All Stories

  1. Treatment and diagnosis of severe KPC-producing Klebsiella pneumoniae infections: a perspective on what has changed over last decades

    Article • Annals of Medicine, March 2023, Taylor & Francis

    Tommaso Giani

  2. KPC-53, a KPC-3 variant of clinical origin associated with reduced susceptibility to ceftazidime-avibactam

    Article • Antimicrobial Agents and Chemotherapy, October 2020, ASM Journals

    Tommaso Giani

  3. mcr-1 Gene Expression Modulates the Inflammatory Response of Human Macrophages to Escherichia coli

    Article • Infection and Immunity, June 2020, ASM Journals

    Tommaso Giani

  4. Ceftazidime-Avibactam Resistance Associated with Increased blaKPC-3 Gene Copy Number Mediated by pKpQIL Plasmid Derivatives in Sequence Type 258 Klebsiella pneumoniae

    Article • Antimicrobial Agents and Chemotherapy, January 2020, ASM Journals

    Tommaso Giani

  5. TEM-184, a Novel TEM-Derived Extended-Spectrum β-Lactamase with Enhanced Activity against Aztreonam

    Article • Antimicrobial Agents and Chemotherapy, June 2018, ASM Journals

    Tommaso Giani

  6. Molecular antibiogram in diagnostic clinical microbiology: advantages and challenges

    Article • Future Microbiology, April 2017, Future Medicine

    Tommaso Giani

  7. Mechanisms of Antibacterial Resistance

    Article • January 2017, Elsevier

    Tommaso Giani

  8. Plasmid-mediated or chromosomally mediated colistin resistance in Klebsiella pneumoniae ?

    Article • The Lancet Infectious Diseases, January 2017, Elsevier

    Tommaso Giani

  9. Inhibitory activity of avibactam against selected β-lactamases expressed in an isogenic Escherichia coli strain

    Article • Diagnostic Microbiology and Infectious Disease, September 2016, Elsevier

    Tommaso Giani, Wright Nichols

  10. Molecular epidemiology of KPC-producing Klebsiella pneumoniae from invasive infections in Italy: increasing diversity with predominance of the ST512 clade II sublineage

    Article • Journal of Antimicrobial Chemotherapy, September 2016, Oxford University Press (OUP)

    Tommaso Giani

  11. mcr-1.2, a NewmcrVariant Carried on a Transferable Plasmid from a Colistin-Resistant KPC Carbapenemase-Producing Klebsiella pneumoniae Strain of Sequence Type 512

    Article • Antimicrobial Agents and Chemotherapy, July 2016, ASM Journals

    Tommaso Giani

  12. Complete Genome Sequence of the First KPC-Type Carbapenemase-Positive Proteus mirabilis Strain from a Bloodstream Infection

    Article • Genome Announcements, June 2016, ASM Journals

    Tommaso Giani

  13. Characterization of KPC-encoding plasmids from two endemic settings, Greece and Italy

    Article • Journal of Antimicrobial Chemotherapy, June 2016, Oxford University Press (OUP)

    Tommaso Giani

  14. Performance of the BD MAX™ instrument with Check-Direct CPE real-time PCR for the detection of carbapenemase genes from rectal swabs, in a setting with endemic dissemination of carbapenemase-producing Enterobacteriaceae

    Article • Diagnostic Microbiology and Infectious Disease, June 2016, Elsevier

    Tommaso Giani

  15. First Detection of themcr-1Colistin Resistance Gene in Escherichia coli in Italy

    Article • Antimicrobial Agents and Chemotherapy, March 2016, ASM Journals

    Tommaso Giani, Dr Francesco Luzzaro, Francesco Luzzaro

  16. Draft Genome Sequence ofProteus mirabilisNO-051/03, Representative of a Multidrug-Resistant Clone Spreading in Europe and Expressing the CMY-16 AmpC-Type β-Lactamase

