All Stories

  1. Synthetic glycol-split heparin tri- and tetrasaccharides provide new insights into structural peculiarities for antiheparanase activity
  2. A Heparan Sulfate Mimetic RAFT Copolymer Inhibits SARS‐CoV‐2 Infection and Ameliorates Viral‐Induced Inflammation
  3. Synthetic Access to l-Guluronic Acid via Fluorine-Directed C-5 Epimerization
  4. Synthesis of a deuterated disaccharide internal standard for LC-MS/MS quantitation of heparan sulfate in biological samples
  5. Sulfated Alginate for Biomedical Applications
  6. Amphiphilic Heparinoids as Potent Antiviral Agents against SARS-CoV-2
  7. Site-Selective Photobromination of O-Acetylated Carbohydrates in Benzotrifluoride
  8. Origins of Temperature‐Dependent Anomeric Selectivity in Glycosylations with an L‐Idose Thioglycoside
  9. Site-Selective Photobromination of O-Acetylated Carbohydrates in Benzotrifluoride
  10. Synthetic Access to L-Guluronic Acid via Fluorine-Directed C-5 Epimerization
  11. Antiviral Activities of Heparan Sulfate Mimetic RAFT Polymers Against Mosquito-borne Viruses
  12. Synthesis of sulfated alginate from its tributylammonium salt: Comparing the sulfating agents H2SO4-DCC and SO3·py
  13. Synthesis of a Deuterated Disaccharide Internal Standard for Lc-Ms/Ms Quantitation of Heparan Sulfate  in Biological Samples
  14. Identification of a Pentasaccharide Lead Compound with High Affinity to the SARS-CoV-2 Spike Protein via In Silico Screening
  15. C-5 Epimerisation of D-Mannopyranosyl Fluorides: The Influence of Anomeric Configuration on Radical Reactivity
  16. Substrate reduction therapy in aDrosophila melanogastermodel of Sanfilippo syndrome
  17. A prohibitin-targeting drug modifies aspects of disease in a mouse model of Sanfilippo syndrome
  18. Synthesis of Uronic Acid 1‐Azasugars as Putative Inhibitors of α‐Iduronidase, β‐Glucuronidase and Heparanase**
  19. Siderophore conjugates to combat antibiotic-resistant bacteria
  20. An Enzymatic Activity Assay for Heparanase That Is Useful for Evaluating Clinically Relevant Inhibitors and Studying Kinetics
  21. Synthesis of a Gal-β-(1→4)-Gal disaccharide as a ligand for the fimbrial adhesin UcaD
  22. Evidence for Multiple Binding Modes in the Initial Contact Between SARS‐CoV‐2 Spike S1 Protein and Cell Surface Glycans**
  23. Synthesis of Uronic Acid 1-Azasugars as Putative Inhibitors of a-Iduronidase, b-Glucuronidase and Heparanase
  24. An Improved Protocol for the Stereoselective Synthesis of β-d-Glycosyl Fluorides from 2-O-Acyl Thioglycosides
  25. Initial contact between SARS-CoV-2 spike S1 protein and cell surface glycans involves multiple binding modes
  26. Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike–ACE2 Interaction
  27. Au‐NHC complexes with thiocarboxylate ligands: Synthesis, structure, stability, thiol exchange and in vitro anticancer activity
  28. Tumour cell-activated platelets modulate the immunological activity of CD4+, CD8+, and NK cells, which is efficiently antagonized by heparin
  29. Structural Insights into Pixatimod (PG545) Inhibition of Heparanase, a Key Enzyme in Cancer and Viral Infections
  30. SARS-CoV-2 Triggers Complement Activation through Interactions with Heparan Sulfate
  31. SARS‐CoV‐2 triggers complement activation through interactions with heparan sulfate
  32. Development of Improved Synthetic Routes to Pixatimod (PG545), a Sulfated Oligosaccharide-Steroid Conjugate
  33. From Cancer to COVID‐19: A Perspective on Targeting Heparan Sulfate‐Protein Interactions
  34. Corrigendum: Heparanase Promotes Syndecan-1 Expression to Mediate Fibrillar Collagen and Mammographic Density in Human Breast Tissue Cultured ex vivo
  35. A Substituent‐Directed Strategy for the Selective Synthesis of L‐Hexoses: An Expeditious Route to L‐Idose
  36. Inhibition of Tumor–Host Cell Interactions Using Synthetic Heparin Mimetics
  37. Evidence of a putative glycosaminoglycan binding site on the glycosylated SARS-CoV-2 spike protein N-terminal domain
