All Stories

  1. Response of Cancer Stem Cells and Human Skin Fibroblasts to Picosecond-Scale Electron Irradiation at 1010 to 1011 Gy/s

    Article • International Journal of Radiation Oncology*Biology*Physics, November 2023, Elsevier

    Dr Stephen J McMahon

  2. Most DNA repair defects do not modify the relationship between relative biological effectiveness and linear energy transfer in CRISPR‐edited cells

    Article • Medical Physics, September 2023, Wiley

    Dr Stephen J McMahon

  3. High-LET radiation induces large amounts of rapidly-repaired sublethal damage

    Article • Scientific Reports, July 2023, Springer Science + Business Media

    Dr Stephen J McMahon

  4. Validation of In Vitro Trained Transcriptomic Radiosensitivity Signatures in Clinical Cohorts

    Article • Cancers, July 2023, MDPI AG

    Dr Stephen J McMahon

  5. Characterization of Intrinsic Radiation Sensitivity in a Diverse Panel of Normal, Cancerous and CRISPR-Modified Cell Lines

    Article • International Journal of Molecular Sciences, April 2023, MDPI AG

    Dr Stephen J McMahon

  6. Modelling oxygen effects on the in- and out-of-field radiosensitivity of cells exposed to intensity-modulated radiation fields

    Article • Physics in Medicine and Biology, April 2023, Institute of Physics Publishing

    Dr Stephen J McMahon

  7. Investigating the potential contribution of inter-track interactions within ultra-high dose-rate proton therapy

    Article • Physics in Medicine and Biology, February 2023, Institute of Physics Publishing

    Dr Stephen J McMahon

  8. Cellular irradiations with laser-driven carbon ions at ultra-high dose rates

    Article • Physics in Medicine and Biology, January 2023, Institute of Physics Publishing

    Dr Stephen J McMahon

  9. DNA Repair Inhibitors Potentiate Fractionated Radiotherapy More Than Single-Dose Radiotherapy in Breast Cancer Cells

    Article • Cancers, August 2022, MDPI AG

    Dr Stephen J McMahon

  10. A computational approach to quantifying miscounting of radiation-induced double-strand break immunofluorescent foci

    Article • Communications Biology, July 2022, Springer Science + Business Media

    Dr Stephen J McMahon

  11. High-dose femtosecond-scale gamma-ray beams for radiobiological applications

    Article • Physics in Medicine and Biology, April 2022, Institute of Physics Publishing

    Dr Stephen J McMahon

  12. RadSigBench: a framework for benchmarking functional genomics signatures of cancer cell radiosensitivity

    Article • Briefings in Bioinformatics, January 2022, Oxford University Press (OUP)

    Dr Stephen J McMahon

  13. Evaluating Iodine-125 DNA Damage Benchmarks of Monte Carlo DNA Damage Models

    Article • Cancers, January 2022, MDPI AG

    Dr Stephen J McMahon

  14. Investigating spatial fractionation and radiation induced bystander effects: a mathematical modelling approach

    Article • Physics in Medicine and Biology, November 2021, Institute of Physics Publishing

    Dr Stephen J McMahon

  15. A Brief Overview of the Preclinical and Clinical Radiobiology of Microbeam Radiotherapy

    Article • Clinical Oncology, November 2021, Elsevier

    Dr Stephen J McMahon

  16. Theranostic AGuIX nanoparticles as radiosensitizer: A phase I, dose-escalation study in patients with multiple brain metastases (NANO-RAD trial)

    Article • Radiotherapy and Oncology, July 2021, Elsevier

    Dr Stephen J McMahon

  17. A Mechanistic DNA Repair and Survival Model (Medras): Applications to Intrinsic Radiosensitivity, Relative Biological Effectiveness and Dose-Rate

    Article • Frontiers in Oncology, June 2021, Frontiers

    Dr Stephen J McMahon

  18. TOPAS a tool to evaluate the impact of cell geometry and radionuclide on alpha particle therapy

    Article • Biomedical Physics & Engineering Express, April 2021, Institute of Physics Publishing

    Dr Stephen J McMahon

  19. Oxygen enhancement ratios of cancer cells after exposure to intensity modulated x-ray fields: DNA damage and cell survival

    Article • Physics in Medicine and Biology, April 2021, Institute of Physics Publishing

    Dr Stephen J McMahon

  20. Proton RBE models: commonalities and differences

    Article • Physics in Medicine and Biology, February 2021, Institute of Physics Publishing

