All Stories

  1. Lead optimization of resilient next-generation transthyretin stabilizers for multiple target-product profiles: approaching the CNS

    Article • Amyloid, March 2019, Taylor & Francis

    Teresa Pinho e Melo, PhD Rui M Brito, Zaida Almeida

  2. Evaluation by fluorescence, STD-NMR, docking and semi-empirical calculations of the o-NBA photo-acid interaction with BSA

    Article • Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, December 2016, Elsevier

    PhD Rui M Brito

  3. A novel bis-furan scaffold for transthyretin stabilization and amyloid inhibition

    Article • European Journal of Medicinal Chemistry, October 2016, Elsevier

    PhD Rui M Brito, Zaida Almeida, Teresa Pinho e Melo, Dora Cristina Silva Costa

  4. A New Folding Kinetic Mechanism for Human Transthyretin and the Influence of the Amyloidogenic V30M Mutation

    Article • International Journal of Molecular Sciences, August 2016, MDPI AG

    PhD Rui M Brito, Zaida Almeida

  5. Enhancing Scoring Performance of Docking-Based Virtual Screening Through Machine Learning

    Article • Current Bioinformatics, August 2016, Bentham Science Publishers

    PhD Rui M Brito

  6. Effect of ethyleneoxide groups of anionic surfactants on lipase activity

    Article • Biotechnology Progress, June 2016, Wiley

    PhD Rui M Brito, Zaida Almeida

  7. A look into amyloid formation by transthyretin: aggregation pathway and a novel kinetic model

    Article • Physical Chemistry Chemical Physics, January 2015, Royal Society of Chemistry

    PhD Rui M Brito, Zaida Almeida

  8. “Structural characterization of the minimal segment of TDP-43 competent for aggregation”

    Article • Archives of Biochemistry and Biophysics, March 2014, Elsevier

    PhD Rui M Brito

  9. A Serpin Released by an Entomopathogen Impairs Clot Formation in Insect Defense System

    Article • PLoS ONE, July 2013, PLOS

    PhD Rui M Brito

  10. The Apoptogenic Toxin AIP56 Is a Metalloprotease A-B Toxin that Cleaves NF-κb P65

    Article • PLoS Pathogens, February 2013, PLOS

    Dr Sandra Macedo-Ribeiro, PhD Rui M Brito

  11. VEGF-Functionalized Dextran Has Longer Intracellular Bioactivity than VEGF in Endothelial Cells

    Article • Biomacromolecules, September 2012, American Chemical Society (ACS)

    PhD Rui M Brito

  12. Changes in Channel Trafficking and Protein Stability Caused by LQT2 Mutations in the PAS Domain of the HERG Channel

    Article • PLoS ONE, March 2012, PLOS

    PhD Rui M Brito

  13. Functional and conformational changes in the aspartic protease cardosin A induced by TFE

    Article • International Journal of Biological Macromolecules, March 2012, Elsevier

    PhD Rui M Brito

  14. The V30M Amyloidogenic Mutation Decreases the Rate of Refolding Kinetics of the Tetrameric Protein Transthyretin

    Article • Spectroscopy An International Journal, January 2012, Hindawi Publishing Corporation

    PhD Rui M Brito

  15. Modeling of the Toll-like receptor 3 and a putative Toll-like receptor 3 antagonist encoded by the African swine fever virus

    Article • Protein Science, January 2011, Wiley

    PhD Rui M Brito

  16. Assessing the Effect of 2D Fingerprint Filtering on ILP-Based Structure-Activity Relationships Toxicity Studies in Drug Design

    Article • January 2011, Springer Science + Business Media

    PhD Rui M Brito

  17. FH8 - a small EF-hand protein from Fasciola hepatica

    Article • FEBS Journal, November 2010, Wiley

    PhD Rui M Brito

  18. Biological activity of heterologous murine interleukin-10 and preliminary studies on the use of a dextrin nanogel as a delivery system

    Article • International Journal of Pharmaceutics, November 2010, Elsevier

    PhD Rui M Brito

  19. Toward the Discovery of Functional Transthyretin Amyloid Inhibitors: Application of Virtual Screening Methods

    Article • Journal of Chemical Information and Computer Sciences, October 2010, American Chemical Society (ACS)

    PhD Rui M Brito

  20. P-found: Grid-enabling distributed repositories of protein folding and unfolding simulations for data mining

    Article • Future Generation Computer Systems, March 2010, Elsevier

    PhD Rui M Brito

  21. Potentially amyloidogenic conformational intermediates populate the unfolding landscape of transthyretin: Insights from molecular dynamics simulations