  38. Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin
  39. GlycoTorch Vina: Docking Designed and Tested for Glycosaminoglycans
  40. Heparanase Promotes Syndecan-1 Expression to Mediate Fibrillar Collagen and Mammographic Density in Human Breast Tissue Cultured ex vivo
  41. Sulfonated RAFT Copolymers as Heparin Mimetics: Synthesis, Reactivity Ratios, and Anticoagulant Activity
  42. A Fluorogenic Heparan Sulfate Disaccharide for the Measurement of Heparanase Activity
  43. Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 By Disrupting The Spike-ACE2 interaction
  44. Heparanase promotes Syndecan-1 expression to mediate fibrillar collagen and mammographic density in human breast tissue cultured ex vivo
  45. GlycoTorch Vina: Improved Docking of Sulfated Sugars Using QM-derived Scoring Functions
  46. PI-88 and Related Heparan Sulfate Mimetics
  47. Mucopolysaccharidosis type II (Hunter syndrome): Clinical and biochemical aspects of the disease and approaches to its diagnosis and treatment
  48. Structural insights into heparanase activity using a fluorogenic heparan sulfate disaccharide
  49. Anticoagulant Heparin Mimetics via RAFT Polymerization
  50. Synthetic Disaccharide Standards Enable Quantitative Analysis of Stored Heparan Sulfate in MPS IIIA Murine Brain Regions
  51. PG545 treatment reduces RRV-induced elevations of AST, ALT with secondary lymphoid organ alterations in C57BL/6 mice
  52. Dual targeting of dengue virus virions and NS1 protein with the heparan sulfate mimic PG545
  53. In Vitro Enzymatic Digestibility of Glutaraldehyde-Crosslinked Chitosan Nanoparticles in Lysozyme Solution and Their Applicability in Pulmonary Drug Delivery
  54. Cross-Species Analysis of Glycosaminoglycan Binding Proteins Reveals Some Animal Models Are “More Equal” than Others
  55. The Development of Assays for Heparanase Enzymatic Activity: Towards a Gold Standard
  56. Applications of Ion Mobility-Mass Spectrometry in Carbohydrate Chemistry and Glycobiology
  57. Structural and conformational studies of the heparan sulfate mimetic PI-88
  58. Glycosylations of Simple Acceptors with 2-O -Acyl l -Idose or l -Iduronic Acid Donors Reveal Only a Minor Role for Neighbouring-Group Participation
  59. Heparin mimetics with anticoagulant activity
  60. Prophylactic Antiheparanase Activity by PG545 Is Antiviral In Vitro and Protects against Ross River Virus Disease in Mice
  61. Synthesis and mass spectrometric analysis of disaccharides from methanolysis of heparan sulfate
  62. New structural insights into the oligosaccharide phosphate fraction of Pichia ( Hansenula ) holstii NRRL Y2448 phosphomannan
  63. Carbohydrate– N -heterocyclic carbene metal complexes: Synthesis, catalysis and biological studies
  64. Glycosaminoglycans and Their Mimetics
  65. Effects of Chemical Conjugation of l-Leucine to Chitosan on Dispersibility and Controlled Release of Drug from a Nanoparticulate Dry Powder Inhaler Formulation
  66. Recent advances in chitosan-based nanoparticulate pulmonary drug delivery
  67. Synthesis of Mannose-Cholesterol Conjugates for Targeted Liposomal Drug Delivery
  68. The Tortoise and the Hare: Evolving Regulatory Landscapes for Biosimilars
  69. The stereoselectivities of tributyltin hydride-mediated reductions of 5-bromo-d-glucuronides tol-iduronides are dependent on the anomeric substituent: syntheses and DFT calculations
  70. Proteoglycans: Potential Agents in Mammographic Density and the Associated Breast Cancer Risk
  71. Investigations into the decomposition of aminoacyl-substituted monosaccharide scaffolds from a drug discovery library
  72. Synthetic Approaches to l-Iduronic Acid and l-Idose
  73. Synthesis and Toxicological Evaluation of a Chitosan- l -Leucine Conjugate for Pulmonary Drug Delivery Applications
  74. ChemInform Abstract: Attempted Synthesis of the Imidazylate (III) of an α-Hydroxylactone (I) Results in Unexpected Chlorination: Synthesis and X-Ray Crystal Structure of 5-Chloro-5-deoxy-1,2-O-isopropylidene-β-L-idurono-6,3-lactone (II).
