All Stories

  1. Direct phosphorylation events involved in HIF-α regulation: the role of GSK-3β

    Article • Hypoxia, April 2014, Taylor & Francis

    Professor Thomas Kietzmann

  2. Nutritional Countermeasures Targeting Reactive Oxygen Species in Cancer: From Mechanisms to Biomarkers and Clinical Evidence

    Article • Antioxidants and Redox Signaling, December 2013, Mary Ann Liebert Inc

    Professor Thomas Kietzmann

  3. Resveratrol Suppresses PAI-1 Gene Expression in a HumanIn VitroModel of Inflamed Adipose Tissue

    Article • Oxidative Medicine and Cellular Longevity, January 2013, Hindawi Publishing Corporation

    Professor Thomas Kietzmann

  4. GSK-3  regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1 

    Article • Blood, December 2011, American Society of Hematology

    Professor Thomas Kietzmann

  5. Taschenlehrbuch Biochemie

    Article • January 2011, Thieme Publishing Group

    Professor Thomas Kietzmann

  6. Auf einen Blick

    Article • January 2011, Thieme Publishing Group

    Professor Thomas Kietzmann

  7. 5.1 Funktionelle Kategorien

    Article • January 2011, Thieme Publishing Group

    Professor Thomas Kietzmann

  8. 5.2 Aminosäurezusammensetzung

    Article • January 2011, Thieme Publishing Group

    Professor Thomas Kietzmann

  9. 5.3 Peptidbindung

    Article • January 2011, Thieme Publishing Group

    Professor Thomas Kietzmann

  10. 5.4 Allgemeine Proteinstruktur

    Article • January 2011, Thieme Publishing Group

    Professor Thomas Kietzmann

  11. 5.5 Spezielle Proteineigenschaften

    Article • January 2011, Thieme Publishing Group

    Professor Thomas Kietzmann

  12. 6.2 Cofaktoren

    Article • January 2011, Thieme Publishing Group

    Professor Thomas Kietzmann

  13. 6.5 Enzymkinetik

    Article • January 2011, Thieme Publishing Group

    Professor Thomas Kietzmann

  14. 12.2 Nukleinsäuren

    Article • January 2011, Thieme Publishing Group

    Professor Thomas Kietzmann

  15. 13.1 Zellzyklus

    Article • January 2011, Thieme Publishing Group

    Professor Thomas Kietzmann

  16. 13.2 Apoptose

    Article • January 2011, Thieme Publishing Group

    Professor Thomas Kietzmann

  17. 14.1 RNA-Arten

    Article • January 2011, Thieme Publishing Group

    Professor Thomas Kietzmann

  18. 17.1 Virenaufbau

    Article • January 2011, Thieme Publishing Group

    Professor Thomas Kietzmann

  19. 17.4 Retroviren

    Article • January 2011, Thieme Publishing Group

    Professor Thomas Kietzmann

  20. 18.3 Tumorsuppressorgene

    Article • January 2011, Thieme Publishing Group

    Professor Thomas Kietzmann

  21. 18.5 Tumortherapie

    Article • January 2011, Thieme Publishing Group

    Professor Thomas Kietzmann

  22. 19.2 Therapeutische Anwendung

    Article • January 2011, Thieme Publishing Group

    Professor Thomas Kietzmann

  23. 2.1 Die chemische Organisation des Lebens

    Article • January 2011, Thieme Publishing Group

    Professor Thomas Kietzmann

  24. 2.2 Die Entstehung von Zellen: Prokaryonten und Eukaryonten

    Article • January 2011, Thieme Publishing Group

    Professor Thomas Kietzmann

  25. 12.1 Nukleotide, die Grundbausteine der Nukleinsäuren

    Article • January 2011, Thieme Publishing Group

    Professor Thomas Kietzmann

  26. 13.3 Replikation der DNA

    Article • January 2011, Thieme Publishing Group

    Professor Thomas Kietzmann

  27. 13.4 Mutationen und DNA-Reparatur

