All Stories

  1. Characterization of Trypanosoma cruzi Sirtuins as Possible Drug Targets for Chagas Disease

    Article • Antimicrobial Agents and Chemotherapy, May 2015, ASM Journals

    Professor Sergio Schenkman

  2. A message from the Editor

    Article • Cell Biology International, January 2015, Wiley

    Professor Sergio Schenkman

  3. Genome of the Avirulent Human-Infective Trypanosome—Trypanosoma rangeli

    Article • PLoS Neglected Tropical Diseases, September 2014, PLOS

    Professor Sergio Schenkman

  4. Stress Induces Changes in the Phosphorylation of Trypanosoma cruzi RNA Polymerase II, Affecting Its Association with Chromatin and RNA Processing

    Article • Eukaryotic Cell, May 2014, ASM Journals

    Professor Sergio Schenkman

  5. Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: implications for Chagas disease drug discovery and development

    Article • Scientific Reports, April 2014, Springer Science + Business Media

    Professor Sergio Schenkman

  6. ORC1/CDC6 and MCM7 distinct associate with chromatin through Trypanosoma cruzi life cycle

    Article • Molecular and Biochemical Parasitology, February 2014, Elsevier

    Professor Sergio Schenkman

  7. Structural Characterization of the Cell Division Cycle inStrigomonas culicis, an Endosymbiont-Bearing Trypanosomatid

    Article • Microscopy and Microanalysis, January 2014, Oxford University Press (OUP)

    Professor Sergio Schenkman

  8. Oral Exposure to Phytomonas serpens Attenuates Thrombocytopenia and Leukopenia during Acute Infection with Trypanosoma cruzi

    Article • PLoS ONE, July 2013, PLOS

    Professor Sergio Schenkman

  9. Differential Expression Profiles in the Midgut of Triatoma infestans Infected with Trypanosoma cruzi

    Article • PLoS ONE, May 2013, PLOS

    Professor Sergio Schenkman

  10. Eukaryotic initiation factor 5A dephosphorylation is required for translational arrest in stationary phase cells

    Article • Biochemical Journal, April 2013, Portland Press Ltd.

    Professor Sergio Schenkman

  11. Predicting the Proteins of Angomonas deanei, Strigomonas culicis and Their Respective Endosymbionts Reveals New Aspects of the Trypanosomatidae Family

    Article • PLoS ONE, April 2013, PLOS

    Professor Sergio Schenkman

  12. Chromatin modifications in trypanosomes due to stress

    Article • Cellular Microbiology, February 2013, Hindawi Publishing Corporation

    Professor Sergio Schenkman

  13. Trypanosomatid Pin1‐Type Peptidyl‐Prolyl Isomerase Is Cytosolic and Not Essential for Cell Proliferation

    Article • Journal of Eukaryotic Microbiology, December 2012, Wiley

    Professor Sergio Schenkman

  14. Functional characterization of TcCYC2 cyclin from Trypanosoma cruzi

    Article • Experimental Parasitology, December 2012, Elsevier

    Professor Sergio Schenkman

  15. How to invade, replicate, and escape from host organisms. A challenge in defining virulence factors for parasites

    Article • Microbes and Infection, December 2012, Elsevier

    Professor Sergio Schenkman

  16. Trypanosoma cruzi trans-sialidase as a multifunctional enzyme in Chagas’ disease

    Article • Cellular Microbiology, July 2012, Hindawi Publishing Corporation

    Professor Sergio Schenkman

  17. DNA polymerase beta from Trypanosoma cruzi is involved in kinetoplast DNA replication and repair of oxidative lesions

    Article • Molecular and Biochemical Parasitology, June 2012, Elsevier

    Professor Sergio Schenkman

  18. Characterization of anti-silencing factor 1 in Leishmania major

    Article • Memórias do Instituto Oswaldo Cruz, May 2012, FapUNIFESP (SciELO)

    Professor Sergio Schenkman

  19. A Novel Monoclonal Antibody Against the C-terminus of β-Tubulin Recognizes Endocytic Organelles in Trypanosoma cruzi

    Article • Protein and Peptide Letters, April 2012, Bentham Science Publishers

    Professor Sergio Schenkman, Prof Kai Hilpert

  20. Design, synthesis and the effect of 1,2,3-triazole sialylmimetic neoglycoconjugates on Trypanosoma cruzi and its cell surface trans-sialidase