  75. Attempted Synthesis of the Imidazylate of an α-Hydroxylactone Results in Unexpected Chlorination: Synthesis and X-Ray Crystal Structure of 5-Chloro-5-deoxy-1,2-O-isopropylidene-β-l-idurono-6,3-lactone
  76. Low-molecular-weight heparin biosimilars: potential implications for clinical practice
  77. 1H NMR spectroscopic studies establish that heparanase is a retaining glycosidase
  78. Structure and stereochemistry of an anti-inflammatory anhydrosugar from the Australian marine sponge Plakinastrella clathrata and the synthesis of two analogues
  79. Heparan sulfate inhibitors and their therapeutic implications in inflammatory illnesses
  80. ChemInform Abstract: A Focused Sulfated Glycoconjugate Ugi Library for Probing Heparan Sulfate-Binding Angiogenic Growth Factors.
  81. MicroRNAs Regulate Tumor Angiogenesis Modulated by Endothelial Progenitor Cells
  82. A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors
  83. Synthesis of Disaccharides Containing 6-Deoxy-a-L-talose as Potential Heparan Sulfate Mimetics
  84. Synthesis of a Heparan Sulfate Mimetic Library Targeting FGF and VEGF via Click Chemistry on a Monosaccharide Template
  85. Discovery of PG545: A Highly Potent and Simultaneous Inhibitor of Angiogenesis, Tumor Growth, and Metastasis
  86. Potent anti-respiratory syncytial virus activity of a cholestanol-sulfated tetrasaccharide conjugate
  87. PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models
  88. Synthesis of simple heparanase substrates
  89. Lipophile-conjugated sulfated oligosaccharides as novel microbicides against HIV-1
  90. A highly lipophilic sulfated tetrasaccharide glycoside related to muparfostat (PI-88) exhibits virucidal activity against herpes simplex virus
  91. Synthesis and Biological Evaluation of Polysulfated Oligosaccharide Glycosides as Inhibitors of Angiogenesis and Tumor Growth
  92. Development of a colorimetric assay for heparanase activity suitable for kinetic analysis and inhibitor screening
  93. Synthesis of a heparan sulfate mimetic disaccharide with a conformationally locked residue from a common intermediate
  94. ChemInform Abstract: An Improved Synthetic Route to the Potent Angiogenesis Inhibitor Benzyl Manα(1→3)Manα(1→3)-Manα (1→3)Manα(1→2)-Man Hexadecasulfate.
  95. The PG500 series: novel heparan sulfate mimetics as potent angiogenesis and heparanase inhibitors for cancer therapy
  96. An Improved Synthetic Route to the Potent Angiogenesis Inhibitor Benzyl Manα(1→3)-Manα(1→3)-Manα(1→3)-Manα(1→2)-Man Hexadecasulfate
  97. A surface plasmon resonance-based solution affinity assay for heparan sulfate-binding proteins
  98. Synthesis and heparanase inhibitory activity of sulfated mannooligosaccharides related to the antiangiogenic agent PI-88
  99. Design, synthesis, FGF-1 binding, and molecular modeling studies of conformationally flexible heparin mimetic disaccharides
  100. Molecular basis for resistance of herpes simplex virus type 1 mutants to the sulfated oligosaccharide inhibitor PI-88
  101. Herpes Simplex Virus Type 2 Glycoprotein G Is Targeted by the Sulfated Oligo- and Polysaccharide Inhibitors of Virus Attachment to Cells
  102. PI-88 and Novel Heparan Sulfate Mimetics Inhibit Angiogenesis
  103. Enantiospecific synthesis of the heparanase inhibitor (+)-trachyspic acid and stereoisomers from a common precursor
  104. Inhibition of Plasmodium falciparum Growth In Vitro and Adhesion to Chondroitin-4-Sulfate by the Heparan Sulfate Mimetic PI-88 and Other Sulfated Oligosaccharides
  105. Synthesis, Biological Activity, and Preliminary Pharmacokinetic Evaluation of Analogues of a Phosphosulfomannan Angiogenesis Inhibitor (PI-88)
  106. Towards the synthesis of aryl glucuronides as potential heparanase probes. An interesting outcome in the glycosidation of glucuronic acid with 4-hydroxycinnamic acid
