All Stories

  1. Progress of CDK4/6 Inhibitor Palbociclib in the Treatment of Cancer

    Article • Anti-Cancer Agents in Medicinal Chemistry, January 2019, Bentham Science Publishers

    Dr Yingjie Zhang

  2. JAK/STAT Signal Transduction: Promising Attractive Targets for Immune, Inflammatory and Hematopoietic Diseases

    Article • Current Drug Targets, March 2018, Bentham Science Publishers

    Dr Yingjie Zhang

  3. Design, Synthesis and Biological Evaluation of Novel Tamibarotene Derivative as Multitarget Anticancer Agent

    Article • Letters in Drug Design & Discovery, August 2016, Bentham Science Publishers

    Dr Yingjie Zhang

  4. Discovery of Multi-target Anticancer Agents Based on HDAC Inhibitor MS-275 and 5-FU

    Article • Medicinal Chemistry, January 2016, Bentham Science Publishers

    Dr Yingjie Zhang

  5. Design, synthesis, and antitumor evaluation of histone deacetylase inhibitors with L-phenylglycine scaffold

    Article • Drug Design Development and Therapy, October 2015, Dove Medical Press

    Dr Yingjie Zhang

  6. Synthesis of chiral ND-322, ND-364 and ND-364 derivatives as selective inhibitors of human gelatinase

    Article • Bioorganic & Medicinal Chemistry, October 2015, Elsevier

    Dr Yingjie Zhang

  7. Development of N-hydroxybenzamide derivatives with indole-containing cap group as histone deacetylases inhibitors

    Article • Bioorganic & Medicinal Chemistry, October 2015, Elsevier

    Dr Yingjie Zhang

  8. Discovery of a series of novel compounds with moderate anti-hepatitis C virus NS3 protease activity in vitro

    Article • Bioorganic & Medicinal Chemistry, September 2015, Elsevier

    Dr Yingjie Zhang

  9. Correction to Design, Synthesis, and Antitumor Evaluation of Novel Histone Deacetylase Inhibitors Equipped with a Phenylsulfonylfuroxan Module as a Nitric Oxide Donor

    Article • Journal of Medicinal Chemistry, August 2015, American Chemical Society (ACS)

    Dr Yingjie Zhang

  10. Synthesis and biological evaluation of novel histone deacetylases inhibitors with nitric oxide releasing activity

    Article • Bioorganic & Medicinal Chemistry, August 2015, Elsevier

    Dr Yingjie Zhang

  11. Design, Synthesis, and Antitumor Evaluation of Novel Histone Deacetylase Inhibitors Equipped with a Phenylsulfonylfuroxan Module as a Nitric Oxide Donor

    Article • Journal of Medicinal Chemistry, May 2015, American Chemical Society (ACS)

    Dr Yingjie Zhang

  12. Isoform-selective histone deacetylase inhibitors: the trend and promise of disease treatment

    Article • Epigenomics, February 2015, Future Medicine

    Dr Yingjie Zhang

  13. Histone deacetylase inhibitors merged with protein tyrosine kinase inhibitors

    Article • Drug Discoveries & Therapeutics, January 2015, International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA)

    Dr Yingjie Zhang

  14. Enhanced anticancer activity of 5-FU in combination with Bestatin: Evidence in human tumor-derived cell lines and an H22 tumor-bearing mouse

    Article • Drug Discoveries & Therapeutics, January 2015, International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA)

    Dr Yingjie Zhang

  15. Development of 3-hydroxycinnamamide-based HDAC inhibitors with potent in vitro and in vivo anti-tumor activity

    Article • European Journal of Medicinal Chemistry, January 2015, Elsevier

    Dr Yingjie Zhang

  16. Discovery of N-Substituted Oseltamivir Derivatives as Potent and Selective Inhibitors of H5N1 Influenza Neuraminidase

    Article • Journal of Medicinal Chemistry, October 2014, American Chemical Society (ACS)

    Dr Yingjie Zhang

  17. Superior activity of a new histone deacetylase inhibitor (ZYJ-34c) in inhibiting growth of human leukemia cells by inducing p21WAF1 expression and cell cycle arrest

    Article • Anti-Cancer Drugs, August 2014, Wolters Kluwer Health

    Dr Yingjie Zhang

  18. Design, synthesis and preliminary evaluation of α-sulfonyl γ-(glycinyl-amino)proline peptidomimetics as matrix metalloproteinase inhibitors

    Article • Bioorganic & Medicinal Chemistry, June 2014, Elsevier

    Dr Yingjie Zhang

  19. Discovery of the First N -Hydroxycinnamamide-Based Histone Deacetylase 1/3 Dual Inhibitors with Potent Oral Antitumor Activity

    Article • Journal of Medicinal Chemistry, April 2014, American Chemical Society (ACS)