    Article • Bioorganic & Medicinal Chemistry, January 2012, Elsevier

    Professor Sergio Schenkman

  21. Infestin 1R, an intestinal subtilisin inhibitor from Triatoma infestans able to impair mammalian cell invasion by Trypanosoma cruzi

    Article • Experimental Parasitology, December 2011, Elsevier

    Professor Sergio Schenkman

  22. Visual Genome-Wide RNAi Screening to Identify Human Host Factors Required for Trypanosoma cruzi Infection

    Article • PLoS ONE, May 2011, PLOS

    Professor Sergio Schenkman

  23. Three‐dimensional reconstruction of Trypanosoma cruzi epimastigotes and organelle distribution along the cell division cycle

    Article • Cytometry Part A, May 2011, Wiley

    Professor Sergio Schenkman

  24. Biochemical characterization of a protein tyrosine phosphatase from Trypanosoma cruzi involved in metacyclogenesis and cell invasion

    Article • Biochemical and Biophysical Research Communications, May 2011, Elsevier

    Professor Sergio Schenkman

  25. Probing the acceptor substrate binding site of Trypanosoma cruzi trans-sialidase with systematically modified substrates and glycoside libraries

    Article • Organic & Biomolecular Chemistry, January 2011, Royal Society of Chemistry

    Professor Sergio Schenkman

  26. Nuclear Structure of Trypanosoma cruzi

    Article • January 2011, Elsevier

    Professor Sergio Schenkman

  27. Cell homeostasis in a Leishmania major mutant overexpressing the spliced leader RNA is maintained by an increased proteolytic activity

    Article • The International Journal of Biochemistry & Cell Biology, October 2010, Elsevier

    Professor Sergio Schenkman

  28. Identification of an atypical peptidyl-prolyl cis/trans isomerase from trypanosomatids

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, September 2010, Elsevier

    Professor Sergio Schenkman

  29. The Bacterium Endosymbiont of Crithidia deanei Undergoes Coordinated Division with the Host Cell Nucleus

    Article • PLoS ONE, August 2010, PLOS

    Professor Sergio Schenkman

  30. ‘Click chemistry’ synthesis of a library of 1,2,3-triazole-substituted galactose derivatives and their evaluation against Trypanosoma cruzi and its cell surface trans-sialidase

    Article • Bioorganic & Medicinal Chemistry, April 2010, Elsevier

    Professor Sergio Schenkman

  31. Cyclooligomerisation of azido-alkyne-functionalised sugars: synthesis of 1,6-linked cyclic pseudo-galactooligosaccharides and assessment of their sialylation by Trypanosoma cruzi trans-sialidase

    Article • Chemical Science, January 2010, Royal Society of Chemistry

    Professor Sergio Schenkman

  32. Chromatin and nuclear organization inTrypanosoma cruzi

    Article • Future Microbiology, October 2009, Future Medicine

    Professor Sergio Schenkman

  33. Trypanosoma cruzi bromodomain factor 2 (BDF2) binds to acetylated histones and is accumulated after UV irradiation

    Article • International Journal for Parasitology, May 2009, Elsevier

    Professor Sergio Schenkman

  34. Distinct acetylation of Trypanosoma cruzi histone H4 during cell cycle, parasite differentiation, and after DNA damage

    Article • Chromosoma, April 2009, Springer Science + Business Media

    Professor Sergio Schenkman

  35. The Trypanosoma cruzi nucleic acid binding protein Tc38 presents changes in the intramitochondrial distribution during the cell cycle

    Article • BMC Microbiology, February 2009, Springer Science + Business Media

    Professor Sergio Schenkman

  36. Co‐ordinated expression of lymphoid and myeloid specific transcription factors during B‐1b cell differentiation into mononuclear phagocytes in vitro

    Article • Immunology, December 2008, Wiley

    Professor Sergio Schenkman

  37. Biochemical studies with DNA polymerase β and DNA polymerase β-PAK of Trypanosoma cruzi suggest the involvement of these proteins in mitochondrial DNA maintenance

