All Stories

  1. Sulfated Alginate for Biomedical Applications
  2. Amphiphilic Heparinoids as Potent Antiviral Agents against SARS-CoV-2
  3. Site-Selective Photobromination of O-Acetylated Carbohydrates in Benzotrifluoride
  4. Origins of Temperature‐Dependent Anomeric Selectivity in Glycosylations with an L‐Idose Thioglycoside
  5. Antiviral Activities of Heparan Sulfate Mimetic RAFT Polymers Against Mosquito-borne Viruses
  6. Synthesis of sulfated alginate from its tributylammonium salt: Comparing the sulfating agents H2SO4-DCC and SO3·py
  7. Identification of a Pentasaccharide Lead Compound with High Affinity to the SARS-CoV-2 Spike Protein via In Silico Screening
  8. C-5 Epimerisation of D-Mannopyranosyl Fluorides: The Influence of Anomeric Configuration on Radical Reactivity
  9. Substrate reduction therapy in aDrosophila melanogastermodel of Sanfilippo syndrome
  10. A prohibitin-targeting drug modifies aspects of disease in a mouse model of Sanfilippo syndrome
  11. Synthesis of Uronic Acid 1‐Azasugars as Putative Inhibitors of α‐Iduronidase, β‐Glucuronidase and Heparanase**
  12. Siderophore conjugates to combat antibiotic-resistant bacteria
  13. An Enzymatic Activity Assay for Heparanase That Is Useful for Evaluating Clinically Relevant Inhibitors and Studying Kinetics
  14. Synthesis of a Gal-β-(1→4)-Gal disaccharide as a ligand for the fimbrial adhesin UcaD
  15. Evidence for Multiple Binding Modes in the Initial Contact Between SARS‐CoV‐2 Spike S1 Protein and Cell Surface Glycans**
  16. An Improved Protocol for the Stereoselective Synthesis of β-d-Glycosyl Fluorides from 2-O-Acyl Thioglycosides
  17. Initial contact between SARS-CoV-2 spike S1 protein and cell surface glycans involves multiple binding modes
  18. Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike–ACE2 Interaction
  19. Au‐NHC complexes with thiocarboxylate ligands: Synthesis, structure, stability, thiol exchange and in vitro anticancer activity
  20. Tumour cell-activated platelets modulate the immunological activity of CD4+, CD8+, and NK cells, which is efficiently antagonized by heparin
  21. Structural Insights into Pixatimod (PG545) Inhibition of Heparanase, a Key Enzyme in Cancer and Viral Infections
  22. SARS-CoV-2 Triggers Complement Activation through Interactions with Heparan Sulfate
  23. SARS‐CoV‐2 triggers complement activation through interactions with heparan sulfate
  24. Development of Improved Synthetic Routes to Pixatimod (PG545), a Sulfated Oligosaccharide-Steroid Conjugate
  25. From Cancer to COVID‐19: A Perspective on Targeting Heparan Sulfate‐Protein Interactions
  26. Corrigendum: Heparanase Promotes Syndecan-1 Expression to Mediate Fibrillar Collagen and Mammographic Density in Human Breast Tissue Cultured ex vivo
  27. A Substituent‐Directed Strategy for the Selective Synthesis of L‐Hexoses: An Expeditious Route to L‐Idose
  28. Inhibition of Tumor–Host Cell Interactions Using Synthetic Heparin Mimetics
  29. Evidence of a putative glycosaminoglycan binding site on the glycosylated SARS-CoV-2 spike protein N-terminal domain
  30. Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin
  31. GlycoTorch Vina: Docking Designed and Tested for Glycosaminoglycans
  32. Heparanase Promotes Syndecan-1 Expression to Mediate Fibrillar Collagen and Mammographic Density in Human Breast Tissue Cultured ex vivo
  33. Sulfonated RAFT Copolymers as Heparin Mimetics: Synthesis, Reactivity Ratios, and Anticoagulant Activity
  34. A Fluorogenic Heparan Sulfate Disaccharide for the Measurement of Heparanase Activity
