All Stories

  1. Injectable Stem Cell-Based Therapies for Myocardial Regeneration: A Review of the Literature

    Article • Journal of Functional Biomaterials, April 2025, MDPI AG

    Dr. Toshiharu Shinoka

  2. Bridging the Gap: Advances and Challenges in Heart Regeneration from In Vitro to In Vivo Applications

    Article • Bioengineering, September 2024, MDPI AG

    Dr. Toshiharu Shinoka

  3. Scaffold and Cell-Based Tissue Engineering Approaches as Alternative Therapy for Blood Vessel Disease

    Article • May 2023, MDPI AG

    Dr. Toshiharu Shinoka

  4. Recent Tissue Engineering Approaches to Mimicking the Extracellular Matrix Structure for Skin Regeneration

    Article • Biomimetics, March 2023, MDPI AG

    Dr. Toshiharu Shinoka

  5. The Application of Porous Scaffolds for Cardiovascular Tissues

    Article • Bioengineering, February 2023, MDPI AG

    Dr. Toshiharu Shinoka

  6. Recent Developments in Biopolymer-Based Hydrogels for Tissue Engineering Applications

    Article • Biomolecules, February 2023, MDPI AG

    Dr. Toshiharu Shinoka

  7. Advances in Cardiac Tissue Engineering

    Article • Bioengineering, November 2022, MDPI AG

    Dr. Toshiharu Shinoka

  8. Clinical Application for Tissue Engineering Focused on Materials

    Article • Biomedicines, June 2022, MDPI AG

    Dr. Toshiharu Shinoka

  9. Pre-clinical Evolution of a Novel Transcatheter Bioabsorbable ASD/PFO Occluder Device

    Article • Pediatric Cardiology, January 2022, Springer Science + Business Media

    Dr. Toshiharu Shinoka

  10. Heparin-Eluting Tissue-Engineered Bioabsorbable Vascular Grafts

    Article • Applied Sciences, May 2021, MDPI AG

    Dr. Toshiharu Shinoka

  11. Electrospun Tissue-Engineered Arterial Graft Thickness Affects Long-Term Composition and Mechanics

    Article • Tissue Engineering Part A, May 2021, Mary Ann Liebert Inc

    Dr. Toshiharu Shinoka

  12. The Real Need for Regenerative Medicine in the Future of Congenital Heart Disease Treatment

    Article • Biomedicines, April 2021, MDPI AG

    Dr. Toshiharu Shinoka

  13. The evaluation of a tissue-engineered cardiac patch seeded with hips derived cardiac progenitor cells in a rat left ventricular model

    Article • PLOS One, June 2020, PLOS

    Dr. Toshiharu Shinoka

  14. 3D printing with MRI in pediatric applications

    Article • Journal of Magnetic Resonance Imaging, July 2019, Wiley

    Dr. Toshiharu Shinoka

  15. Early Natural History of Neotissue Formation in Tissue-Engineered Vascular Grafts in a Murine Model

    Article • Regenerative Medicine, May 2019, Taylor & Francis

    Dr. Toshiharu Shinoka

  16. The Evolution of Tissue Engineered Vascular Graft Technologies: From Preclinical Trials to Advancing Patient Care

    Article • Applied Sciences, March 2019, MDPI AG

    Dr. Toshiharu Shinoka

  17. Magnetic Resonance Imaging of Shear Stress and Wall Thickness in Tissue-Engineered Vascular Grafts

    Article • Tissue Engineering Part C Methods, August 2018, Mary Ann Liebert Inc

    Dr. Toshiharu Shinoka

  18. Angiotensin II receptor I blockade prevents stenosis of tissue engineered vascular grafts

    Article • The FASEB Journal, June 2018, Wiley

    Dr. Toshiharu Shinoka

  19. Tissue engineered vascular grafts for pediatric cardiac surgery

    Article • Translational Pediatrics, April 2018, AME Publishing Company

    Dr. Toshiharu Shinoka

  20. Tissue-engineered Vascular Grafts in Children With Congenital Heart Disease: Intermediate Term Follow-up

    Article • Seminars in Thoracic and Cardiovascular Surgery, February 2018, Elsevier

