All Stories

  1. The crystal structure of phosphorylated MAPK13 reveals common structural features and differences in p38 MAPK family activation

    Article • Acta Crystallographica Section D Biological Crystallography, March 2015, International Union of Crystallography

    Professor Thomas J Brett

  2. Secreted CLCA1 modulates TMEM16A to activate Ca 2+ -dependent chloride currents in human cells

    Article • eLife, March 2015, eLife

    Monica Sala-Rabanal, Professor Thomas J Brett

  3. Secreted Human CLCA1 Activates Calcium-Dependent Chloride Currents via Interaction with TMEM16A (Anoctamin 1)

    Article • Biophysical Journal, January 2015, Elsevier

    Monica Sala-Rabanal, Professor Thomas J Brett

  4. Ebola Virus VP24 Targets a Unique NLS Binding Site on Karyopherin Alpha 5 to Selectively Compete with Nuclear Import of Phosphorylated STAT1

    Article • Cell Host & Microbe, August 2014, Elsevier

    Professor Thomas J Brett

  5. Preparation, crystallization, and preliminary crystallographic analysis of wild-type and mutant human TREM-2 ectodomains linked to neurodegenerative and inflammatory diseases

    Article • Protein Expression and Purification, April 2014, Elsevier

    Professor Thomas J Brett

  6. BST-2/tetherin: Structural biology, viral antagonism, and immunobiology of a potent host antiviral factor

    Article • Molecular Immunology, June 2013, Elsevier

    Professor Thomas J Brett

  7. Self-Cleavage of Human CLCA1 by its Novel Metalloprotease Domain Controls Calcium-Activated Chloride Channel Activation

    Article • Biophysical Journal, January 2013, Elsevier

    Monica Sala-Rabanal, Professor Thomas J Brett

  8. IL-13–induced airway mucus production is attenuated by MAPK13 inhibition

    Article • Journal of Clinical Investigation, November 2012, American Society for Clinical Investigation

    Professor Thomas J Brett

  9. Do GGA Adaptors Bind Internal DXXLL Motifs?

    Article • Traffic, July 2012, Wiley

    Professor Thomas J Brett

  10. Structural and Biophysical Analysis of BST-2/Tetherin Ectodomains Reveals an Evolutionary Conserved Design to Inhibit Virus Release

    Article • Journal of Biological Chemistry, November 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Thomas J Brett

  11. ChemInform Abstract: Synthesis and Structure of Tetrathiophene with a Chiral 1,1′-Binaphthyl Kink.

    Article • ChemInform, May 2010, Wiley

    Professor Thomas J Brett

  12. The Role of CLCA Proteins in Inflammatory Airway Disease

    Article • Annual Review of Physiology, March 2009, Annual Reviews

    Professor Thomas J Brett

  13. Molecular structures of coat and coat-associated proteins: function follows form

    Article • Current Opinion in Cell Biology, August 2006, Elsevier

    Professor Thomas J Brett

  14. Structural definition of the F-actin–binding THATCH domain from HIP1R

    Article • Nature Structural & Molecular Biology, January 2006, Springer Science + Business Media

    Professor Thomas J Brett

  15. N-domain–dependent nonphosphorylated STAT4 dimers required for cytokine-driven activation

    Article • Nature Immunology, January 2004, Springer Science + Business Media

    Professor Thomas J Brett

  16. Structural Basis of Chemokine Sequestration by a Herpesvirus Decoy Receptor

    Article • Cell, November 2002, Elsevier

    Professor Thomas J Brett

  17. Accessory Protein Recruitment Motifs in Clathrin-Mediated Endocytosis

    Article • Structure, June 2002, Elsevier

    Professor Thomas J Brett

  18. Synthesis and structure of tetrathiophene with a chiral 1,1′-binaphthyl kink

    Article • Chemical Communications, January 2001, Royal Society of Chemistry

    Professor Thomas J Brett

  19. Synthesis, Characterization, Crystal Structures, and Reactions of Trigonal Bipyramidal Tin(IV) Complexes Containing a Tetradentate Tripodal Tristhiolatophosphine Ligand. Use in the One-Step Synthesis of an Iron(IV) Complex

    Article • Inorganic Chemistry, May 2000, American Chemical Society (ACS)

    Professor Thomas J Brett

  20. Chemical insight from crystallographic disorder-structural studies of supramolecular photochemical systems. Part 3. The β-cyclodextrin–7-hydroxy-4-methylcoumarin inclusion complex: direct observation of photodimerization by X-ray crystallography

    Article • Journal of the Chemical Society Perkin Transactions 2, January 2000, Royal Society of Chemistry

    Professor Thomas J Brett

  21. Chemical insight from crystallographic disorder-structural studies of supramolecular photochemical systems. Part 2. The β-cyclodextrin–4,7-dimethylcoumarin inclusion complex: a new β-cyclodextrin dimer packing type, unanticipated photoproduct formation...

    Article • Journal of the Chemical Society Perkin Transactions 2, January 2000, Royal Society of Chemistry

    Professor Thomas J Brett

  22. Structural studies of supramolecular β-cyclodextrin complexes with butyrophenone and valerophenone: an explanation for photochemical reaction modification

    Article • Chemical Communications, January 2000, Royal Society of Chemistry

    Professor Thomas J Brett

  23. Chemical insight from crystallographic disorder: structural studies of a supramolecular β-cyclodextrin/coumarin photochemical system

    Article • Chemical Communications, January 1999, Royal Society of Chemistry

    Professor Thomas J Brett

  24. The 20 K structure of p-amino-p′-nitrobiphenyl in the non-constraining environment of its β-cyclodextrin inclusion complex

    Article • Chemical Communications, January 1999, Royal Society of Chemistry

    Professor Thomas J Brett