All Stories

  1. Mechanisms of early placental development in mouse and humans

    Article • Nature Reviews Genetics, September 2019, Springer Science + Business Media

    Dr Wendy Dean

  2. Maternal DNA Methylation Regulates Early Trophoblast Development

    Article • Developmental Cell, January 2016, Elsevier

    Dr Wendy Dean, Vicente Perez-Garcia

  3. Pathways of DNA Demethylation

    Article • January 2016, Springer Science + Business Media

    Dr Wendy Dean

  4. Genome-wide Bisulfite Sequencing in Zygotes Identifies Demethylation Targets and Maps the Contribution of TET3 Oxidation

    Article • Cell Reports, December 2014, Elsevier

    Dr Wendy Dean

  5. Epigenetic memory of the first cell fate decision prevents complete ES cell reprogramming into trophoblast

    Article • Nature Communications, November 2014, Springer Science + Business Media

    Dr Wendy Dean

  6. Processive DNA Demethylation via DNA Deaminase-Induced Lesion Resolution

    Article • PLoS ONE, July 2014, PLOS

    Dr Wendy Dean

  7. First Cell Fate Decisions in Early Development

    Article • January 2014, Elsevier

    Dr Wendy Dean

  8. DNA methylation and demethylation: A pathway to gametogenesis and development

    Article • Molecular Reproduction and Development, December 2013, Wiley

    Dr Wendy Dean

  9. Active demethylation in mouse zygotes involves cytosine deamination and base excision repair

    Article • Epigenetics & Chromatin, November 2013, Springer Science + Business Media

    Dr Cristina Rada, Dr Wendy Dean

  10. Single-cell Hi-C reveals cell-to-cell variability in chromosome structure

    Article • Nature, September 2013, Springer Science + Business Media

    Dr Wendy Dean

  11. FGF Signaling Inhibition in ESCs Drives Rapid Genome-wide Demethylation to the Epigenetic Ground State of Pluripotency

    Article • Cell Stem Cell, September 2013, Elsevier

    Dr Wendy Dean

  12. Regulation of Lineage Specific DNA Hypomethylation in Mouse Trophectoderm

    Article • PLoS ONE, June 2013, PLOS

    Dr Wendy Dean

  13. The Dynamics of Genome-wide DNA Methylation Reprogramming in Mouse Primordial Germ Cells

    Article • Molecular Cell, December 2012, Elsevier

    Dr Bernard Thienpont, Dr Wendy Dean

  14. Reprogramming DNA methylation in the mammalian life cycle: building and breaking epigenetic barriers

    Article • Philosophical Transactions of the Royal Society B Biological Sciences, November 2012, Royal Society Publishing

    Dr Wendy Dean

  15. Epigenetic Regulation of Oocyte Function and Developmental Potential

    Article • October 2012, Springer Science + Business Media

    Dr Wendy Dean

  16. Maintenance of Silent Chromatin through Replication Requires SWI/SNF-like Chromatin Remodeler SMARCAD1

    Article • Molecular Cell, May 2011, Elsevier

    Dr Wendy Dean

  17. Evaluation of epigenetic marks in human embryos derived from IVF and ICSI

    Article • Human Reproduction, July 2010, Oxford University Press (OUP)

    Dr Wendy Dean

  18. Epigenetic regulation of imprinting, reprogramming, and lineage commitment in mammals

    Article • New Biotechnology, April 2010, Elsevier

    Dr Wendy Dean

  19. Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency

    Article • Nature, January 2010, Springer Science + Business Media

    Dr Wendy Dean

  20. Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal

    Article • Nature Reviews Molecular Cell Biology, July 2009, Springer Science + Business Media

    Dr Wendy Dean

  21. Gene Dosage Effects of the Imprinted Delta-Like Homologue 1 (Dlk1/Pref1) in Development: Implications for the Evolution of Imprinting

    Article • PLoS Genetics, February 2009, PLOS

    Dr Wendy Dean

  22. Imprinted Genes and the Coordination of Fetal and Postnatal Growth in Mammals

    Article • October 2008, Wiley

    Dr Wendy Dean

  23. Epigenetic restriction of embryonic cell lineage fate by methylation of Elf5

    Article • Nature Cell Biology, October 2008, Springer Science + Business Media

    Dr Wendy Dean

  24. Cathepsin proteases have distinct roles in trophoblast function and vascular remodelling

    Article • Development, August 2008, The Company of Biologists

    Dr Wendy Dean

  25. The elusive Dnmt1 and its role during early development

    Article • Epigenetics, July 2008, Taylor & Francis

    Dr Wendy Dean

  26. Global Mapping of DNA Methylation in Mouse Promoters Reveals Epigenetic Reprogramming of Pluripotency Genes

    Article • PLoS Genetics, June 2008, PLOS

    Dr Wendy Dean

  27. Epigenetic Signatures - A Gateway to Lineage Determination.

    Article • Biology of Reproduction, May 2008, Oxford University Press (OUP)