    Article • DNA Repair, November 2008, Elsevier

    Professor Sergio Schenkman

  38. Active transcription and ultrastructural changes during Trypanosoma cruzi metacyclogenesis

    Article • Anais da Academia Brasileira de Ciências, March 2008, FapUNIFESP (SciELO)

    Professor Sergio Schenkman

  39. Histone H1 of Trypanosoma cruzi Is Concentrated in the Nucleolus Region and Disperses upon Phosphorylation during Progression to Mitosis

    Article • Eukaryotic Cell, February 2008, ASM Journals

    Professor Sergio Schenkman

  40. A short proregion of trialysin, a pore‐forming protein of Triatoma infestans salivary glands, controls activity by folding the N‐terminal lytic motif

    Article • FEBS Journal, February 2008, Wiley

    Professor Sergio Schenkman

  41. Morphological Events during the Trypanosoma cruzi Cell Cycle

    Article • Protist, April 2007, Elsevier

    Professor Sergio Schenkman

  42. Post-translational modifications of Trypanosoma cruzi histone H4

    Article • Molecular and Biochemical Parasitology, December 2006, Elsevier

    Professor Sergio Schenkman

  43. Expression of trypomastigote trans-sialidase in metacyclic forms of Trypanosoma cruzi increases parasite escape from its parasitophorous vacuole

    Article • Cellular Microbiology, December 2006, Hindawi Publishing Corporation

    Professor Sergio Schenkman

  44. Divalent metal requirements for catalysis and stability of the RNA triphosphatase from Trypanosoma cruzi

    Article • Molecular and Biochemical Parasitology, November 2006, Elsevier

    Professor Sergio Schenkman

  45. Lytic Activity and Structural Differences of Amphipathic Peptides Derived from Trialysin,

    Article • Biochemistry, January 2006, American Chemical Society (ACS)

    Professor Sergio Schenkman

  46. Actively Transcribing RNA Polymerase II Concentrates on Spliced Leader Genes in the Nucleus of Trypanosoma cruzi

    Article • Eukaryotic Cell, May 2005, ASM Journals

    Professor Sergio Schenkman

  47. Comparative analysis of genomic sequences suggests that Trypanosoma cruzi CL Brener contains two sets of non-intercalated repeats of satellite DNA that correspond to T. cruzi I and T. cruzi II types

    Article • Molecular and Biochemical Parasitology, April 2005, Elsevier

    Professor Sergio Schenkman

  48. Trypanosoma cruzi histone H1 is phosphorylated in a typical cyclin dependent kinase site accordingly to the cell cycle

    Article • Molecular and Biochemical Parasitology, March 2005, Elsevier

    Professor Sergio Schenkman

  49. The largest subunit of the RNA polymerase II of Trypanosoma cruzi lacks the repeats in the carboxy-terminal domain and is encoded by several genes

    Article • Parasitology International, September 2003, Elsevier

    Professor Sergio Schenkman

  50. Organization of satellite DNA in the genome of Trypanosoma cruzi

    Article • Molecular and Biochemical Parasitology, June 2003, Elsevier

    Professor Sergio Schenkman

  51. Chromosome Localization Changes in the Trypanosoma cruzi Nucleus

    Article • Eukaryotic Cell, December 2002, ASM Journals

    Professor Sergio Schenkman

  52. Observations on chemical and enzymatic approaches to α-2,3-sialylated octyl β-lactoside

    Article • Tetrahedron, April 2002, Elsevier

    Professor Sergio Schenkman

  53. Histone H1 is phosphorylated in non-replicating and infective forms of Trypanosoma cruzi

    Article • Molecular and Biochemical Parasitology, February 2002, Elsevier

    Professor Sergio Schenkman

  54. Triapsin, an unusual activatable serine protease from the saliva of the hematophagous vector of Chagas' disease Triatoma infestans (Hemiptera: Reduviidae)

    Article • Insect Biochemistry and Molecular Biology, March 2001, Elsevier

    Professor Sergio Schenkman

  55. Transcription rate modulation through the Trypanosoma cruzi life cycle occurs in parallel with changes in nuclear organisation

