All Stories

  1. Prenatal test cohort of a modified rat comparative thyroid assay adding brain thyroid hormone measurements and histology but lowering group size appears able to detect disruption by sodium phenobarbital

    Article • Current Research in Toxicology, January 2024, Elsevier

    Dr Tomoya Yamada

  2. Optimal testing time for cerebral heterotopia formation in the rat comparative thyroid assay, a downstream indicator for perinatal thyroid hormone insufficiency

    Article • Journal of Toxicologic Pathology, January 2024, Japanese Society of Toxicologic Pathology

    Dr Tomoya Yamada

  3. Feasibility study for a downsized comparative thyroid assay with measurement of brain thyroid hormones and histopathology in rats: Case study with 6-propylthiouracil and sodium phenobarbital at high dose

    Article • Regulatory Toxicology and Pharmacology, January 2023, Elsevier

    Dr Tomoya Yamada

  4. Response to Letter to the Editor from Drs. van Kesteren, Pronk, Heusinkveld, Luijten and Hakkert concerning Yamada et al. (2021): Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the con...

    Article • Critical Reviews in Toxicology, May 2022, Taylor & Francis

    Dr Tomoya Yamada

  5. Evaluation of the human hazard of the liver and lung tumors in mice treated with permethrin based on mode of action

    Article • Critical Reviews in Toxicology, January 2022, Taylor & Francis

    Dr Tomoya Yamada

  6. Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)

    Article • Critical Reviews in Toxicology, May 2021, Taylor & Francis

    Dr Tomoya Yamada

  7. Application of humanized mice to toxicology studies: Evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)

    Article • Journal of Toxicologic Pathology, January 2021, Japanese Society of Toxicologic Pathology

    Dr Tomoya Yamada

  8. Comparison of the Hepatic Effects of Phenobarbital in Chimeric Mice Containing Either Rat or Human Hepatocytes With Humanized Constitutive Androstane Receptor and Pregnane X Receptor Mice

    Article • Toxicological Sciences, July 2020, Oxford University Press (OUP)

    Dr Tomoya Yamada

  9. Cell proliferation analysis is a reliable predictor of lack of carcinogenicity: Case study using the pyrethroid imiprothrin on lung tumorigenesis in mice

    Article • Regulatory Toxicology and Pharmacology, June 2020, Elsevier

    Dr Tomoya Yamada

  10. An Evaluation of the Human Relevance of the Liver Tumors Observed in Female Mice Treated With Permethrin Based on Mode of Action

    Article • Toxicological Sciences, February 2020, Oxford University Press (OUP)

    Dr Tomoya Yamada

  11. Toxicological evaluation of carcinogenicity of the pyrethroid imiprothrin in rats and mice

    Article • Regulatory Toxicology and Pharmacology, July 2019, Elsevier

    Dr Tomoya Yamada

  12. Involvement of Peroxisome Proliferator-Activated Receptor-Alpha in Liver Tumor Production by Permethrin in the Female Mouse

    Article • Toxicological Sciences, January 2019, Oxford University Press (OUP)

    Dr Tomoya Yamada

  13. Case examples of an evaluation of the human relevance of the pyrethroids/pyrethrins-induced liver tumours in rodents based on the mode of action

    Article • Toxicology Research, January 2018, Oxford University Press (OUP)

    Dr Tomoya Yamada

  14. Mode of action analysis for rat hepatocellular tumors produced by the synthetic pyrethroid momfluorothrin: evidence for activation of the constitutive androstane receptor (CAR) and mitogenicity in rat hepatocytes

    Article • Toxicological Sciences, May 2017, Oxford University Press (OUP)

    Dr Tomoya Yamada

  15. An Evaluation of the Human Relevance of the Lung Tumors Observed in Female Mice Treated With Permethrin Based on Mode of Action

    Article • Toxicological Sciences, April 2017, Oxford University Press (OUP)

    Dr Tomoya Yamada

  16. Candidate genes responsible for early key events of phenobarbital-promoted mouse hepatocellular tumorigenesis based on differentiation of regulating genes between wild type mice and humanized chimeric mice

