All Stories

  1. Boronic acid with high oxidative stability and utility in biological contexts
  2. A substrate selected by phage display exhibits enhanced side-chain hydrogen bonding to HIV-1 protease
  3. Fine-Tuning Strain and Electronic Activation of Strain-Promoted 1,3-Dipolar Cycloadditions with Endocyclic Sulfamates in SNO-OCTs
  4. Electronic and Steric Optimization of Fluorogenic Probes for Biomolecular Imaging
  5. A Boronic Acid Conjugate of Angiogenin that Shows ROS-Responsive Neuroprotective Activity
  6. A Boronic Acid Conjugate of Angiogenin that Shows ROS-Responsive Neuroprotective Activity
  7. Prolyl 4-Hydroxylase: Substrate Isosteres in Which an (E)- or (Z)-Alkene Replaces the Prolyl Peptide Bond
  8. A prevalent intraresidue hydrogen bond stabilizes proteins
  9. 1,3-Dipolar Cycloaddition with Diazo Groups: Noncovalent Interactions Overwhelm Strain
  10. n→π* Interactions Are Competitive with Hydrogen Bonds
  11. Decreasing Distortion Energies without Strain: Diazo-Selective 1,3-Dipolar Cycloadditions
  12. Rapid cycloaddition of a diazo group with an unstrained dipolarophile
  13. Human Collagen Prolyl 4-Hydroxylase Is Activated by Ligands for Its Iron Center
  14. 1,3-Dipolar Cycloadditions of Diazo Compounds in the Presence of Azides
  15. Crystal structure ofN-(3-oxobutanoyl)-L-homoserine lactone
  16. Replacing a single atom accelerates the folding of a protein and increases its thermostability
  17. Boronic Acid for the Traceless Delivery of Proteins into Cells
  18. Target selection by natural and redesigned PUF proteins
  19. Selective Inhibition of Collagen Prolyl 4-Hydroxylase in Human Cells
  20. Convenient synthesis of collagen-related tripeptides for segment condensation
  21. Coevolution of RtcB and Archease created a multiple-turnover RNA ligase
  22. α/β-Peptide Foldamers Targeting Intracellular Protein–Protein Interactions with Activity in Living Cells
  23. Fluorogenic Assay for Inhibitors of HIV-1 Protease with Sub-picomolar Affinity
  24. Selective inhibition of prolyl 4-hydroxylases by bipyridinedicarboxylates
  25. Optimized Diazo Scaffold for Protein Esterification
  26. Separation of Lignin from Corn Stover Hydrolysate with Quantitative Recovery of Ionic Liquid
  27. 4-ketoproline: An electrophilic proline analog for bioconjugation
  28. Diazo Groups Endure Metabolism and Enable Chemoselectivity in Cellulo
  29. Conformational Stability and Catalytic Activity of PTEN Variants Linked to Cancers and Autism Spectrum Disorders
  30. Catalysis by the Tumor-Suppressor Enzymes PTEN and PTEN-L
  31. Intrinsic site-selectivity of ubiquitin dimer formation
  32. Diazo compounds for the bioreversible esterification of proteins
  33. Thioamides in the collagen triple helix
  34. Creating Site-Specific Isopeptide Linkages Between Proteins with the Traceless Staudinger Ligation
  35. An Evolved Mxe GyrA Intein for Enhanced Production of Fusion Proteins
  36. Affinity of monoclonal antibodies for Globo-series glycans
  37. Optimal Interstrand Bridges for Collagen-like Biomaterials
  38. Bovine Brain Ribonuclease Is the Functional Homolog of Human Ribonuclease 1
  39. Structure of RNA 3′-phosphate cyclase bound to substrate RNA
  40. Functional Evolution of Ribonuclease Inhibitor: Insights from Birds and Reptiles
  41. Pyrazine-derived disulfide-reducing agent for chemical biology
  42. n→π* Interactions Engender Chirality in Carbonyl Groups
  43. Collagen‐based biomaterials for wound healing
  44. Cytotoxicity of Paclitaxel in Breast Cancer Is due to Chromosome Missegregation on Multipolar Spindles
  45. Bright Building Blocks for Chemical Biology
  46. Assignments of RNase A by ADAPT-NMR and enhancer
  47. A Keyn→π* Interaction inN-Acyl Homoserine Lactones
  48. Signatures of n→π* interactions in proteins
  49. A tRNA splicing operon: Archease endows RtcB with dual GTP/ATP cofactor specificity and accelerates RNA ligation
