All Stories

  1. Cell–substrate adhesion drives Scar/WAVE activation and phosphorylation by a Ste20-family kinase, which controls pseudopod lifetime
  2. Control of actin dynamics during cell motility
  3. Analogies in 3D molecular visualisations: development of a cell biology animation ‘How cells move – a new interpretation of old data’
  4. Cell-substrate adhesion drives Scar/WAVE activation and phosphorylation, which controls pseudopod lifetime
  5. Screening by changes in stereotypical behavior during cell motility
  6. WASP restricts active Rac to maintain cells’ front-rear polarisation
  7. PIKfyve/Fab1 is required for efficient V-ATPase and hydrolase delivery to phagosomes, phagosomal killing, and restriction of Legionella infection
  8. Genetic Engineering of Dictyostelium discoideum Cells Based on Selection and Growth on Bacteria
  9. Distinct Interaction Sites of Rac GTPase with WAVE Regulatory Complex Have Non-redundant Functions in Vivo
  10. CYRI is a previously unknown protein that limits the growth and spread of lamellipods
  11. Science careers — improve your effectiveness but keep your passion
  12. Expression of N471D strumpellin leads to defects in the endolysosomal system
  13. PIKfyve/Fab1 is required for efficient V-ATPase and hydrolase delivery to phagosomes, phagosomal killing, and restriction of Legionella infection
  14. Rapid and efficient genetic engineering of both wild type and axenic strains of Dictyostelium discoideum
  15. The trimeric coiled‐coil HSBP 1 protein promotes WASH complex assembly at centrosomes
  16. A G-protein-coupled chemoattractant receptor recognizes lipopolysaccharide for bacterial phagocytosis
  17. The Chemoattractant Glorin Is Inactivated by Ester Cleavage during Early Multicellular Development of Polysphondylium pallidum
  18. Faculty of 1000 evaluation for Observing the cell in its native state: imaging subcellular dynamics in multicellular organisms.
  19. Distinct Interaction Sites of Rac GTPase with WAVE Regulatory Complex Have Nonnredundant Functions in Vivo
  20. LPP3, LPA and self-generated chemotactic gradients in biomedical science
  21. WASP family proteins and formins compete in pseudopod- and bleb-based migration
  22. CYRI (FAM49) proteins are local inhibitors of Scar/WAVE induced lamellipodia that bind directly to active Rac1
  23. LPP3 mediates self-generation of chemotactic LPA gradients by melanoma cells
  24. LPP3 mediates self-generation of chemotactic LPA gradients by melanoma cells
  25. Mroh1, a lysosomal regulator localized by WASH-generated actin
  26. Toxoplasma gondii F-actin forms an extensive filamentous network required for material exchange and parasite maturation
  27. Coordination by Cdc42 of Actin, Contractility, and Adhesion for Melanoblast Movement in Mouse Skin
  28. A plasma membrane template for macropinocytic cups
  29. Inference of the drivers of collective movement in two cell types: Dictyostelium and melanoma
  30. Self-generated chemotactic gradients—cells steering themselves
  31. Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour
  32. Local modulation of chemoattractant concentrations by single cells: dissection using a bulk-surface computational model
  33. Toxoplasma gondii establishes an extensive filamentous network consisting of stable F-actin during replication
  34. Self-Generated Chemoattractant Gradients: Attractant Depletion Extends the Range and Robustness of Chemotaxis
  35. The Inositol-3-Phosphate Synthase Biosynthetic Enzyme Has Distinct Catalytic and Metabolic Roles
  36. A computational method for the coupled solution of reaction–diffusion equations on evolving domains and manifolds: Application to a model of cell migration and chemotaxis
  37. Visualizing Cancer Cell Chemotaxis and Invasion in 2D and 3D
  38. Overflow in science and its implications for trust
  39. Melanomas’ fatal attraction to lysophosphatidic acid trails: a new prognostic and therapeutic approach?
  40. Comparative genome and transcriptome analyses of the social amoeba Acytostelium subglobosum that accomplishes multicellular development without germ-soma differentiation
