Contact

All Stories

  1. The emerging multifunctional roles of ERAP1, ERAP2 and IRAP between antigen processing and renin-angiotensin system modulation

    Article • Frontiers in Immunology, September 2022, Frontiers

    Professor Rosa Sorrentino

  2. A short ERAP2 that binds IRAP is expressed in macrophages independently from gene variation

    Article • March 2022, Cold Spring Harbor Laboratory Press

    Professor Rosa Sorrentino

  3. The Multifaceted Nature of Aminopeptidases ERAP1, ERAP2, and LNPEP: From Evolution to Disease

    Article • Frontiers in Immunology, July 2020, Frontiers

    Professor Rosa Sorrentino

  4. The rs75862629 minor allele in the endoplasmic reticulum aminopeptidases intergenic region affects human leucocyte antigen B27 expression and protects from ankylosing spondylitis in Sardinia

    Article • Rheumatology, June 2019, Oxford University Press (OUP)

    Dr Matteo Piga, Professor Rosa Sorrentino

  5. EBV, CD8 and Ankylosing spondylitis

    Article • Cells, June 2019, MDPI AG

    Marco D'Abramo, Professor Rosa Sorrentino

  6. Ankylosing Spondylitis: A Trade Off of HLA-B27, ERAP, and Pathogen Interconnections? Focus on Sardinia

    Article • Frontiers in Immunology, January 2019, Frontiers

    Professor Rosa Sorrentino

  7. AIF-1 gene does not confer susceptibility to Behçet’s disease: Analysis of extended haplotypes in Sardinian population

    Article • PLoS ONE, September 2018, PLOS

    Dr Matteo Piga, Professor Rosa Sorrentino

  8. An allelic variant in the intergenic region between ERAP1 and ERAP2 correlates with an inverse expression of the two genes

    Article • Scientific Reports, July 2018, Springer Science + Business Media

    Professor Rosa Sorrentino

  9. Expression analysis of HLA-E and NKG2A and NKG2C receptors points at a role for natural killer function in ankylosing spondylitis

    Article • RMD Open, July 2018, BMJ

    Dr Matteo Piga, Professor Rosa Sorrentino

  10. The Peptide Repertoire of HLA-B27 may include Ligands with Lysine at P2 Anchor Position

    Article • PROTEOMICS, March 2018, Wiley

    Professor Rosa Sorrentino

  11. HLA Class I or Class II and Disease Association: Catch the Difference If You Can

    Article • Frontiers in Immunology, November 2017, Frontiers

    Professor Rosa Sorrentino

  12. The interplay between HLA-B27 and ERAP1/ERAP2 aminopeptidases: from anti-viral protection to spondyloarthritis

    Article • Clinical & Experimental Immunology, August 2017, Wiley

    Professor Rosa Sorrentino, maria teresa fiorillo

  13. RNA editing signature during myeloid leukemia cell differentiation

    Article • Leukemia, May 2017, Springer Science + Business Media

    Professor Rosa Sorrentino

  14. The Ankylosing Spondylitis-Associated HLA-B*2705 Presents a B*0702-Restricted EBV Epitope and Sustains the Clonal Amplification of Cytotoxic T Cells in Patients

    Article • World Journal of Surgery, January 2016, The Feinstein Institute for Medical Research (North Shore LIJ Research Institute)

    Dr Matteo Piga, Professor Rosa Sorrentino

  15. Regulation and trafficking of the HLA-E molecules during monocyte-macrophage differentiation

    Article • Journal of Leukocyte Biology, August 2015, Wiley

    Professor Rosa Sorrentino

  16. Single Nucleotide Polymorphisms in the 3′UTR of VPAC-1 Cooperate in Modulating Gene Expression and Impact Differently on the Interaction with miR525-5p

    Article • PLoS ONE, November 2014, PLOS

    Professor Rosa Sorrentino

  17. Reprint of “Genetics of autoimmunity: An update”

    Article • Immunology Letters, October 2014, Elsevier

    Professor Rosa Sorrentino

  18. The multifaceted nature of NLRP12

    Article • Journal of Leukocyte Biology, September 2014, Wiley

    Professor Rosa Sorrentino

  19. Genetics of autoimmunity: An update

    Article • Immunology Letters, March 2014, Elsevier

    Professor Rosa Sorrentino

  20. HLA-B27 and antigen presentation: At the crossroads between immune defense and autoimmunity

    Article • Molecular Immunology, January 2014, Elsevier

    Professor Rosa Sorrentino

  21. Characterization of a Proteasome and TAP-independent Presentation of Intracellular Epitopes by HLA-B27 Molecules

    Article • Journal of Biological Chemistry, July 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Rosa Sorrentino

