All Stories

  1. Evaluating Blood–Brain Barrier Permeability, Cytotoxicity, and Activity of Potential Acetylcholinesterase Inhibitors: In Vitro and In Silico Study
  2. Cytostatic and cytotoxic effects of a hot water and methanol extract of Acokanthera oppositifolia in HepG2 hepatocarcinoma cells
  3. Comparative Evaluation of the Cytotoxicity of Doxorubicin in BT-20 Triple-Negative Breast Carcinoma Monolayer and Spheroid Cultures
  4. Highlights of basic and clinical pharmacology from Africa
  5. Utility of Therapeutic Drug Monitoring in Identifying Clinically Significant Interactions Between St. John's Wort and Prescription Drugs
  6. The VEGF/VEGFR Axis Revisited: Implications for Cancer Therapy
  7. Mechanisms facilitating the uptake of carboxyl–polythene glycol-functionalized gold nanoparticles into multicellular spheroids
  8. Design of Oleanolic Acid-based Hybrid Compounds as Potential Pharmaceutical Scaffolds
  9. Isolation and antioxidant activity of 5-methyldihydroflavasperone from ethanol leaf extract of Guiera senegalensis JF Gmel
  10. Synthesis, Antibacterial, and Cytotoxicity Evaluation of Oleanolic Acid-4-aminoquinoline Based Hybrid Compounds
  11. A Brief Updated Review of Advances to Enhance Resveratrol’s Bioavailability
  12. Zinc oxide nanoparticles induce oxidative stress and histopathological toxicity in the thyroid gland and liver of rats
  13. Protective effect of Erythrina senegalensis sequential extracts against oxidative stress in SC-1 fibroblasts and THP-1 macrophages
  14. Novel N-benzylpiperidine carboxamide derivatives as potential cholinesterase inhibitors for the treatment of Alzheimer's disease
  15. Physicochemical and in vitro cytotoxicity evaluation of polymeric drugs for combination cancer therapy
  16. Synthesis and biological evaluation of 2-chloro-3-[(thiazol-2-yl)amino]-1,4-naphthoquinones
  17. Drugged driving in South Africa: An urgent need for review and reform
  18. Drugged driving in South Africa: An urgent need for review and reform
  19. Natural Products and/or Isolated Compounds on Wound Healing
  20. Herbal remedies used in wound healing
  21. Bioavailability of resveratrol: Possibilities for enhancement
  22. Beneficial anti oxidant effects of folic acid in methomyl toxicity
  23. Bulb extracts of Boophone disticha induce hepatotoxicity by perturbing growth, without significantly impacting cellular viability
  24. Attenuation of oxidative stress and artificial wound closure in C2C12 myoblasts induced by sequential extracts of Boerhavia diffusa
  25. Extracts of Terminalia sericea Enhance Cell Migratory Activity of Endothelial Hybrid and Fibroblast Cells In Vitro
  26. Targeting Alzheimer's disease by investigating previously unexplored chemical space surrounding the cholinesterase inhibitor donepezil
  27. Fatalities involving illicit drug use in Pretoria, South Africa, for the period 2003 - 2012
  28. Application of a LC–MS/MS method developed for the determination of p‐phenylenediamine, N‐acetyl‐p‐phenylenediamine and N,N‐diacetyl‐p‐phenylenediamine in human urine specimens
  29. Standardization of cassava Mahewu fermentation and assessment of the effects of iron sources used for fortification
  30. Development and validation of an LC–MS/MS method for determination of p-phenylenediamine and its metabolites in blood samples
  31. Medicinal plants and their derivatives with amyloid beta inhibitory activity as potential targets for drug discovery
  32. Herbal use for certain medical conditions in South Africa
  33. The effects of the natural enzyme, Pectinex Ultra SP-L, on human cell cultures and bacterial biofilms in vitro
  34. In vitro neuroprotective potential of four medicinal plants against rotenone-induced toxicity in SH-SY5Y neuroblastoma cells
  35. In vitro determination of the anti-aging potential of four southern African medicinal plants
  36. Attenuation of oxidative stress in U937 cells by polyphenolic-rich bark fractions of Burkea africana and Syzygium cordatum
  37. In vitro effect of N-acetylcysteine on hepatocyte injury caused by dichlorodiphenyltrichloroethane and its metabolites
  38. Comparative Toxicity of Pentachlorophenol with its Metabolites tetrachloro-1,2-hydroquinone and Tetrachloro-1,4-benzoquinone in HepG2 Cells
  39. Cytotoxicity and acetylcholinesterase inhibitory activity of an isolated crinine alkaloid from Boophane disticha (Amaryllidaceae)
  40. Effect of an alkaloidal fraction of Tabernaemontana elegans (Stapf.) on selected micro-organisms
  41. Herbal remedies affecting coagulation: A review
  42. In vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from southern Africa
  43. Antioxidant and acetylcholinesterase inhibitory activity of selected southern African medicinal plants
  44. Drug interactions in African herbal remedies
  45. Effects of selected South African plant extracts on haemolysis and coagulation
  46. Use of Yokukansan (TJ‐54) in the treatment of neurological disorders: a review
  47. Toxicity Testing of Two Medicinal Plants, Bridelia micrantha and Antidesma venosum
  48. In-vitro bioactivity of Venda medicinal plants used in the treatment of respiratory conditions
  49. The ability of Warburgia salutaris extracts to protect against crystalline silica-induced cell injury
  50. Antibacterial activity of Venda medicinal plants
  51. Senecio latifolius induces in vitro hepatocytotoxicity in a human cell lineThis article is one of a selection of papers published in this special issue (part 2 of 2) on the Safety and Efficacy of Natural Health Products.