    Article • January 2011, Thieme Publishing Group

    Professor Thomas Kietzmann

  28. 17.2 Der Lebenszyklus von Viren

    Article • January 2011, Thieme Publishing Group

    Professor Thomas Kietzmann

  29. 17.3 Replikation und Expression von Virusgenomen

    Article • January 2011, Thieme Publishing Group

    Professor Thomas Kietzmann

  30. 17.5 Antivirale Abwehr, Prophylaxe und Therapie

    Article • January 2011, Thieme Publishing Group

    Professor Thomas Kietzmann

  31. 18.1 Tumoren und Krebs

    Article • January 2011, Thieme Publishing Group

    Professor Thomas Kietzmann

  32. 18.2 Protoonkogene und Onkogene

    Article • January 2011, Thieme Publishing Group

    Professor Thomas Kietzmann

  33. 18.4 Tumorwachstum, Tumorangiogenese und Metastasierung

    Article • January 2011, Thieme Publishing Group

    Professor Thomas Kietzmann

  34. 19.1 Gentechnik und gentechnische Verfahren

    Article • January 2011, Thieme Publishing Group

    Professor Thomas Kietzmann

  35. 27.2 Somatische Mutation und Tumorentstehung

    Article • January 2011, Thieme Publishing Group

    Professor Thomas Kietzmann

  36. PS1-73 Hypoxia-inducible factor 1α and the glucose-regulated protein 78 are up-regulated by oncostatin M in human hepatocytes and hepatoma cells

    Article • Cytokine, October 2010, Elsevier

    Professor Thomas Kietzmann

  37. Phosphorylation of the von Hippel–Lindau protein (VHL) by protein kinase CK2 reduces its protein stability and affects p53 and HIF-1α mediated transcription

    Article • The International Journal of Biochemistry & Cell Biology, October 2010, Elsevier

    Professor Thomas Kietzmann, Dr. Andreas D. Zimmer

  38. Intracellular Redox Compartments: Mechanisms and Significances

    Article • Antioxidants and Redox Signaling, August 2010, Mary Ann Liebert Inc

    Professor Thomas Kietzmann

  39. The Antioxidant Quercetin Inhibits Cellular Proliferation via HIF-1-Dependent Induction of p21WAF

    Article • Antioxidants and Redox Signaling, August 2010, Mary Ann Liebert Inc

    Professor Thomas Kietzmann

  40. FOXO4 Induces Human Plasminogen Activator Inhibitor-1 Gene Expression via an Indirect Mechanism by Modulating HIF-1α and CREB Levels

    Article • Antioxidants and Redox Signaling, August 2010, Mary Ann Liebert Inc

    Professor Thomas Kietzmann

  41. Reciprocal Regulation of Rac1 and PAK-1 by HIF-1α: A Positive-Feedback Loop Promoting Pulmonary Vascular Remodeling

    Article • Antioxidants and Redox Signaling, August 2010, Mary Ann Liebert Inc

    Professor Thomas Kietzmann

  42. The Hypoxia-Inducible Factor-2α Is Stabilized by Oxidative Stress Involving NOX4

    Article • Antioxidants and Redox Signaling, August 2010, Mary Ann Liebert Inc

    Professor Thomas Kietzmann

  43. Hypoxia-Inducible Factors: Post-translational Crosstalk of Signaling Pathways

    Article • January 2010, Springer Science + Business Media

    Professor Thomas Kietzmann

  44. FOXO1 and HNF-4 are involved in regulation of hepatic glucokinase gene expression by Resveratrol

    Article • Seminars in Musculoskeletal Radiology, January 2010, Thieme Publishing Group

    Professor Thomas Kietzmann

  45. Editorial [Hot topic: The Hypoxia-Inducible Factor (HIF) Pathway as a Target for Prevention and Treatment of Clinical Manifestations (Executive Editor: Thomas Kietzmann)]

    Article • Current Pharmaceutical Design, November 2009, Bentham Science Publishers