    Dr Wendy Dean

  28. Structural differences in centromeric heterochromatin are spatially reconciled on fertilisation in the mouse zygote

    Article • Chromosoma, April 2007, Springer Science + Business Media

    Dr Wendy Dean, Aline Probst

  29. Epigenetic Arbitration of Cell Fate Decisions: Tipping the Bias

    Article • Developmental Cell, February 2007, Elsevier

    Dr Wendy Dean

  30. A developmental window of opportunity for imprinted gene silencing mediated by DNA methylation and the Kcnq1ot1 noncoding RNA

    Article • Mammalian Genome, January 2007, Springer Science + Business Media

    Dr Wendy Dean

  31. Epigenetic Modification Is Central to Genome Reprogramming in Somatic Cell Nuclear Transfer

    Article • Stem Cells, April 2006, Wiley

    Dr Wendy Dean

  32. Regulation of Placental Efficiency for Nutrient Transport by Imprinted Genes

    Article • Placenta, April 2006, Elsevier

    Dr Wendy Dean

  33. Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems

    Article • Proceedings of the National Academy of Sciences, December 2005, Proceedings of the National Academy of Sciences

    Dr Wendy Dean

  34. Dynamic chromatin modifications characterise the first cell cycle in mouse embryos

    Article • Developmental Biology, April 2005, Elsevier

    Dr Wendy Dean

  35. Mammalian Epigenomics: Reprogramming the Genome for Development and Therapy

    Article • March 2005, Wiley

    Dr Wendy Dean

  36. DNA methylation in mammalian development and disease

    Article • Birth Defects Research Part C Embryo Today Reviews, January 2005, Wiley

    Dr Wendy Dean

  37. Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation

    Article • Nature Genetics, October 2004, Springer Science + Business Media

    Dr Wendy Dean

  38. Activation-induced Cytidine Deaminase Deaminates 5-Methylcytosine in DNA and Is Expressed in Pluripotent Tissues

    Article • Journal of Biological Chemistry, September 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Wendy Dean

  39. Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM

    Article • Journal of Clinical Investigation, August 2004, American Society for Clinical Investigation

    Dr Wendy Dean

  40. The imprinted signaling protein XLαs is required for postnatal adaptation to feeding

    Article • Nature Genetics, July 2004, Springer Science + Business Media

    Dr Wendy Dean

  41. Epigenetic reprogramming during early development in mammals

    Article • Reproduction, June 2004, Bioscientifica

    Dr Wendy Dean

  42. Placental-specific insulin-like growth factor 2 ( Igf2 ) regulates the diffusional exchange characteristics of the mouse placenta

    Article • Proceedings of the National Academy of Sciences, May 2004, Proceedings of the National Academy of Sciences

    Dr Wendy Dean

  43. IMPRINTING AND EPIGENETIC REPROGRAMMING IN MAMMALIAN DEVELOPMENT

    Article • Cold Spring Harbor Symposia on Quantitative Biology, January 2004, Cold Spring Harbor Laboratory Press

    Dr Wendy Dean

  44. Chromosome Loops, Insulators, and Histone Methylation: New Insights into Regulation of Imprinting in Clusters

    Article • Cold Spring Harbor Symposia on Quantitative Biology, January 2004, Cold Spring Harbor Laboratory Press

    Dr Wendy Dean

  45. Chromosome Loops, Insulators, and Histone Methylation: New Insights into Regulation of Imprinting in Clusters

    Article • Cold Spring Harbor Symposia on Quantitative Biology, January 2004, Cold Spring Harbor Laboratory Press

    Dr Wendy Dean

  46. Epigenetic asymmetry in the mammalian zygote and early embryo: relationship to lineage commitment?

    Article • Philosophical Transactions of the Royal Society B Biological Sciences, August 2003, Royal Society Publishing

