All Stories

  1. Understanding tuberculosis transmission and progression: A prospective cohort study of index cases and close contacts in Moldova

    Article • PLoS ONE, December 2024, PLOS

    Dr Valeriu Crudu

  2. Classification of unsequenced Mycobacterium tuberculosis strains in a high-burden setting using a pairwise logistic regression approach

    Article • December 2024, Society for General Microbiology

    Dr Valeriu Crudu

  3. Author Correction: The recent rapid expansion of multidrug resistant Ural lineage Mycobacterium tuberculosis in Moldova

    Article • Nature Communications, October 2024, Springer Science + Business Media

    Dr Valeriu Crudu

  4. Impact and cost-effectiveness of the 6-month BPaLM regimen for rifampicin-resistant tuberculosis in Moldova: A mathematical modeling analysis

    Article • PLoS Medicine, May 2024, PLOS

    Dr Valeriu Crudu

  5. Comparison of QTc interval changes in drug-resistant tuberculosis patients on delamanid-containing regimens versus shorter treatment regimens

    Article • International Journal of Risk & Safety in Medicine, May 2024, IOS Press

    Dr Valeriu Crudu

  6. A new method for detecting mixed Mycobacterium tuberculosis infection and reconstructing constituent strains provides insights into transmission

    Article • April 2024, Cold Spring Harbor Laboratory Press

    Dr Valeriu Crudu

  7. The recent rapid expansion of multidrug resistant Ural lineage Mycobacterium tuberculosis in Moldova

    Article • Nature Communications, April 2024, Springer Science + Business Media

    Dr Valeriu Crudu

  8. Identifying local foci of tuberculosis transmission in Moldova using a spatial multinomial logistic regression model

    Article • EBioMedicine, April 2024, Elsevier

    Dr Valeriu Crudu

  9. Identification of differentially recognized T cell epitopes in the spectrum of tuberculosis infection

    Article • Nature Communications, January 2024, Springer Science + Business Media

    Dr Valeriu Crudu

  10. Predicting stringent QuantiFERON-TB Gold Plus conversions in contacts of tuberculosis patients

    Article • Journal of Microbiology Immunology and Infection, August 2023, Elsevier

    Dr Valeriu Crudu

  11. Impact and cost-effectiveness of the 6-month BPaLM regimen for rifampicin-resistant tuberculosis: a mathematical modeling analysis

    Article • July 2023, Cold Spring Harbor Laboratory Press

    Dr Valeriu Crudu

  12. Geographical analysis and evaluation of M. tuberculosis genome sequencing at the national level

    Article • Bulletin of the Academy of Sciences of Moldova Medical Sciences, February 2023, Editorial Office "Bulletin of the Academy of Sciences of Moldova. Medical Sciences"

    Dr Valeriu Crudu

  13. Pharmacokinetics of antitubercular drugs in patients hospitalized with HIV-associated tuberculosis: a population modeling analysis

    Article • Wellcome Open Research, November 2022, Faculty of 1000, Ltd.

    Dr Valeriu Crudu

  14. Predicting resistance to fluoroquinolones among patients with rifampicin-resistant tuberculosis using machine learning methods

    Article • PLOS Digital Health, June 2022, PLOS

    Dr Valeriu Crudu

  15. Phylogeography and transmission of M. tuberculosis in Moldova: A prospective genomic analysis

    Article • PLoS Medicine, February 2022, PLOS

    Dr Valeriu Crudu, Dr Valeriu Crudu

  16. Integrating landmark modeling framework and machine learning algorithms for dynamic prediction of tuberculosis treatment outcomes

    Article • Journal of the American Medical Informatics Association, February 2022, Oxford University Press (OUP)

    Dr Valeriu Crudu

  17. Detection of isoniazid, fluoroquinolone, ethionamide, amikacin, kanamycin, and capreomycin resistance by the Xpert MTB/XDR assay: a cross-sectional multicentre diagnostic accuracy study

    Article • The Lancet Infectious Diseases, February 2022, Elsevier

    Dr Valeriu Crudu

  18. Benchmarking the empirical accuracy of short-read sequencing across the M. tuberculosis genome

    Article • Bioinformatics, January 2022, Oxford University Press (OUP)

    Dr Valeriu Crudu

  19. Emergence of bedaquiline-resistance in a high-burden country of tuberculosis

    Article • European Respiratory Journal, September 2021, European Respiratory Society (ERS)

    Dr Valeriu Crudu

  20. Evolution and emergence of multidrug-resistant Mycobacterium tuberculosis in Chisinau, Moldova

    Article • Microbial Genomics, August 2021, Society for General Microbiology

    Dr Valeriu Crudu

  21. Rapid Detection of Extensively Drug-Resistant Tuberculosis in Clinical Samples Using a Novel Tabletop Platform: Protocol for a Prospective Clinical Study

    Article • JMIR Research Protocols, July 2021, JMIR Publications Inc.