  50. Effects of a second-generation human anti-ErbB2 ImmunoRNase on trastuzumab-resistant tumors and cardiac cells
  51. Organocatalysts of oxidative protein folding inspired by protein disulfide isomerase
  52. Interplay of Hydrogen Bonds and n→π* Interactions in Proteins
  53. Thiols and Selenols as Electron-Relay Catalysts for Disulfide-Bond Reduction
  54. Detection of Boronic Acids through Excited-State Intramolecular Proton-Transfer Fluorescence
  55. Conversion of Azides into Diazo Compounds in Water
  56. Contribution of Electrostatics to the Binding of Pancreatic-Type Ribonucleases to Membranes
  57. Facile Chemical Functionalization of Proteins through Intein-Linked Yeast Display
  58. Simulated Moving Bed Chromatography: Separation and Recovery of Sugars and Ionic Liquid from Biomass Hydrolysates
  59. Human Ribonuclease with a Pendant Poly(Ethylene Glycol) Inhibits Tumor Growth in Mice
  60. Bioavailable affinity label for collagen prolyl 4-hydroxylase
  61. n→π* Interactions of Amides and Thioamides: Implications for Protein Stability
  62. Pyramidalization of a carbonyl C atom in (2S)-N-(selenoacetyl)proline methyl ester
  63. Structures of the Noncanonical RNA Ligase RtcB Reveal the Mechanism of Histidine Guanylylation
  64. Fluorogenic Probe for Constitutive Cellular Endocytosis
  65. Protein prosthesis: β‐peptides as reverse‐turn surrogates
  66. Organocatalytic conversion of cellulose into a platform chemical
  67. An n→π* interaction reduces the electrophilicity of the acceptor carbonyl group
  68. A divalent protecting group for benzoxaboroles
  69. n→π* interactions in poly(lactic acid) suggest a role in protein folding
  70. Fluorogenic label to quantify the cytosolic delivery of macromolecules
  71. A novel fully human antitumor ImmunoRNase resistant to the RNase inhibitor
  72. Intimate Interactions with Carbonyl Groups: Dipole–Dipole or n→π*?
  73. Ribonucleoside 3′-Phosphates as Pro-Moieties for an Orally Administered Drug
  74. Synthesis of 5-Fluoro- and 5-Hydroxymethanoprolines via Lithiation of N-BOC-methanopyrrolidines. Constrained Cγ-Exo and Cγ-Endo Flp and Hyp Conformer Mimics
  75. Interaction of Nucleic Acids with the Glycocalyx
  76. Ribonuclease-Activated Cancer Prodrug
  77. A Potent, Versatile Disulfide-Reducing Agent from Aspartic Acid
  78. Boronate-Mediated Biologic Delivery
  79. tRNA Ligase Catalyzes the GTP-Dependent Ligation of RNA with3′-Phosphate and 5′-Hydroxyl Termini
  80. Peptides that anneal to natural collagen in vitro and ex vivo
  81. Trimethyl lock: a trigger for molecular release in chemistry, biology, and pharmacology
  82. Diazo compounds as highly tunable reactants in 1,3-dipolar cycloaddition reactions with cycloalkynes
  83. Rational Design and Evaluation of Mammalian Ribonuclease Cytotoxins
  84. A conserved interaction with the chromophore of fluorescent proteins
  85. Arginine Residues Are More Effective than Lysine Residues in Eliciting the Cellular Uptake of Onconase
  86. Sensitive fluorogenic substrate for alkaline phosphatase
  87. Ann→π* Interaction in Aspirin: Implications for Structure and Reactivity
  88. ChemInform Abstract: An Evaluation of Peptide-Bond Isosteres
  89. Mechanism of Ribonuclease A Endocytosis: Analogies to Cell-Penetrating Peptides
  90. Bovine Pancreatic Ribonuclease: Fifty Years of the First Enzymatic Reaction Mechanism
  91. Chemoselectivity in Chemical Biology: Acyl Transfer Reactions with Sulfur and Selenium
  92. Site-specific folate conjugation to a cytotoxic protein
  93. Site-specific PEGylation endows a mammalian ribonuclease with antitumor activity
  94. An Evaluation of Peptide-Bond Isosteres
  95. Interstrand Dipole-Dipole Interactions Can Stabilize the Collagen Triple Helix
  96. Synthesis of Conformationally Constrained 5-Fluoro- and 5-Hydroxymethanopyrrolidines. Ring-Puckered Mimics ofGauche- andAnti-3-Fluoro- and 3-Hydroxypyrrolidines