  35. Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 By Disrupting The Spike-ACE2 interaction
  36. Heparanase promotes Syndecan-1 expression to mediate fibrillar collagen and mammographic density in human breast tissue cultured ex vivo
  37. GlycoTorch Vina: Improved Docking of Sulfated Sugars Using QM-derived Scoring Functions
  38. PI-88 and Related Heparan Sulfate Mimetics
  39. Mucopolysaccharidosis type II (Hunter syndrome): Clinical and biochemical aspects of the disease and approaches to its diagnosis and treatment
  40. Structural insights into heparanase activity using a fluorogenic heparan sulfate disaccharide
  41. Anticoagulant Heparin Mimetics via RAFT Polymerization
  42. Synthetic Disaccharide Standards Enable Quantitative Analysis of Stored Heparan Sulfate in MPS IIIA Murine Brain Regions
  43. PG545 treatment reduces RRV-induced elevations of AST, ALT with secondary lymphoid organ alterations in C57BL/6 mice
  44. Dual targeting of dengue virus virions and NS1 protein with the heparan sulfate mimic PG545
  45. In Vitro Enzymatic Digestibility of Glutaraldehyde-Crosslinked Chitosan Nanoparticles in Lysozyme Solution and Their Applicability in Pulmonary Drug Delivery
  46. Cross-Species Analysis of Glycosaminoglycan Binding Proteins Reveals Some Animal Models Are “More Equal” than Others
  47. The Development of Assays for Heparanase Enzymatic Activity: Towards a Gold Standard
  48. Applications of Ion Mobility-Mass Spectrometry in Carbohydrate Chemistry and Glycobiology
  49. Structural and conformational studies of the heparan sulfate mimetic PI-88
  50. Glycosylations of Simple Acceptors with 2-O -Acyl l -Idose or l -Iduronic Acid Donors Reveal Only a Minor Role for Neighbouring-Group Participation
  51. Heparin mimetics with anticoagulant activity
  52. Prophylactic Antiheparanase Activity by PG545 Is Antiviral In Vitro and Protects against Ross River Virus Disease in Mice
  53. Synthesis and mass spectrometric analysis of disaccharides from methanolysis of heparan sulfate
  54. New structural insights into the oligosaccharide phosphate fraction of Pichia ( Hansenula ) holstii NRRL Y2448 phosphomannan
  55. Carbohydrate– N -heterocyclic carbene metal complexes: Synthesis, catalysis and biological studies
  56. Glycosaminoglycans and Their Mimetics
  57. Effects of Chemical Conjugation of l-Leucine to Chitosan on Dispersibility and Controlled Release of Drug from a Nanoparticulate Dry Powder Inhaler Formulation
  58. Recent advances in chitosan-based nanoparticulate pulmonary drug delivery
  59. Synthesis of Mannose-Cholesterol Conjugates for Targeted Liposomal Drug Delivery
  60. The Tortoise and the Hare: Evolving Regulatory Landscapes for Biosimilars
  61. The stereoselectivities of tributyltin hydride-mediated reductions of 5-bromo-d-glucuronides tol-iduronides are dependent on the anomeric substituent: syntheses and DFT calculations
  62. Proteoglycans: Potential Agents in Mammographic Density and the Associated Breast Cancer Risk
  63. Investigations into the decomposition of aminoacyl-substituted monosaccharide scaffolds from a drug discovery library
  64. Synthetic Approaches to l-Iduronic Acid and l-Idose
  65. Synthesis and Toxicological Evaluation of a Chitosan- l -Leucine Conjugate for Pulmonary Drug Delivery Applications
  66. ChemInform Abstract: Attempted Synthesis of the Imidazylate (III) of an α-Hydroxylactone (I) Results in Unexpected Chlorination: Synthesis and X-Ray Crystal Structure of 5-Chloro-5-deoxy-1,2-O-isopropylidene-β-L-idurono-6,3-lactone (II).