  22. Interaction Pattern of Arg 62 in the A-Pocket of Differentially Disease-Associated HLA-B27 Subtypes Suggests Distinct TCR Binding Modes

    Article • PLoS ONE, March 2012, PLOS

    Professor Rosa Sorrentino

  23. Susceptibility to ankylosing spondylitis but not disease outcome is influenced by the level of HLA-B27 expression, which shows moderate variability over time

    Article • Scandinavian Journal of Rheumatology, February 2012, Taylor & Francis

    Dr Matteo Piga, Professor Rosa Sorrentino

  24. Gender-dependent association of type 2 diabetes with the vasoactive intestinal peptide receptor 1

    Article • Gene, February 2012, Elsevier

    Professor Rosa Sorrentino

  25. Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

    Article • Nature Genetics, August 2011, Springer Science + Business Media

    Professor Rosa Sorrentino, Professor Janusz Antoni Jankowski

  26. Divergent Effect of Cobalt and Beryllium Salts on the Fate of Peripheral Blood Monocytes and T Lymphocytes

    Article • Toxicological Sciences, October 2010, Oxford University Press (OUP)

    Professor Rosa Sorrentino

  27. The Expression of Vasoactive Intestinal Peptide Receptor 1 Is Negatively Modulated by MicroRNA 525-5p

    Article • PLoS ONE, August 2010, PLOS

    Professor Ralph A Tripp, Professor Rosa Sorrentino

  28. CD8+ T-cell mediated self-reactivity in HLA-B27 context as a consequence of dual peptide conformation

    Article • Clinical Immunology, June 2010, Elsevier

    Professor Rosa Sorrentino

  29. Age-dependent association of idiopathic achalasia with vasoactive intestinal peptide receptor 1 gene

    Article • Neurogastroenterology & Motility, June 2009, Wiley

    Professor Rosa Sorrentino

  30. The interplay between the geographic distribution of HLA-B27 alleles and their role in infectious and autoimmune diseases: A unifying hypothesis

    Article • Autoimmunity Reviews, March 2009, Elsevier

    Professor Rosa Sorrentino

  31. HLA-E gene polymorphism associates with ankylosing spondylitis in Sardinia

    Article • Arthritis Research & Therapy, January 2009, Springer Science + Business Media

    Professor Rosa Sorrentino

  32. T-Cell Responses Against Viral and Self-Epitopes and HLA-B27 Subtypes Differentially Associated with Ankylosing Spondylitis

    Article • January 2009, Springer Science + Business Media

    Professor Rosa Sorrentino

  33. A functional polymorphism of the vasoactive intestinal peptide receptor 1 gene correlates with the presence of HLA-B *2705 in Sardinia

    Article • Genes & Immunity, July 2008, Springer Science + Business Media

    Professor Rosa Sorrentino

  34. Citrullination-dependent Differential Presentation of a Self-peptide by HLA-B27 Subtypes

    Article • Journal of Biological Chemistry, July 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Rosa Sorrentino

  35. HLA-B27 and Ankylosing Spondylitis geographic distribution as the result of a genetic selection induced by malaria endemic? A review supporting the hypothesis

    Article • Autoimmunity Reviews, May 2008, Elsevier

    Professor Rosa Sorrentino

  36. HLA-B27 and ankylosing spondylitis geographic distribution versus malaria endemic: casual or causal liaison?

    Article • Annals of the Rheumatic Diseases, January 2008, BMJ

    Professor Rosa Sorrentino

  37. Prospective meta-analysis of interleukin 1 gene complex polymorphisms confirms associations with ankylosing spondylitis

    Article • Annals of the Rheumatic Diseases, November 2007, BMJ

    Professor Rosa Sorrentino, Gilberto Vargas-Alarcón

  38. A sardinian patient with ankylosing spondylitis and HLA–B*2709 co-occurring with HLA–B*1403

    Article • Arthritis & Rheumatism, January 2007, Wiley

    Antonella Mameli, Professor Rosa Sorrentino

  39. Identification of previously unrecognized predisposing factors for ankylosing spondylitis from analysis of HLA–B27 extended haplotypes in sardinia

    Article • Arthritis & Rheumatism, January 2007, Wiley

    Professor Rosa Sorrentino

  40. The pathogenetic role of HLA-B27 and its subtypes

    Article • Autoimmunity Reviews, January 2007, Elsevier

    Professor Rosa Sorrentino

  41. Characterization of CD8+ T cell repertoire in identical twins discordant and concordant for multiple sclerosis

    Article • Journal of Leukocyte Biology, November 2006, Wiley

    Professor Rosa Sorrentino

  42. The C Terminus of the Nucleoprotein of Influenza A Virus Delivers Antigens Transduced by Tat to the trans-Golgi Network and Promotes an Efficient Presentation through HLA Class I

