Contact

All Stories

  1. Polyphenols of cambuci (Campomanesia phaea (O. Berg.)) fruit ameliorate insulin resistance and hepatic steatosis in obese mice

    Article • Food Chemistry, March 2021, Elsevier

    Ph.D. William T Festuccia

  2. Liver lipidome signature and metabolic pathways in nonalcoholic fatty liver disease induced by a high-sugar diet

    Article • The Journal of Nutritional Biochemistry, January 2021, Elsevier

    Ph.D. William T Festuccia

  3. Mild-cold water swimming does not exacerbate white adipose tissue browning and brown adipose tissue activation in mice

    Article • Journal of Physiology and Biochemistry, October 2020, Springer Science + Business Media

    Ph.D. William T Festuccia

  4. Palmitoleic acid reduces high fat diet-induced liver inflammation by promoting PPAR-γ-independent M2a polarization of myeloid cells

    Article • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, October 2020, Elsevier

    Ph.D. William T Festuccia

  5. Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise

    Article • Proceedings of the National Academy of Sciences, September 2020, Proceedings of the National Academy of Sciences

    Ph.D. William T Festuccia

  6. Interleukin-6 and the Gut Microbiota Influence Melanoma Progression in Obese Mice

    Article • Nutrition and Cancer, May 2020, Taylor & Francis

    Ph.D. William T Festuccia

  7. Depletion of Ric-8B leads to reduced mTORC2 activity

    Article • PLoS Genetics, May 2020, PLOS

    Ph.D. William T Festuccia, Bettina Malnic

  8. Lipoatrophy‐Associated Insulin Resistance and Hepatic Steatosis are Attenuated by Intake of Diet Rich in Omega 3 Fatty Acids

    Article • Molecular Nutrition & Food Research, April 2020, Wiley

    Ph.D. William T Festuccia

  9. Regulation of Adipocyte and Macrophage Functions by mTORC1 and 2 in Metabolic Diseases

    Article • Molecular Nutrition & Food Research, March 2020, Wiley

    Ph.D. William T Festuccia

  10. The Hepatokine TSK does not affect brown fat thermogenic capacity, body weight gain, and glucose homeostasis

    Article • Molecular Metabolism, December 2019, Elsevier

    Ph.D. William T Festuccia, Dr Alexandre Caron

  11. Dietary sulfur amino acid restriction upregulates DICER to confer beneficial effects

    Article • Molecular Metabolism, November 2019, Elsevier

    Ph.D. William T Festuccia

  12. Human Cachexia Induces Changes in Mitochondria, Autophagy and Apoptosis in the Skeletal Muscle

    Article • Cancers, August 2019, MDPI AG

    Ph.D. William T Festuccia

  13. The hepatokine Tsukushi is released in response to NAFLD and impacts cholesterol homeostasis

    Article • JCI Insight, August 2019, American Society for Clinical Investigation

    Dr Alexandre Caron, Ph.D. William T Festuccia

  14. Leukotriene‐B4 modulates macrophage metabolism and fat loss in type 1 diabetic mice

    Article • Journal of Leukocyte Biology, June 2019, Wiley

    Ph.D. William T Festuccia

  15. Depletion of Ric-8B leads to reduced mTORC2 activity

    Article • June 2019, Cold Spring Harbor Laboratory Press

    Ph.D. William T Festuccia

  16. Sympathetic Regulation of Slc2a4 Gene Expression: Participation of a Putative cAMP Responsive Element (CRE) Site in the Slc2a4 Promoter

    Article • Cellular Physiology and Biochemistry, March 2019, Cell Physiol Biochem Press GmbH and Co KG

    Ph.D. William T Festuccia

  17. Eicosapentaenoic Acid Reduces Adiposity, Glucose Intolerance and Increases Oxygen Consumption Independently of Uncoupling Protein 1