    Dr Valeriu Crudu

  22. Phylogeography and transmission of M. tuberculosis in Moldova

    Article • July 2021, Cold Spring Harbor Laboratory Press

    Dr Valeriu Crudu

  23. Clinical evaluation of the Xpert MTB/XDR assay for rapid detection of isoniazid, fluoroquinolone, ethionamide and second-line drug resistance: A cross-sectional multicentre diagnostic accuracy study

    Article • May 2021, Cold Spring Harbor Laboratory Press

    Dr Valeriu Crudu

  24. Genomic sequence characteristics and the empiric accuracy of short-read sequencing

    Article • April 2021, Cold Spring Harbor Laboratory Press

    Dr Valeriu Crudu

  25. Laboratory costs of diagnosing TB in a high multidrug-resistant TB setting

    Article • The International Journal of Tuberculosis and Lung Disease, March 2021, International Union Against Tuberculosis and Lung Disease

    Dr Valeriu Crudu

  26. Evolution and emergence of multidrug-resistant Mycobacterium tuberculosis in Chisinau, Moldova

    Article • February 2021, Cold Spring Harbor Laboratory Press

    Dr Valeriu Crudu

  27. Rapid Detection of Extensively Drug-Resistant Tuberculosis in Clinical Samples Using a Novel Tabletop Platform: Protocol for a Prospective Clinical Study (Preprint)

    Article • December 2020, JMIR Publications Inc.

    Dr Valeriu Crudu

  28. Molecular Detection of Mycobacterium tuberculosis in Oral Mucosa from Patients with Presumptive Tuberculosis

    Article • Journal of Clinical Medicine, December 2020, MDPI AG

    Dr Valeriu Crudu

  29. Impact of bedaquiline on treatment outcomes of multidrug-resistant tuberculosis in a high-burden country

    Article • European Respiratory Journal, December 2020, European Respiratory Society (ERS)

    Dr Valeriu Crudu

  30. Automated high-throughput digital fluorescence microscopy for TB diagnosis

    Article • The International Journal of Tuberculosis and Lung Disease, October 2020, International Union Against Tuberculosis and Lung Disease

    Dr Valeriu Crudu

  31. A retrospective genomic analysis of drug-resistant strains of M. tuberculosis in a high-burden setting, with an emphasis on comparative diagnostics and reactivation and reinfection status

    Article • BMC Infectious Diseases, January 2020, Springer Science + Business Media

    Dr Valeriu Crudu

  32. A retrospective genomic analysis of drug-resistant strains of M. tuberculosis in a high-burden setting, with an emphasis on comparative diagnostics and reactivation and reinfection status.

    Article • December 2019, Research Square

    Dr Valeriu Crudu

  33. Prediction of multiple drug resistant pulmonary tuberculosis against drug sensitive pulmonary tuberculosis by CT nodular consolidation sign

    Article • November 2019, Cold Spring Harbor Laboratory Press

    Dr Valeriu Crudu

  34. Assessing tuberculosis control priorities in high-burden settings: a modelling approach

    Article • The Lancet Global Health, May 2019, Elsevier

    Dr Valeriu Crudu

  35. Failing treatment of multidrug-resistant tuberculosis: a matter of definition

    Article • The International Journal of Tuberculosis and Lung Disease, April 2019, International Union Against Tuberculosis and Lung Disease

    Dr Valeriu Crudu

  36. Building a tuberculosis-free world: The Lancet Commission on tuberculosis

    Article • The Lancet, March 2019, Elsevier

    Dr Valeriu Crudu

  37. Acute phase proteins and IP-10 as triage tests for the diagnosis of tuberculosis: systematic review and meta-analysis

    Article • Clinical Microbiology and Infection, February 2019, Elsevier

    Dr Valeriu Crudu

  38. Beyond the SNP Threshold: Identifying Outbreak Clusters Using Inferred Transmissions

    Article • Molecular Biology and Evolution, January 2019, Oxford University Press (OUP)

    Dr Valeriu Crudu

  39. Clinical Management of Multidrug-Resistant Tuberculosis in 16 European Countries

    Article • American Journal of Respiratory and Critical Care Medicine, August 2018, American Thoracic Society

