All Stories

  1. Concentrations of Transition Metal Ions in Rat Lungs after Tobacco Smoke Exposure and Treatment with His-Leu Dipeptide

    Article • Molecules, January 2023, MDPI AG

    Tomasz Fraczyk

  2. Ni(II) Ions May Target the Entire Melatonin Biosynthesis Pathway—A Plausible Mechanism of Nickel Toxicity

    Article • Molecules, August 2022, MDPI AG

    Tomasz Fraczyk

  3. Neglected N-Truncated Amyloid-β Peptide and Its Mixed Cu–Zn Complexes

    Article • The Protein Journal, June 2022, Springer Science + Business Media

    Tomasz Fraczyk

  4. Ni2+-Assisted Hydrolysis May Affect the Human Proteome; Filaggrin Degradation Ex Vivo as an Example of Possible Consequences

    Article • Frontiers in Molecular Biosciences, March 2022, Frontiers

    Tomasz Fraczyk

  5. Intermediate Cu(II)-Thiolate Species in the Reduction of Cu(II)GHK by Glutathione: A Handy Chelate for Biological Cu(II) Reduction

    Article • Inorganic Chemistry, November 2021, American Chemical Society (ACS)

    Tomasz Fraczyk

  6. Ternary Cu2+ Complexes of Human Serum Albumin and Glycyl-l-histidyl-l-lysine

    Article • Inorganic Chemistry, November 2021, American Chemical Society (ACS)

    Tomasz Fraczyk

  7. Phosphorylation Impacts Cu(II) Binding by ATCUN Motifs

    Article • Inorganic Chemistry, June 2021, American Chemical Society (ACS)

    Tomasz Fraczyk

  8. Cu(II)‐Binding N‐Terminal Sequences of Human Proteins

    Article • Chemistry & Biodiversity, March 2021, Wiley

    Tomasz Fraczyk

  9. Design and in Vitro Characterization of Tricyclic Benzodiazepine Derivatives as Potent and Selective Antileukemic Agents

    Article • Chemistry & Biodiversity, December 2020, Wiley

    Tomasz Fraczyk

  10. The Palladium(II) Complex of Aβ4−16 as Suitable Model for Structural Studies of Biorelevant Copper(II) Complexes of N-Truncated Beta-Amyloids

    Article • International Journal of Molecular Sciences, December 2020, MDPI AG

    Tomasz Fraczyk

  11. Ternary Cu(II) Complex with GHK Peptide and Cis-Urocanic Acid as a Potential Physiologically Functional Copper Chelate

    Article • International Journal of Molecular Sciences, August 2020, MDPI AG

    Tomasz Fraczyk

  12. Peptide bond cleavage in the presence of Ni-containing particles

    Article • Metallomics, May 2020, Oxford University Press (OUP)

    Tomasz Fraczyk

  13. Peptide Bond Cleavage by Ni(II) Ions within the Nuclear Localization Signal Sequence

    Article • Chemistry & Biodiversity, January 2020, Wiley

    Tomasz Fraczyk

  14. The Sub‐picomolar Cu2+Dissociation Constant of Human Serum Albumin

    Article • ChemBioChem, October 2019, Wiley

    Tomasz Fraczyk

  15. Interplay between Copper, Neprilysin, and N-Truncation of β-Amyloid

    Article • Inorganic Chemistry, May 2018, American Chemical Society (ACS)

    Tomasz Fraczyk

  16. New insights into interactions between the nucleotide-binding domain of CFTR and keratin 8

    Article • Protein Science, January 2017, Wiley

    Tomasz Fraczyk

  17. Effect of surfactants on surface activity and rheological properties of type I collagen at air/water interface

    Article • Colloids and Surfaces B Biointerfaces, December 2016, Elsevier

    Tomasz Fraczyk

  18. On the ability of CuAβ1-x peptides to form ternary complexes: Neurotransmitter glutamate is a competitor while not a ternary partner

    Article • Journal of Inorganic Biochemistry, March 2016, Elsevier

    Tomasz Fraczyk

  19. Metal assisted peptide bond hydrolysis: Chemistry, biotechnology and toxicological implications

    Article • Coordination Chemistry Reviews, March 2016, Elsevier

    Tomasz Fraczyk

  20. Effect of enzymatic hydrolysis on surface activity and surface rheology of type I collagen

    Article • Colloids and Surfaces B Biointerfaces, January 2016, Elsevier

    Tomasz Fraczyk

  21. Phosphorylation of thymidylate synthase affects slow-binding inhibition by 5-fluoro-dUMP and N4-hydroxy-dCMP

    Article • Molecular BioSystems, January 2016, Royal Society of Chemistry

    Tomasz Fraczyk

  22. Properties of phosphorylated thymidylate synthase

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, December 2015, Elsevier

    Tomasz Fraczyk

  23. A Functional Role for Aβ in Metal Homeostasis? N-Truncation and High-Affinity Copper Binding

    Article • Angewandte Chemie, July 2015, Wiley

    Tomasz Fraczyk

  24. Crystal structure of Trichinella spiralis thymidylate synthase complexed with dUMP

    Article • June 2015, Protein Data Bank, Rutgers University

    Tomasz Fraczyk

  25. Unusual Zn(II) Affinities of Zinc Fingers of Poly(ADP-ribose) Polymerase 1 (PARP-1) Nuclear Protein

    Article • Chemical Research in Toxicology, January 2015, American Chemical Society (ACS)