    Article • Protein Science, February 2010, Wiley

    PhD Rui M Brito

  22. Spatial Clustering of Molecular Dynamics Trajectories in Protein Unfolding Simulations

    Article • January 2009, Springer Science + Business Media

    PhD Rui M Brito

  23. Comparative Study of Classification Algorithms Using Molecular Descriptors in Toxicological DataBases

    Article • January 2009, Springer Science + Business Media

    PhD Rui M Brito

  24. Flash vacuum pyrolysis of 2,2-dioxo-1H,3H-pyrrolo[1,2-c]thiazoles and 2-vinyl-1H-pyrroles

    Article • Tetrahedron, October 2008, Elsevier

    Teresa Pinho e Melo, PhD Rui M Brito, Maria Isabel Soares

  25. Grid Computing Solutions for Distributed Repositories of Protein Folding and Unfolding Simulations

    Article • January 2008, Springer Science + Business Media

    PhD Rui M Brito

  26. P-found: The Protein Folding and Unfolding Simulation Repository

    Article • September 2006, Institute of Electrical & Electronics Engineers (IEEE)

    PhD Rui M Brito

  27. Mining Approximate Motifs in Time Series

    Article • January 2006, Springer Science + Business Media

    PhD Rui M Brito

  28. Towards Data Warehousing and Mining of Protein Unfolding Simulation Data

    Article • Journal of Clinical Monitoring and Computing, October 2005, Springer Science + Business Media

    PhD Rui M Brito

  29. Detection of Hydrophobic Clusters in Molecular Dynamics Protein Unfolding Simulations Using Association Rules

    Article • January 2005, Springer Science + Business Media

    PhD Rui M Brito

  30. Protein Folding and Unfolding Simulations: A New Challenge for Data Mining

    Article • OMICS A Journal of Integrative Biology, July 2004, Mary Ann Liebert Inc

    PhD Rui M Brito

  31. Amyloid Formation by Transthyretin: From Protein Stability to Protein Aggregation

    Article • Current Medicinal Chemistry - Immunology Endocrine & Metabolic Agents, December 2003, Bentham Science Publishers

    PhD Rui M Brito

  32. Comparative calorimetric study of non-amyloidogenic and amyloidogenic variants of the homotetrameric protein transthyretin

    Article • Biophysical Chemistry, December 2000, Elsevier

    PhD Rui M Brito

  33. The Tetrameric Protein Transthyretin Dissociates to a Non-native Monomer in Solution: A NOVEL MODEL FOR AMYLOIDOGENESIS

    Article • Journal of Biological Chemistry, November 1999, American Society for Biochemistry & Molecular Biology (ASBMB)

    PhD Rui M Brito

  34. Solution Structures of the C-Terminal Domain of Cardiac Troponin C Free and Bound to the N-Terminal Domain of Cardiac Troponin I

    Article • Biochemistry, October 1999, American Chemical Society (ACS)

    PhD Rui M Brito

  35. Solution Structures of the C-Terminal Domain of Cardiac Troponin C Free and Bound to the N-Terminal Domain of Cardiac Troponin I † , ‡

    Article • Biochemistry, June 1999, American Chemical Society (ACS)

    PhD Rui M Brito

  36. The amyloidogenic potential of transthyretin variants correlates with their tendency to aggregate in solution

    Article • FEBS Letters, December 1997, Wiley

    PhD Rui M Brito

  37. Assignment and calcium dependence of methionyl .epsilon.C and .epsilon.H resonances in cardiac troponin C

    Article • Biochemistry, December 1994, American Chemical Society (ACS)

    PhD Rui M Brito

  38. Conformational changes in the metal-binding sites of cardiac troponin C induced by calcium binding

    Article • Biochemistry, February 1992, American Chemical Society (ACS)

    PhD Rui M Brito

  39. Comparative NMR studies on cardiac troponin C and a mutant incapable of binding calcium at site II

    Article • Biochemistry, October 1991, American Chemical Society (ACS)

    PhD Rui M Brito

  40. Conformation of NADP+ bound to a type II dihydrofolate reductase

    Article • Biochemistry, February 1991, American Chemical Society (ACS)

    PhD Rui M Brito

  41. Characterization and stereochemistry of cofactor oxidation by a type II dihydrofolate reductase

    Article • Biochemistry, October 1990, American Chemical Society (ACS)

    PhD Rui M Brito

  42. Determination of the critical micelle concentration of surfactants using the fluorescent probe N-phenyl-1-naphthylamine

    Article • Analytical Biochemistry, February 1986, Elsevier

    PhD Rui M Brito

  43. On Mining Protein Unfolding Simulation Data with Inductive Logic Programming

    Article • Springer Science + Business Media

    PhD Rui M Brito

  44. Using Data Mining Techniques to Probe the Role of Hydrophobic Residues in Protein Folding and Unfolding Simulations

    Article • IGI Global

    PhD Rui M Brito

  45. A Knowledge Discovery Method for the Characterization of Protein Unfolding Processes

    Article • Springer Science + Business Media

    PhD Rui M Brito