    Dr Frank van Leth, Dr Valeriu Crudu

  40. Beyond the SNP threshold: identifying outbreak clusters using inferred transmissions

    Article • May 2018, Cold Spring Harbor Laboratory Press

    Dr Valeriu Crudu

  41. Cost analysis of rapid diagnostics for drug-resistant tuberculosis

    Article • BMC Infectious Diseases, March 2018, Springer Science + Business Media

    Dr Valeriu Crudu

  42. Reply: Benefit of the Shorter Multidrug-Resistant Tuberculosis Treatment Regimen in California and Modified Eligibility Criteria

    Article • American Journal of Respiratory and Critical Care Medicine, December 2017, American Thoracic Society

    Dr Frank van Leth, Professor JEROME ROBERT, Dr Valeriu Crudu

  43. Tuberculosis Treatment Outcomes in Europe: Based on Treatment Completion, Not Cure

    Article • American Journal of Respiratory and Critical Care Medicine, November 2017, American Thoracic Society

    Dr Frank van Leth, Dr Valeriu Crudu

  44. High-dose isoniazid in the shorter-course multidrug-resistant tuberculosis regimen in the Republic of Moldova

    Article • European Respiratory Journal, October 2017, European Respiratory Society (ERS)

    Dr Valeriu Crudu

  45. Lack of evidence of isoniazid efficacy for the treatment of MDR/XDR-TB in the presence of thekatG315T mutation

    Article • European Respiratory Journal, October 2017, European Respiratory Society (ERS)

    Dr Valeriu Crudu

  46. The TB Portals: database for M/XDR TB

    Article • Journal of Clinical Microbiology, September 2017, ASM Journals

    Alexander Rosenthal, Dr Valeriu Crudu

  47. Treatment outcomes of MDR-TB and HIV co-infection in Europe

    Article • European Respiratory Journal, June 2017, European Respiratory Society (ERS)

    Dr Valeriu Crudu

  48. FATE: the new partnership to Fight Against TB in Central and Eastern Europe

    Article • The Lancet Infectious Diseases, April 2017, Elsevier

    Dr Valeriu Crudu

  49. Genomic analysis of globally diverse Mycobacterium tuberculosis strains provides insights into the emergence and spread of multidrug resistance

    Article • Nature Genetics, January 2017, Springer Science + Business Media

    Dr Valeriu Crudu, Willy SSENGOOBA

  50. MDR-TB in Eastern Europe in the era of the TB elimination action framework

    Article • The International Journal of Tuberculosis and Lung Disease, January 2017, International Union Against Tuberculosis and Lung Disease

    Dr Valeriu Crudu

  51. Armed conflict and population displacement as drivers of the evolution and dispersal of Mycobacterium tuberculosis

    Article • Proceedings of the National Academy of Sciences, November 2016, Proceedings of the National Academy of Sciences

    Dr Valeriu Crudu

  52. Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages

    Article • Nature Genetics, October 2016, Springer Science + Business Media

    Jennifer Guthrie, Dr Valeriu Crudu, Willy SSENGOOBA

  53. Limited Benefit of the New Shorter Multidrug-Resistant Tuberculosis Regimen in Europe

    Article • American Journal of Respiratory and Critical Care Medicine, October 2016, American Thoracic Society

    Dr Frank van Leth, Professor JEROME ROBERT, Dr Valeriu Crudu

  54. Urgent need to rethink treatment outcome definitions in tuberculosis

    Article • The New England Journal of Medicine and Surgery and the Collateral Branches of Science, September 2016, New England Journal of Medicine (NEJM/MMS)

    Dr Frank van Leth, Dr Valeriu Crudu

  55. Shedding light on the performance of a pyrosequencing assay for drug-resistant tuberculosis diagnosis

    Article • BMC Infectious Diseases, August 2016, Springer Science + Business Media

    Dr Valeriu Crudu

  56. Errata

    Article • The International Journal of Tuberculosis and Lung Disease, July 2016, International Union Against Tuberculosis and Lung Disease

    Dr Valeriu Crudu

  57. Rapid Drug Susceptibility Testing of Drug-Resistant Mycobacterium tuberculosis Isolates Directly from Clinical Samples by Use of Amplicon Sequencing: a Proof-of-Concept Study

    Article • Journal of Clinical Microbiology, May 2016, ASM Journals

    Dr Valeriu Crudu

  58. A performance evaluation of MTBDRplus version 2 for the diagnosis of multidrug-resistant tuberculosis

    Article • The International Journal of Tuberculosis and Lung Disease, May 2016, International Union Against Tuberculosis and Lung Disease