    Dr Stephen J McMahon

  21. Advances in modelling gold nanoparticle radiosensitization using new Geant4-DNA physics models

    Article • Physics in Medicine and Biology, November 2020, Institute of Physics Publishing

    Dr Stephen J McMahon

  22. Cardiac sub-volume targeting demonstrates regional radiosensitivity in the mouse heart

    Article • Radiotherapy and Oncology, November 2020, Elsevier

    Dr Stephen J McMahon

  23. Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions

    Article • Physics in Medicine and Biology, October 2020, Institute of Physics Publishing

    Zdenka Kuncic, Dr Stephen J McMahon

  24. History and current perspectives on the biological effects of high-dose spatial fractionation and high dose-rate approaches: GRID, Microbeam & FLASH radiotherapy

    Article • British Journal of Radiology, September 2020, British Institute of Radiology

    Dr Stephen J McMahon

  25. Effects of Gadolinium MRI Contrast Agents on DNA Damage and Cell Survival when Used in Combination with Radiation

    Article • Radiation Research, August 2020, Radiation Research Society

    Dr Stephen J McMahon

  26. Targeted Alpha Therapy: Current Clinical Applications

    Article • Cancer Biotherapy & Radiopharmaceuticals, August 2020, Mary Ann Liebert Inc

    Dr Stephen J McMahon

  27. Cellular Response to Proton Irradiation: A Simulation Study with TOPAS-nBio

    Article • Radiation Research, May 2020, Radiation Research Society

    Dr Stephen J McMahon

  28. A parameter sensitivity study for simulating DNA damage after proton irradiation using TOPAS-nBio

    Article • Physics in Medicine and Biology, April 2020, Institute of Physics Publishing

    Dr Stephen J McMahon

  29. A Quantitative Analysis of the Role of Oxygen Tension in FLASH Radiation Therapy

    Article • International Journal of Radiation Oncology*Biology*Physics, March 2020, Elsevier

    Dr Stephen J McMahon

  30. Intensity Modulated Radiation Fields Induce Protective Effects and Reduce Importance of Dose-Rate Effects

    Article • Scientific Reports, July 2019, Springer Science + Business Media

    Dr Stephen J McMahon

  31. Using the Proton Energy Spectrum and Microdosimetry to Model Proton Relative Biological Effectiveness

    Article • International Journal of Radiation Oncology*Biology*Physics, June 2019, Elsevier

    Dr Stephen J McMahon

  32. Predicting In Vitro Cancer Cell Survival Based on Measurable Cell Characteristics

    Article • Radiation Research, April 2019, Radiation Research Society

    Dr Stephen J McMahon

  33. Mechanistic Modeling of Radium-223 Treatment of Bone Metastases

    Article • International Journal of Radiation Oncology*Biology*Physics, April 2019, Elsevier

    Dr Stephen J McMahon

  34. Preclinical Evaluation of Dose-Volume Effects and Lung Toxicity Occurring In and Out-of-Field

    Article • International Journal of Radiation Oncology*Biology*Physics, April 2019, Elsevier

    Dr Stephen J McMahon

  35. Mechanistic Modelling of Radiation Responses

    Article • Cancers, February 2019, MDPI AG

    Dr Stephen J McMahon

  36. The linear quadratic model: usage, interpretation and challenges

    Article • Physics in Medicine and Biology, November 2018, Institute of Physics Publishing

    Dr Stephen J McMahon

  37. A New Standard DNA Damage (SDD) Data Format

    Article • Radiation Research, November 2018, Radiation Research Society

    Zdenka Kuncic, Dr Stephen J McMahon

  38. LET-weighted doses effectively reduce biological variability in proton radiotherapy planning

    Article • Physics in Medicine and Biology, October 2018, Institute of Physics Publishing

    Dr Stephen J McMahon

  39. AGuIX® from bench to bedside—Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine

    Article • British Journal of Radiology, September 2018, British Institute of Radiology

    Dr Stephen J McMahon

  40. Proton relative biological effectiveness (RBE): a multiscale problem

    Article • British Journal of Radiology, July 2018, British Institute of Radiology

    Dr Stephen J McMahon

  41. Toward A variable RBE for proton beam therapy

    Article • Radiotherapy and Oncology, July 2018, Elsevier

    Dr Stephen J McMahon

  42. Investigation of dose-rate effects and cell-cycle distribution under protracted exposure to ionizing radiation for various dose-rates