    Article • Journal of Virology, December 2005, ASM Journals

    Professor Rosa Sorrentino

  43. Conformational Dimorphism of Self-peptides and Molecular Mimicry in a Disease-associated HLA-B27 Subtype

    Article • Journal of Biological Chemistry, October 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Rosa Sorrentino

  44. Distribution of HLA-B27 subtypes in Sardinia and continental Italy and their association with spondylarthropathies

    Article • Arthritis & Rheumatism, January 2005, Wiley

    Professor Rosa Sorrentino

  45. Allele-dependent Similarity between Viral and Self-peptide Presentation by HLA-B27 Subtypes

    Article • Journal of Biological Chemistry, November 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Rosa Sorrentino

  46. Dual, HLA-B27 Subtype-dependent Conformation of a Self-peptide

    Article • Journal of Experimental Medicine, January 2004, Rockefeller University Press

    Professor Rosa Sorrentino

  47. Two distinctive HLA haplotypes harbor the B27 alleles negatively or positively associated with ankylosing spondylitis in Sardinia: Implications for disease pathogenesis

    Article • Arthritis & Rheumatism, May 2003, Wiley

    Professor Rosa Sorrentino

  48. Increased level of HLA-B27 expression in ankylosing spondylitis patients compared with healthy HLA-B27-positive subjects: a possible further susceptibility factor for the development of disease

    Article • Rheumatology, December 2002, Oxford University Press (OUP)

    Professor Rosa Sorrentino

  49. T cell response to N-formylated peptides in humans

    Article • European Journal of Immunology, September 2001, Wiley

    Professor Rosa Sorrentino

  50. HLA-DP Allele-Specific T Cell Responses to Beryllium Account for DP-Associated Susceptibility to Chronic Beryllium Disease

    Article • The Journal of Immunology, March 2001, The American Association of Immunologists

    Professor Rosa Sorrentino

  51. Tolerance induction in indirect alloresponses by analogs of HLA-derived peptides

    Article • Transplantation Proceedings, February 2001, Elsevier

    Professor Rosa Sorrentino

  52. CD8+ T-cell autoreactivity to an HLA-B27–restricted self-epitope correlates with ankylosing spondylitis

    Article • Journal of Clinical Investigation, July 2000, American Society for Clinical Investigation

    Professor Rosa Sorrentino

  53. HLA-DP molecules bind cobalt: a possible explanation for the genetic association with hard metal disease

    Article • European Journal of Immunology, July 1999, Wiley

    Professor Rosa Sorrentino

  54. The naturally occurring polymorphism Asp116 → His116 , differentiating the ankylosing spondylitis-associated HLA-B*2705 from the non-associated HLA-B*2709 subtype, influences peptide-specific CD8 T cell recognition

    Article • European Journal of Immunology, August 1998, Wiley

    Professor Rosa Sorrentino

  55. Susceptibility to hard metal lung disease is strongly associated with the presence of glutamate 69 in HLA-DPβ chain

    Article • European Journal of Immunology, October 1997, Wiley

    Professor Rosa Sorrentino

  56. Predominant T-helper 1 cytokine profile of hepatitis B virus nucleocapsid-specific T cells in acute self-limited hepatitis B

    Article • Hepatology, April 1997, Wiley

    Professor Rosa Sorrentino

  57. Susceptibility to ankylosing spondylitis correlates with the C-terminal residue of peptides presented by various HLA-B27 subtypes

    Article • European Journal of Immunology, February 1997, Wiley

    Professor Rosa Sorrentino

  58. HLA-DPB1 MISMATCH AT POSITION 69 IS ASSOCIATED WITH HIGH HELPER T LYMPHOCYTE PRECURSOR FREQUENCIES IN UNRELATED BONE MARROW TRANSPLANT PAIRS1

    Article • Transplantation, November 1996, Wolters Kluwer Health

    Professor Rosa Sorrentino

  59. Relevance of residue 116 of HLA-B27 in determining susceptibility to ankylosing spondylitis

    Article • European Journal of Immunology, November 1995, Wiley

    Professor Rosa Sorrentino

  60. Ultrastructural allelic variation in HLA-DQB1 promoter elements

    Article • Human Immunology, August 1995, Elsevier

    Professor Rosa Sorrentino

  61. The Asp116-His116 substitution in a novel HLA-B27 subtype influences the acceptance of the peptide C-terminal anchor

    Article • Immunogenetics, January 1995, Springer Science + Business Media

    Professor Rosa Sorrentino

  62. Anchor residue motifs of HLA class-I-binding peptides analyzed by the direct binding of synthetic peptides to HLA class I α chains