  97. Potentiation of ribonuclease cytotoxicity by a poly(amidoamine) dendrimer
  98. Signature of n→π* interactions in α-helices
  99. Conversion of Fructose into 5-(Hydroxymethyl)furfural in Sulfolane
  100. ChemInform Abstract: Carpe Diubiquitin
  101. Disruption and Formation of Surface Salt Bridges Are Coupled to DNA Binding by the Integration Host Factor: A Computational Analysis
  102. Tunable, Post-translational Hydroxylation of Collagen Domains inEscherichia coli
  103. Functional and structural analyses of N-acylsulfonamide-linked dinucleoside inhibitors of RNase A
  104. Ribonuclease S redux
  105. Synthesis and utility of fluorogenic acetoxymethyl ethers
  106. Oligomers of a 5-Carboxy-methanopyrrolidine β-Amino Acid. A Search for Order
  107. Cellular Uptake of Ribonuclease A Relies on Anionic Glycans
  108. Carpe Diubiquitin
  109. Carpe Diubiquitin
  110. Antitumor Activity of Ribonuclease Multimers Created by Site-Specific Covalent Tethering
  111. Synthesis of Furfural from Xylose and Xylan
  112. The Aberrance of the 4SDiastereomer of 4-Hydroxyproline
  113. n→π* interactions in proteins
  114. A Stereoelectronic Effect in Prebiotic Nucleotide Synthesis
  115. n→ π* Interaction andn)(π Pauli Repulsion Are Antagonistic for Protein Stability
  116. Quantum mechanical origin of the conformational preferences of 4-thiaproline and its S-oxides
  117. Prolyl 4-hydroxylase
  118. Fermentable sugars by chemical hydrolysis of biomass
  119. Advances in Bioconjugation
  120. Stereoelectronic and steric effects in side chains preorganize a protein main chain
  121. 1,9-Bis(2-pyridyl)-1,2,8,9-tetrathia-5-oxanonane
  122. 5(6)-anti-Substituted-2-azabicyclo[2.1.1]hexanes: A Nucleophilic Displacement Route
  123. Stringency of the 2-His–1-Asp Active-Site Motif in Prolyl 4-Hydroxylase
  124. Structure and Function ofBacillus subtilisYphP, a Prokaryotic Disulfide Isomerase with a CXC Catalytic Motif,
  125. Origin of the stability conferred upon collagen by fluorination
  126. ROMP from ROMP: A New Approach to Graft Copolymer Synthesis
  127. Onconase cytotoxicity relies on the distribution of its positive charge
  128. Silencing an Inhibitor Unleashes a Cytotoxic Enzyme
  129. Nature of Amide Carbonyl−Carbonyl Interactions in Proteins
  130. Collagen Structure and Stability
  131. Ribonuclease Inhibitor Regulates Neovascularization by Human Angiogenin
  132. Direct and continuous assay for prolyl 4-hydroxylase
  133. Simple Chemical Transformation of Lignocellulosic Biomass into Furans for Fuels and Chemicals
  134. Coulombic effects on the traceless Staudinger ligation in water
  135. Fluorogenic affinity label for the facile, rapid imaging of proteins in live cells
  136. Polyarginine as a multifunctional fusion tag
  137. Modulating Collagen Triple-Helix Stability with 4-Chloro, 4-Fluoro, and 4-Methylprolines
  138. Chapter 2 Protein Engineering with the Traceless Staudinger Ligation
  139. Variants of ribonuclease inhibitor that resist oxidation
  140. Green fluorescent protein as a signal for protein-protein interactions
  141. Ribonuclease S-peptide as a carrier in fusion proteins
  142. Interaction of onconase with the human ribonuclease inhibitor protein
  143. Olefin metathesis for chemical biology
  144. Peptides and peptidomimetics as prototypes
  145. A Phosphine-Mediated Conversion of Azides into Diazo Compounds
  146. A highly sensitive fluorogenic probe for cytochrome P450 activity in live cells
  147. Design and Characterization of an HIV-Specific Ribonuclease Zymogen
  148. Hydrolytic Stability of Hydrazones and Oximes
  149. Conformational Preferences of Substrates for Human Prolyl 4-Hydroxylase†
  150. Hydrolytic Stability of Hydrazones and Oximes
  151. Catalysis of Protein Folding by an Immobilized Small-Molecule Dithiol
  152. Practical syntheses of 4-fluoroprolines