    Dr. Toshiharu Shinoka

  21. Role of Bone Marrow Mononuclear Cell Seeding for Nanofiber Vascular Grafts

    Article • Tissue Engineering Part A, January 2018, Mary Ann Liebert Inc

    Chin Siang Ong, Dr. Toshiharu Shinoka

  22. Toward a patient-specific tissue engineered vascular graft

    Article • Journal of Tissue Engineering, January 2018, SAGE Publications

    Dr. Toshiharu Shinoka

  23. Novel application and serial evaluation of tissue-engineered portal vein grafts in a murine model

    Article • Regenerative Medicine, December 2017, Future Medicine

    Dr. Toshiharu Shinoka

  24. Tissue-engineered vascular grafts for congenital cardiac disease: Clinical experience and current status

    Article • Trends in Cardiovascular Medicine, November 2017, Elsevier

    Dr. Toshiharu Shinoka

  25. Fast-degrading bioresorbable arterial vascular graft with high cellular infiltration inhibits calcification of the graft

    Article • Journal of Vascular Surgery, July 2017, Elsevier

    Dr. Toshiharu Shinoka

  26. What is the best material for extracardiac Fontan operation?

    Article • Journal of Thoracic and Cardiovascular Surgery, June 2017, Elsevier

    Dr. Toshiharu Shinoka

  27. Tissue Engineering in Vascular Medicine

    Article • May 2017, Bentham Science Publishers

    Dr. Toshiharu Shinoka

  28. Preclinical study of patient-specific cell-free nanofiber tissue-engineered vascular grafts using 3-dimensional printing in a sheep model

    Article • Journal of Thoracic and Cardiovascular Surgery, April 2017, Elsevier

    Chin Siang Ong, Dr. Toshiharu Shinoka

  29. Tropoelastin inhibits intimal hyperplasia of mouse bioresorbable arterial vascular grafts

    Article • Acta Biomaterialia, April 2017, Elsevier

    Professor Anthony S Weiss, Dr. Toshiharu Shinoka

  30. TRANSMURAL MACROPHAGE MIGRATION IN TISSUE ENGINEERED VASCULAR GRAFT PROMOTES EXTRACELLULAR MATRIX FORMATION FOR VASCULAR REMODELING MORE THAN HOST CIRCULATING INFLAMMATORY CELL MIGRATION

    Article • Journal of the American College of Cardiology, March 2017, Elsevier

    Dr. Toshiharu Shinoka

  31. Nanofiber composites in vascular tissue engineering

    Article • January 2017, Elsevier

    Dr. Toshiharu Shinoka

  32. Tissue-engineered cardiac patch seeded with human induced pluripotent stem cell derived cardiomyocytes promoted the regeneration of host cardiomyocytes in a rat model

    Article • Journal of Cardiothoracic Surgery, December 2016, Springer Science + Business Media

    Dr. Toshiharu Shinoka

  33. Current Status of Tissue Engineering Heart Valve

    Article • World Journal for Pediatric and Congenital Heart Surgery, November 2016, SAGE Publications

    Dr. Toshiharu Shinoka

  34. Novel Bioresorbable Vascular Graft With Sponge-Type Scaffold as a Small-Diameter Arterial Graft

    Article • The Annals of Thoracic Surgery, September 2016, Elsevier

    Dr. Toshiharu Shinoka

  35. Deconstructing the Tissue Engineered Vascular Graft: Evaluating Scaffold Pre-Wetting, Conditioned Media Incubation, and Determining the Optimal Mononuclear Cell Source

    Article • ACS Biomaterials Science & Engineering, August 2016, American Chemical Society (ACS)