    Article • Scientific Reports, May 2018, Springer Science + Business Media

    Dr Stephen J McMahon

  43. The Radiobiology of Proton Therapy: Challenges and Opportunities Around Relative Biological Effectiveness

    Article • Clinical Oncology, February 2018, Elsevier

    Dr Stephen J McMahon

  44. Microbeam evolution: From single cell irradiation to preclinical studies

    Article • International Journal of Radiation Biology, January 2018, Taylor & Francis

    Dr Stephen J McMahon

  45. Small field dosimetry for the small animal radiotherapy research platform (SARRP)

    Article • Radiation Oncology, December 2017, Springer Science + Business Media

    Dr Stephen J McMahon

  46. The Impact of Hypoxia on Out-of-Field Cell Survival after Exposure to Modulated Radiation Fields

    Article • Radiation Research, December 2017, Radiation Research Society

    Dr Stephen J McMahon

  47. Dual effects of radiation bystander signaling in urothelial cancer: purinergic-activation of apoptosis attenuates survival of urothelial cancer and normal urothelial cells

    Article • Oncotarget, October 2017, Impact Journals, LLC

    Dr Stephen J McMahon

  48. A general mechanistic model enables predictions of the biological effectiveness of different qualities of radiation

    Article • Scientific Reports, September 2017, Nature

    Dr Stephen J McMahon

  49. A novel CBCT-based method for derivation of CTV-PTV margins for prostate and pelvic lymph nodes treated with stereotactic ablative radiotherapy

    Article • Radiation Oncology, August 2017, Springer Science + Business Media

    Dr Stephen J McMahon

  50. Comparing stochastic proton interactions simulated using TOPAS-nBio to experimental data from fluorescent nuclear track detectors

    Article • Physics in Medicine and Biology, March 2017, Institute of Physics Publishing

    Dr Stephen J McMahon

  51. A mechanistic study of gold nanoparticle radiosensitisation using targeted microbeam irradiation

    Article • Scientific Reports, March 2017, Nature

    Dr Stephen J McMahon

  52. Prostate cancer treated with brachytherapy; an exploratory study of dose-dependent biomarkers and quality of life

    Article • Radiation Oncology, March 2017, Springer Science + Business Media

    Dr Stephen J McMahon

  53. An overview of current practice in external beam radiation oncology with consideration to potential benefits and challenges for nanotechnology

    Article • Cancer Nanotechnology, February 2017, Springer Science + Business Media

    Dr Stephen J McMahon

  54. Dependence of gold nanoparticle radiosensitization on cell geometry

    Article • Nanoscale, January 2017, Royal Society of Chemistry

    Dr Stephen J McMahon

  55. Mitochondria as a target for radiosensitisation by gold nanoparticles

    Article • Journal of Physics Conference Series, January 2017, Institute of Physics Publishing

    Dr Stephen J McMahon

  56. Modelling responses to spatially fractionated radiation fields using preclinical image-guided radiotherapy

    Article • British Journal of Radiology, January 2017, British Institute of Radiology

    Dr Stephen J McMahon

  57. Mechanistic Modelling of DNA Repair and Cellular Survival Following Radiation-Induced DNA Damage

    Article • Scientific Reports, September 2016, Nature

    Dr Stephen J McMahon

  58. Dose enhancement effects to the nucleus and mitochondria from gold nanoparticles in the cytosol

    Article • Physics in Medicine and Biology, July 2016, Institute of Physics Publishing

    Dr Stephen J McMahon, Zdenka Kuncic

  59. Protein disulphide isomerase as a target for nanoparticle-mediated sensitisation of cancer cells to radiation

    Article • Nanotechnology, April 2016, Institute of Physics Publishing

    Dr Stephen J McMahon

  60. Imaging and radiation effects of gold nanoparticles in tumour cells

    Article • Scientific Reports, January 2016, Nature

    Dr Stephen J McMahon

  61. Optimising element choice for nanoparticle radiosensitisers

    Article • Nanoscale, January 2016, Royal Society of Chemistry

    Dr Stephen J McMahon

  62. Roadmap to Clinical Use of Gold Nanoparticles for Radiation Sensitization

    Article • International Journal of Radiation Oncology*Biology*Physics, January 2016, Elsevier

    Dr Stephen J McMahon

  63. Impact of fractionation on out-of-field survival and DNA damage responses following exposure to intensity modulated radiation fields

    Article • Physics in Medicine and Biology, December 2015, Institute of Physics Publishing