  153. Evasion of Ribonuclease Inhibitor as a Determinant of Ribonuclease Cytotoxicity
  154. Jeremy R. Knowles (1935−2008)
  155. 4-Chloroprolines: Synthesis, conformational analysis, and effect on the collagen triple helix
  156. Bright Ideas for Chemical Biology
  157. Stabilization of the Collagen Triple Helix byO-Methylation of Hydroxyproline Residues
  158. Genetic selection for peptide inhibitors of angiogenin
  159. Trimethyl Lock: A Stable Chromogenic Substrate for Esterases
  160. Electronic and steric effects on the rate of the traceless Staudinger ligation
  161. Structural Basis for Catalysis by Onconase
  162. Self-assembled collagen-like peptide fibers as templates for metallic nanowires
  163. Ribonucleases as Novel Chemotherapeutics
  164. Catalysis of imido group hydrolysis in a maleimide conjugate
  165. Olefin Metathesis in Homogeneous Aqueous Media Catalyzed by Conventional Ruthenium Catalysts
  166. Intraspecies Regulation of Ribonucleolytic Activity
  167. Increasing the potency of a cytotoxin with an arginine graft
  168. Protein Prosthesis:  1,5-Disubstituted[1,2,3]triazoles ascis-Peptide Bond Surrogates
  169. Using Measurements of Anchoring Energies of Liquid Crystals on Surfaces To Quantify Proteins Captured by Immobilized Ligands
  170. Water-Soluble Phosphinothiols for Traceless Staudinger Ligation and Integration with Expressed Protein Ligation
  171. Cytotoxic Ribonucleases:  The Dichotomy of Coulombic Forces
  172. Tuning the pKaof Fluorescein to Optimize Binding Assays
  173. Genetic selection reveals the role of a buried, conserved polar residue
  174. General Method for Site-Specific Protein Immobilization by Staudinger Ligation
  175. Inhibition of Human Pancreatic Ribonuclease by the Human Ribonuclease Inhibitor Protein
  176. Arginine Grafting to Endow Cell Permeability
  177. Multilayered Films Fabricated from an Oligoarginine-Conjugated Protein Promote Efficient Surface-Mediated Protein Transduction
  178. Salicylaldimine Ruthenium Alkylidene Complexes: Metathesis Catalysts Tuned for Protic Solvents
  179. Is glycine a surrogate for a D-amino acid in the collagen triple helix?
  180. A ribonuclease zymogen activated by the NS3 protease of the hepatitis C virus
  181. Staudinger Ligation of Peptides at Non-Glycyl Residues
  182. Synthesis and characterization of a novel class of reducing agents that are highly neuroprotective for retinal ganglion cells
  183. Energetics of ann→π* Interaction that Impacts Protein Structure
  184. Macrocyclic Scaffold for the Collagen Triple Helix
  185. Genetic Selection for Critical Residues in Ribonucleases
  186. Reactivity of Intein Thioesters: Appending a Functional Group to a Protein
  187. Characterization of Protein Immobilization at Silver Surfaces by Near Edge X-ray Absorption Fine Structure Spectroscopy
  188. Latent Blue and Red Fluorophores Based on the Trimethyl Lock
  189. Internalization of cationic peptides: the road less (or more?) traveled
  190. Reaction Mechanism and Kinetics of the Traceless Staudinger Ligation
  191. Reciprocity of Steric and Stereoelectronic Effects in the Collagen Triple Helix
  192. Fluorogenic Label for Biomolecular Imaging
  193. 2005 Emil Thomas Kaiser Award
  194. Contrast Agents for Magnetic Resonance Imaging Synthesized with Ring-Opening Metathesis Polymerization
  195. Semisynthesis and Characterization of Mammalian Thioredoxin Reductase†
  196. Self-assembly of synthetic collagen triple helices
  197. Stereoelectronic effects on polyproline conformation
  198. Cytotoxicity of Bovine Seminal Ribonuclease:  Monomer versus Dimer†
  199. Disruption of Shape-Complementarity Markers to Create Cytotoxic Variants of Ribonuclease A
  200. Stereoelectronic and Steric Effects in the Collagen Triple Helix:  Toward a Code for Strand Association
  201. Catalysis of Protein Disulfide Bond Isomerization in a Homogeneous Substrate†