    Dr Valeriu Crudu, Dr Valeriu Crudu

  59. Frequency and Distribution of Tuberculosis Resistance-Associated Mutations between Mumbai, Moldova, and Eastern Cape

    Article • Antimicrobial Agents and Chemotherapy, April 2016, ASM Journals

    Dr Valeriu Crudu, Dr Valeriu Crudu

  60. In reply

    Article • The International Journal of Tuberculosis and Lung Disease, March 2016, International Union Against Tuberculosis and Lung Disease

    Dr Valeriu Crudu, Dr Valeriu Crudu

  61. MTBDRplusand MTBDRslAssays: Absence of Wild-Type Probe Hybridization and Implications for Detection of Drug-Resistant Tuberculosis

    Article • Journal of Clinical Microbiology, January 2016, ASM Journals

    Dr Valeriu Crudu, Dr Valeriu Crudu

  62. Nosocomial transmission of multidrug-resistant tuberculosis

    Article • The International Journal of Tuberculosis and Lung Disease, December 2015, International Union Against Tuberculosis and Lung Disease

    Dr Valeriu Crudu, Dr Valeriu Crudu

  63. Beyond multidrug-resistant tuberculosis in Europe: a TBNET study

    Article • The International Journal of Tuberculosis and Lung Disease, December 2015, International Union Against Tuberculosis and Lung Disease

    Dr Frank van Leth, Dr Valeriu Crudu

  64. Predicting differential rifamycin resistance in clinical Mycobacterium tuberculosis isolates by specific rpoB mutations

    Article • The International Journal of Tuberculosis and Lung Disease, October 2015, International Union Against Tuberculosis and Lung Disease

    Dr Valeriu Crudu, Dr Valeriu Crudu

  65. Out-patient MDR-TB care in Moldova

    Article • September 2015, European Respiratory Society (ERS)

    Dr Valeriu Crudu, Dr Valeriu Crudu

  66. Transmission ofmycobacterium tuberculosisUral 163-15 lineage causing multidrug-resistant tuberculosis among hospitalized patients

    Article • September 2015, European Respiratory Society (ERS)

    Dr Valeriu Crudu, Dr Valeriu Crudu

  67. Performance Comparison of Three Rapid Tests for the Diagnosis of Drug-Resistant Tuberculosis

    Article • PLoS ONE, August 2015, PLOS

    Dr Valeriu Crudu, Dr Valeriu Crudu

  68. Detection of Low-Level Mixed-Population Drug Resistance in Mycobacterium tuberculosis Using High Fidelity Amplicon Sequencing

    Article • PLoS ONE, May 2015, PLOS

    Dr Valeriu Crudu, Dr Valeriu Crudu

  69. Phenotypic and genotypic diversity in a multinational sample of drug-resistant Mycobacterium tuberculosis isolates

    Article • The International Journal of Tuberculosis and Lung Disease, April 2015, International Union Against Tuberculosis and Lung Disease

    Dr Valeriu Crudu, Dr Valeriu Crudu

  70. Combined Antigen-Specific Interferon-γ and Interleukin-2 Release Assay (FluoroSpot) for the Diagnosis of Mycobacterium tuberculosis Infection

    Article • PLoS ONE, March 2015, PLOS

    Dr Valeriu Crudu, Dr Valeriu Crudu

  71. Multidrug-Resistant Tuberculosis in Europe, 2010–2011

    Article • Emerging Infectious Diseases, March 2015, Centers for Disease Control and Prevention (CDC)

    Dr Valeriu Crudu, Dr Valeriu Crudu, Dr Simon Tiberi, Dr Emanuele Pontali, Dr Frank van Leth

  72. Prognostic significance of novel katG mutations in Mycobacterium tuberculosis

    Article • International Journal of Mycobacteriology, March 2015, Elsevier

    Dr Valeriu Crudu, Dr Valeriu Crudu

  73. Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage

    Article • Nature Genetics, January 2015, Springer Science + Business Media

    Dr Valeriu Crudu, Dr Valeriu Crudu, Caroline Allix-Béguec

  74. Novel katG mutations causing isoniazid resistance in clinical M. tuberculosis isolates

    Article • Emerging Microbes & Infections, January 2015, Taylor & Francis

    Dr Valeriu Crudu, Dr Valeriu Crudu

  75. The Global Consortium for Drug-resistant Tuberculosis Diagnostics (GCDD): design of a multi-site, head-to-head study of three rapid tests to detect extensively drug-resistant tuberculosis