    Article • Toxicology Research, January 2017, Oxford University Press (OUP)

    Dr Tomoya Yamada

  17. Evaluation of the human relevance of the constitutive androstane receptor-mediated mode of action for rat hepatocellular tumor formation by the synthetic pyrethroid momfluorothrin

    Article • The Journal of Toxicological Sciences, January 2017, Japanese Society of Toxicology

    Dr Tomoya Yamada

  18. Mode of Action and Assessment of Human Relevance for Chemical-Induced Animal Tumors

    Article • January 2016, Elsevier

    Dr Tomoya Yamada

  19. Lack of effect of metofluthrin and sodium phenobarbital on replicative DNA synthesis and Ki-67 mRNA expression in cultured human hepatocytes

    Article • Toxicology Research, January 2015, Oxford University Press (OUP)

    Dr Tomoya Yamada

  20. Human Hepatocytes Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogen Sodium Phenobarbital in an In Vivo Study Using a Chimeric Mouse with Humanized Liver

    Article • Toxicological Sciences, August 2014, Oxford University Press (OUP)

    Dr Tomoya Yamada

  21. Well-Differentiated Teratoma in a Mouse Uterus

    Article • Toxicologic Pathology, June 2011, SAGE Publications

    Dr Tomoya Yamada

  22. Mammal Toxicology of Synthetic Pyrethroids

    Article • January 2011, Springer Science + Business Media

    Dr Satoshi Kawamura, Dr Tomoya Yamada

  23. Comparison of the effects of the synthetic pyrethroid Metofluthrin and phenobarbital on CYP2B form induction and replicative DNA synthesis in cultured rat and human hepatocytes

    Article • Toxicology, April 2009, Elsevier

    Dr Tomoya Yamada

  24. Case Study: An Evaluation of the Human Relevance of the Synthetic Pyrethroid Metofluthrin-Induced Liver Tumors in Rats Based on Mode of Action

    Article • Toxicological Sciences, January 2009, Oxford University Press (OUP)

    Dr Tomoya Yamada

  25. Mode of Action Analysis for the Synthetic Pyrethroid Metofluthrin-Induced Rat Liver Tumors: Evidence for Hepatic CYP2B Induction and Hepatocyte Proliferation

    Article • Toxicological Sciences, January 2009, Oxford University Press (OUP)

    Dr Tomoya Yamada

  26. Reliable Safety Assessment Depends on Species Differences in Epigenetic Mechanisms of Gene Regulation

    Article • ChemInform, July 2007, Wiley

    Dr Tomoya Yamada

  27. Reliable Safety Assessment Depends on Species Differences in Epigenetic Mechanisms of Gene Regulation

    Article • YAKUGAKU ZASSHI, January 2007, Pharmaceutical Society of Japan

    Dr Tomoya Yamada

  28. Functional genomics may allow accurate categorization of the benzimidazole fungicide benomyl: lack of ability to act via steroid-receptor-mediated mechanisms

    Article • Toxicology and Applied Pharmacology, May 2005, Elsevier

    Dr Tomoya Yamada

  29. Evaluation for reliability and feasibility of the draft protocol for the enhanced rat 28-day subacute study (OECD Guideline 407) using androgen antagonist flutamide

    Article • Toxicology, July 2004, Elsevier

    Dr Tomoya Yamada

  30. Enhanced Rat Hershberger Assay Appears Reliable for Detection of Not Only (Anti-)androgenic Chemicals but Also Thyroid Hormone Modulators

    Article • Toxicological Sciences, January 2004, Oxford University Press (OUP)

    Dr Tomoya Yamada

  31. OECD Validation of the Hershberger Assay in Japan: Phase 2 Dose Response of Methyltestosterone, Vinclozolin, and p,p´-DDE

    Article • Environmental Health Perspectives, September 2003, Environmental Health Perspectives

