All Stories

  1. Survey of Drug Oxidation Activities in Hepatic and Intestinal Microsomes of Individual Common Marmosets, a New Nonhuman Primate Animal Model

    Article • Current Drug Metabolism, April 2019, Bentham Science Publishers

    Professor Hiroshi Yamazaki, Yasuhiro Uno

  2. Functionally relevant genetic variants of glutathione S-transferase GSTM5 in cynomolgus and rhesus macaques

    Article • Xenobiotica, September 2018, Taylor & Francis

    Professor Hiroshi Yamazaki, Yasuhiro Uno

  3. Limited expression of functional cytochrome p450 2c subtypes in the liver and small intestine of domestic cats

    Article • Xenobiotica, July 2018, Taylor & Francis

    Yasuhiro Uno

  4. Marmoset cytochrome P450 2B6, a propofol hydroxylase expressed in liver

    Article • Xenobiotica, February 2018, Taylor & Francis

    Professor Hiroshi Yamazaki, Yasuhiro Uno

  5. Molecular cloning and tissue distribution of a novel marmoset ABC transporter

    Article • Biopharmaceutics & Drug Disposition, December 2017, Wiley

    Professor Hiroshi Yamazaki, Yasuhiro Uno

  6. Development of genotyping method for functionally relevant variants of cytochromes P450 in cynomolgus macaques

    Article • Journal of Veterinary Pharmacology and Therapeutics, July 2017, Wiley

    Professor Hiroshi Yamazaki, Yasuhiro Uno

  7. Effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome P450 probes caffeine, warfarin, omeprazole, metoprolol and midazolam in common marmosets genotyped for cytochrome P450 2C19

    Article • Xenobiotica, July 2017, Taylor & Francis

    Professor Hiroshi Yamazaki, Yasuhiro Uno

  8. Marmoset pulmonary cytochrome P450 2F1 oxidizes biphenyl and 7-ethoxycoumarin and hepatic human P450 substrates

    Article • Xenobiotica, July 2017, Taylor & Francis

    Professor Hiroshi Yamazaki, Yasuhiro Uno

  9. Efavirenz clearances in vitro and in vivo in six cynomolgus monkeys associated with polymorphic cytochrome P450 2C9 and simulated by individual physiologically based pharmacokinetic models

    Article • Biopharmaceutics & Drug Disposition, July 2017, Wiley

    Professor Hiroshi Yamazaki, Yasuhiro Uno

  10. Hepatic expression of cytochrome P450 enzymes in non-human primate species

    Article • Journal of Medical Primatology, June 2017, Wiley

    Professor Hiroshi Yamazaki, Yasuhiro Uno

  11. Functional characterization and tissue expression of marmoset cytochrome P450 2E1

    Article • Biopharmaceutics & Drug Disposition, June 2017, Wiley

    Professor Hiroshi Yamazaki, Yasuhiro Uno

  12. Terfenadine t-butyl hydroxylation catalyzed by human and marmoset cytochrome P450 3A and 4F enzymes in livers and small intestines

    Article • Xenobiotica, May 2017, Taylor & Francis

    Professor Hiroshi Yamazaki, Yasuhiro Uno

  13. Pre-incubation with cyclosporine A potentiates its inhibitory effects on pitavastatin uptake mediated by recombinantly expressed cynomolgus monkey hepatic organic anion transporting polypeptide

    Article • Biopharmaceutics & Drug Disposition, October 2016, Wiley

    Yasuhiro Uno

  14. In vivoindividual variations in pharmacokinetics of efavirenz in cynomolgus monkeys genotyped for cytochrome P450 2C9

    Article • Biopharmaceutics & Drug Disposition, September 2016, Wiley

    Professor Hiroshi Yamazaki, Yasuhiro Uno

  15. Identification of putative substrates for cynomolgus monkey cytochrome P450 2C8 by substrate depletion assays with 22 human P450 substrates and inhibitors

    Article • Biopharmaceutics & Drug Disposition, July 2016, Wiley

    Professor Hiroshi Yamazaki, Yasuhiro Uno

  16. Analysis of gene expression for microminipig liver transcriptomes using parallel long-read technology and short-read sequencing

    Article • Biopharmaceutics & Drug Disposition, May 2016, Wiley

    Professor Hiroshi Yamazaki, Yasuhiro Uno

  17. Similar substrate specificity of cynomolgus monkey cytochrome P450 2C19 to reported human P450 2C counterpart enzymes by evaluation of 89 drug clearances

    Article • Biopharmaceutics & Drug Disposition, December 2015, Wiley

    Professor Hiroshi Yamazaki, Yasuhiro Uno