  41. Impaired neutrophil directional chemotactic accuracy in chronic periodontitis patients
  42. Faculty of 1000 evaluation for An inside-out origin for the eukaryotic cell.
  43. Faculty of 1000 evaluation for Dictyostelium uses ether-linked inositol phospholipids for intracellular signalling.
  44. Melanoma Cells Break Down LPA to Establish Local Gradients That Drive Chemotactic Dispersal
  45. PIP3-dependent macropinocytosis is incompatible with chemotaxis
  46. Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence
  47. SCAR/WAVE
  48. WASH complex conservation: don’t WASH away the family!
  49. Predicting cell shapes in melanomas
  50. The interaction between pseudopods and extracellular signalling during chemotaxis and directed migration
  51. Abi Is Required for Modulation and Stability but Not Localization or Activation of the SCAR/WAVE Complex
  52. p21-Activated Kinase (PAK) Regulates Cytoskeletal Reorganization and Directional Migration in Human Neutrophils
  53. WASH is required for lysosomal recycling and efficient autophagic and phagocytic digestion
  54. The use of streptavidin conjugates as immunoblot loading controls and mitochondrial markers for use withDictyostelium discoideum
  55. Cyclical Action of the WASH Complex: FAM21 and Capping Protein Drive WASH Recycling, Not Initial Recruitment
  56. Loss of Scar/WAVE Complex Promotes N-WASP- and FAK-Dependent Invasion
  57. Measuring Chemotaxis Using Direct Visualization Microscope Chambers
  58. Phosphorylation of Actin-related Protein 2 (Arp2) Is Required for Normal Development and cAMP Chemotaxis inDictyostelium
  59. N-WASP coordinates the delivery and F-actin–mediated capture of MT1-MMP at invasive pseudopods
  60. Scar/WAVE3 contributes to motility and plasticity of lamellipodial dynamics but not invasion in three dimensions
  61. SCAR knockouts inDictyostelium: WASP assumes SCAR’s position and upstream regulators in pseudopods
  62. Pseudopod Growth and Evolution during Cell Movement Is Controlled through SCAR/WAVE Dephosphorylation
  63. The Rac GEF ZizB regulates development, cell motility and cytokinesis in Dictyostelium
  64. How a paper on RAC set the standard
  65. The induction of autophagy by mechanical stress
  66. The Arp2/3 activator WASH regulates  5 1-integrin-mediated invasive migration
  67. Rac1 Drives Melanoblast Organization during Mouse Development by Orchestrating Pseudopod- Driven Motility and Cell-Cycle Progression
  68. Activated factor XI inhibits chemotaxis of polymorphonuclear leukocytes
  69. Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis
  70. Chemotaxis: A Feedback-Based Computational Model Robustly Predicts Multiple Aspects of Real Cell Behaviour
  71. Behavioral and Structural Differences in Migrating Peripheral Neutrophils from Patients with Chronic Obstructive Pulmonary Disease
  72. In Vitro Aberrant Neutrophil Migration In COPD Is A Generic Phenomena And Is Not Related To Surface-Expression Of Chemoattractant Receptors Or Systemic Inflammation