  202. Reconstitution of a Defunct Glycolytic Pathway via Recruitment of Ambiguous Sugar Kinases†
  203. Peptide Bond Isosteres:  Ester or (E)-Alkene in the Backbone of the Collagen Triple Helix
  204. Chemical Synthesis of Proteins
  205. Latent Fluorophore Based on the Trimethyl Lock
  206. Binding of non-natural 3′-nucleotides to ribonuclease A
  207. Synthetic Surfaces for Ribonuclease Adsorption
  208. O-acylation of hydroxyproline residues: Effect on peptide-bond isomerization and collagen stability
  209. Ribonuclease Inhibitor: Structure and Function
  210. Production of human prolyl 4-hydroxylase in Escherichia coli
  211. Substituted 2-Azabicyclo[2.1.1]hexanes as Constrained Proline Analogues:  Implications for Collagen Stability
  212. Imaging the Binding Ability of Proteins Immobilized on Surfaces with Different Orientations by Using Liquid Crystals
  213. Identifying Latent Enzyme Activities:  Substrate Ambiguity within Modern Bacterial Sugar Kinases†
  214. Zinc(II)-mediated inhibition of ribonuclease Sa by an N-hydroxyurea nucleotide and its basis
  215. Pathway for Polyarginine Entry into Mammalian Cells †
  216. Glycosylation of onconase increases its conformational stability and toxicity for cancer cells
  217. Comprehensive comparison of the cytotoxic activities of onconase and bovine seminal ribonuclease
  218. Contribution of Active-Site Residues to the Function of Onconase, a Ribonuclease with Antitumoral Activity†
  219. Site-Specific Protein Immobilization by Staudinger Ligation
  220. Catalysis of Protein Folding by Protein Disulfide Isomerase and Small-Molecule Mimics
  221. Stereoelectronic Effects on Collagen Stability:  The Dichotomy of 4-Fluoroproline Diastereomers
  222. Compensating effects on the cytotoxicity of ribonuclease A variants
  223. An electronic effect on protein structure
  224. Potent Inhibition of Ribonuclease A by Oligo(vinylsulfonic Acid)
  225. Protein Prosthesis:  A Nonnatural Residue Accelerates Folding and Increases Stability
  226. Activation of the Prolyl Hydroxylase Oxygen-sensor Results in Induction of GLUT1, Heme Oxygenase-1, and Nitric-oxide Synthase Proteins and Confers Protection from Metabolic Inhibition to Cardiomyocytes
  227. Effect of 3-Hydroxyproline Residues on Collagen Stability
  228. Protein Assembly by Orthogonal Chemical Ligation Methods
  229. The CXC Motif:  A Functional Mimic of Protein Disulfide Isomerase†
  230. Catalysis by Ribonuclease A Is Limited by the Rate of Substrate Association†
  231. Ribonuclease inhibitor as an intracellular sentry
  232. Zinc(II)-mediated inhibition of a ribonuclease by an N-hydroxyurea nucleotide
  233. Creation of a zymogen
  234. X-ray Structure of Two Crystalline Forms of aStreptomycete Ribonuclease with Cytotoxic Activity
  235. Secretory ribonucleases are internalized by a dynamin-independent endocytic pathway
  236. Genetic screen to dissect protein–protein interactions: ribonuclease inhibitor–ribonuclease A as a model system
  237. Fluorescence Assay for the Binding of Ribonuclease A to the Ribonuclease Inhibitor Protein
  238. Protein Prosthesis:  A Semisynthetic Enzyme with a β-Peptide Reverse Turn
  239. Staudinger Ligation of α-Azido Acids Retains Stereochemistry
  240. Evolution of Ribonuclease Inhibitor by Exon Duplication
  241. Collagen Stability:  Insights from NMR Spectroscopic and Hybrid Density Functional Computational Investigations of the Effect of Electronegative Substituents on Prolyl Ring Conformations
  242. KFERQ Sequence in Ribonuclease A-mediated Cytotoxicity
  243. The Ribonucleolytic Activity of Angiogenin†
  244. Translocation of a β-Peptide Across Cell Membranes
  245. Semisynthesis of Proteins Containing Selenocysteine
  246. Insights on the conformational stability of collagen
  247. Adjacent cysteine residues as a redox switch
  248. Endowing Human Pancreatic Ribonuclease with Toxicity for Cancer Cells