    Dr Wendy Dean

  47. Epigenetic Marking Correlates with Developmental Potential in Cloned Bovine Preimplantation Embryos

    Article • Current Biology, July 2003, Elsevier

    Dr Wendy Dean

  48. Silent clones speak up

    Article • Nature, May 2003, Springer Science + Business Media

    Dr Wendy Dean

  49. Epigenetic reprogramming in early mammalian development and following somatic nuclear transfer

    Article • Seminars in Cell and Developmental Biology, February 2003, Elsevier

    Dr Wendy Dean

  50. Regulation of supply and demand for maternal nutrients in mammals by imprinted genes

    Article • The Journal of Physiology, February 2003, Wiley

    Dr Wendy Dean

  51. Regulation of supply and demand for maternal nutrients in mammals by imprinted genes

    Article • The Journal of Physiology, January 2003, Wiley

    Dr Wendy Dean

  52. Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse

    Article • genesis, January 2003, Wiley

    Dr Wendy Dean

  53. Mammalian epigenomics: reprogramming the genome for development and therapy

    Article • Theriogenology, January 2003, Elsevier

    Dr Wendy Dean

  54. Epigenetic reprogramming: Back to the beginning

    Article • Nature, November 2002, Springer Science + Business Media

    Dr Wendy Dean

  55. Nucleus Replacement in Mammalian Oocytes

    Article • Cloning and Stem Cells, September 2002, Mary Ann Liebert Inc

    Dr Wendy Dean

  56. The mouse Zac1 locus: basis for imprinting and comparison with human ZAC

    Article • Gene, June 2002, Elsevier

    Dr Wendy Dean

  57. Placental-specific IGF-II is a major modulator of placental and fetal growth

    Article • Nature, June 2002, Springer Science + Business Media

    Dr Wendy Dean

  58. Generation of Monoparental Embryos for Investigation into Genomic Imprinting

    Article • January 2002, Springer Science + Business Media

    Dr Wendy Dean

  59. Dynamic Reprogramming of DNA Methylation in the Early Mouse Embryo

    Article • Developmental Biology, January 2002, Elsevier

    Dr Wendy Dean

  60. An intragenic methylated region in the imprintedIgf2gene augments transcription

    Article • EMBO Reports, December 2001, Wiley

    Dr Wendy Dean

  61. Conservation of methylation reprogramming in mammalian development: Aberrant reprogramming in cloned embryos

    Article • Proceedings of the National Academy of Sciences, November 2001, Proceedings of the National Academy of Sciences

    Dr Wendy Dean

  62. DNA methylation and mammalian epigenetics

    Article • Electrophoresis, August 2001, Wiley

    Dr Wendy Dean

  63. Genomic imprinting: Mother maintains methylation marks

    Article • Current Biology, July 2001, Elsevier

    Dr Wendy Dean

  64. Culture of preimplantation embryos and its long-term effects on gene expression and phenotype

    Article • Human Reproduction Update, July 2001, Oxford University Press (OUP)

    Dr Wendy Dean

  65. Epigenetic targeting in the mouse zygote marks DNA for later methylation: a mechanism for maternal effects in development

    Article • Mechanisms of Development, May 2001, Elsevier

    Dr Wendy Dean

  66. Environmental effects on genomic imprinting in mammals

    Article • Toxicology Letters, March 2001, Elsevier

    Dr Wendy Dean

  67. Deletion of a silencer element in Igf2 results in loss of imprinting independent of H19

    Article • Nature Genetics, October 2000, Springer Science + Business Media

    Dr Wendy Dean

  68. Active demethylation of the paternal genome in the mouse zygote

    Article • Current Biology, April 2000, Elsevier

    Dr Wendy Dean

  69. Igf2 imprinting in development and disease

    Article • January 2000, Springer Science + Business Media

    Dr Wendy Dean

  70. Overexpression of Insulin-Like Growth Factor-II in Transgenic Mice Is Associated with Pancreatic Islet Cell Hyperplasia1

    Article • Endocrinology, May 1999, Endocrine Society

    Dr Wendy Dean

  71. Evidence that Hoxa expression domains are evolutionarily transposed in spinal ganglia, and are established by forward spreading in paraxial mesoderm

    Article • Mechanisms of Development, April 1999, Elsevier

    Dr Wendy Dean

  72. Control of fetal growth by genomic imprinting

    Article • Biochemical Society Transactions, February 1999, Portland Press Ltd.

    Dr Wendy Dean

  73. Syntenic Organization of the Mouse Distal Chromosome 7 Imprinting Cluster and the Beckwith-Wiedemann Syndrome Region in Chromosome 11p15.5

    Article • Human Molecular Genetics, July 1998, Oxford University Press (OUP)

    Dr Wendy Dean

  74. The 5′ hypermutation boundary of x chains is independent of local and neighbouring sequences and related to the distance from the initiation of transcription

    Article • European Journal of Immunology, December 1997, Wiley

    Dr Cristina Rada, Dr Wendy Dean

  75. Loss of the maternal H19 gene induces changes in Igf 2 methylation in both cis and trans

    Article • Proceedings of the National Academy of Sciences, September 1997, Proceedings of the National Academy of Sciences

    Dr Wendy Dean

  76. Epigenetic inheritance in the mouse

    Article • Current Biology, April 1997, Elsevier

    Dr Wendy Dean

  77. Dynamic methylation adjustment and counting as part of imprinting mechanisms.

    Article • Proceedings of the National Academy of Sciences, June 1996, Proceedings of the National Academy of Sciences

    Dr Wendy Dean

  78. Haldane's rule and heterogametic female and male sterility in the mouse

    Article • Genome, April 1994, Canadian Science Publishing

    Dr Wendy Dean

  79. Relocalization of small ribonucleoprotein particles (snRNPs) during the first cell cycle of mouse embryo development is independent of RNA synthesis, DNA synthesis and cytokinesis

    Article • Cell Differentiation and Development, July 1990, Elsevier

    Dr Wendy Dean

  80. Localization and expression of U1 RNA in early mouse embryo development

    Article • Developmental Biology, June 1988, Elsevier

    Gerald Schatten, Dr Wendy Dean

  81. Effect of delaying DNA replication on blastocyst formation in the mouse

    Article • Differentiation, June 1984, Elsevier

    Dr Wendy Dean

  82. Using Immunofluorescence to Observe Methylation Changes in Mammalian Preimplantation Embryos

    Article • Springer Science + Business Media

    Dr Wendy Dean