    Dr. Toshiharu Shinoka

  36. Tissue-Engineered Small Diameter Arterial Vascular Grafts from Cell-Free Nanofiber PCL/Chitosan Scaffolds in a Sheep Model

    Article • PLOS One, July 2016, PLOS

    Dr. Toshiharu Shinoka, Chin Siang Ong

  37. Pilot Mouse Study of 1 mm Inner Diameter (ID) Vascular Graft Using Electrospun Poly(ester urea) Nanofibers

    Article • Advanced Healthcare Materials, July 2016, Wiley

    Dr. Toshiharu Shinoka

  38. tissue engineering

    Article • The FASEB Journal, July 2016, Federation of American Societies For Experimental Biology (FASEB)

    Dr. Toshiharu Shinoka, Dr JUAN DE DIOS RUIZ-ROSADO

  39. Rational design of an improved tissue-engineered vascular graft: determining the optimal cell dose and incubation time

    Article • Regenerative Medicine, March 2016, Future Medicine

    Dr. Toshiharu Shinoka

  40. Neotissue remodeling of tissue-engineered arterial graft

    Article • February 2016, International Association of Physical Chemists (IAPC)

    Dr. Toshiharu Shinoka

  41. Long-Term Functional Efficacy of a Novel Electrospun Poly(Glycerol Sebacate)-Based Arterial Graft in Mice

    Article • Annals of Biomedical Engineering, January 2016, Springer Science + Business Media

    Dr. Toshiharu Shinoka

  42. Current Status of Tissue Engineered Vascular Graft in Pediatric Cardiac Surgery

    Article • Frontiers in Bioengineering and Biotechnology, January 2016, Frontiers

    Dr. Toshiharu Shinoka

  43. Effect of cell seeding on neotissue formation in a tissue engineered trachea

    Article • Journal of Pediatric Surgery, January 2016, Elsevier

    Dr. Toshiharu Shinoka

  44. A mouse model of endocardial fibroelastosis

    Article • Cardiovascular Pathology, November 2015, Elsevier

    Dr. Toshiharu Shinoka

  45. Current Status of Cardiovascular Tissue Engineering

    Article • International Journal of Clinical Therapeutics and Diagnosis, October 2015, SciDoc Publishers LLC

    Dr. Toshiharu Shinoka

  46. Evaluation of remodeling process in small-diameter cell-free tissue-engineered arterial graft

    Article • Journal of Vascular Surgery, September 2015, Elsevier

    Dr. Toshiharu Shinoka

  47. Potential Molecular Mechanism of Retrograde Aortic Arch Stenosis in the Hybrid Approach to Hypoplastic Left Heart Syndrome

    Article • The Annals of Thoracic Surgery, September 2015, Elsevier

    Dr. Toshiharu Shinoka

  48. Hemodynamic Characterization of a Mouse Model for Investigating the Cellular and Molecular Mechanisms of Neotissue Formation in Tissue-Engineered Heart Valves

    Article • Tissue Engineering Part C Methods, September 2015, Mary Ann Liebert Inc

    Dr. Toshiharu Shinoka

  49. Influence of Posttransplant Lymphoproliferative Disorder on Survival in Children After Heart Transplantation

    Article • Pediatric Cardiology, July 2015, Springer Science + Business Media

    Dr. Toshiharu Shinoka

  50. Cilostazol, Not Aspirin, Prevents Stenosis of Bioresorbable Vascular Grafts in a Venous ModelSignificance

    Article • Arteriosclerosis Thrombosis and Vascular Biology, July 2015, Wolters Kluwer Health

    Dr. Toshiharu Shinoka

  51. The innate immune system contributes to tissue-engineered vascular graft performance

    Article • The FASEB Journal, June 2015, Federation of American Societies For Experimental Biology (FASEB)