  249. Quantitative Analysis of the Effect of Salt Concentration on Enzymatic Catalysis
  250. Cleavage of 3‘,5‘-Pyrophosphate-Linked Dinucleotides by Ribonuclease A and Angiogenin†,‡
  251. High-Level Soluble Production and Characterization of Porcine Ribonuclease Inhibitor
  252. Contribution of tertiary amides to the conformational stability of collagen triple helices
  253. Cancer chemotherapy – ribonucleases to the rescue
  254. Selenocysteine in Native Chemical Ligation and Expressed Protein Ligation
  255. Contribution of the Active Site Histidine Residues of Ribonuclease A to Nucleic Acid Binding†
  256. Conformational Stability of Collagen Relies on a Stereoelectronic Effect
  257. High-Yielding Staudinger Ligation of a Phosphinothioester and Azide To Form a Peptide
  258. Fast, Facile, Hypersensitive Assays for Ribonucleolytic Activity
  259. A Highly Active Immobilized Ribonuclease
  260. Excavating an Active Site:  The Nucleobase Specificity of Ribonuclease A†
  261. Contribution of Individual Disulfide Bonds to the Oxidative Folding of Ribonuclease A†
  262. Native disulfide bond formation in proteins
  263. Pentavalent Organo-Vanadates as Transition State Analogues for Phosphoryl Transfer Reactions
  264. Effect of bovine seminal ribonuclease and bovine pancreatic ribonuclease A on bovine oocyte maturation
  265. Decavanadate Inhibits Catalysis by Ribonuclease A
  266. Genetic selection for dissociative inhibitors of designated protein–protein interactions
  267. A synapomorphic disulfide bond is critical for the conformational stability and cytotoxicity of an amphibian ribonuclease
  268. Conformational Stability Is a Determinant of Ribonuclease A Cytotoxicity
  269. Staudinger Ligation:  A Peptide from a Thioester and Azide
  270. Sulfur Shuffle:  Modulating Enzymatic Activity by Thiol-Disulfide Interchange
  271. Prolyl 4-hydroxylase is required for viability and morphogenesis in Caenorhabditis elegans
  272. A Ribonuclease A Variant with Low Catalytic Activity but High Cytotoxicity
  273. Origin of the ‘inactivation’ of ribonuclease A at low salt concentration
  274. Dimer formation by a “monomeric” protein
  275. Contribution of disulfide bonds to the conformational stability and catalytic activity of ribonuclease A
  276. [16] Green fluorescent protein chimeras to probe protein-protein interactions
  277. [23] The S·tag fusion system for protein purification
  278. A small-molecule catalyst of protein folding in vitro and in vivo
  279. Chemical Mechanism of DNA Cleavage by the Homing Endonuclease I-PpoI†
  280. Hypersensitive substrate for ribonucleases
  281. The CXXC motif: crystal structure of an active-site variant of Escherichia coli thioredoxin
  282. Extending the Limits to Enzymatic Catalysis:  Diffusion of Ribonuclease A in One Dimension†
  283. His ... Asp Catalytic Dyad of Ribonuclease A: Histidine pKa Values in the Wild-Type, D121N, and D121A Enzymes
  284. A hyperstable collagen mimic
  285. A New Remote Subsite in Ribonuclease A
  286. Coulombic Effects of Remote Subsites on the Active Site of Ribonuclease A†
  287. His···Asp Catalytic Dyad of Ribonuclease A:  Conformational Stability of the Wild-Type, D121N, D121A, and H119A Enzymes†
  288. No Role for Pepstatin-A-Sensitive Acidic Proteinases in Reovirus Infections of L or MDCK Cells
  289. Evans Osteotomy in the Adult Foot: An Anatomic Study of Structures at Risk
  290. Ribonuclease A variants with potent cytotoxic activity
  291. Coulombic Forces in Protein−RNA Interactions:  Binding and Cleavage by Ribonuclease A and Variants at Lys7, Arg10, and Lys66†
  292. Increasing the secretory capacity of Saccharomyces cerevisiae for production of single-chain antibody fragments
  293. Structure and stability of the P93G variant of ribonuclease A
  294. His···Asp Catalytic Dyad of Ribonuclease A:  Structure and Function of the Wild-Type, D121N, and D121A Enzymes†