    Dr Tomoya Yamada

  32. Lack of estrogenic or (anti-)androgenic effects of d-phenothrin in the uterotrophic and Hershberger assays

    Article • Toxicology, April 2003, Elsevier

    Dr Tomoya Yamada

  33. Lack of (Anti-) Androgenic or Estrogenic Effects of Three Pyrethroids (Esfenvalerate, Fenvalerate, and Permethrin) in the Hershberger and Uterotrophic Assays

    Article • Regulatory Toxicology and Pharmacology, April 2002, Elsevier

    Dr Tomoya Yamada

  34. Lack of changes in brain muscarinic receptor and motor activity of mice after neonatal inhalation exposure tod-allethrin

    Article • Journal of Applied Toxicology, January 2002, Wiley

    Dr Tomoya Yamada

  35. Dissection and weighing of accessory sex glands after formalin fixation, and a 5-day assay using young mature rats are reliable and feasible in the Hershberger assay

    Article • Toxicology, May 2001, Elsevier

    Dr Tomoya Yamada

  36. Comparative Evaluation of a 5-Day Hershberger Assay Utilizing Mature Male Rats and a Pubertal Male Assay for Detection of Flutamide's Antiandrogenic Activity

    Article • Toxicological Sciences, February 2000, Oxford University Press (OUP)

    Dr Tomoya Yamada

  37. Evaluation of a 5-day Hershberger assay using young mature male rats. Methyltestosterone and p,p'-DDE, but not fenitrothion, exhibited androgenic or antiandrogenic activity in vivo.

    Article • The Journal of Toxicological Sciences, January 2000, Japanese Society of Toxicology

    Dr Tomoya Yamada

  38. Loss of the gene encoding mannose 6-phosphate/insulin-like growth factor II receptor is an early event in liver carcinogenesis

    Article • Proceedings of the National Academy of Sciences, September 1997, Proceedings of the National Academy of Sciences

    Dr Tomoya Yamada

  39. Imprinted genes in liver carcinogenesis

    Article • The FASEB Journal, January 1997, Wiley

    Dr Tomoya Yamada

  40. A Possible Mechanism for the Increase in Serum Luteinizing Hormone Levels in Male Rats by Oxolinic Acid

    Article • Toxicology and Applied Pharmacology, September 1995, Elsevier

    Dr Tomoya Yamada

  41. Species-Specific Mechanism in Rat Leydig Cell Tumorigenesis by Procymidone

    Article • Toxicology and Applied Pharmacology, April 1995, Elsevier

    Dr Tomoya Yamada

  42. Effect of chronic l-DOPA administration on serum luteinizing hormone levels in male rats

    Article • Toxicology, March 1995, Elsevier

    Dr Tomoya Yamada

  43. The Correlation of Serum Luteinizing Hormone Levels with the Induction of Leydig Cell Tumors in Rats by Oxolinic Acid

    Article • Toxicology and Applied Pharmacology, November 1994, Elsevier

    Dr Tomoya Yamada

  44. Carcinogenicity studies of oxolinic acid in rats and mice

    Article • Food and Chemical Toxicology, May 1994, Elsevier

    Dr Tomoya Yamada

  45. The affinity of procymidone to androgen receptor in rats and mice.

    Article • The Journal of Toxicological Sciences, January 1993, Japanese Society of Toxicology

    Dr Tomoya Yamada

  46. Effects of procymidone on reproductive organs and serum gonadotropins in male rats.

    Article • The Journal of Toxicological Sciences, January 1993, Japanese Society of Toxicology

    Dr Tomoya Yamada

  47. Hormonal disregulation mechanism in the rat thyroid tumor induced by diniconazole.

    Article • The Journal of Toxicological Sciences, January 1993, Japanese Society of Toxicology

    Dr Tomoya Yamada

  48. Effects of diethofencarb on thyroid function and hepatic UDP-glucuronyltransferase activity in rats.

    Article • The Journal of Toxicological Sciences, January 1992, Japanese Society of Toxicology

    Dr Tomoya Yamada