    Dr. Toshiharu Shinoka

  52. Comparison of the Biological Equivalence of Two Methods for Isolating Bone Marrow Mononuclear Cells for Fabricating Tissue-Engineered Vascular Grafts

    Article • Tissue Engineering Part C Methods, June 2015, Mary Ann Liebert Inc

    Dr. Toshiharu Shinoka

  53. Biomechanical Diversity Despite Mechanobiological Stability in Tissue Engineered Vascular Grafts Two Years Post-Implantation

    Article • Tissue Engineering Part A, May 2015, Mary Ann Liebert Inc

    Dr. Toshiharu Shinoka

  54. Development of Small Diameter Nanofiber Tissue Engineered Arterial Grafts

    Article • PLOS One, April 2015, PLOS

    Dr. Toshiharu Shinoka

  55. A new tissue-engineered biodegradable surgical patch for high-pressure systems

    Article • Interactive Cardiovascular and Thoracic Surgery, February 2015, Oxford University Press (OUP)

    Dr. Toshiharu Shinoka

  56. Contrasting Biofunctionalization Strategies for the Enhanced Endothelialization of Biodegradable Vascular Grafts

    Article • Biomacromolecules, February 2015, American Chemical Society (ACS)

    Dr. Toshiharu Shinoka

  57. TGFβR1 Inhibition Blocks the Formation of Stenosis in Tissue-Engineered Vascular Grafts

    Article • Journal of the American College of Cardiology, February 2015, Elsevier

    Dr. Toshiharu Shinoka

  58. First Report of Histological Evaluation of Human Tissue-Engineered Vasculature

    Article • Journal of Biotechnology & Biomaterials, January 2015, OMICS Publishing Group

    Dr. Toshiharu Shinoka

  59. Preliminary Experience in the Use of an Extracellular Matrix (CorMatrix) as a Tube Graft: Word of Caution

    Article • Seminars in Thoracic and Cardiovascular Surgery, January 2015, Elsevier

    Dr. Toshiharu Shinoka

  60. Comparison of a Closed System to a Standard Open Technique for Preparing Tissue-Engineered Vascular Grafts

    Article • Tissue Engineering Part C Methods, January 2015, Mary Ann Liebert Inc

    Dr. Toshiharu Shinoka

  61. Well-organized neointima of large-pore poly(l-lactic acid) vascular graft coated with poly(l-lactic-co-ε-caprolactone) prevents calcific deposition compared to small-pore electrospun poly(l-lactic acid) graft in a mouse aortic implantation model

    Article • Atherosclerosis, December 2014, Elsevier

    Dr. Toshiharu Shinoka

  62. Development of a Tissue-Engineering Vascular Graft for Use in Congenital Heart Surgery

    Article • EBioMedicine, November 2014, Elsevier

    Dr. Toshiharu Shinoka

  63. Targeted imaging of matrix metalloproteinase activity in the evaluation of remodeling tissue-engineered vascular grafts implanted in a growing lamb model

    Article • Journal of Thoracic and Cardiovascular Surgery, November 2014, Elsevier

    Dr. Toshiharu Shinoka

  64. Transplantation of Pulmonary Valve Using a Mouse Model of Heterotopic Heart Transplantation

    Article • Journal of Visualized Experiments, July 2014, MyJove Corporation

    Dr. Toshiharu Shinoka

  65. Implantation of Inferior Vena Cava Interposition Graft in Mouse Model

    Article • Journal of Visualized Experiments, June 2014, MyJove Corporation

    Dr. Toshiharu Shinoka

  66. Vessel Bioengineering

    Article • Circulation Journal, January 2014, Japanese Circulation Society

    Dr. Toshiharu Shinoka

  67. Vessel Regeneration and Bioengineering**Shuhei Tara and Ethan W. Dean contributed equally to the preparation of this manuscript and should be listed as cofirst authors.