    Dr Stephen J McMahon

  64. Gold nanoparticle induced vasculature damage in radiotherapy: Comparing protons, megavoltage photons, and kilovoltage photons

    Article • Medical Physics, October 2015, American Association of Physicists in Medicine (AAPM)

    Dr Stephen J McMahon

  65. Time and Cell Type Dependency of Survival Responses in Co-cultured Tumor and Fibroblast Cells after Exposure to Modulated Radiation Fields

    Article • Radiation Research, June 2015, Radiation Research Society

    Dr Stephen J McMahon

  66. Cellular signalling effects in high precision radiotherapy

    Article • Physics in Medicine and Biology, May 2015, Institute of Physics Publishing

    Dr Stephen J McMahon

  67. Biological modeling of gold nanoparticle enhanced radiotherapy for proton therapy

    Article • Physics in Medicine and Biology, May 2015, Institute of Physics Publishing

    Dr Stephen J McMahon

  68. Comparing gold nano-particle enhanced radiotherapy with protons, megavoltage photons and kilovoltage photons: a Monte Carlo simulation

    Article • Physics in Medicine and Biology, November 2014, Institute of Physics Publishing

    Dr Stephen J McMahon

  69. Conventional in vivo irradiation procedures are insufficient to accurately determine tumor responses to non-uniform radiation fields

    Article • International Journal of Radiation Biology, November 2014, Taylor & Francis

    Dr Stephen J McMahon

  70. The role of mitochondrial function in gold nanoparticle mediated radiosensitisation

    Article • Cancer Nanotechnology, September 2014, Springer Science + Business Media

    Dr Stephen J McMahon

  71. The use of theranostic gadolinium-based nanoprobes to improve radiotherapy efficacy

    Article • British Journal of Radiology, September 2014, British Institute of Radiology

    Dr Stephen J McMahon

  72. Relative Biological Effectiveness Variation Along Monoenergetic and Modulated Bragg Peaks of a 62-MeV Therapeutic Proton Beam: A Preclinical Assessment

    Article • International Journal of Radiation Oncology*Biology*Physics, September 2014, Elsevier

    Dr Stephen J McMahon

  73. Investigation into the radiobiological consequences of pre-treatment verification imaging with megavoltage X-rays in radiotherapy

    Article • British Journal of Radiology, April 2014, British Institute of Radiology

    Dr Stephen J McMahon

  74. Investigating the Potential Impact of Four-dimensional Computed Tomography (4DCT) on Toxicity, Outcomes and Dose Escalation for Radical Lung Cancer Radiotherapy

    Article • Clinical Oncology, March 2014, Elsevier

    Dr Stephen J McMahon

  75. Gold nanoparticle cellular uptake, toxicity and radiosensitisation in hypoxic conditions

    Article • Radiotherapy and Oncology, February 2014, Elsevier

    Dr Stephen J McMahon

  76. Implications of Intercellular Signaling for Radiation Therapy: A Theoretical Dose-Planning Study

    Article • International Journal of Radiation Oncology*Biology*Physics, December 2013, Elsevier

    Dr Stephen J McMahon

  77. Investigating the influence of respiratory motion on the radiation induced bystander effect in modulated radiotherapy

    Article • Physics in Medicine and Biology, November 2013, Institute of Physics Publishing

    Dr Stephen J McMahon

  78. Bystander Signalling: Exploring Clinical Relevance Through New Approaches and New Models

    Article • Clinical Oncology, October 2013, Elsevier

    Dr Stephen J McMahon

  79. Antiproton induced DNA damage: proton like in flight, carbon-ion like near rest

    Article • Scientific Reports, May 2013, Nature

    Dr Stephen J McMahon

  80. Inverse planned constant dose rate volumetric modulated arc therapy (VMAT) as an efficient alternative to five-field intensity modulated radiation therapy (IMRT) for prostate

    Article • Journal of Radiotherapy in Practice, April 2013, Cambridge University Press

    Dr Stephen J McMahon

  81. CORRIGENDUM: Biological consequences of nanoscale energy deposition near irradiated heavy atom nanoparticles

    Article • Scientific Reports, April 2013, Nature

    Dr Stephen J McMahon

  82. An in vitro study of the radiobiological effects of flattening filter free radiotherapy treatments

    Article • Physics in Medicine and Biology, February 2013, Institute of Physics Publishing