    Dr Yingjie Zhang

  20. Progress of HDAC Inhibitor Panobinostat in the Treatment of Cancer

    Article • Current Drug Targets, April 2014, Bentham Science Publishers

    Dr Yingjie Zhang

  21. VEGF Signal System: The Application of Antiangiogenesis

    Article • Current Medicinal Chemistry, February 2014, Bentham Science Publishers

    Dr Yingjie Zhang

  22. Discovery of N-(3-((7H-purin-6-yl)thio)-4-hydroxynaphthalen-1-yl)-sulfonamide derivatives as novel protein kinase and angiogenesis inhibitors for the treatment of cancer: Synthesis and biological evaluation. Part III

    Article • Bioorganic & Medicinal Chemistry, February 2014, Elsevier

    Dr Yingjie Zhang

  23. Developments of Polo-like Kinase 1 (Plk1) Inhibitors as Anti-Cancer Agents

    Article • Mini-Reviews in Medicinal Chemistry, December 2013, Bentham Science Publishers

    Dr Yingjie Zhang

  24. Histone Deacetylase Inhibitors with Enhanced Enzymatic Inhibition Effects and Potent in vitro and in vivo Antitumor Activities

    Article • ChemMedChem, November 2013, Wiley

    Dr Yingjie Zhang

  25. Discovery of 4-amino-2-(thio)phenol derivatives as novel protein kinase and angiogenesis inhibitors for the treatment of cancer: Synthesis and biological evaluation. Part II

    Article • European Journal of Medicinal Chemistry, November 2013, Elsevier

    Dr Yingjie Zhang

  26. 3D QSAR and docking studies of a series of histone deacetylase inhibitors

    Article • Medicinal Chemistry Research, October 2013, Springer Science + Business Media

    Dr Yingjie Zhang

  27. Design and Synthesis of a Tetrahydroisoquinoline-Based Hydroxamate Derivative (ZYJ-34v), An Oral Active Histone Deacetylase Inhibitor with Potent Antitumor Activity

    Article • Chemical Biology & Drug Design, July 2013, Wiley

    Dr Yingjie Zhang

  28. Progress Review on Kinesin Spindle Protein Inhibitors as Anti- Cancer Agents

    Article • June 2013, Bentham Science Publishers

    Dr Yingjie Zhang

  29. Synthesis and biological evaluation of N-(4-hydroxy-3-mercaptonaphthalen-1-yl)amides as inhibitors of angiogenesis and tumor growth

    Article • European Journal of Medicinal Chemistry, June 2013, Elsevier

    Dr Yingjie Zhang

  30. Development of N -Hydroxycinnamamide-Based Histone Deacetylase Inhibitors with an Indole-Containing Cap Group

    Article • ACS Medicinal Chemistry Letters, February 2013, American Chemical Society (ACS)

    Dr Yingjie Zhang

  31. Discovery of a pair of diastereomers as potent HDACs inhibitors: determination of absolute configuration, biological activity comparison and computational study

    Article • RSC Advances, January 2013, Royal Society of Chemistry

    Professor Yuemao Shen, Dr Yingjie Zhang

  32. Design, synthesis and primary activity assay of tripeptidomimetics as histone deacetylase inhibitors with linear linker and branched cap group

    Article • European Journal of Medicinal Chemistry, November 2011, Elsevier

    Dr Yingjie Zhang

  33. Discovery of a Tetrahydroisoquinoline-Based Hydroxamic Acid Derivative (ZYJ-34c) as Histone Deacetylase Inhibitor with Potent Oral Antitumor Activities

    Article • Journal of Medicinal Chemistry, August 2011, American Chemical Society (ACS)

    Dr Yingjie Zhang

  34. Design, synthesis and biological evaluation of tyrosine-based hydroxamic acid analogs as novel histone deacetylases (HDACs) inhibitors

    Article • Bioorganic & Medicinal Chemistry, August 2011, Elsevier

    Dr Yingjie Zhang

  35. Development of Tetrahydroisoquinoline-Based Hydroxamic Acid Derivatives: Potent Histone Deacetylase Inhibitors with Marked in Vitro and in Vivo Antitumor Activities

    Article • Journal of Medicinal Chemistry, April 2011, American Chemical Society (ACS)

    Dr Yingjie Zhang

  36. Applications and Modifications of 1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid (Tic) in Peptides and Peptidomimetics Design and Discovery

    Article • Current Protein and Peptide Science, December 2010, Bentham Science Publishers

    Dr Yingjie Zhang

  37. Design, synthesis and preliminary activity assay of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as novel Histone deacetylases (HDACs) inhibitors

    Article • Bioorganic & Medicinal Chemistry, March 2010, Elsevier

    Dr Yingjie Zhang

  38. The Structure and Function of Histone Deacetylases: The Target for Anti-cancer Therapy

    Article • Current Medicinal Chemistry, November 2008, Bentham Science Publishers

    Dr Yingjie Zhang

  39. Progress on Kinesin Spindle Protein Inhibitors as Anti-Cancer Agents

    Article • Anti-Cancer Agents in Medicinal Chemistry, August 2008, Bentham Science Publishers

    Dr Yingjie Zhang

  40. Progress on Kinesin Spindle Protein Inhibitors as Anti-Cancer Agents

    Article • Anti-Cancer Agents in Medicinal Chemistry, August 2008, Bentham Science Publishers

    Dr Yingjie Zhang