  107. The Synthesis and Biological Evaluation of Two Analogues of the C-Riboside Showdomycin.
  108. Use of Sulfated Linked Cyclitols as Heparan Sulfate Mimetics to Probe the Heparin/Heparan Sulfate Binding Specificity of Proteins
  109. The Synthesis and Biological Evaluation of Two Analogues of the C -Riboside Showdomycin
  110. The synthesis of phosphorylated disaccharide components of the extracellular phosphomannan of Pichia (Hansenula) holstii NRRL Y-2448
  111. A Synthetic Heparanase Inhibitor Reduces Proteinuria in Passive Heymann Nephritis
  112. Application of the Four-Component Ugi Condensation for the Preparation of Sulfated Glycoconjugate Libraries.
  113. The Development of Inhibitors of Heparanase, a Key Enzyme Involved in Tumour Metastasis, Angiogenesis and Inflammation
  114. The low molecular weight heparan sulfate-mimetic, PI-88, inhibits cell-to-cell spread of herpes simplex virus
  115. Application of the four-component Ugi condensation for the preparation of sulfated glycoconjugate libraries
  116. Probing the Interactions of Phosphosulfomannans with Angiogenic Growth Factors by Surface Plasmon Resonance
  117. Preparation and anticoagulant activity of the phosphosulfomannan PI-88
  118. PROBING THE INTERACTIONS OF PI-88 WITH ANGIOGENIC GROWTH FACTORS BY SURFACE PLASMON RESONANCE
  119. SULFATED OLIGOSACCHARIDE-BASED INHIBITORS OF TUMOUR GROWTH AND METASTASIS
  120. INHIBITION OF HERPES SIMPLEX VIRUS INFECTION BY PI-88, AN ANTAGONIST OF HEPARAN SULFATE-PROTEIN INTERACTIONS
  121. HEPARAN SULFATE-MIMETICS AS INHIBITORS OF CANCER
  122. Determination of the composition of the oligosaccharide phosphate fraction of Pichia (Hansenula) holstii NRRL Y-2448 phosphomannan by capillary electrophoresis and HPLC
  123. Synthesis of [14C]- and [35S]-labelled PI-88 for pharmacokinetic and tissue distribution studies
  124. Characterisation of the Anticoagulant Properties of a Range of Structurally Diverse Sulfated Oligosaccharides
  125. Large-scale preparation of the oligosaccharide phosphate fraction of Pichia holstii NRRL Y-2448 phosphomannan for use in the manufacture of PI-88
  126. Article
  127. Convergent synthesis of a fluorescence-quenched glycopeptide as a potential substrate for peptide: N-glycosidases
  128. N-Glycosyl phosphonamidates: potential transition-state analogue inhibitors of glycopeptidases
  129. Internally quenched fluorogenic, α-helical dimeric peptides and glycopeptides for the evaluation of the effect of glycosylation on the conformation of peptides
  130. The Synthesis of Some Epoxyalkyl b-C-Glycosides as Potential Inhibitors of b-Glucan Hydrolases
  131. Analysis of the1H NMR spectra of some diethyl phosphonates
  132. Synthesis of 2′- and 2″-O-acylated maltotriosides as potential fluorescence-quenched substrates for α-amylase
  133. Approaches to the Synthesis of Retronecine From Some Pyrrolidine Precursors
  134. The Synthesis of Some Pyrrolidines as Potential Precursors to Retronecine
  135. An Improvement in the Preparation of Some Carbohydrate Benzylidene Acetals