    Professor Thomas Kietzmann

  46. Kinases as Upstream Regulators of the HIF System: Their Emerging Potential as Anti-Cancer Drug Targets

    Article • Current Pharmaceutical Design, November 2009, Bentham Science Publishers

    Professor Thomas Kietzmann

  47. Hypoxia-inducible factor 1α is upregulated by oncostatin M via Jak/STAT3 and the MEK/Erk1/2 pathway

    Article • Cytokine, October 2009, Elsevier

    Professor Thomas Kietzmann

  48. FoxO1 and HNF-4 Are Involved in Regulation of Hepatic Glucokinase Gene Expression by Resveratrol

    Article • Journal of Biological Chemistry, September 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Thomas Kietzmann

  49. Hypoxia-inducible factor 1α is up-regulated by oncostatin M and participates in oncostatin M signaling #

    Article • Hepatology, July 2009, Wolters Kluwer Health

    Professor Thomas Kietzmann

  50. The sirtuin activator represses glucokinase expression via the combined action of FoxO1 and HNF-4

    Article • Seminars in Musculoskeletal Radiology, January 2009, Thieme Publishing Group

    Professor Thomas Kietzmann

  51. Hepatocyte-specific deficiency of SOD-2 causes liver failure and promotes tumorigenesis

    Article • Seminars in Musculoskeletal Radiology, January 2009, Thieme Publishing Group

    Professor Thomas Kietzmann

  52. Metabolic, hormonal and environmental regulation of plasminogen activator inhibitor-1 (PAI-1) expression: Lessons from the liver

    Article • Thrombosis and Haemostasis, November 2008, Schattauer GmbH

    Professor Thomas Kietzmann

  53. Plasminogen activator inhibitor-1 (PAI-1): A molecule at the crossroads to cell survival or cell death

    Article • Thrombosis and Haemostasis, November 2008, Schattauer GmbH

    Professor Thomas Kietzmann

  54. Opposite Expression of the Antioxidant Heme Oxygenase-1 in Primary Cells and Tumor Cells: Regulation by Interaction of USF-2 and Fra-1

    Article • Antioxidants and Redox Signaling, July 2008, Mary Ann Liebert Inc

    Professor Thomas Kietzmann

  55. Transcriptional Regulation of Serine/Threonine Kinase-15 (STK15) Expression by Hypoxia and HIF-1

    Article • Molecular Biology of the Cell, June 2008, American Society for Cell Biology (ASCB)

    Professor Thomas Kietzmann

  56. HIF-1α Signaling Upstream of NKX2.5 Is Required for Cardiac Development in Xenopus

    Article • Journal of Biological Chemistry, February 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Thomas Kietzmann

  57. Inhibition of phorbol ester-dependent peroxiredoxin I gene activation by lipopolysaccharide via phosphorylation of RelA/p65 at serine 276 in monocytes

    Article • Free Radical Biology and Medicine, February 2008, Elsevier

    Professor Thomas Kietzmann

  58. CREB binding to the hypoxia-inducible factor-1 responsive elements in the plasminogen activator inhibitor-1 promoter mediates the glucagon effect

    Article • Thrombosis and Haemostasis, July 2007, Schattauer GmbH

    Professor Thomas Kietzmann

  59. Deficiency of manganese superoxide dismutase in hepatocytes disrupts zonated gene expression in mouse liver

    Article • Archives of Biochemistry and Biophysics, June 2007, Elsevier

    Professor Thomas Kietzmann

  60. Glycogen Synthase Kinase 3 Phosphorylates Hypoxia-Inducible Factor 1α and Mediates Its Destabilization in a VHL-Independent Manner

    Article • Molecular and Cellular Biology, February 2007, ASM Journals

    Professor Thomas Kietzmann

  61. Superoxide and Derived Reactive Oxygen Species in the Regulation of Hypoxia‐Inducible Factors

    Article • January 2007, Elsevier

    Professor Thomas Kietzmann

  62. The MODY2 gene glucokinase is negatively regulated by FoxO forkhead transcription factors

    Article • Seminars in Musculoskeletal Radiology, January 2007, Thieme Publishing Group