    Article • Genome Announcements, February 2016, ASM Journals

    Tommaso Giani

  17. Colistin Resistance Caused by Inactivation of the MgrB Regulator Is Not Associated with Decreased Virulence of Sequence Type 258 KPC Carbapenemase-Producing Klebsiella pneumoniae

    Article • Antimicrobial Agents and Chemotherapy, January 2016, ASM Journals

    Tommaso Giani

  18. Draft Genome Sequence of the First HypermucoviscousKlebsiella quasipneumoniaesubsp.quasipneumoniaeIsolate from a Bloodstream Infection

    Article • Genome Announcements, September 2015, ASM Journals

    Tommaso Giani

  19. Impact of a clinical microbiology–intensive care consulting program in a cardiothoracic intensive care unit

    Article • American Journal of Infection Control, September 2015, Elsevier

    Tommaso Giani

  20. Large Nosocomial Outbreak of Colistin-Resistant, Carbapenemase-Producing Klebsiella pneumoniae Traced to Clonal Expansion of anmgrBDeletion Mutant

    Article • Journal of Clinical Microbiology, July 2015, ASM Journals

    Tommaso Giani

  21. In vitro activity of ceftazidime, ceftaroline and aztreonam alone and in combination with avibactam against European Gram-negative and Gram-positive clinical isolates

    Article • International Journal of Antimicrobial Agents, June 2015, Elsevier

    Tommaso Giani

  22. Bactericidal activity of ceftaroline against mature Staphylococcus aureus biofilms

    Article • International Journal of Antimicrobial Agents, May 2015, Elsevier

    Tommaso Giani

  23. Polymyxin Resistance Caused bymgrBInactivation Is Not Associated with Significant Biological Cost in Klebsiella pneumoniae

    Article • Antimicrobial Agents and Chemotherapy, February 2015, ASM Journals

    Tommaso Giani

  24. Accuracy of different methods for susceptibility testing of gentamicin with KPC carbapenemase-producing Klebsiella pneumoniae

    Article • Diagnostic Microbiology and Infectious Disease, February 2015, Elsevier

    Tommaso Giani

  25. Methicillin-resistant Staphylococcus aureus in hospitalized patients from the Bolivian Chaco

    Article • International Journal of Infectious Diseases, January 2015, Elsevier

    Tommaso Giani

  26. Catheter-related bacteremia by Cupriavidus metallidurans

    Article • Diagnostic Microbiology and Infectious Disease, January 2015, Elsevier

    Tommaso Giani

  27. Colistin resistance superimposed to endemic carbapenem-resistant Klebsiella pneumoniae: a rapidly evolving problem in Italy, November 2013 to April 2014

    Article • Eurosurveillance, October 2014, European Centre for Disease Control and Prevention (ECDC)

    Tommaso Giani

  28. MgrB Inactivation Is a Common Mechanism of Colistin Resistance in KPC-Producing Klebsiella pneumoniae of Clinical Origin

    Article • Antimicrobial Agents and Chemotherapy, July 2014, ASM Journals

    Tommaso Giani

  29. Characterization of pFOX-7a, a conjugative IncL/M plasmid encoding the FOX-7 AmpC-type  -lactamase, involved in a large outbreak in a neonatal intensive care unit

    Article • Journal of Antimicrobial Chemotherapy, June 2014, Oxford University Press (OUP)

    Tommaso Giani

  30. Epidemic Diffusion of OXA-23-Producing Acinetobacter baumannii Isolates in Italy: Results of the First Cross-Sectional Countrywide Survey

    Article • Journal of Clinical Microbiology, June 2014, ASM Journals

    Dr Francesco Luzzaro, Tommaso Giani, Francesco Luzzaro

  31. In VivoEvolution to Colistin Resistance by PmrB Sensor Kinase Mutation in KPC-Producing Klebsiella pneumoniae Is Associated with Low-Dosage Colistin Treatment

