and Closantel Inhibit SPAK and OSR1 Kinases by Binding to a Highly Conserved Allosteric Site on Their C-terminal Domains

    Article • ChemMedChem, April 2017, Wiley

    Dr Youcef Mehellou

  7. Kinetin Riboside and Its ProTides Activate the Parkinson’s Disease Associated PTEN-Induced Putative Kinase 1 (PINK1) Independent of Mitochondrial Depolarization

    Article • Journal of Medicinal Chemistry, March 2017, American Chemical Society (ACS)

    Dr Youcef Mehellou

  8. Towards the Development of Small-Molecule MO25 Binders as Potential Indirect SPAK/OSR1 Kinase Inhibitors

    Article • ChemBioChem, January 2017, Wiley

    Dr Youcef Mehellou

  9. Nucleoside Phosphate and Phosphonate Prodrug Clinical Candidates

    Article • Journal of Medicinal Chemistry, December 2016, American Chemical Society (ACS)

    Dr Youcef Mehellou

  10. Organometallic Nucleoside Analogues: Effect of Hydroxyalkyl Linker Length on Cancer Cell Line Toxicity

    Article • European Journal of Inorganic Chemistry, November 2016, Wiley

    Dr Youcef Mehellou, Dr Media Khursheed Ismail

  11. The ProTides Boom

    Article • ChemMedChem, May 2016, Wiley

    Dr Youcef Mehellou

  12. Organometallic Nucleoside Analogues with Ferrocenyl Linker Groups: Synthesis and Cancer Cell Line Studies

    Article • Journal of Medicinal Chemistry, July 2014, American Chemical Society (ACS)

    Dr Youcef Mehellou

  13. The CUL3–KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

    Article • Biochemical Journal, April 2013, Portland Press Ltd.

    Dr Youcef Mehellou

  14. Structural insights into the activation of MST3 by MO25

    Article • Biochemical and Biophysical Research Communications, February 2013, Elsevier

    Dr Youcef Mehellou

  15. Synthesis of pdCpAs and transfer RNAs activated with thiothreonine and derivatives

    Article • Bioorganic & Medicinal Chemistry, April 2012, Elsevier

    Dr Youcef Mehellou

  16. SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation

    Article • Biochemical Journal, January 2012, Portland Press Ltd.

    Dr Youcef Mehellou

  17. MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

    Article • The EMBO Journal, March 2011, Wiley

    Dr Youcef Mehellou

  18. Phosphoramidate Prodrugs Deliver with Potency Against Hepatitis C Virus

    Article • ChemMedChem, September 2010, Wiley

    Dr Youcef Mehellou

  19. Phosphoramidates of 2′-β-d-arabinouridine (AraU) as phosphate prodrugs; design, synthesis, in vitro activity and metabolism

    Article • Bioorganic & Medicinal Chemistry, April 2010, Elsevier

    Dr Youcef Mehellou

  20. Twenty-Six Years of Anti-HIV Drug Discovery: Where Do We Stand and Where Do We Go?

    Article • Journal of Medicinal Chemistry, January 2010, American Chemical Society (ACS)

    Dr Youcef Mehellou

  21. The design, synthesis and antiviral evaluation of a series of 5-trimethylsilyl-1-β-D-(arabinofuranosyl)uracil phosphoramidate ProTides

    Article • Antiviral Chemistry and Chemotherapy, January 2010, SAGE Publications

    Dr Youcef Mehellou

  22. Aryloxy Phosphoramidate Triesters: a Technology for Delivering Monophosphorylated Nucleosides and Sugars into Cells

    Article • ChemMedChem, November 2009, Wiley

    Dr Youcef Mehellou

  23. An investigation into the anti-HIV activity of 2′,3′-didehydro-2′,3′-dideoxyuridine (d4U) and 2′,3′-dideoxyuridine (ddU) phosphoramidate ‘ProTide’ derivatives

    Article • Organic & Biomolecular Chemistry, January 2009, Royal Society of Chemistry

    Dr Youcef Mehellou

  24. Design, synthesis, and anti-HIV activity of 2′,3′-didehydro-2′,3′-dideoxyuridine (d4U), 2′,3′-dideoxyuridine (ddU) phosphoramidate ‘ProTide’ derivatives

    Article • Bioorganic & Medicinal Chemistry Letters, July 2007, Elsevier

    Dr Youcef Mehellou