    Dr Stephen J McMahon

  83. A Kinetic-Based Model of Radiation-Induced Intercellular Signalling

    Article • PLoS ONE, January 2013, PLOS

    Dr Stephen J McMahon

  84. Gold Nanoparticles for Imaging and Radiotherapy

    Article • January 2013, Elsevier

    Dr Stephen J McMahon

  85. Relative biological effectiveness (RBE) and out-of-field cell survival responses to passive scattering and pencil beam scanning proton beam deliveries

    Article • Physics in Medicine and Biology, October 2012, Institute of Physics Publishing

    Dr Stephen J McMahon

  86. In-vitro investigation of out-of-field cell survival following the delivery of conformal, intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) plans

    Article • Physics in Medicine and Biology, October 2012, Institute of Physics Publishing

    Dr Stephen J McMahon

  87. A Computational Model of Cellular Response to Modulated Radiation Fields

    Article • International Journal of Radiation Oncology*Biology*Physics, September 2012, Elsevier

    Dr Stephen J McMahon

  88. DNA Damage Responses following Exposure to Modulated Radiation Fields

    Article • PLoS ONE, August 2012, PLOS

    Dr Stephen J McMahon

  89. Cell type-dependent uptake, localization, and cytotoxicity of 1.9 nm gold nanoparticles

    Article • International Journal of Nanomedicine, June 2012, Taylor & Francis

    Dr Stephen J McMahon

  90. Dose, dose-rate and field size effects on cell survival following exposure to non-uniform radiation fields

    Article • Physics in Medicine and Biology, May 2012, Institute of Physics Publishing

    Dr Stephen J McMahon

  91. Physical basis and biological mechanisms of gold nanoparticle radiosensitization

    Article • Nanoscale, January 2012, Royal Society of Chemistry

    Dr Stephen J McMahon

  92. Cold atmospheric pressure plasma jets: Interaction with plasmid DNA and tailored electron heating using dual-frequency excitation

    Article • January 2012, American Institute of Physics

    Dr Stephen J McMahon

  93. Comment on ‘Implications on clinical scenario of gold nanoparticle radiosensitization in regards to photon energy, nanoparticle size, concentration and location’

    Article • Physics in Medicine and Biology, December 2011, Institute of Physics Publishing

    Dr Stephen J McMahon

  94. Energy Dependence of Gold Nanoparticle Radiosensitization in Plasmid DNA

    Article • The Journal of Physical Chemistry C, October 2011, American Chemical Society (ACS)

    Dr Stephen J McMahon

  95. Nanodosimetric effects of gold nanoparticles in megavoltage radiation therapy

    Article • Radiotherapy and Oncology, September 2011, Elsevier

    Dr Stephen J McMahon

  96. Biological consequences of nanoscale energy deposition near irradiated heavy atom nanoparticles

    Article • Scientific Reports, June 2011, Nature

    Dr Stephen J McMahon

  97. A Robust Curve-Fitting Procedure for the Analysis of Plasmid DNA Strand Break Data from Gel Electrophoresis

    Article • Radiation Research, June 2011, Radiation Research Society

    Dr Stephen J McMahon

  98. Characterization and parametrization in terms of atomic number of x-ray emission from K -shell filling during ion-surface interactions

    Article • Physical Review A, February 2011, American Physical Society (APS)

    Dr Stephen J McMahon

  99. Cell-Specific Radiosensitization by Gold Nanoparticles at Megavoltage Radiation Energies

    Article • International Journal of Radiation Oncology*Biology*Physics, February 2011, Elsevier

    Dr Stephen J McMahon

  100. Cold atmospheric pressure plasma jet interactions with plasmid DNA

    Article • Applied Physics Letters, January 2011, American Institute of Physics

    Dr Stephen J McMahon

  101. Variance reduction of Monte-Carlo radiation transport via scalar flux continuity — A practical radiation treatment planning approach

    Article • October 2010, Institute of Electrical & Electronics Engineers (IEEE)

    Dr Stephen J McMahon

  102. Evaluation of cytotoxicity and radiation enhancement using 1.9 nm gold particles: potential application for cancer therapy

    Article • Nanotechnology, July 2010, Institute of Physics Publishing

    Dr Stephen J McMahon

  103. Dielectronic recombination in He-like, Li-like, and Be-like highly charged ions in the KLL and KLM manifolds

    Article • Physical Review A, February 2010, American Physical Society (APS)

    Dr Stephen J McMahon

  104. Radiotherapy in the presence of contrast agents: a general figure of merit and its application to gold nanoparticles

    Article • Physics in Medicine and Biology, September 2008, Institute of Physics Publishing

    Dr Stephen J McMahon