    Article • Antimicrobial Agents and Chemotherapy, May 2014, ASM Journals

    Tommaso Giani

  32. Diversity of Capsular Polysaccharide Gene Clusters in Kpc-Producing Klebsiella pneumoniae Clinical Isolates of Sequence Type 258 Involved in the Italian Epidemic

    Article • PLoS ONE, May 2014, PLOS

    Tommaso Giani

  33. Emergence of Escherichia coli ST131 sub-clone H30 producing VIM-1 and KPC-3 carbapenemases, Italy

    Article • Journal of Antimicrobial Chemotherapy, May 2014, Oxford University Press (OUP)

    Tommaso Giani

  34. Cross-Infection of Solid Organ Transplant Recipients by a Multidrug-Resistant Klebsiella pneumoniae Isolate Producing the OXA-48 Carbapenemase, Likely Derived from a Multiorgan Donor

    Article • Journal of Clinical Microbiology, April 2014, ASM Journals

    Dr Francesco Luzzaro, Tommaso Giani, Francesco Luzzaro

  35. Rapid Resistome Fingerprinting and Clonal Lineage Profiling of Carbapenem-Resistant Klebsiella pneumoniae Isolates by Targeted Next-Generation Sequencing

    Article • Journal of Clinical Microbiology, January 2014, ASM Journals

    Tommaso Giani

  36. Carbapenemase-producing Enterobacteriaceae during 2011-12 in the Bolzano area (Northern Italy): increasing diversity in a low-endemicity setting

    Article • Diagnostic Microbiology and Infectious Disease, December 2013, Elsevier

    Tommaso Giani

  37. Breakthrough Bacteremia by Linezolid-Susceptible Enterococcus faecalis under Linezolid Treatment in a Severe Polytrauma Patient

    Article • Antimicrobial Agents and Chemotherapy, November 2013, ASM Journals

    Tommaso Giani

  38. Large Oligoclonal Outbreak Due to Klebsiella pneumoniae ST14 and ST26 Producing the FOX-7 AmpC  -Lactamase in a Neonatal Intensive Care Unit

    Article • Journal of Clinical Microbiology, October 2013, ASM Journals

    Tommaso Giani

  39. In VivoEmergence of Colistin Resistance in Klebsiella pneumoniae Producing KPC-Type Carbapenemases Mediated by Insertional Inactivation of the PhoQ/PhoPmgrBRegulator

    Article • Antimicrobial Agents and Chemotherapy, August 2013, ASM Journals

    Tommaso Giani

  40. Synergistic Activity of Colistin plus Rifampin against Colistin-Resistant KPC-Producing Klebsiella pneumoniae

    Article • Antimicrobial Agents and Chemotherapy, June 2013, ASM Journals

    Tommaso Giani

  41. Assessment of the Phoenix™ automated system and EUCAST breakpoints for antimicrobial susceptibility testing against isolates expressing clinically relevant resistance mechanisms

    Article • Clinical Microbiology and Infection, November 2012, Elsevier

    Tommaso Giani

  42. Rapid detection of intestinal carriage of Klebsiella pneumoniae producing KPC carbapenemase during an outbreak

    Article • Journal of Hospital Infection, June 2012, Elsevier

    Tommaso Giani

  43. Evaluation of the New NucliSENS EasyQ KPC Test for Rapid Detection of Klebsiella pneumoniae Carbapenemase Genes (blaKPC)

    Article • Journal of Clinical Microbiology, May 2012, ASM Journals

    Tommaso Giani

  44. Epidemiological characterization and distribution of carbapenem-resistant Acinetobacter baumannii clinical isolates in Italy