    Article • Molecular Nutrition & Food Research, February 2019, Wiley

    Ph.D. William T Festuccia

  18. Immunometabolism: Molecular Mechanisms, Diseases, and Therapies 2018

    Article • Mediators of Inflammation, January 2019, Hindawi Publishing Corporation

    Ph.D. William T Festuccia

  19. Fish Oil Protects Wild Type and Uncoupling Protein 1‐Deficient Mice from Obesity and Glucose Intolerance by Increasing Energy Expenditure

    Article • Molecular Nutrition & Food Research, January 2019, Wiley

    Ph.D. William T Festuccia

  20. PPARγ is a major regulator of branched-chain amino acid blood levels and catabolism in white and brown adipose tissues

    Article • Metabolism, December 2018, Elsevier

    Dr Alexandre Caron, Ph.D. William T Festuccia

  21. Exercise rescues the immune response fine-tuned impaired by peroxisome proliferator-activated receptors γ deletion in macrophages

    Article • Journal of Cellular Physiology, September 2018, Wiley

    Ph.D. William T Festuccia

  22. Integrated Proteomics Reveals Apoptosis-related Mechanisms Associated with Placental Malaria*

    Article • Molecular & Cellular Proteomics, September 2018, American Society for Biochemistry & Molecular Biology (ASBMB)

    Ph.D. William T Festuccia, Dr. Claudio Romero Farias Marinho

  23. Demethylation and epigenetic modification with 5-Azacytidine reduces IDH1 mutant glioma growth in combination with Temozolomide

    Article • Neuro-Oncology, September 2018, Oxford University Press (OUP)

    Ph.D. William T Festuccia

  24. Interscapular brown adipose tissue denervation does not promote the oxidative activity of inguinal white adipose tissue in male mice

    Article • AJP Endocrinology and Metabolism, August 2018, American Physiological Society

    Dr Alexandre Caron, Ph.D. William T Festuccia

  25. Constitutive Activation of the Nutrient Sensor mTORC1 in Myeloid Cells Induced by Tsc1 Deletion Protects Mice from Diet-Induced Obesity

    Article • Molecular Nutrition & Food Research, August 2018, Wiley

    Ph.D. William T Festuccia

  26. Regulation of Metabolic Disease-Associated Inflammation by Nutrient Sensors

    Article • Mediators of Inflammation, July 2018, Hindawi Publishing Corporation

    Ph.D. William T Festuccia

  27. Cagaita fruit ( Eugenia dysenterica DC.) and obesity: Role of polyphenols on already established obesity

    Article • Food Research International, January 2018, Elsevier

    Ph.D. William T Festuccia

  28. Regulation of adiposity by mTORC1

    Article • Einstein (São Paulo), December 2017, FapUNIFESP (SciELO)

    Ph.D. William T Festuccia

  29. A novel peptide that improves metabolic parameters without adverse central nervous system effects

    Article • Scientific Reports, November 2017, Springer Science + Business Media

    Ph.D. William T Festuccia

  30. Adipocyte mTORC1 deficiency promotes adipose tissue inflammation and NLRP3 inflammasome activation via oxidative stress and de novo ceramide synthesis

    Article • Journal of Lipid Research, July 2017, American Society for Biochemistry & Molecular Biology (ASBMB)

    Ph.D. William T Festuccia

  31. Dectin-1 Activation Exacerbates Obesity and Insulin Resistance in the Absence of MyD88

    Article • Cell Reports, June 2017, Elsevier

    Ph.D. William T Festuccia

  32. mTORC1 inhibition with rapamycin exacerbates adipose tissue inflammation in obese mice and dissociates macrophage phenotype from function

    Article • Immunobiology, February 2017, Elsevier

    Ph.D. William T Festuccia

  33. Turning up the heat against metabolic syndrome and non-alcoholic fatty liver disease

    Article • Clinical Science, January 2017, Portland Press Ltd.