  67. Attempted Synthesis of the Imidazylate of an α-Hydroxylactone Results in Unexpected Chlorination: Synthesis and X-Ray Crystal Structure of 5-Chloro-5-deoxy-1,2-O-isopropylidene-β-l-idurono-6,3-lactone
  68. Low-molecular-weight heparin biosimilars: potential implications for clinical practice
  69. 1H NMR spectroscopic studies establish that heparanase is a retaining glycosidase
  70. Structure and stereochemistry of an anti-inflammatory anhydrosugar from the Australian marine sponge Plakinastrella clathrata and the synthesis of two analogues
  71. Heparan sulfate inhibitors and their therapeutic implications in inflammatory illnesses
  72. ChemInform Abstract: A Focused Sulfated Glycoconjugate Ugi Library for Probing Heparan Sulfate-Binding Angiogenic Growth Factors.
  73. MicroRNAs Regulate Tumor Angiogenesis Modulated by Endothelial Progenitor Cells
  74. A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors
  75. Synthesis of Disaccharides Containing 6-Deoxy-a-L-talose as Potential Heparan Sulfate Mimetics
  76. Synthesis of a Heparan Sulfate Mimetic Library Targeting FGF and VEGF via Click Chemistry on a Monosaccharide Template
  77. Discovery of PG545: A Highly Potent and Simultaneous Inhibitor of Angiogenesis, Tumor Growth, and Metastasis
  78. Potent anti-respiratory syncytial virus activity of a cholestanol-sulfated tetrasaccharide conjugate
  79. PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models
  80. Synthesis of simple heparanase substrates
  81. Lipophile-conjugated sulfated oligosaccharides as novel microbicides against HIV-1
  82. A highly lipophilic sulfated tetrasaccharide glycoside related to muparfostat (PI-88) exhibits virucidal activity against herpes simplex virus
  83. Synthesis and Biological Evaluation of Polysulfated Oligosaccharide Glycosides as Inhibitors of Angiogenesis and Tumor Growth
  84. Development of a colorimetric assay for heparanase activity suitable for kinetic analysis and inhibitor screening
  85. Synthesis of a heparan sulfate mimetic disaccharide with a conformationally locked residue from a common intermediate
  86. ChemInform Abstract: An Improved Synthetic Route to the Potent Angiogenesis Inhibitor Benzyl Manα(1→3)Manα(1→3)-Manα (1→3)Manα(1→2)-Man Hexadecasulfate.
  87. The PG500 series: novel heparan sulfate mimetics as potent angiogenesis and heparanase inhibitors for cancer therapy
  88. An Improved Synthetic Route to the Potent Angiogenesis Inhibitor Benzyl Manα(1→3)-Manα(1→3)-Manα(1→3)-Manα(1→2)-Man Hexadecasulfate
  89. A surface plasmon resonance-based solution affinity assay for heparan sulfate-binding proteins
  90. Synthesis and heparanase inhibitory activity of sulfated mannooligosaccharides related to the antiangiogenic agent PI-88
  91. Design, synthesis, FGF-1 binding, and molecular modeling studies of conformationally flexible heparin mimetic disaccharides
  92. Molecular basis for resistance of herpes simplex virus type 1 mutants to the sulfated oligosaccharide inhibitor PI-88
  93. Herpes Simplex Virus Type 2 Glycoprotein G Is Targeted by the Sulfated Oligo- and Polysaccharide Inhibitors of Virus Attachment to Cells
  94. PI-88 and Novel Heparan Sulfate Mimetics Inhibit Angiogenesis
  95. Enantiospecific synthesis of the heparanase inhibitor (+)-trachyspic acid and stereoisomers from a common precursor
  96. Inhibition of Plasmodium falciparum Growth In Vitro and Adhesion to Chondroitin-4-Sulfate by the Heparan Sulfate Mimetic PI-88 and Other Sulfated Oligosaccharides
  97. Synthesis, Biological Activity, and Preliminary Pharmacokinetic Evaluation of Analogues of a Phosphosulfomannan Angiogenesis Inhibitor (PI-88)
  98. Towards the synthesis of aryl glucuronides as potential heparanase probes. An interesting outcome in the glycosidation of glucuronic acid with 4-hydroxycinnamic acid
