All Stories

  1. Elucidating Mitochondrial Electron Transport Chain Supercomplexes in the Heart During Ischemia–Reperfusion

    Article • Antioxidants & Redox Signaling, July 2017, Mary Ann Liebert Inc

    Dr Sabzali Javadov, Sabzali Javadov, MD, PhD, FAHA

  2. The Role of SIRT3 in Mediating Cardioprotective Effects of RAS Inhibition on Cardiac Ischemia-Reperfusion

    Article • Journal of Pharmacy & Pharmaceutical Sciences, October 2015, JPPS Journal

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  3. Cardiac Metabolic Pathways Affected in the Mouse Model of Barth Syndrome

    Article • PLoS ONE, June 2015, PLOS

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  4. Regulation of Apoptotic Endonucleases by EndoG

    Article • DNA and Cell Biology, May 2015, Mary Ann Liebert Inc

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  5. The calcium-ROS-pH triangle and mitochondrial permeability transition: challenges to mimic cardiac ischemia-reperfusion

    Article • Frontiers in Physiology, March 2015, Frontiers

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  6. H9c2 and HL-1 cells demonstrate distinct features of energy metabolism, mitochondrial function and sensitivity to hypoxia-reoxygenation

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, February 2015, Elsevier

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  7. Mitochondria-targeted ROS scavenger improves post-ischemic recovery of cardiac function and attenuates mitochondrial abnormalities in aged rats

    Article • Journal of Molecular and Cellular Cardiology, December 2014, Elsevier

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov, Walter Frontera

  8. Inhibition of JNK Aggravates the Recovery of Rat Hearts after Global Ischemia: The Role of Mitochondrial JNK

    Article • PLoS ONE, November 2014, PLOS

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  9. Crosstalk between mitogen-activated protein kinases and mitochondria in cardiac diseases: Therapeutic perspectives

    Article • Pharmacology & Therapeutics, November 2014, Elsevier

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  10. Downregulation of SIRT3 Exerts Mitochondrial Dysfunction in Cultured Cardiomyocytes

    Article • Free Radical Biology and Medicine, November 2014, Elsevier

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  11. Angiotensin II and Ischemic Preconditioning Synergize to Improve Mitochondrial Function While Showing Additive Effects on Ventricular Postischemic Recovery

    Article • Journal of Cardiovascular Pharmacology, August 2014, Wolters Kluwer Health

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  12. Letter to the editor: "Cyclosporin A in left ventricular remodeling after myocardial infarction"

    Article • AJP Heart and Circulatory Physiology, March 2014, American Physiological Society

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  13. Crosstalk between AMPK activation and angiotensin II‐induced hypertrophy in cardiomyocytes: the role of mitochondria

    Article • Journal of Cellular and Molecular Medicine, January 2014, Wiley

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  14. Cardiac-specific VLCAD deficiency induces dilated cardiomyopathy and cold intolerance

    Article • AJP Heart and Circulatory Physiology, November 2013, American Physiological Society

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  15. Mitochondria: the cell powerhouse and nexus of stress

    Article • Frontiers in Physiology, January 2013, Frontiers

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  16. Mitochondrial Permeability Transition and Cell Death: The Role of Cyclophilin D

    Article • Frontiers in Physiology, January 2013, Frontiers

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  17. Cytoskeleton and regulation of mitochondrial function: the role of beta-tubulin II

    Article • Frontiers in Physiology, January 2013, Frontiers

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  18. The Role of PPARα in Metformin-Induced Attenuation of Mitochondrial Dysfunction in Acute Cardiac Ischemia/Reperfusion in Rats

    Article • International Journal of Molecular Sciences, June 2012, MDPI AG

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  19. Role of NF-κB and p38 MAPK activation in mediating angiotensin II and endothelin-1-induced stimulation in leptin production and cardiomyocyte hypertrophy

    Article • Molecular and Cellular Biochemistry, April 2012, Springer Science + Business Media

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  20. Mitochondrial Permeability Transition: Known Phenomenon with Unknown Molecular Identity

    Article • Anatomy & Physiology, January 2012, OMICS Publishing Group

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  21. Direct Renin Inhibition Exerts an Anti-hypertrophic Effect Associated with Improved Mitochondrial Function in Post-infarction Heart Failure in Diabetic Rats

    Article • Cellular Physiology and Biochemistry, January 2012, Karger Publishers

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  22. Ouabain increases iNOS-dependent nitric oxide generation which contributes to the hypertrophic effect of the glycoside: possible role of peroxynitrite formation

    Article • Molecular and Cellular Biochemistry, December 2011, Springer Science + Business Media

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  23. mTOR mediates RhoA-dependent leptin-induced cardiomyocyte hypertrophy

    Article • Molecular and Cellular Biochemistry, February 2011, Springer Science + Business Media

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  24. Targeting the Mitochondrial Permeability Transition: Cardiac Ischemia-Reperfusion Versus Carcinogenesis

    Article • Cellular Physiology and Biochemistry, January 2011, Karger Publishers

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  25. Expression of mitochondrial fusion–fission proteins during post-infarction remodeling: the effect of NHE-1 inhibition

    Article • Basic Research in Cardiology, October 2010, Springer Science + Business Media

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  26. Nitric oxide inhibits endothelin-1-induced neonatal cardiomyocyte hypertrophy via a RhoA-ROCK-dependent pathway

    Article • Journal of Molecular and Cellular Cardiology, December 2009, Elsevier

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  27. Mitochondrial Permeability Transition Pore Opening as a Promising Therapeutic Target in Cardiac Diseases

    Article • Journal of Pharmacology and Experimental Therapeutics, June 2009, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  28. Anti-hypertrophic effect of NHE-1 inhibition involves GSK-3β-dependent attenuation of mitochondrial dysfunction