    Article • January 2014, Elsevier

    Dr. Toshiharu Shinoka

  68. Tissue-Engineered Vascular Grafts in Pediatric Cardiovascular Surgery -Past, Now, and Future

    Article • Pediatric Cardiology and Cardiac Surgery, January 2014, The Japanese Society of Pediatric Cardiology and Cardiac Surgery

    Dr. Toshiharu Shinoka

  69. Stem cells in tissue-engineered blood vessels for cardiac repair

    Article • January 2014, Elsevier

    Dr. Toshiharu Shinoka

  70. Contributor contact details

    Article • January 2014, Elsevier

    Dr. Toshiharu Shinoka

  71. List of Contributors

    Article • January 2014, Elsevier

    Dr. Toshiharu Shinoka

  72. Tissue Engineering in the Vasculature

    Article • The Anatomical Record, December 2013, Wiley

    Dr. Toshiharu Shinoka

  73. Tissue Engineered Small-Diameter Arterial Graft: In Vivo Evaluation of an Electrospun Nanofiber Scaffold

    Article • Journal of Surgical Research, February 2013, Elsevier

    Dr. Toshiharu Shinoka

  74. Concise Review: Tissue-Engineered Vascular Grafts for Cardiac Surgery: Past, Present, and Future

    Article • Stem Cells Translational Medicine, June 2012, Wiley

    Dr. Toshiharu Shinoka

  75. Tissue-engineered vascular grafts for use in the treatment of congenital heart disease: from the bench to the clinic and back again

    Article • Regenerative Medicine, May 2012, Future Medicine

    Dr. Toshiharu Shinoka

  76. Evaluation of the use of an induced puripotent stem cell sheet for the construction of tissue-engineered vascular grafts

    Article • Journal of Thoracic and Cardiovascular Surgery, March 2012, Elsevier

    Dr. Toshiharu Shinoka

  77. Modified Starnes Procedure in a Neonate With Severe Tricuspid Regurgitation

    Article • The Annals of Thoracic Surgery, February 2012, Elsevier

    Dr. Toshiharu Shinoka

  78. Characterization of the Natural History of Extracellular Matrix Production in Tissue-Engineered Vascular Grafts during Neovessel Formation

    Article • Cells Tissues Organs, January 2012, Karger Publishers

    Dr. Toshiharu Shinoka

  79. A critical role for macrophages in neovessel formation and the development of stenosis in tissue-engineered vascular grafts

    Article • The FASEB Journal, December 2011, Federation of American Societies For Experimental Biology (FASEB)

    Dr. Toshiharu Shinoka

  80. Development of an Operator-Independent Method for Seeding Tissue-Engineered Vascular Grafts

    Article • Tissue Engineering Part C Methods, July 2011, Mary Ann Liebert Inc

    Dr. Toshiharu Shinoka

  81. Vascular tissue engineering: Towards the next generation vascular grafts

    Article • Advanced Drug Delivery Reviews, April 2011, Elsevier

    Dr. Toshiharu Shinoka

  82. Restoring Blood Vessels

    Article • January 2011, Springer Science + Business Media

    Dr. Toshiharu Shinoka

  83. TISSUE ENGINEERED BLOOD VESSELS: FROM THE BENCH TO THE BEDSIDE AND BACK AGAIN (DEVELOPMENT OF A VASCULAR CONDUIT FOR USE IN CONGENITAL HEART SURGERY)

    Article • October 2010, World Scientific Pub Co Pte Lt

    Dr. Toshiharu Shinoka

  84. Embryonic stem cell therapy; A novel cell delivery method

    Article • Journal of the American College of Surgeons, September 2010, Elsevier

    Dr. Toshiharu Shinoka

  85. Cell-Seeding Techniques in Vascular Tissue Engineering

    Article • Tissue Engineering Part B Reviews, June 2010, Mary Ann Liebert Inc

    Dr. Toshiharu Shinoka

  86. Tissue-engineered vascular grafts: does cell seeding matter?

    Article • Journal of Pediatric Surgery, June 2010, Elsevier

    Dr. Toshiharu Shinoka

  87. Tissue-engineered vascular grafts transform into mature blood vessels via an inflammation-mediated process of vascular remodeling