    Ph.D. William T Festuccia

  34. Critical review of beige adipocyte thermogenic activation and contribution to whole-body energy expenditure

    Article • Hormone Molecular Biology and Clinical Investigation, January 2017, De Gruyter

    Ph.D. William T Festuccia

  35. Immunometabolism: Molecular Mechanisms, Diseases, and Therapies 2016

    Article • Mediators of Inflammation, January 2017, Hindawi Publishing Corporation

    Ph.D. William T Festuccia

  36. mTORC1 is Required for Brown Adipose Tissue Recruitment and Metabolic Adaptation to Cold

    Article • Scientific Reports, November 2016, Nature

    Dr Alexandre Caron, Ph.D. William T Festuccia

  37. High-fat diet-induced hypertension and autonomic imbalance are associated with an upregulation of CART in the dorsomedial hypothalamus of mice

    Article • Physiological Reports, June 2016, Wiley

    Ph.D. William T Festuccia

  38. Fat-specific Dicer deficiency accelerates aging and mitigates several effects of dietary restriction in mice

    Article • Aging, May 2016, Impact Journals, LLC

    Ph.D. William T Festuccia

  39. Constitutive adipocyte mTORC1 activation enhances mitochondrial activity and reduces visceral adiposity in mice

    Article • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, May 2016, Elsevier

    Ph.D. William T Festuccia

  40. Peroxisome proliferator-activated receptorγactivation favours selective subcutaneous lipid deposition by coordinately regulating lipoprotein lipase modulators, fatty acid transporters and lipogenic enzymes

    Article • Acta Physiologica, March 2016, Wiley

    Ph.D. William T Festuccia

  41. Hypothalamic stearoyl-CoA desaturase-2 (SCD2) controls whole-body energy expenditure

    Article • International Journal of Obesity, September 2015, Nature

    Ph.D. William T Festuccia

  42. Regulation of brown adipose tissue recruitment, metabolism and thermogenic function by peroxisome proliferator-activated receptorγ

    Article • Temperature, March 2015, Taylor & Francis

    Ph.D. William T Festuccia

  43. Omega-3 fatty acids protect from diet-induced obesity, glucose intolerance, and adipose tissue inflammation through PPARγ-dependent and PPARγ-independent actions

    Article • Molecular Nutrition & Food Research, March 2015, Wiley

    Ph.D. William T Festuccia

  44. Phenolic compounds from cambuci (Campomanesia phaea O. Berg) fruit attenuate glucose intolerance and adipose tissue inflammation induced by a high-fat, high-sucrose diet

    Article • Food Research International, March 2015, Elsevier

    Ph.D. William T Festuccia

  45. PP082-MON: HER2-Associated Lipogenic Phenotype Modulation by Docosahexaenoic Acid (DHA) Induces Apoptosis in Breast Tumor Cells Harboring HER2 Overexpression

    Article • Clinical Nutrition, September 2014, Elsevier

    Ph.D. William T Festuccia

  46. Myeloid-Specific Rictor Deletion Induces M1 Macrophage Polarization and Potentiates In Vivo Pro-Inflammatory Response to Lipopolysaccharide

    Article • PLoS ONE, April 2014, PLOS

    Ph.D. William T Festuccia

  47. PPAR  activation attenuates glucose intolerance induced by mTOR inhibition with rapamycin in rats

    Article • AJP Endocrinology and Metabolism, March 2014, American Physiological Society

    Ph.D. William T Festuccia

  48. Immunometabolism: Molecular Mechanisms, Diseases, and Therapies

    Article • Mediators of Inflammation, January 2014, Hindawi Publishing Corporation

    Ph.D. William T Festuccia

  49. Palmitoleate attenuates diet induced insulin resistance and hepatic inflammation independently of PPAR-α

    Article • Cancer & Metabolism, January 2014, Springer Science + Business Media

    Ph.D. William T Festuccia

  50. Palmitoleic acid (n-7) increases white adipocytes GLUT4 content and glucose uptake in association with AMPK activation