  52. Screening of Venda medicinal plants for antifungal activity against Candida albicans
  53. Evaluation of Athrixia bush tea for cytotoxicity, antioxidant activity, caffeine content and presence of pyrrolizidine alkaloids
  54. Medicinal Applications and Toxicological Activities ofAloe. Products
  55. Cytotoxicity of six South African medicinal plant extracts used in the treatment of cancer
  56. Studies on antibacterial, anti-inflammatory and antioxidant activity of herbal remedies used in the treatment of benign prostatic hyperplasia and prostatitis
  57. URANIUM CONCENTRATIONS IN SOUTH AFRICAN HERBAL REMEDIES
  58. Nephrotoxicity Associated With Exposure to Plant Toxins, With Particular Reference to Africa
  59. Antioxidant and genotoxic properties of South African herbal extracts
  60. GC/MS identification of toxic pyrrolizidine alkaloids in traditional remedies given to two sets of twins
  61. Adulteration of South African Traditional Herbal Remedies
  62. Acute Renal Failure Associated with the Use of Traditional Folk Remedies in South Africa
  63. Studies on antibacterial, antioxidant and fibroblast growth stimulation of wound healing remedies from South Africa
  64. Antioxidant scavenging potential of South African export herbal teas
  65. CNS effects after muti ingestion: what is the cause?
  66. Phytomedicines for the prostate
  67. Traditional herbal remedies used by South African women for gynaecological complaints
  68. Death Due to Use of Traditional Medicines in Africa: A Preventable Cause of Neonatal and Infant Mortality
  69. The cytotoxic effects of a traditional Zulu remedy, impila (Callilepis laureola)
  70. Structural characterization of chromone C‐glucosides in a toxic herbal remedy
  71. Hepatic veno-occlusive disease as a result of a traditional remedy: confirmation of toxic pyrrolizidine alkaloids as the cause, using an in vitro technique
  72. A severe case of multiple metal poisoning in a child treated with a traditional medicine
  73. A fatal case of pepper poisoning
  74. Gas chromatographic–mass spectrometric confirmation of atractyloside in a patient poisoned with Callilepis laureola
  75. Pyrrolizidine Poisoning: A Neglected Area in Human Toxicology
  76. The effect of Senecio latifolius a plant used as a South African traditional medicine, on a human hepatoma cell line
  77. Letters to the Editor
  78. The toxicity of Callilepis laureola, a South African traditional herbal medicine
  79. The Biochemistry and Toxicity of Atractyloside: A Review
  80. Metal concentrations in plants and urine from patients treated with traditional remedies
  81. Clinical and Analytical Aspects of Pyrrolizidine Poisoning Caused by South African Traditional Medicines
  82. Detection of poisoning by Impila (Callilepis laureola) in a mother and child
  83. The Toxicology of African Herbal Remedies
  84. Purification and characterization of progesterone-binding globulin in the pregnant Cape porcupine, Hystrix africaeaustralis
  85. Concentrations of plasma total and unbound progesterone and testosterone during pregnancy in Cape porcupines, Hystrix africaeaustralis
  86. Sex-specific androgen binding in spotted hyaena (Crocuta crocuta) plasma
  87. Properties of proteins binding plasma progesterone in pregnant Cape porcupines (Hystrix africaeaustralis)
  88. Reproductive inhibition in the Cape porcupine, Hystrix africaeaustralis