All Stories

  1. scMMO-atlas: a single cell multimodal omics atlas and portal for exploring fine cell heterogeneity and cell dynamics
  2. Decreased GATA3 levels cause changed mouse cutaneous innate lymphoid cell fate, facilitating hair follicle recycling
  3. Single cell analyses of cancer cells identified two regulatorily and functionally distinct categories in differentially expressed genes among tumor subclones
  4. The chromatin accessibility dynamics during cell fate specifications in zebrafish early embryogenesis
  5. Single-cell transcriptomic analysis of chondrocytes in cartilage and pathogenesis of osteoarthritis
  6. Sirpα on tumor-associated myeloid cells restrains antitumor immunity in colorectal cancer independent of its interaction with CD47
  7. The bone–liver interaction modulates immune and hematopoietic function through Pinch-Cxcl12-Mbl2 pathway
  8. Proline uptake promotes activation of lymphoid tissue inducer cells to maintain gut homeostasis
  9. The chromatin accessibility dynamics during cell fate specifications in zebrafish early embryogenesis
  10. Differentiation and migration of hematopoietic stem and progenitor cells cross multiple tissues
  11. Exploring the dynamics and influencing factors of CD4 T cell activation using single-cell RNA-seq
  12. A fast and globally optimal solution for RNA-seq quantification
  13. Progress in single-cell multimodal sequencing and multi-omics data integration
  14. Glucose-induced CRL4COP1-p53 axis amplifies glycometabolism to drive tumorigenesis
  15. Single cell analyses of cancer cells identified two regulatorily and functionally distinct categories in differentially expressed genes among tumor subclones
  16. Anti-PD-1 therapy achieves favorable outcomes in HBV-positive non-liver cancer
  17. Mapping of alternative polyadenylation site usage at single-cell resolution
  18. Dissecting Complex Traits Using Omics Data: A Review on the Linear Mixed Models and Their Application in GWAS
  19. ISSAAC-seq enables sensitive and flexible multimodal profiling of chromatin accessibility and gene expression in single cells
  20. Sensitive, flexible and modular single-cell multi-omics profiling with ISSAAC-seq
  21. Dynamics, signals and influencing factors of CD4 T cell activation revealed by single cell RNA-seq
  22. Anti-PD1 therapy achieved better outcomes in non-liver cancer patients with HBV infection
  23. Single-Cell RNA Sequencing Unravels Upregulation of Immune Cell Crosstalk in Relapsed Pediatric Ependymoma
  24. Single-cell RNA Sequencing of Pediatric Ependymoma Unravels Subclonal Heterogeneity Associated with Patient Survival
  25. ISSAAC-seq enables sensitive and flexible multimodal profiling of chromatin accessibility and gene expression in single cells
  26. Cross-Tissue Characterization of Heterogeneities of Mesenchymal Stem Cells and Their Differentiation Potentials
  27. Reinvestigation of Classic T Cell Subsets and Identification of Novel Cell Subpopulations by Single-Cell RNA Sequencing
  28. Comprehensive mapping of the alternative polyadenylation site usage and its dynamics at single cell resolution
  29. A Comprehensive Characterization of Monoallelic Expression During Hematopoiesis and Leukemogenesis via Single-Cell RNA-Sequencing
  30. A topology-preserving dimensionality reduction method for single-cell RNA-seq data using graph autoencoder
  31. The Tyrosine Kinase-Driven Networks of Novel Long Non-coding RNAs and Their Molecular Targets in Myeloproliferative Neoplasms
  32. A plate-based single-cell ATAC-seq workflow for fast and robust profiling of chromatin accessibility
  33. Mesenchymal stem cell subpopulations and their heterogeneity of response to inductions revealed by single-cell RNA-seq
  34. Kssd: sequence dimensionality reduction by k-mer substring space sampling enables real-time large-scale datasets analysis
  35. scGAE: topology-preserving dimensionality reduction for single-cell RNA-seq data using graph autoencoder
  36. Re-investigation of classic T cell subsets and identification of novel cell subpopulations by single-cell RNA sequencing
  37. Integrated decoding hematopoiesis and leukemogenesis using single-cell sequencing and its medical implication
  38. Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice
  39. Reclassification of classic T cell subsets and identification of novel cell types by single-cell RNA sequencing
  40. Single-Cell Transcriptome Analysis Reveals Six Subpopulations Reflecting Distinct Cellular Fates in Senescent Mouse Embryonic Fibroblasts
  41. Diploid genome architecture revealed by multi-omic data of hybrid mice
  42. Inhibition of Glycolysis in Pathogenic TH17 Cells through Targeting a miR -21–Peli1–c-Rel Pathway Prevents Autoimmunity
  43. The MicroRNA miR-22 Represses Th17 Cell Pathogenicity by Targeting PTEN-Regulated Pathways
  44. Integrated decoding hematopoiesis and leukemogenesis at single-cell resolution and its clinical implication
  45. Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice
  46. H4K20me3 methyltransferase SUV420H2 shapes the chromatin landscape of pluripotent embryonic stem cells
  47. Visualization of Single Cell RNA-Seq Data Using t-SNE in R
  48. Exploring the Changing Landscape of Cell-to-Cell Variation After CTCF Knockdown via Single Cell RNA-seq
  49. Exploring the changing landscape of cell-to-cell variation after CTCF knockdown via single cell RNA-seq
  50. Exploring the Changing Landscape of Cell-to-Cell Variation After CTCF Knockdown via Single Cell RNA-seq
  51. Exploring the Changing Landscape of Cell-to-Cell Variation After CTCF Knockdown via Single Cell RNA-seq
  52. Principles of 3D Nucleus Organization and Epigenetic Regulation in Diploid Genome Revealed by Multi-omic Data from Hybrid Mouse
  53. Accumulated degeneration of transcriptional regulation contributes to disease development and detrimental clinical outcomes of Alzheimer’s disease
  54. Sequences Dimensionality-Reduction by K-mer Substring Space Sampling Enables Effective Resemblance- and Containment-Analysis for Large-Scale omics-data
  55. Publisher Correction: Principles of nucleosome organization revealed by single-cell micrococcal nuclease sequencing
  56. Principles of nucleosome organization revealed by single-cell micrococcal nuclease sequencing
  57. Trac-looping measures genome structure and chromatin accessibility
  58. Transformation of Accessible Chromatin and 3D Nucleome Underlies Lineage Commitment of Early T Cells
  59. Deregulation of TGF-β1 signaling induces glycolysis by chromatin remodeling in pathogenic TH17 cells
  60. CTCF-Mediated Enhancer-Promoter Interaction Is a Critical Regulator of Cell-to-Cell Variation of Gene Expression
  61. Genome-wide identification of histone H2A and histone variant H2A.Z-interacting proteins by bPPI-seq
  62. Erratum to: Genome-wide incorporation dynamics reveal distinct categories of turnover for the histone variant H3.3
  63. Genome-wide detection of DNase I hypersensitive sites in single cells and FFPE tissue samples
  64. Evaluating information content of SNPs for sample-tagging in re-sequencing projects
  65. A genome wide pattern of population structure and admixture in peninsular Malaysia Malays
  66. Y Chromosomes of 40% Chinese Descend from Three Neolithic Super-Grandfathers
  67. Copy number variations and genetic admixtures in three Xinjiang ethnic minority groups
  68. Distribution of ancestral chromosomal segments in admixed genomes and its implications for inferring population history and admixture mapping
  69. Association of Two Variants in SMAD7 with the Risk of Congenital Heart Disease in the Han Chinese Population
  70. A panel of ancestry informative markers to estimate and correct potential effects of population stratification in Han Chinese
  71. Genome-wide incorporation dynamics reveal distinct categories of turnover for the histone variant H3.3
  72. Exploring Population Admixture Dynamics via Empirical and Simulated Genome-wide Distribution of Ancestral Chromosomal Segments
  73. A systematic characterization of genes underlying both complex and Mendelian diseases
  74. Genome-wide detection of natural selection in African Americans pre- and post-admixture
  75. A Map of Copy Number Variations in Chinese Populations
  76. A Genome-Wide Search for Signals of High-Altitude Adaptation in Tibetans
  77. Genomic Dissection of Population Substructure of Han Chinese and Its Implication in Association Studies
  78. Haplotype-Sharing Analysis Showing Uyghurs Are Unlikely Genetic Donors