All Stories

  1. Structural insights into the interaction of papain-like protease 2 from the alphacoronavirus porcine epidemic diarrhea virus and ubiquitin

    Article • Acta Crystallographica Section D Structural Biology, June 2021, International Union of Crystallography

    Professor Scott D Pegan

  2. Flipping the substrate preference of Hazara virus ovarian tumour domain protease through structure-based mutagenesis

    Article • Acta Crystallographica Section D Structural Biology, October 2020, International Union of Crystallography

    Professor Scott D Pegan

  3. Determining the molecular drivers of species-specific interferon-stimulated gene product 15 interactions with nairovirus ovarian tumor domain proteases

    Article • PLoS ONE, December 2019, PLOS

    Professor Scott D Pegan

  4. Probing the impact of nairovirus genomic diversity on viral ovarian tumor domain protease (vOTU) structure and deubiquitinase activity

    Article • PLoS Pathogens, January 2019, PLOS

    Professor Scott D Pegan

  5. Structure of interferon-stimulated gene product 15 (ISG15) from the bat species Myotis davidii and the impact of interdomain ISG15 interactions on viral protein engagement

    Article • Acta Crystallographica Section D Structural Biology, January 2019, International Union of Crystallography

    Professor Scott D Pegan

  6. Single-dose replicon particle vaccine provides complete protection against Crimean-Congo hemorrhagic fever virus in mice

    Article • Emerging Microbes & Infections, January 2019, Taylor & Francis

    Professor Scott D Pegan, Dr Éric Bergeron, Stephen Welch

  7. Biochemical and Structural Insights into the Preference of Nairoviral DeISGylases for Interferon-Stimulated Gene Product 15 Originating from Certain Species

    Article • Journal of Virology, July 2016, ASM Journals

    Dr Éric Bergeron, Professor Scott D Pegan

  8. Inherent dynamics within the Crimean‐Congo Hemorrhagic fever virus protease are localized to the same region as substrate interactions

    Article • Protein Science, January 2015, Wiley

    Professor Scott D Pegan

  9. CHICKEN TRIOSEPHOSPHATE ISOMERASE WITH LOOP6 MUTATIONS, V167P AND W168E.

    Article • August 2014, Protein Data Bank, Rutgers University

    Professor Scott D Pegan

  10. Enzyme Architecture: The Effect of Replacement and Deletion Mutations of Loop 6 on Catalysis by Triosephosphate Isomerase

    Article • Biochemistry, May 2014, American Chemical Society (ACS)

    Professor Scott D Pegan

  11. The vOTU domain of highly-pathogenic porcine reproductive and respiratory syndrome virus displays a differential substrate preference

    Article • Virology, April 2014, Elsevier

    Dr Kay S Faaberg, Professor Scott D Pegan

  12. A Noncompetitive Inhibitor forMycobacterium tuberculosis’s Class IIa Fructose 1,6-Bisphosphate Aldolase

    Article • Biochemistry, December 2013, American Chemical Society (ACS)

    Professor Scott D Pegan

  13. Diversity of Ubiquitin and ISG15 Specificity among Nairoviruses' Viral Ovarian Tumor Domain Proteases

    Article • Journal of Virology, January 2013, ASM Journals

    Professor Scott D Pegan

  14. Active Site Loop Dynamics of a Class IIa Fructose 1,6-Bisphosphate Aldolase from Mycobacterium tuberculosis

    Article • Biochemistry, January 2013, American Chemical Society (ACS)

    Professor Scott D Pegan

  15. Structural and Biochemical Characterization of Human Adenylosuccinate Lyase (ADSL) and the R303C ADSL Deficiency-Associated Mutation

    Article • Biochemistry, August 2012, American Chemical Society (ACS)

    Professor Scott D Pegan

  16. Structural and functional characterization ofMycobacterium tuberculosistriosephosphate isomerase

    Article • Acta Crystallographica Section D Biological Crystallography, November 2011, International Union of Crystallography

    Professor Scott D Pegan

  17. X‐ray structural studies of quinone reductase 2 nanomolar range inhibitors

    Article • Protein Science, May 2011, Wiley

    Professor Scott D Pegan

  18. Kinetic and Structural Characterization of a Heterohexamer 4-Oxalocrotonate Tautomerase from Chloroflexus aurantiacus J-10-fl: Implications for Functional and Structural Diversity in the Tautomerase Superfamily,

    Article • Biochemistry, May 2010, American Chemical Society (ACS)

    Professor Scott D Pegan

  19. A Universal, Fully Automated High Throughput Screening Assay for Pyrophosphate and Phosphate Release from Enzymatic Reactions

    Article • Combinatorial Chemistry & High Throughput Screening, January 2010, Bentham Science Publishers

    Professor Scott D Pegan

  20. An Antimicrobial Guanidine-Bearing Sesterterpene from the Cultured Cyanobacterium Scytonema sp.

    Article • Journal of Natural Products, November 2009, American Chemical Society (ACS)

    Professor Scott D Pegan

  21. Natural product leads for drug discovery: Isolation, synthesis and biological evaluation of 6-cyano-5-methoxyindolo[2,3-a]carbazole based ligands as antibacterial agents

    Article • Bioorganic & Medicinal Chemistry, October 2009, Elsevier

    Professor Scott D Pegan

  22. Structural Basis for Catalysis of a Tetrameric Class IIa Fructose 1,6-Bisphosphate Aldolase from Mycobacterium tuberculosis

    Article • Journal of Molecular Biology, March 2009, Elsevier

    Professor Scott D Pegan

  23. Structural and mechanistic analysis oftrans-3-chloroacrylic acid dehalogenase activity

    Article • Acta Crystallographica Section D Biological Crystallography, November 2008, International Union of Crystallography

    Professor Scott D Pegan

  24. P2‐350: Yeast cell‐based genetic and chemical screens for inhibitors of Aβ42 oligomerization

    Article • Alzheimer s & Dementia, July 2008, Wiley

    Professor Scott D Pegan

  25. Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase

    Article • Bioorganic & Medicinal Chemistry Letters, June 2008, Elsevier

    Professor Scott D Pegan

  26. Erratum: Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification

    Article • Nature Neuroscience, June 2005, Springer Science + Business Media

    Professor Scott D Pegan

  27. High-throughput backbone resonance assignment of small 13C,15N-labeled proteins by a triple-resonance experiment with four sequential connectivity pathways using chemical shift-dependent, apparent (1H,13C): HNCACBcodedHAHB

    Article • Journal of Magnetic Resonance, December 2003, Elsevier

    Professor Scott D Pegan