    Article • Human Immunology, November 1993, Elsevier

    Professor Rosa Sorrentino

  63. HLA-DPB1 glutamate 69: a genetic marker of beryllium disease

    Article • Science, October 1993, American Association for the Advancement of Science

    Professor Rosa Sorrentino

  64. HLA class I binding of synthetic nonamer peptides carrying major anchor residue motifs of HLA-B27 (B*2705)-binding peptides

    Article • Immunogenetics, March 1993, Springer Science + Business Media

    Professor Rosa Sorrentino

  65. Strong genetic association between HLA-DR3 and a polymorphic variation in the regulatory region of the HSP70-1 gene

    Article • Immunogenetics, January 1993, Springer Science + Business Media

    Professor Rosa Sorrentino

  66. A new approach to HLA-DPB1 typing combining DNA heteroduplex analysis with allele-specific amplification and enzyme restriction

    Article • Immunogenetics, July 1992, Springer Science + Business Media

    Professor Rosa Sorrentino

  67. Probe-Less Genomic Typing of ARG52 (Type 1 Diabetes-Associated) and Non-Arg52 (Non-Type 1 Diabetes-Associated) HLA-DQA1 Alleles

    Article • Autoimmunity, January 1992, Taylor & Francis

    Professor Rosa Sorrentino

  68. Subgrouping of DR4 alleles by DNA heteroduplex analysis

    Article • Human Immunology, January 1992, Elsevier

    Professor Rosa Sorrentino

  69. Detection of complex alleles by direct analysis of DNA heteroduplexes

    Article • Immunogenetics, February 1991, Springer Science + Business Media

    Professor Rosa Sorrentino

  70. Arg74 in HLA-DRBI and DRB3 controls a DR3-related epitope

    Article • Immunogenetics, January 1990, Springer Science + Business Media

    Professor Rosa Sorrentino

  71. DNA typing of anHLA-DR bilocus specificity by gene amplification and oligonucleotide hybridization

    Article • Immunogenetics, January 1989, Springer Science + Business Media

    Professor Rosa Sorrentino

  72. Detection of HLA-DP serological allodeterminants by the use of radioiodinated DP molecules

    Article • European Journal of Immunology, January 1987, Wiley

    Professor Rosa Sorrentino

  73. DNA restriction fragment length polymorphism of HLA-DR2: Correlation with HLA-DR2-associated functions

    Article • Journal of Neuroimmunology, September 1986, Elsevier

    Professor Rosa Sorrentino

  74. Structural organization of the DR subregion of the human major histocompatibility complex.

    Article • Proceedings of the National Academy of Sciences, August 1985, Proceedings of the National Academy of Sciences

    Professor Rosa Sorrentino

  75. Genetic Complexity and Expression of Human Class II Histocompatibility Antigens

    Article • Immunological Reviews, June 1985, Wiley

    Professor Rosa Sorrentino

  76. Current view of the human Ia system based on serological and immunochemical analysis

    Article • Human Immunology, September 1983, Elsevier

    Professor Rosa Sorrentino

  77. Microfingerprinting analysis of human Ia molecules favours a three loci model

    Article • Molecular Immunology, March 1983, Elsevier

    Professor Rosa Sorrentino

  78. Human Ia molecules carrying DC1 or BR4X7 determinants are not homologous to murine I-E molecules

    Article • Immunogenetics, September 1982, Springer Science + Business Media

    Professor Rosa Sorrentino

  79. Human Ia molecules carrying DC1 determinants differ in both α- and β-subunits from Ia molecules carrying DR determinants

    Article • Nature, July 1981, Springer Science + Business Media

    Professor Rosa Sorrentino

  80. Binding of one monoclonal antibody to human Ia molecules can be enhanced by a second monoclonal antibody

    Article • European Journal of Immunology, January 1981, Wiley

    Professor Rosa Sorrentino, MD, PhD Roberto S Accolla

  81. Biochemical controls of the G1 phase of a mammalian cell cycle I. Analysis of chromatin proteins in temperature-sensitive variants

    Article • Cell Biology International Reports, April 1980, Wiley

    Professor Rosa Sorrentino

  82. Effect of cytosine arabinoside triphosphate on the incorporation of3H-thymidine in mitochondria isolated from HeLa cells

    Article • Journal of Cellular Physiology, October 1979, Wiley

    Professor Rosa Sorrentino

  83. Conditional expression of the transformed phenotype in an ?epithelial-like? cell line

    Article • Cell Biology International Reports, August 1979, Wiley

    Professor Rosa Sorrentino