  73. Functional analysis of Dictyostelium IBARa reveals a conserved role of the I-BAR domain in endocytosis
  74. Career postdocs increase scrap heap
  75. Actin on disease – Studying the pathobiology of cell motility using Dictyostelium discoideum
  76. Actin-Based Motility: WAVE Regulatory Complex Structure Reopens Old SCARs
  77. Dogma bites back – the evidence for branched actin
  78. Modeling Cell Movement and Chemotaxis Using Pseudopod-Based Feedback
  79. An Improved Chamber for Direct Visualisation of Chemotaxis
  80. WASP Family Proteins: Their Evolution and Its Physiological Implications
  81. SCAR/WAVE is activated at mitosis and drives myosin-independent cytokinesis
  82. Understanding eukaryotic chemotaxis: a pseudopod-centred view
  83. Use of the parameterised finite element method to robustly and efficiently evolve the edge of a moving cell
  84. Chemotaxis: finding the way forward with Dictyostelium
  85. Actin Dynamics at the Leading Edge: From Simple Machinery to Complex Networks
  86. WASP and SCAR/WAVE proteins: the drivers of actin assembly
  87. Aberrant Chemotaxis of Blood Neutrophils from COPD Patients; Correcting Abnormal Migration.
  88. Loss of Dictyostelium HSPC300 causes a scar-like phenotype and loss of SCAR protein
  89. Chemotaxis: TorC before You Akt…
  90. F-BAR domains: multifunctional regulators of membrane curvature
  91. Dictyostelium MEGAPs: F-BAR domain proteins that regulate motility and membrane tubulation in contractile vacuoles
  92. Abi Mutants in Dictyostelium Reveal Specific Roles for the SCAR/WAVE Complex in Cytokinesis
  93. Chemotaxis in Dictyostelium: how to walk straight using parallel pathways
  94. Cyclic AMP signalling in Dictyostelium: G-proteins activate separate Ras pathways using specific RasGEFs
  95. A major role for Scar/WAVE-1 downstream of GPVI in platelets
  96. Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions
  97. Replacement of the essential Dictyostelium Arp2 gene by its Entamoeba homologue using parasexual genetics
  98. Entamoeba histolyticacell movement: A central role for self-generated chemokines and chemorepellents
  99. RacG Regulates Morphology, Phagocytosis, and Chemotaxis
  100. Cell motility and SCAR localisation in axenically growing Dictyostelium cells
  101. Moving matters: signals and mechanisms in directed cell migration
  102. Nap1 Regulates Dictyostelium Cell Motility and Adhesion through SCAR-Dependent and -Independent Pathways
  103. Regulation of actin assembly by SCAR/WAVE proteins
  104. Regulation of actin assembly by SCAR/WAVE proteins
  105. Phospholipase D activity is essential for actin localization and actin-based motility in Dictyostelium
  106. Control of SCAR activity inDictyostelium discoideum
  107. Presidential candidates failed peer-review test
  108. The identification ofDictyostelium phosphoproteins altered in response to the activation of RasG
  109. Identification of phospholipase B from Dictyostelium discoideum reveals a new lipase family present in mammals, flies and nematodes, but not yeast
  110. Regulation of WASP
  111. Solving the WAVE function
  112. Monitor – biology
  113. PIR121 Regulates Pseudopod Dynamics and SCAR Activity in Dictyostelium
  114. Impact factors: target the funding bodies
  115. Protein conformation: through a lens, darkly
  116. Dictyostelium Chemotaxis: Fascism Through the Back Door?
  117. Robert Insall
  118. Linked regulation of motility and integrin function in activated migrating neutrophils revealed by interference in remodelling of the cytoskeleton
  119. Pseudopodium dynamics and rapid cell movement inDictyostelium Ras pathway mutants
  120. Methanol and acriflavine resistance in Dictyostelium are caused by loss of catalase
  121. PIP3, PIP2, and Cell Movement—Similar Messages, Different Meanings?
  122. Dynamics of theDictyosteliumArp2/3 complex in endocytosis, cytokinesis, and chemotaxis
  123. The Whole Organism, and nothing but the Organism
  124. WASP homology sequences in baculoviruses
  125. Cytoskeleton
  126. Dictyostelium: an ideal organism for genetic dissection of Ras signalling networks
  127. Small GTPases in Dictyostelium: lessons from a social amoeba
  128. A novel Dictyostelium RasGEF is required for normal endocytosis, cell motility and multicellular development
  129. The PKB that doesn’t need to jump
  130. Ca2+ signalling is not required for chemotaxis in Dictyostelium
  131. Purification and cloning of phosphatidylinositol transfer proteins from Dictyostelium discoideum: homologues of both mammalian PITPs and Saccharomyces cerevisiae Sec14p are found in the same cell
  132. Purification and cloning of phosphatidylinositol transfer proteins from Dictyostelium discoideum: homologues of both mammalian PITPs and Saccharomyces cerevisiae Sec14p are found in the same cell
  133. Too much of a good thing?
  134. Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3
  135. A cell for all reasons
  136. A Novel Ras-interacting Protein Required for Chemotaxis and Cyclic Adenosine Monophosphate Signal Relay inDictyostelium
  137. Signaling to Actin Dynamics
  138. PKB starts to jump
  139. Identification of Phosphatidylinositol transfer proteins from Dictyostelium
  140. Correspondence
  141. Cynicism and credulity
  142. Scar1 and the related Wiskott–Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex
  143. Keeping it in the family
  144. The helC gene encodes a putative DEAD-box RNA helicase required for development in Dictyostelium discoideum
  145. The right stuff
  146. DictyosteliumRasG Is Required for Normal Motility and Cytokinesis, But Not Growth
  147. The talk's the thing
  148. TheDictyosteliumMitogen-activated Protein Kinase ERK2 Is Regulated by Ras and cAMP-dependent Protein Kinase (PKA) and Mediates PKA Function
  149. The enemy within
  150. The art of MBoC
  151. The aimless RasGEF is required for processing of chemotactic signals through G-protein-coupled receptors in Dictyostelium
  152. Osmoregulation: Cyclic GMP and the big squeeze
  153. Seven Helix Chemoattractant Receptors Transiently Stimulate Mitogen-activated Protein Kinase inDictyostelium
  154. And now it's time for tea
  155. Signaling through chemoattractant receptors in Dictyostelium
  156. Glycogen synthase kinase and Dictyostelium development: old pathways pointing in new directions?
  157. CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium
  158. Two cAMP receptors activate common signaling pathways in Dictyostelium.
  159. Multiple cyclic AMP receptors are linked to adenylyl cyclase in Dictyostelium.
  160. Differentiation-inducing-factor dechlorinase, a novel cytosolic dechlorinating enzyme from Dictyostelium discoideum
  161. A G-rich sequence element common to Dictyostelium genes which differ radically in their patterns of expression
  162. Parasexual Genetics Using Axenic Cells
  163. Scar, WASp and the Arp2/3 Complex inDictyostelium Migration