  99. The Synthesis and Biological Evaluation of Two Analogues of the C-Riboside Showdomycin.
  100. Use of Sulfated Linked Cyclitols as Heparan Sulfate Mimetics to Probe the Heparin/Heparan Sulfate Binding Specificity of Proteins
  101. The Synthesis and Biological Evaluation of Two Analogues of the C -Riboside Showdomycin
  102. The synthesis of phosphorylated disaccharide components of the extracellular phosphomannan of Pichia (Hansenula) holstii NRRL Y-2448
  103. A Synthetic Heparanase Inhibitor Reduces Proteinuria in Passive Heymann Nephritis
  104. Application of the Four-Component Ugi Condensation for the Preparation of Sulfated Glycoconjugate Libraries.
  105. The Development of Inhibitors of Heparanase, a Key Enzyme Involved in Tumour Metastasis, Angiogenesis and Inflammation
  106. The low molecular weight heparan sulfate-mimetic, PI-88, inhibits cell-to-cell spread of herpes simplex virus
  107. Application of the four-component Ugi condensation for the preparation of sulfated glycoconjugate libraries
  108. Probing the Interactions of Phosphosulfomannans with Angiogenic Growth Factors by Surface Plasmon Resonance
  109. Preparation and anticoagulant activity of the phosphosulfomannan PI-88
  110. PROBING THE INTERACTIONS OF PI-88 WITH ANGIOGENIC GROWTH FACTORS BY SURFACE PLASMON RESONANCE
  111. SULFATED OLIGOSACCHARIDE-BASED INHIBITORS OF TUMOUR GROWTH AND METASTASIS
  112. INHIBITION OF HERPES SIMPLEX VIRUS INFECTION BY PI-88, AN ANTAGONIST OF HEPARAN SULFATE-PROTEIN INTERACTIONS
  113. HEPARAN SULFATE-MIMETICS AS INHIBITORS OF CANCER
  114. Determination of the composition of the oligosaccharide phosphate fraction of Pichia (Hansenula) holstii NRRL Y-2448 phosphomannan by capillary electrophoresis and HPLC
  115. Synthesis of [14C]- and [35S]-labelled PI-88 for pharmacokinetic and tissue distribution studies
  116. Characterisation of the Anticoagulant Properties of a Range of Structurally Diverse Sulfated Oligosaccharides
  117. Large-scale preparation of the oligosaccharide phosphate fraction of Pichia holstii NRRL Y-2448 phosphomannan for use in the manufacture of PI-88
  118. Article
  119. Convergent synthesis of a fluorescence-quenched glycopeptide as a potential substrate for peptide: N-glycosidases
  120. N-Glycosyl phosphonamidates: potential transition-state analogue inhibitors of glycopeptidases
  121. Internally quenched fluorogenic, α-helical dimeric peptides and glycopeptides for the evaluation of the effect of glycosylation on the conformation of peptides
  122. The Synthesis of Some Epoxyalkyl b-C-Glycosides as Potential Inhibitors of b-Glucan Hydrolases
  123. Analysis of the1H NMR spectra of some diethyl phosphonates
  124. Synthesis of 2′- and 2″-O-acylated maltotriosides as potential fluorescence-quenched substrates for α-amylase
  125. Approaches to the Synthesis of Retronecine From Some Pyrrolidine Precursors
  126. The Synthesis of Some Pyrrolidines as Potential Precursors to Retronecine
  127. An Improvement in the Preparation of Some Carbohydrate Benzylidene Acetals