    Tomasz Fraczyk

  26. Ni(ii) ions cleave and inactivate human alpha-1 antitrypsin hydrolytically, implicating nickel exposure as a contributing factor in pathologies related to antitrypsin deficiency

    Article • Metallomics, January 2015, Oxford University Press (OUP)

    Tomasz Fraczyk

  27. Human Annexins A1, A2, and A8 as Potential Molecular Targets for Ni(II) Ions

    Article • Chemical Research in Toxicology, November 2014, American Chemical Society (ACS)

    Tomasz Fraczyk

  28. cis-Urocanic acid as a potential nickel(ii) binding molecule in the human skin

    Article • Dalton Transactions, January 2014, Royal Society of Chemistry

    Tomasz Fraczyk

  29. Revised Coordination Model and Stability Constants of Cu(II) Complexes of Tris Buffer

    Article • Inorganic Chemistry, December 2013, American Chemical Society (ACS)

    Tomasz Fraczyk

  30. Crystal structure of Trichinella spiralis thymidylate synthase complexed with dUMP

    Article • July 2013, Protein Data Bank, Rutgers University

    Tomasz Fraczyk

  31. Crystal structures of thymidylate synthase from nematodes, Trichinella spiralis and Caenorhabditis elegans, as a potential template for species-specific drug design

    Article • Pteridines, May 2013, De Gruyter

    Tomasz Fraczyk

  32. Tyrosinenitration affects thymidylate synthase properties

    Article • Organic & Biomolecular Chemistry, January 2012, Royal Society of Chemistry

    Piotr Stefanowicz, Tomasz Fraczyk

  33. Phosphorylation of basic amino acid residues in proteins: important but easily missed.

    Article • Acta Biochimica Polonica, May 2011, Polskie Towarzystwo Biochemiczne (Polish Biochemical Society)

    Tomasz Fraczyk

  34. Electron capture dissociation mass spectrometric analysis of lysine-phosphorylated peptides

    Article • Bioscience Reports, September 2010, Portland Press Ltd.

    Piotr Stefanowicz, Tomasz Fraczyk

  35. Phosphorylation of thymidylate synthase from various sources by human protein kinase CK2 and its catalytic subunits

    Article • Bioorganic Chemistry, June 2010, Elsevier

    Tomasz Fraczyk

  36. Mechanism of influence of phosphorylation on serine 124 on a decrease of catalytic activity of human thymidylate synthase

    Article • Bioorganic & Medicinal Chemistry, May 2010, Elsevier

    Tomasz Fraczyk

  37. Thiophosphorylation of free amino acids and enzyme protein by thiophosphoramidate ions

    Article • Bioorganic Chemistry, April 2010, Elsevier

    Tomasz Fraczyk

  38. Crystal structure of mouse thymidylate synthase in complex with dUMP

    Article • February 2010, Protein Data Bank, Rutgers University

    Tomasz Fraczyk

  39. The Synthesis, Reactivity and NMR Investigation on 15N-Thiophosphoramidates (Supplementary Material)

    Article • Letters in Organic Chemistry, December 2009, Bentham Science Publishers

    Tomasz Fraczyk

  40. Altered mouse leukemia L1210 thymidylate synthase, associated with cell resistance to 5-fluoro-dUrd, is not mutated but rather reflects posttranslational modification.

    Article • Acta Biochimica Polonica, February 2006, Polskie Towarzystwo Biochemiczne (Polish Biochemical Society)

    Tomasz Fraczyk

  41. Melatonin attenuates diabetes‐induced oxidative stress in rabbits

    Article • Journal of Pineal Research, November 2005, Wiley

    Tomasz Fraczyk

  42. Developmental arrest inCaenorhabditis elegansdauer larvae causes high expression of enzymes involved in thymidylate biosynthesis, similar to that found inTrichinellamuscle larvae

    Article • Parasitology, May 2005, Cambridge University Press

    Tomasz Fraczyk

  43. Diabetes-induced changes in glucose synthesis, intracellular glutathione status and hydroxyl free radical generation in rabbit kidney-cortex tubules

    Article • Molecular and Cellular Biochemistry, June 2004, Springer Science + Business Media

    Tomasz Fraczyk

  44. Differential effects of vanadium, tungsten and molybdenum on inhibition of glucose formation in renal tubules and hepatocytes of control and diabetic rabbits: Beneficial action of melatonin and N-acetylcysteine

    Article • Molecular and Cellular Biochemistry, June 2004, Springer Science + Business Media

    Tomasz Fraczyk