    Article • Trials, November 2014, Springer Science + Business Media

    Dr Valeriu Crudu, Dr Valeriu Crudu

  76. Evaluation of Pyrosequencing for Detecting Extensively Drug-Resistant Mycobacterium tuberculosis among Clinical Isolates from Four High-Burden Countries

    Article • Antimicrobial Agents and Chemotherapy, November 2014, ASM Journals

    Dr Valeriu Crudu, Dr Valeriu Crudu

  77. Management of patients with multidrug-resistant/extensively drug-resistant tuberculosis in Europe: a TBNET consensus statement

    Article • European Respiratory Journal, March 2014, European Respiratory Society (ERS)

    Dr Valeriu Crudu, Dr Valeriu Crudu, Dr Frank van Leth, Dr Enrico Tortoli, Dirk Wagner

  78. High risk and rapid appearance of multidrug resistance during tuberculosis treatment in Moldova

    Article • European Respiratory Journal, February 2014, European Respiratory Society (ERS)

    Dr Valeriu Crudu, Dr Valeriu Crudu

  79. Second-line drug susceptibility breakpoints for Mycobacterium tuberculosis using the MODS assay

    Article • The International Journal of Tuberculosis and Lung Disease, February 2014, International Union Against Tuberculosis and Lung Disease

    Dr Valeriu Crudu, Dr Valeriu Crudu

  80. Predicting Extensively Drug-Resistant Mycobacterium tuberculosis Phenotypes with Genetic Mutations

    Article • Journal of Clinical Microbiology, December 2013, ASM Journals

    Dr Valeriu Crudu, Dr Valeriu Crudu

  81. Publisher's Expression of Concern: Geographical Differences Associated with SNPs in Nine Gene Targets among Resistant Clinical Isolates of Mycobacterium tuberculosis

    Article • Journal of Clinical Microbiology, September 2013, ASM Journals

    Dr Valeriu Crudu

  82. Geographical Differences Associated with Single-Nucleotide Polymorphisms (SNPs) in Nine Gene Targets among Resistant Clinical Isolates of Mycobacterium tuberculosis

    Article • Journal of Clinical Microbiology, June 2013, ASM Journals

    Professor James T. Douglas, Dr Valeriu Crudu, Dr Valeriu Crudu

  83. Risk factors and timing of default from treatment for non-multidrug-resistant tuberculosis in Moldova

    Article • The International Journal of Tuberculosis and Lung Disease, March 2013, International Union Against Tuberculosis and Lung Disease

    Dr Valeriu Crudu, Dr Valeriu Crudu

  84. Periodontal Disease Is an Independent Predictor of Intracardiac Calcification

    Article • BioMed Research International, January 2013, Hindawi Publishing Corporation

    Dr Valeriu Crudu

  85. Assessing spatial heterogeneity of multidrug-resistant tuberculosis in a high-burden country

    Article • European Respiratory Journal, October 2012, European Respiratory Society (ERS)

    Dr Valeriu Crudu, Dr Valeriu Crudu

  86. Middle‐of‐the‐night PCI does not affect subsequent day PCI success and complication rates by the same operator

    Article • Catheterization and Cardiovascular Interventions, March 2012, Wiley

    Dr Valeriu Crudu

  87. First Evaluation of an Improved Assay for Molecular Genetic Detection of Tuberculosis as Well as Rifampin and Isoniazid Resistances

    Article • Journal of Clinical Microbiology, February 2012, ASM Journals

    Dr Valeriu Crudu, Dr Valeriu Crudu

  88. Complications related to access site after percutaneous coronary interventions

    Article • Catheterization and Cardiovascular Interventions, March 2011, Wiley

    Dr Valeriu Crudu

  89. Can total cardiac calcium predict the coronary calcium score?

    Article • International Journal of Cardiology, January 2011, Elsevier

    Dr Valeriu Crudu

  90. Assessment Of The Nosocomial Transmission Of MDR TB In Moldova Using DNA Fingerprinting Of M.tuberculosis

    Article • May 2010, American Thoracic Society

    Dr Valeriu Crudu, Dr Valeriu Crudu

  91. Relationship between intensive diuresis and QRS morphology change

    Article • European Journal of Heart Failure Supplements, June 2008, Oxford University Press (OUP)

    Dr Valeriu Crudu

  92. Increasing tuberculosis case detection: lessons from the Republic of Moldova

    Article • Bulletin of the World Health Organization, January 2008, WHO Press

    Dr Valeriu Crudu