All Stories

  1. Dual-peptide functionalized acetalated dextran-based nanoparticles for sequential targeting of macrophages during myocardial infarction

    Article • Nanoscale, January 2020, Royal Society of Chemistry

    Virpi Talman, Prof. Hélder Santos

  2. Missing Selectivity of Targeted 4β-Phorbol Prodrugs Expected to be Potential Chemotherapeutics

    Article • ACS Medicinal Chemistry Letters, December 2019, American Chemical Society (ACS)

    Virpi Talman, Professor Søren Brøgger Christensen

  3. Synthesis, Identification, and Structure–Activity Relationship Analysis of GATA4 and NKX2-5 Protein–Protein Interaction Modulators

    Article • Journal of Medicinal Chemistry, August 2019, American Chemical Society (ACS)

    Virpi Talman

  4. Abstract 924: The Role of Protein Kinase C Isoforms in Cardiomyocyte Hypertrophy

    Article • Circulation Research, August 2019, Wolters Kluwer Health

    Virpi Talman

  5. Abstract 781: Doxorubicin-Induced Cardiotoxicity and Novel GATA4-Targeted Compounds

    Article • Circulation Research, August 2019, Wolters Kluwer Health

    Virpi Talman

  6. Molecular Atlas of Postnatal Mouse Heart Development

    Article • Journal of the American Heart Association, October 2018, Wolters Kluwer Health

    Virpi Talman

  7. Protein kinase C -activating isophthalate derivatives mitigate Alzheimer's disease-related cellular alterations

    Article • Neuropharmacology, October 2018, Elsevier

    Virpi Talman

  8. Cardiomyocyte—Endothelial Cell Interactions in Cardiac Remodeling and Regeneration

    Article • Frontiers in Cardiovascular Medicine, July 2018, Frontiers

    Virpi Talman

  9. Stem cells are the most sensitive screening tool to identify toxicity of GATA4-targeted novel small-molecule compounds

    Article • Archives of Toxicology, July 2018, Springer Science + Business Media

    Virpi Talman

  10. Anticancer activity of the protein kinase C modulator HMI-1a3 in 2D and 3D cell culture models of androgen-responsive and androgen-unresponsive prostate cancer

    Article • FEBS Open Bio, April 2018, Wiley

    Virpi Talman

  11. Scaffold hopping from (5-hydroxymethyl) isophthalates to multisubstituted pyrimidines diminishes binding affinity to the C1 domain of protein kinase C

    Article • PLoS ONE, April 2018, PLOS

    Virpi Talman

  12. Dual-Drug Delivery Using Dextran-Functionalized Nanoparticles Targeting Cardiac Fibroblasts for Cellular Reprogramming

    Article • Advanced Functional Materials, January 2018, Wiley

    Virpi Talman, Prof. Hélder Santos

  13. Drug Delivery: Drug-Loaded Multifunctional Nanoparticles Targeted to the Endocardial Layer of the Injured Heart Modulate Hypertrophic Signaling (Small 33/2017)

    Article • Small, September 2017, Wiley

    Virpi Talman

  14. Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5

    Article • Journal of Medicinal Chemistry, August 2017, American Chemical Society (ACS)

    Virpi Talman

  15. Drug-Loaded Multifunctional Nanoparticles Targeted to the Endocardial Layer of the Injured Heart Modulate Hypertrophic Signaling

    Article • Small, July 2017, Wiley

    Prof. Hélder Santos, Virpi Talman

  16. Cardiac fibrosis in myocardial infarction—from repair and remodeling to regeneration

    Article • Cell and Tissue Research, June 2016, Springer Science + Business Media

    Virpi Talman

  17. Protein Kinase C Activation as a Potential Therapeutic Strategy in Alzheimer's Disease: Is there a Role for Embryonic Lethal Abnormal Vision-like Proteins?

    Article • Basic & Clinical Pharmacology & Toxicology, April 2016, Wiley

    Virpi Talman

  18. Beyond the affinity for protein kinase C: exploring 2-phenyl-3-hydroxypropyl pivalate analogues as C1 domain-targeting ligands

    Article • MedChemComm, January 2015, Royal Society of Chemistry

    Virpi Talman

  19. C1 domain-targeted isophthalates as protein kinase C modulators: structure-based design, structure–activity relationships and biological activities

    Article • Biochemical Society Transactions, November 2014, Portland Press Ltd.

    Virpi Talman

  20. Evidence for a role of MRCK in mediating HeLa cell elongation induced by the C1 domain ligand HMI-1a3

    Article • European Journal of Pharmaceutical Sciences, May 2014, Elsevier

    Virpi Talman

  21. The C1 domain-targeted isophthalate derivative HMI-1b11 promotes neurite outgrowth and GAP-43 expression through PKCα activation in SH-SY5Y cells

    Article • Pharmacological Research, July 2013, Elsevier

    Dr Cecilia Osera, Virpi Talman

  22. Stereoselective synthesis of (3-aminodecahydro-1,4-methanonaphthalen-2-yl)methanols targeted to the C1 domain of protein kinase C

    Article • Tetrahedron, November 2011, Elsevier

    Virpi Talman

  23. Correction: C1 Domain-Targeted Isophthalate Derivatives Induce Cell Elongation and Cell Cycle Arrest in HeLa Cells

    Article • PLoS ONE, June 2011, PLOS

    Virpi Talman

  24. Current Status and Future Prospects of C1 Domain Ligands as Drug Candidates

    Article • Current Topics in Medicinal Chemistry, June 2011, Bentham Science Publishers

    Virpi Talman

  25. C1 Domain-Targeted Isophthalate Derivatives Induce Cell Elongation and Cell Cycle Arrest in HeLa Cells

    Article • PLoS ONE, May 2011, PLOS

    Virpi Talman

  26. Design, Synthesis, and Biological Activity of Isophthalic Acid Derivatives Targeted to the C1 Domain of Protein Kinase C

    Article • Journal of Medicinal Chemistry, July 2009, American Chemical Society (ACS)

    Virpi Talman

  27. Screening of natural compounds and their derivatives as potential protein kinase C inhibitors

    Article • Drug Development Research, October 2004, Wiley

    Virpi Talman