    Article • Proceedings of the National Academy of Sciences, March 2010, Proceedings of the National Academy of Sciences

    Dr. Toshiharu Shinoka

  88. Late-term results of tissue-engineered vascular grafts in humans

    Article • Journal of Thoracic and Cardiovascular Surgery, February 2010, Elsevier

    Dr. Toshiharu Shinoka

  89. Characterization of small-diameter electrospun tissue-engineered arterial grafts

    Article • Journal of the American College of Surgeons, September 2009, Elsevier

    Dr. Toshiharu Shinoka

  90. Tissue-engineered arterial grafts: long-term results after implantation in a small animal model

    Article • Journal of Pediatric Surgery, June 2009, Elsevier

    Dr. Toshiharu Shinoka

  91. 114. Evaluation of the Role of Selective Cell Seeding on Neovessel Formation in Tissue Engineered Vascular Grafts

    Article • Journal of Surgical Research, February 2009, Elsevier

    Dr. Toshiharu Shinoka

  92. Tissue-engineered Vascular Grafts Demonstrate Evidence of Growth and Development When Implanted in a Juvenile Animal Model

    Article • Transactions of the Meeting of the American Surgical Association, January 2008, Wolters Kluwer Health

    Dr. Toshiharu Shinoka

  93. 7C-3 In Vivo Assessment Method of Tissue-Engineered Vascular Wall Based on Quantitative Elastic Modulus Measurement

    Article • October 2007, Institute of Electrical & Electronics Engineers (IEEE)

    Dr. Toshiharu Shinoka

  94. Double-outlet right ventricle with left malposition of the great arteries and total anomalous pulmonary venous connection

    Article • General Thoracic and Cardiovascular Surgery, February 2007, Springer Science + Business Media

    Dr. Toshiharu Shinoka

  95. Clinical Application of Tissue Engineered Vascular Graft Utilizing Biodegradable Polymer Scaffold

    Article • Kobunshi, January 2004, Society of Polymer Science, Japan

    Dr. Toshiharu Shinoka

  96. Tissue Engineered Heart Valves: Autologous Cell Seeding on Biodegradable Polymer Scaffold

    Article • Artificial Organs, May 2002, Wiley

    Dr. Toshiharu Shinoka

  97. Tissue engineering of autologous aorta using a new biodegradable polymer

    Article • The Annals of Thoracic Surgery, December 1999, Elsevier

    Dr. Toshiharu Shinoka

  98. Postischemic hyperthermia exacerbates neurologic injury after deep hypothermic circulatory arrest

    Article • Journal of Thoracic and Cardiovascular Surgery, November 1998, Elsevier

    Dr. Toshiharu Shinoka

  99. Creation Of Viable Pulmonary Artery Autografts Through Tissue Engineering

    Article • Journal of Thoracic and Cardiovascular Surgery, March 1998, Elsevier

    Dr. Toshiharu Shinoka

  100. Diastolic ventricular function immediately before and after Fontan procedure

    Article • Journal of the American College of Cardiology, February 1998, Elsevier

    Dr. Toshiharu Shinoka

  101. Tissue engineering heart valves: Valve leaflet replacement study in a lamb model

    Article • The Annals of Thoracic Surgery, December 1995, Elsevier

    Dr. Toshiharu Shinoka

  102. Konno Procedure for Congenital Aortic Stenosis with a Single Coronary Artery from the Left Coronary Sinus

    Article • Journal of Cardiac Surgery, December 1992, Wiley

    Dr. Toshiharu Shinoka

  103. CHAPTER 9. Smart Biomaterials for Cardiovascular Tissue Engineering

    Article • Royal Society of Chemistry

    Dr. Toshiharu Shinoka