  295. Ribonuclease A
  296. Code for collagen's stability deciphered
  297. Degenerate DNA recognition by I-PpoI endonuclease
  298. Gastric Inlet Patch Containing Submucosally Infiltrating Adenocarcinoma
  299. General Acid/Base Catalysis in the Active Site ofEscherichia coliThioredoxin†
  300. Microscopic pKaValues ofEscherichia coliThioredoxin†
  301. Ribonucleases Endowed with Specific Toxicity for Spermatogenic Layers
  302. Nature's transitory covalent bond
  303. The CXXC Motif:  A Rheostat in the Active Site†
  304. Computer-aided breast cancer detection and diagnosis of masses using difference of Gaussians and derivative-based feature saliency
  305. Short Communication
  306. Contribution of a tyrosine side chain to ribonuclease A catalysis and stability-Contribution of Tyr 97 to RNase A catalysis and stability
  307. Production of Human Pancreatic Ribonuclease inSaccharomyces cerevisiaeandEscherichia coli
  308. Substrate Binding and Turnover by the Highly Specific I-PpoI Endonuclease†
  309. Inductive Effects on the Energetics of Prolyl Peptide Bond Isomerization:  Implications for Collagen Folding and Stability
  310. Limits to Catalysis by Ribonuclease A
  311. Mechanism of Ribonuclease Cytotoxicity
  312. The Essential Function of Protein-disulfide Isomerase Is to Unscramble Non-native Disulfide Bonds
  313. Production of Rat Protein Disulfide Isomerase in Saccharomyces cerevisiae
  314. A Residue to Residue Hydrogen Bond Mediates the Nucleotide Specificity of Ribonuclease A
  315. Ribonuclease A: Revealing Structure-Function Relationships with Semisynthesis
  316. Replacing a Surface Loop Endows Ribonuclease A with Angiogenic Activity
  317. Structural Basis for the Biological Activities of Bovine Seminal Ribonuclease
  318. Analysis of Receptor-Ligand Interactions
  319. Dibromobimane as a Fluorescent Crosslinking Reagent
  320. The Extent to Which Ribonucleases Cleave Ribonucleic Acid
  321. Engineering ribonuclease A: production, purification and characterization of wild-type enzyme and mutants at Gln11
  322. A Misfolded but Active Dimer of Bovine Seminal Ribonuclease
  323. Energetics of Catalysis by Ribonucleases: Fate of the 2',3'-Cyclic Phosphodiester Intermediate
  324. Value of General Acid-Base Catalysis to Ribonuclease A
  325. Peptide Tags for a Dual Affinity Fusion System
  326. Structural Determinants of Enzymic Processivity
  327. Amide-Amide and Amide-Water Hydrogen Bonds: Implications for Protein Folding and Stability
  328. RNS2: a senescence-associated RNase of Arabidopsis that diverged from the S-RNases before speciation.
  329. Thermodynamic origin of prolyl peptide bond isomers
  330. Solvent effects on the energetics of prolyl peptide bond isomerization
  331. Binding energy and enzymatic catalysis
  332. Evolutionary optimization of the catalytic effectiveness of an enzyme
  333. Triosephosphate isomerase catalysis is diffusion controlled
  334. Kinetics and thermodynamics of the interaction of 5-fluoro-2'-deoxyuridylate with thymidylate synthase
  335. Enzyme relaxation in the reaction catalyzed by triosephosphate isomerase: detection and kinetic characterization of two unliganded forms of the enzyme
  336. Reaction energetics of a mutant triose phosphate isomerase in which the active-site glutamate has been changed to aspartate
  337. The Mechanistic Pathway of a Mutant Triosephosphate Isomerase
  338. Active site of triosephosphate isomerase: in vitro mutagenesis and characterization of an altered enzyme.
  339. Mechanistic studies on the pyridoxal phosphate enzyme 1-aminocyclopropane-1-carboxylate deaminase from Pseudomonas sp
  340. Mechanistic studies on the reactions of bacterial methionine .gamma.-lyase with olefinic amino acids
  341. Fluorescence Gel Retardation Assay to Detect Protein–Protein Interactions
  342. Fluorescence Polarization Assay to Quantify Protein–Protein Interactions