    Professor Thomas Kietzmann

  63. NOX2 and NOX4 Mediate Proliferative Response in Endothelial Cells

    Article • Antioxidants and Redox Signaling, September 2006, Mary Ann Liebert Inc

    Professor Thomas Kietzmann

  64. The Endoplasmic Reticulum: Folding, Calcium Homeostasis, Signaling, and Redox Control

    Article • Antioxidants and Redox Signaling, September 2006, Mary Ann Liebert Inc

    Professor Thomas Kietzmann

  65. The role of hypoxia inducible factor-1 in cell metabolism – a possible target in cancer therapy

    Article • Expert Opinion on Therapeutic Targets, July 2006, Informa Healthcare

    Professor Thomas Kietzmann

  66. Regulation of rat heme oxygenase-1 expression by interleukin-6 via the Jak/STAT pathway in hepatocytes

    Article • Journal of Hepatology, July 2006, Elsevier

    Professor Thomas Kietzmann

  67. Influence of ischemia/hypoxia on the HIF-1 activity and expression of hypoxia-dependent genes in the cochlea of the newborn rat

    Article • April 2006, Elsevier

    Professor Thomas Kietzmann

  68. Subcellular localization of rat Abca5, a rat ATP-binding-cassette transporter expressed in Leydig cells, and characterization of its splice variant apparently encoding a half-transporter

    Article • Biochemical Journal, January 2006, Portland Press Ltd.

    Professor Thomas Kietzmann

  69. Oxygen-Dependent Modulation of Insulin-Like Growth Factor Binding Protein Biosynthesis in Primary Cultures of Rat Hepatocytes

    Article • Endocrinology, December 2005, Endocrine Society

    Professor Thomas Kietzmann

  70. Reactive oxygen species in the control of hypoxia-inducible factor-mediated gene expression

    Article • Seminars in Cell and Developmental Biology, August 2005, Elsevier

    Professor Thomas Kietzmann

  71. Glucokinase: old enzyme, new target

    Article • Expert Opinion on Therapeutic Patents, June 2005, Informa Healthcare

    Professor Thomas Kietzmann

  72. Thrombin activates the p21-activated kinase in pulmonary artery smooth muscle cells. Role in tissue factor expression

    Article • Thrombosis and Haemostasis, May 2005, Schattauer GmbH

    Professor Thomas Kietzmann

  73. Transcriptional regulation of plasminogen activator inhibitor-1 expression by insulin-like growth factor-1 via MAP kinases and hypoxia-inducible factor-1 in HepG2 cells

    Article • Thrombosis and Haemostasis, May 2005, Schattauer GmbH

    Professor Thomas Kietzmann, Professor Trine Fink

  74. Upregulation of heme oxygenase-1 gene by turpentine oil-induced localized inflammation: involvement of interleukin-6

    Article • Laboratory Investigation, March 2005, Elsevier

    Professor Thomas Kietzmann

  75. Role of NF-kB and p38 MAP Kinase Signaling Pathways in the Lipopolysaccharide-Dependent Activation of Heme Oxygenase-1 Gene Expression

    Article • Antioxidants and Redox Signaling, October 2004, Mary Ann Liebert Inc

    Professor Thomas Kietzmann

  76. Role of NF-κB and p38 MAP Kinase Signaling Pathways in the Lipopolysaccharide-Dependent Activation of Heme Oxygenase-1 Gene Expression

    Article • Antioxidants and Redox Signaling, October 2004, Mary Ann Liebert Inc

    Professor Thomas Kietzmann

  77. Oxidative Stress and Hypoxia: Implications for Plasminogen Activator Inhibitor-1 Expression

    Article • Antioxidants and Redox Signaling, August 2004, Mary Ann Liebert Inc

    Professor Thomas Kietzmann

  78. Enhanced Plasminogen Activator Inhibitor-1 Expression in Transgenic Mice with Hepatocyte-Specific Overexpression of Superoxide Dismutase or Glutathione Peroxidase