    Article • Molecular and Biochemical Parasitology, January 2001, Elsevier

    Professor Sergio Schenkman

  56. Hydrolase and sialyltransferase activities of Trypanosoma cruzi trans -sialidase towards NeuAc-α-2,3-Gal-β- O -PNP

    Article • Bioorganic & Medicinal Chemistry Letters, January 2001, Elsevier

    Professor Sergio Schenkman

  57. The use of the green fluorescent protein to monitor and improve transfection in Trypanosoma cruzi

    Article • Molecular and Biochemical Parasitology, November 2000, Elsevier

    Professor Sergio Schenkman

  58. Synthesis of sialyloligosaccharides using the trans-sialidase from Trypanosoma cruzi: novel branched and di-sialylated products from digalactoside acceptors

    Article • Chemical Communications, January 2000, Royal Society of Chemistry

    Professor Sergio Schenkman

  59. Comparison of antibody and protective immune responses against Trypanosoma cruzi infection elicited by immunization with a parasite antigen delivered as naked DNA or recombinant protein

    Article • Parasite Immunology, February 1999, Wiley

    Professor Sergio Schenkman

  60. Expression and localization of Trypanosoma cruzi trans sialidase

    Article • Parasitology International, August 1998, Elsevier

    Professor Sergio Schenkman

  61. Immunization with a plasmid DNA containing the gene of trans-sialidase reduces Trypanosoma cruzi infection in mice

    Article • Vaccine, May 1998, Elsevier

    Professor Sergio Schenkman

  62. Two distinct groups of mucin-like genes are differentially expressed in the developmental stages of Trypanosoma cruzi1Note: Nucleotide sequence data reported in this paper are available in the EMBL, GenBank™, and DDJB databases under the accession numb...

    Article • Molecular and Biochemical Parasitology, May 1998, Elsevier

    Professor Sergio Schenkman

  63. American trypanosomiasis

    Article • Current Opinion in Infectious Diseases, October 1997, Wolters Kluwer Health

    Professor Sergio Schenkman

  64. Chemoenzymatic synthesis of GM3, Lewis x and sialyl Lewis x oligosaccharides in 13C-enriched form

    Article • Tetrahedron Letters, August 1997, Elsevier

    Professor Sergio Schenkman

  65. Temperature differences for trans -glycosylation and hydrolysis reaction reveal an acceptor binding site in the catalytic mechanism of Trypanosoma cruzi trans -sialidase

    Article • Glycobiology, January 1997, Oxford University Press (OUP)

    Professor Sergio Schenkman

  66. Organization of trans-sialidase genes in Trypanosoma cruzi

    Article • Molecular and Biochemical Parasitology, May 1996, Elsevier

    Professor Sergio Schenkman

  67. Trans-sialidase genes expressed in mammalian forms of Trypanosoma cruzi evolved from ancestor genes expressed in insect forms of the parasite

    Article • Journal of Molecular Evolution, August 1995, Springer Science + Business Media

    Professor Sergio Schenkman

  68. Trypanosoma cruzi trans-sialidase gene lacking C-terminal repeats and expressed in epimastigote forms

    Article • Molecular and Biochemical Parasitology, March 1995, Elsevier

    Professor Sergio Schenkman

  69. A sialidase activity in the midgut of the insect Triatoma infestans is responsible for the low levels of sialic acid in Trypanosoma cruzi growing in the insect vector

    Article • Glycobiology, January 1995, Oxford University Press (OUP)

    Professor Sergio Schenkman

  70. Structural and Functional Properties of Trypanosoma Trans-Sialidase

    Article • Annual Review of Microbiology, October 1994, Annual Reviews

    Professor Sergio Schenkman

  71. trans-Sialidase and Sialic Acid Accepters from Insect to Mammalian Stages of Trypanosoma cruzi

    Article • Experimental Parasitology, September 1994, Elsevier

    Professor Sergio Schenkman

  72. Trans-sialidase from Trypanosoma cruzi epimastigotes is expressed at the stationary phase and is different from the enzyme expressed in trypomastigotes