    Article • Clinical Microbiology and Infection, February 2012, Elsevier

    Tommaso Giani

  45. Escherichia coli from Italy Producing OXA-48 Carbapenemase Encoded by a Novel Tn1999Transposon Derivative

    Article • Antimicrobial Agents and Chemotherapy, January 2012, ASM Journals

    Tommaso Giani

  46. VIM-1-Producing Pseudomonas mosselii Isolates in Italy, Predating Known VIM-Producing Index Strains

    Article • Antimicrobial Agents and Chemotherapy, January 2012, ASM Journals

    Tommaso Giani

  47. Direct identification from Bact/Alert™ blood culture bottles by MALDI-TOF

    Article • Microbiologia Medica, December 2011, PAGEPress Publications

    Tommaso Giani

  48. Direct identification of bacteria in blood culture by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry: a new methodological approach

    Article • Rapid Communications in Mass Spectrometry, July 2011, Wiley

    Tommaso Giani

  49. Diabetic Foot Osteomyelitis Due to Klebsiella pneumoniae Carbapenemase-Producing Klebsiella pneumoniae

    Article • Infectious Diseases in Clinical Practice, July 2011, Wolters Kluwer Health

    Tommaso Giani

  50. Persistent Carriage and Infection by Multidrug-Resistant Escherichia coli ST405 Producing NDM-1 Carbapenemase: Report on the First Italian Cases

    Article • Journal of Clinical Microbiology, April 2011, ASM Journals

    Tommaso Giani

  51. Evolution and Spread of a Multidrug-Resistant Proteus mirabilis Clone with Chromosomal AmpC-Type Cephalosporinases in Europe

    Article • Antimicrobial Agents and Chemotherapy, March 2011, ASM Journals

    Tommaso Giani

  52. Isolation of Klebsiella pneumoniae strains with altered susceptibility to carbapenems not carbapenemase mediated

    Article • Microbiologia Medica, December 2009, PAGEPress Publications

    Tommaso Giani

  53. Emergence in Italy of Klebsiella pneumoniae Sequence Type 258 Producing KPC-3 Carbapenemase

    Article • Journal of Clinical Microbiology, September 2009, ASM Journals

    Tommaso Giani

  54. Characterization of pABVA01, a Plasmid Encoding the OXA-24 Carbapenemase from Italian Isolates of Acinetobacter baumannii

    Article • Antimicrobial Agents and Chemotherapy, June 2009, ASM Journals

    Paolo Visca, Dr Francesco Luzzaro, Tommaso Giani, Francesco Luzzaro

  55. Spread of multidrug-resistant Proteus mirabilis isolates producing an AmpC-type β-lactamase: epidemiology and clinical management

    Article • International Journal of Antimicrobial Agents, April 2009, Elsevier

    Dr Francesco Luzzaro, Tommaso Giani, Francesco Luzzaro

  56. blaACT-2 : UN NUOVO DETERMINANTE DI RESISTENZA DI CLASSE C NELLA SPECIE ENTEROBACTER

    Article • Microbiologia Medica, September 2007, PAGEPress Publications

    Tommaso Giani

  57. CORRELAZIONE TRA VARIANTI ALLELICHE DEI GENI blaOXA-51-SIMILI E CLONALITÀ IN ACINETOBACTER BAUMANNII

    Article • Microbiologia Medica, September 2007, PAGEPress Publications

    Tommaso Giani

  58. P1005 Resident OXA-51-like carbapenemases in Acinetobacter baumannii: a useful marker for genotyping?

    Article • International Journal of Antimicrobial Agents, March 2007, Elsevier

    Dr Francesco Luzzaro, Tommaso Giani, Francesco Luzzaro

  59. O430 Detection of CTX-M-14 βlactamase lactamase in Escherichia coli from a long-term care and rehabilitation facility in northern Italy

    Article • International Journal of Antimicrobial Agents, March 2007, Elsevier

    Tommaso Giani

  60. CMY-16, a Novel Acquired AmpC-Type β-Lactamase of the CMY/LAT Lineage in Multifocal Monophyletic Isolates of Proteus mirabilis from Northern Italy

    Article • Antimicrobial Agents and Chemotherapy, February 2006, ASM Journals

    Dr Francesco Luzzaro, Tommaso Giani, Francesco Luzzaro