    Article • Antioxidants and Redox Signaling, August 2004, Mary Ann Liebert Inc

    Professor Thomas Kietzmann

  79. Signal Transducing Kinases and Cancer

    Article • TumorDiagnostik & Therapie, August 2004, Thieme Publishing Group

    Professor Thomas Kietzmann

  80. Nuclear localization of the hypoxia-regulated pro-apoptotic protein BNIP3 after global brain ischemia in the rat hippocampus

    Article • Brain Research, March 2004, Elsevier

    Professor Thomas Kietzmann

  81. Redox-sensitive regulation of the HIF pathway under non-hypoxic conditions in pulmonary artery smooth muscle cells

    Article • Biological Chemistry, January 2004, De Gruyter

    Professor Thomas Kietzmann

  82. Modulation of glucokinase expression by hypoxia-inducible factor 1 and upstream stimulatory factor 2 in primary rat hepatocytes

    Article • Biological Chemistry, January 2004, De Gruyter

    Professor Thomas Kietzmann

  83. Oxygen-Dependent Regulation of Hepatic Glucose Metabolism

    Article • January 2004, Elsevier

    Professor Thomas Kietzmann

  84. Expression of hypoxia-inducible factor-1 in the cochlea of newborn rats

    Article • Hearing Research, September 2003, Elsevier

    Professor Thomas Kietzmann

  85. Redox Signaling through NADPH Oxidases: Involvement in Vascular Proliferation and Coagulation

    Article • Annals of the New York Academy of Sciences, November 2002, Wiley

    Professor Thomas Kietzmann

  86. Hypoxia-inducible factor-1 and hypoxia response elements mediate the induction of plasminogen activator inhibitor-1 gene expression by insulin in primary rat hepatocytes

    Article • Blood, September 2002, American Society of Hematology

    Professor Thomas Kietzmann

  87. Signaling cross-talk between hypoxia and glucose via hypoxia-inducible factor 1 and glucose response elements

    Article • Biochemical Pharmacology, September 2002, Elsevier

    Professor Thomas Kietzmann

  88. Activation of glucokinase gene expression by hepatic nuclear factor 4α in primary hepatocytes

    Article • Biochemical Journal, July 2002, Portland Press Ltd.

    Professor Thomas Kietzmann

  89. Hypoxia-induced cell death and changes in hypoxia-inducible factor-1 activity in PC12 cells upon exposure to nerve growth factor

    Article • Molecular Brain Research, July 2002, Elsevier

    Professor Thomas Kietzmann

  90. Molecular Mechanism of Heme Oxygenase-1 Gene Induction by Activation of the Protein Kinase A-Dependent Signaling Pathway

    Article • January 2002, Springer Science + Business Media

    Professor Thomas Kietzmann

  91. Hypoxia-Inducible Factor-1 (Hif-1) in Experimental Brain Ischemia

    Article • The Scientific World JOURNAL, January 2002, Hindawi Publishing Corporation

    Professor Thomas Kietzmann

  92. Selective cardiorespiratory and catecholaminergic areas express the hypoxia‐inducible factor‐1α (HIF‐1α) under in vivo hypoxia in rat brainstem

    Article • European Journal of Neuroscience, December 2001, Wiley

    Professor Thomas Kietzmann

  93. Hypoxia and hypoxia-inducible factor modulated gene expression in brain: involvement in neuroprotection and cell death

    Article • European Archives of Psychiatry and Clinical Neuroscience, August 2001, Springer Science + Business Media

    Professor Thomas Kietzmann

  94. Cross-Talk between the Signals Hypoxia and Glucose at the Glucose Response Element of the L-Type Pyruvate Kinase Gene1

    Article • Endocrinology, June 2001, Endocrine Society

    Professor Thomas Kietzmann

  95. Perivenous expression of the mRNA of the three hypoxia-inducible factor α-subunits, HIF1α, HIF2α and HIF3α, in rat liver

    Article • Biochemical Journal, March 2001, Portland Press Ltd.