    Article • Molecular and Biochemical Parasitology, September 1993, Elsevier

    Professor Sergio Schenkman

  73. Mucin-like glycoproteins linked to the membrane by glycosylphosphatidylinositol anchor are the major acceptors of sialic acid in a reaction catalyzed by trans-sialidase in metacyclic forms of Trypanosoma cruzi

    Article • Molecular and Biochemical Parasitology, June 1993, Elsevier

    Professor Sergio Schenkman

  74. Trypanosoma cruzi trans-sialidase and cell invasion

    Article • Parasitology Today, June 1993, Elsevier

    Professor Sergio Schenkman

  75. Evidence for the participation of the Ssp-3 antigen in the invasion of nonphagocytic mammalian cells by Trypanosoma cruzi

    Article • The Journal of Experimental Medicine, June 1992, Rockefeller University Press

    Professor Sergio Schenkman

  76. Trypanosoma cruzi trans-sialidase and neuraminidase activities can be mediated by the same enzymes

    Article • The Journal of Experimental Medicine, February 1992, Rockefeller University Press

    Professor Sergio Schenkman

  77. CHARACTERIZATION OF THE PLASMA GLYCOSYLPHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE D (GPI-PLD)

    Article • January 1992, Elsevier

    Professor Sergio Schenkman

  78. Substrate specificity of the Trypanosoma cruzi trans-sialidase

    Article • Glycobiology, January 1992, Oxford University Press (OUP)

    Professor Sergio Schenkman

  79. A novel cell surface trans-sialidase of trypanosoma cruzi generates a stage-specific epitope required for invasion of mammalian cells

    Article • Cell, June 1991, Elsevier

    Professor Sergio Schenkman

  80. Attachment of Trypanosoma cruzi trypomastigotes to receptors at restricted cell surface domains

    Article • Experimental Parasitology, January 1991, Elsevier

    Professor Sergio Schenkman

  81. Expression inEscherichia coli of a gene coding for epitopes of a diagnostic antigen ofParacoccidioides brasiliensis

    Article • Experimental Mycology, September 1989, Elsevier

    Professor Sergio Schenkman

  82. Trypanosoma cruzi: mechanisms of cell-invasion and intracellular survival

    Article • Memórias do Instituto Oswaldo Cruz, November 1988, FapUNIFESP (SciELO)

    Professor Sergio Schenkman

  83. Identification of C3 Acceptors Responsible for Complement Activation in Crithidia fasciculata1

    Article • The Journal of Protozoology, November 1988, Wiley

    Professor Sergio Schenkman

  84. Trypanosoma cruzi invade a mammalian epithelial cell in a polarized manner

    Article • Cell, October 1988, Elsevier

    Professor Sergio Schenkman

  85. Glycophosphatidylinositol-anchored proteins in metacyclic trypomastigotes of Trypanosoma cruzi

    Article • Molecular and Biochemical Parasitology, June 1988, Elsevier

    Professor Sergio Schenkman

  86. Identification of an acid-lipase in human serum which is capable of solubilizing glycophosphatidylinositol-anchored proteins

    Article • Biochemical and Biophysical Research Communications, January 1988, Elsevier

    Professor Sergio Schenkman

  87. Monoclonal Antibodies and the Structure of Bacterial Membrane Proteins

    Article • January 1985, Elsevier

    Professor Sergio Schenkman

  88. Locating peptides generated by limited proteolysis in known protein sequences by means of computer search

    Article • Biochemical and Biophysical Research Communications, December 1984, Elsevier

    Professor Sergio Schenkman

  89. Immunolabelling of bacteriophage lambda receptor protein (LamB) on thin sections of E. coli embedded in Lowicryl

    Article • Biology of the Cell, January 1984, Wiley

    Professor Sergio Schenkman

  90. Effects of temperature and lipid composition on the serum albumin-induced aggregation and fusion of small unilamellar vesicles

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, December 1981, Elsevier

    Professor Sergio Schenkman

  91. A kinetic and structural study of two-step aggregation and fusion of neutral phospholipid vesicles promoted by serum albumin at low pH

    Article • Chemistry and Physics of Lipids, March 1981, Elsevier

    Professor Sergio Schenkman