    Article • Lipids in Health and Disease, January 2014, Springer Science + Business Media

    Ph.D. William T Festuccia

  51. Palmitoleic acid (n-7) increases white adipocyte lipolysis and lipase content in a PPARα-dependent manner

    Article • AJP Endocrinology and Metabolism, November 2013, American Physiological Society

    Ph.D. William T Festuccia

  52. A comparative perspective on lipid storage in animals

    Article • Journal of Cell Science, April 2013, The Company of Biologists

    Ph.D. William T Festuccia

  53. PPAR  activation attenuates cold-induced upregulation of thyroid status and brown adipose tissue PGC-1  and D2

    Article • AJP Regulatory Integrative and Comparative Physiology, October 2012, American Physiological Society

    Ph.D. William T Festuccia

  54. DEPTOR Cell-Autonomously Promotes Adipogenesis, and Its Expression Is Associated with Obesity

    Article • Cell Metabolism, August 2012, Elsevier

    Ph.D. William T Festuccia

  55. Tributyrin attenuates obesity-associated inflammation and insulin resistance in high-fat-fed mice

    Article • AJP Endocrinology and Metabolism, July 2012, American Physiological Society

    Ph.D. William T Festuccia

  56. Major involvement of mTOR in the PPAR -induced stimulation of adipose tissue lipid uptake and fat accretion

    Article • Journal of Lipid Research, March 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Ph.D. William T Festuccia

  57. Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: importance of the mitochondrial function

    Article • Lipids in Health and Disease, January 2012, Springer Science + Business Media

    Ph.D. William T Festuccia

  58. Control of Brown Adipose Tissue Glucose and Lipid Metabolism by PPARγ

    Article • Frontiers in Endocrinology, January 2011, Frontiers

    Ph.D. William T Festuccia

  59. Basal adrenergic tone is required for maximal stimulation of rat brown adipose tissue UCP1 expression by chronic PPAR-  activation

    Article • AJP Regulatory Integrative and Comparative Physiology, April 2010, American Physiological Society

    Ph.D. William T Festuccia

  60. Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue

    Article • Diabetes, March 2010, American Diabetes Association

    Ph.D. William T Festuccia

  61. Hypothalamic Actions of Tumor Necrosis Factor α Provide the Thermogenic Core for the Wastage Syndrome in Cachexia

    Article • Endocrinology, February 2010, Endocrine Society

    Ph.D. William T Festuccia

  62. Preliminary report: pharmacologic 11β-hydroxysteroid dehydrogenase type 1 inhibition increases hepatic fat oxidation in vivo and expression of related genes in rats fed an obesogenic diet

    Article • Metabolism, January 2010, Elsevier

    Ph.D. William T Festuccia

  63. Depot specificities of PPARγ ligand actions on lipid and glucose metabolism and their implication in PPARγ-mediated body fat redistribution

    Article • Clinical Lipidology, October 2009, Future Medicine

    Ph.D. William T Festuccia

  64. Rosiglitazone-induced heart remodelling is associated with enhanced turnover of myofibrillar protein and mTOR activation

    Article • Journal of Molecular and Cellular Cardiology, July 2009, Elsevier

    Ph.D. William T Festuccia

  65. Additive action of 11β-HSD1 inhibition and PPAR-γ agonism on hepatic steatosis and triglyceridemia in diet-induced obese rats

    Article • International Journal of Obesity, February 2009, Nature

    Ph.D. William T Festuccia

  66. The PPAR  agonist rosiglitazone enhances rat brown adipose tissue lipogenesis from glucose without altering glucose uptake

    Article • AJP Regulatory Integrative and Comparative Physiology, February 2009, American Physiological Society

    Ph.D. William T Festuccia

  67. Depot-specific effects of the PPAR  agonist rosiglitazone on adipose tissue glucose uptake and metabolism

    Article • Journal of Lipid Research, February 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Ph.D. William T Festuccia