    Professor Thomas Kietzmann

  96. Differential effects of hypoxia on untreated and NGF treated PC12 cells

    Article • Life Sciences, October 2000, Elsevier

    Professor Thomas Kietzmann

  97. Physiological oxygen tensions modulate expression of the mdr1b multidrug-resistance gene in primary rat hepatocyte cultures

    Article • Biochemical Journal, September 2000, Portland Press Ltd.

    Professor Thomas Kietzmann

  98. Perivenous localization of insulin receptor protein in rat liver, and regulation of its expression by glucose and oxygen in hepatocyte cultures

    Article • Biochemical Journal, June 2000, Portland Press Ltd.

    Professor Thomas Kietzmann

  99. Serum-Free, Long-Term Cultures of Human Hepatocytes: Maintenance of Cell Morphology, Transcription Factors, and Liver-Specific Functions

    Article • Biochemical and Biophysical Research Communications, March 2000, Elsevier

    Professor Thomas Kietzmann

  100. Oxygen: Modulator of metabolic zonation and disease of the liver

    Article • Hepatology, February 2000, Wolters Kluwer Health

    Professor Thomas Kietzmann

  101. Identification of an oxygen-responsive element in the 5′-flanking sequence of the rat cytosolic phosphoenolpyruvate carboxykinase-1 gene, modulating its glucagon-dependent activation

    Article • Biochemical Journal, May 1999, Portland Press Ltd.

    Professor Thomas Kietzmann

  102. Periportal localization of glucagon receptor mRNA in rat liver and regulation of its expression by glucose and oxygen in hepatocyte cultures

    Article • FEBS Letters, January 1998, Wiley

    Professor Thomas Kietzmann

  103. Constitutive and lipopolysaccharide regulated gene expression of the antioxidant heme oxygenase-1 in kupffer cells of rat liver

    Article • Journal of Hepatology, January 1998, Elsevier

    Professor Thomas Kietzmann

  104. Role of oxygen in the zonation of carbohydrate metabolism and gene expression in liver

    Article • Kidney International, February 1997, Elsevier

    Professor Thomas Kietzmann

  105. Diminution of the O2 responsiveness of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene in rat hepatocytes by long-term culture at venous PO2

    Article • Kidney International, February 1997, Elsevier

    Professor Thomas Kietzmann

  106. Regulation of the gluconeogenic phosphoenolpyruvate carboxykinase and the glycolytic aldolase A gene expression by O2 in rat hepatocyte cultures. Involvement of hydrogen peroxide as mediator in the response to O2

    Article • FEBS Letters, June 1996, Wiley

    Professor Thomas Kietzmann

  107. Modulation of Hemopexin Gene Expression by Physiological Oxygen Tensions in Primary Rat Hepatocyte Cultures

    Article • Biochemical and Biophysical Research Communications, August 1995, Elsevier

    Professor Thomas Kietzmann

  108. Basal and insulin-stimulated phosphoenolpyruvate carboxykinase (PCK) mRNA degradation is not modulated by oxygen in contrast to it's glucagon-dependent induction in primary rat hepatocyte cultures

    Article • Hepatology, April 1994, Elsevier

    Professor Thomas Kietzmann

  109. Oxygen sensed via a ferro-heme protein modulates the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase (PCK) gene in rat hepatocyte cultures

    Article • Hepatology, October 1993, Elsevier

    Professor Thomas Kietzmann

  110. Modulation of the glucagon‐dependent activation of the phosphoenolpyruvate carboxykinase gene by oxygen in rat hepatocyte cultures Evidence for a heme protein as oxygen sensor

    Article • FEBS Letters, October 1992, Wiley

    Professor Thomas Kietzmann

  111. Involvement of Intracellular Reactive Oxygen Species in the Control of Gene Expression by Oxygen

    Article • Springer Science + Business Media

    Professor Thomas Kietzmann