    Article • Journal of Molecular and Cellular Cardiology, June 2009, Elsevier

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  29. Estrogen exerts concentration-dependent pro-and anti-hypertrophic effects on adult cultured ventricular myocytes. Role of NHE-1 in estrogen-induced hypertrophy

    Article • Journal of Molecular and Cellular Cardiology, March 2009, Elsevier

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  30. The role of NHE-1 in myocardial hypertrophy and remodelling

    Article • Journal of Molecular and Cellular Cardiology, April 2008, Elsevier

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  31. Leptin-induced cardiomyocyte hypertrophy involves selective caveolae and RhoA/ROCK-dependent p38 MAPK translocation to nuclei

    Article • Cardiovascular Research, September 2007, European Society of Cardiology

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov, Dr Subrata Chakrabarti

  32. NHE-1 inhibition-induced cardioprotection against ischaemia/reperfusion is associated with attenuation of the mitochondrial permeability transition

    Article • Cardiovascular Research, September 2007, European Society of Cardiology

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  33. Actin Cytoskeleton Dynamics Promotes Leptin-Induced Vascular Smooth Muscle Hypertrophy via RhoA/ROCK- and Phosphatidylinositol 3-Kinase/Protein Kinase B-Dependent Pathways

    Article • Journal of Pharmacology and Experimental Therapeutics, June 2007, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov, Dr Subrata Chakrabarti

  34. Mitochondrial Permeability Transition Pore Opening as an Endpoint to Initiate Cell Death and as a Putative Target for Cardioprotection

    Article • Cellular Physiology and Biochemistry, January 2007, Karger Publishers

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  35. Essential role of Rho/ROCK-dependent processes and actin dynamics in mediating leptin-induced hypertrophy in rat neonatal ventricular myocytes

    Article • Cardiovascular Research, October 2006, European Society of Cardiology

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  36. Distinct KATP Channels Mediate the Antihypertrophic Effects of Adenosine Receptor Activation in Neonatal Rat Ventricular Myocytes

    Article • Journal of Pharmacology and Experimental Therapeutics, September 2006, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  37. An autocrine role for leptin in mediating the cardiomyocyte hypertrophic effects of angiotensin II and endothelin-1

    Article • Journal of Molecular and Cellular Cardiology, August 2006, Elsevier

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  38. NHE-1 inhibition improves cardiac mitochondrial function through regulation of mitochondrial biogenesis during postinfarction remodeling

    Article • AJP Heart and Circulatory Physiology, June 2006, American Physiological Society

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  39. A60. Inhibition of NHE-1 attenuates MAPKs upregulation in hypertrophied car-diomyocytes through mitochondria

    Article • Journal of Molecular and Cellular Cardiology, June 2006, Elsevier

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  40. A106. PPAR_α activation is associated with angiotensin II induced leptin production in cardiomyocyte mediated by JAK_STAT

    Article • Journal of Molecular and Cellular Cardiology, June 2006, Elsevier

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  41. A30. Identification of KATP channels as mediators of antihypertrophic effects of adenosine receptor activation

    Article • Journal of Molecular and Cellular Cardiology, June 2006, Elsevier

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  42. Antihypertrophic Effect of Na+/H+ Exchanger Isoform 1 Inhibition Is Mediated by Reduced Mitogen-Activated Protein Kinase Activation Secondary to Improved Mitochondrial Integrity and Decreased Generation of Mitochondrial-Derived Reactive Oxygen Species

    Article • Journal of Pharmacology and Experimental Therapeutics, March 2006, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  43. NHE-1 inhibition improves impaired mitochondrial permeability transition and respiratory function during postinfarction remodelling in the rat

    Article • Journal of Molecular and Cellular Cardiology, January 2005, Elsevier

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  44. Analysis of Erythrocyte and Platelet Membrane Proteins in Various Forms of  -Thalassemia

    Article • Biochemistry (Moscow), July 2004, Springer Science + Business Media

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  45. Ischaemic Preconditioning Inhibits Opening of Mitochondrial Permeability Transition Pores in the Reperfused Rat Heart

    Article • The Journal of Physiology, June 2003, Wiley

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  46. Protection of hearts from reperfusion injury by propofol is associated with inhibition of the mitochondrial permeability transition

    Article • Cardiovascular Research, January 2000, European Society of Cardiology

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  47. Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, August 1998, Elsevier

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  48. Effect of global ischemia on calcium sensitivity of diabetic rat hearts

    Article • Pathophysiology, June 1998, Elsevier

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  49. Cardiac performance and lipid metabolism of alloxan-induced diabetic rats: Effect of global ischemia

    Article • Pathophysiology, June 1998, Elsevier

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  50. Biochemical aspects of the protective action of phosphocreatine on the ischemicmyocardium

    Article • Journal of Molecular and Cellular Cardiology, January 1987, Elsevier

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  51. Contents of high energy phosphates and rates of mitochondrial oxidative reactions: Significance for cardiac contractile function

    Article • Journal of Molecular and Cellular Cardiology, January 1987, Elsevier

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  52. Effect of phosphocreatine and related compounds on the phospholipid metabolism of ischemic heart

    Article • Biochemical Medicine and Metabolic Biology, June 1986, Elsevier

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  53. Analysis of the antiarrhythmic action of phosphocreatine in acute myocardial ischemia in the dog

    Article • Journal of Molecular and Cellular Cardiology, January 1986, Elsevier

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov

  54. The Permeability Transition Pore in Myocardial Ischemia and Reperfusion

    Article • Springer Science + Business Media

    Sabzali Javadov, MD, PhD, FAHA, Dr Sabzali Javadov