  68. Tissue-specific postprandial clearance is the major determinant of PPAR -induced triglyceride lowering in the rat

    Article • AJP Regulatory Integrative and Comparative Physiology, October 2008, American Physiological Society

    Ph.D. William T Festuccia

  69. Peroxisome Proliferator-Activated Receptor-γ-Mediated Positive Energy Balance in the Rat Is Associated with Reduced Sympathetic Drive to Adipose Tissues and Thyroid Status

    Article • Endocrinology, May 2008, Endocrine Society

    Ph.D. William T Festuccia

  70. 11beta-HSD1 inhibition improves triglyceridemia through reduced liver VLDL secretion and partitions lipids toward oxidative tissues

    Article • AJP Endocrinology and Metabolism, July 2007, American Physiological Society

    Ph.D. William T Festuccia

  71. Depot-Specific Modulation of Rat Intraabdominal Adipose Tissue Lipid Metabolism by Pharmacological Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1

    Article • Endocrinology, May 2007, Endocrine Society

    Ph.D. William T Festuccia

  72. Involvement of adipose tissues in the early hypolipidemic action of PPAR  agonism in the rat

    Article • AJP Regulatory Integrative and Comparative Physiology, December 2006, American Physiological Society

    Ph.D. William T Festuccia

  73. Mechanisms of the Depot Specificity of Peroxisome Proliferator-Activated Receptor   Action on Adipose Tissue Metabolism

    Article • Diabetes, September 2006, American Diabetes Association

    Ph.D. William T Festuccia

  74. PPARγ agonism increases rat adipose tissue lipolysis, expression of glyceride lipases, and the response of lipolysis to hormonal control

    Article • Diabetologia, August 2006, Springer Science + Business Media

    Ph.D. William T Festuccia

  75. Increased glyceroneogenesis in adipose tissue from rats adapted to a high-protein, carbohydrate-free diet: role of dietary fatty acids

    Article • Metabolism, January 2006, Elsevier

    Ph.D. William T Festuccia

  76. Adaptation to a high protein, carbohydrate-free diet induces a marked reduction of fatty acid synthesis and lipogenic enzymes in rat adipose tissue that is rapidly reverted by a balanced diet

    Article • Canadian Journal of Physiology and Pharmacology, June 2005, Canadian Science Publishing

    Ph.D. William T Festuccia

  77. Brown adipose tissue glyceroneogenesis is activated in rats exposed to cold

    Article • Pflügers Archiv - European Journal of Physiology, November 2004, Springer Science + Business Media

    Ph.D. William T Festuccia

  78. Sympathetic innervation of white adipose tissue and its regulation of fat cell number

    Article • AJP Regulatory Integrative and Comparative Physiology, June 2004, American Physiological Society

    Ph.D. William T Festuccia

  79. Control of glyceroneogenic activity in rat brown adipose tissue

    Article • AJP Regulatory Integrative and Comparative Physiology, July 2003, American Physiological Society

    Ph.D. William T Festuccia

  80. Expression of glycerokinase in brown adipose tissue is stimulated by the sympathetic nervous system

    Article • AJP Regulatory Integrative and Comparative Physiology, June 2003, American Physiological Society

    Ph.D. William T Festuccia

  81. Glucose uptake, glucose transporter GLUT4, and glycolytic enzymes in brown adipose tissue from rats adapted to a high-protein diet

    Article • Metabolism, November 2002, Elsevier

    Ph.D. William T Festuccia

  82. Glycerokinase activity in brown adipose tissue: a sympathetic regulation?

    Article • AJP Regulatory Integrative and Comparative Physiology, April 2002, American Physiological Society

    Ph.D. William T Festuccia

  83. Consumo máximo de oxigênio e limiar anaeróbio de jogadores de futebol: comparação entre as diferentes posições

    Article • April 2002, FapUNIFESP (SciELO)

    Ph.D. William T Festuccia