All Stories

  1. Dual factors required for cytochrome-P450-mediated hydrocarbon ring contraction in bacterial gibberellin phytohormone biosynthesis
  2. Dynamic evolution of terpenoid biosynthesis in the Lamiaceae
  3. Oryzalexin S biosynthesis: a cross-stitched disappearing pathway
  4. Plant (di)terpenoid evolution: from pigments to hormones and beyond
  5. Investigation of Acid–Base Catalysis in Halimadienyl Diphosphate Synthase Involved in Mycobacterium tuberculosis Virulence
  6. Rice diterpenoid phytoalexins are involved in defence against parasitic nematodes and shape rhizosphere nematode communities
  7. Production of the plant hormone gibberellin by rhizobia increases host legume nodule size
  8. Origin and early evolution of the plant terpene synthase family
  9. Deceptive Complexity in Formation of Cleistantha-8,12-diene
  10. Tanshinones: Leading the way into Lamiaceae labdane-related diterpenoid biosynthesis
  11. Dissecting the labdane‐related diterpenoid biosynthetic gene clusters in rice reveals directional cross‐cluster phytotoxicity
  12. Mining of the Catharanthus roseus Genome Leads to Identification of a Biosynthetic Gene Cluster for Fungicidal Sesquiterpenes
  13. Rice contains a biosynthetic gene cluster associated with production of the casbane‐type diterpenoid phytoalexin ent ‐10‐oxodepressin
  14. A (conditional) role for labdane‐related diterpenoid natural products in rice stomatal closure
  15. Interdependent evolution of biosynthetic gene clusters for momilactone production in rice
  16. Unraveling a Tangled Skein: Evolutionary Analysis of the Bacterial Gibberellin Biosynthetic Operon
  17. Probing Enzymatic Structure and Function in the Dihydroxylating Sesquiterpene Synthase ZmEDS
  18. Why are momilactones always associated with biosynthetic gene clusters in plants?
  19. Doing the gene shuffle to close synteny: dynamic assembly of biosynthetic gene clusters
  20. The honeysuckle genome provides insight into the molecular mechanism of carotenoid metabolism underlying dynamic flower coloration
  21. Genome of Tripterygium wilfordii and identification of cytochrome P450 involved in triptolide biosynthesis
  22. Introducing selective agrochemical manipulation of gibberellin metabolism into a cereal crop
  23. Magnesium-specific ring expansion/contraction catalysed by the class II diterpene cyclase from pleuromutilin biosynthesis
  24. Unraveling a tangled skein: Evolutionary analysis of the bacterial gibberellin biosynthetic operon
  25. Author Correction: CYP72A enzymes catalyse 13-hydrolyzation of gibberellins
  26. Conserved bases for the initial cyclase in gibberellin biosynthesis: from bacteria to plants
  27. CYP72A enzymes catalyse 13-hydrolyzation of gibberellins
  28. Combinatorial biosynthesis and the basis for substrate promiscuity in class I diterpene synthases
  29. Switching on a Nontraditional Enzymatic Base—Deprotonation by Serine in the ent-Kaurene Synthase from Bradyrhizobium japonicum
  30. Identification of RoCYP01 (CYP716A155) enables construction of engineered yeast for high-yield production of betulinic acid
  31. The genome of the medicinal plant Andrographis paniculata provides insight into the biosynthesis of the bioactive diterpenoid neoandrographolide
  32. Correction: cis or trans with class II diterpene cyclases
  33. A Third Class: Functional Gibberellin Biosynthetic Operon in Beta-Proteobacteria
  34. Isoprenyl diphosphate synthases: the chain length determining step in terpene biosynthesis
  35. Arginine in the FARM and SARM: A Role in Chain-Length Determination for Arginine in the Aspartate-Rich Motifs of Isoprenyl Diphosphate Synthases from Mycobacterium tuberculosis
  36. Probing the specificity of CYP112 in bacterial gibberellin biosynthesis
  37. Catalytic Bases and Stereocontrol in Lamiaceae Class II Diterpene Cyclases
  38. Diverging Mechanisms: Cytochrome-P450-Catalyzed Demethylation and γ-Lactone Formation in Bacterial Gibberellin Biosynthesis
  39. Diverging Mechanisms: Cytochrome‐P450‐Catalyzed Demethylation and γ‐Lactone Formation in Bacterial Gibberellin Biosynthesis
  40. Inferring Roles in Defense from Metabolic Allocation of Rice Diterpenoids
  41. Direct production of dihydroxylated sesquiterpenoids by a maize terpene synthase
  42. Changing Face: A Key Residue for the Addition of Water by Sclareol Synthase
  43. Premutilin Synthase: Ring Rearrangement by a Class II Diterpene Cyclase
  44. Identification and functional characterization of diterpene synthases for triptolide biosynthesis from Tripterygium wilfordii
  45. Biosynthesis of Diterpenoids in Tripterygium Adventitious Root Cultures
  46. Investigating the Phylogenetic Range of Gibberellin Biosynthesis in Bacteria
  47. Characterizing the enzyme that catalyzes the final step bacterial gibberellin biosynthesis
  48. A Pair of Residues That Interactively Affect Diterpene Synthase Product Outcome
  49. Probing Labdane-Related Diterpenoid Biosynthesis in the Fungal Genus Aspergillus
  50. Production of gibberellin, a plant hormone, by Xanthomonas oryzae, a bacterial pathogen of rice
  51. cis or trans with class II diterpene cyclases
  52. 18O2labeling experiments illuminate the oxidation of ent-kaurene in bacterial gibberellin biosynthesis
  53. Identification of a Dolabellane Type Diterpene Synthase and other Root-Expressed Diterpene Synthases in Arabidopsis
  54. Extending a Single Residue Switch for Abbreviating Catalysis in Plant ent-Kaurene Synthases
  55. Insight into the mechanism of the ring contraction reaction in bacterial gibberellin biosynthesis
  56. A biosynthetic gene cluster in rhizobia is responsible for producing gibberellin phytohormones
  57. Molecular Diversity of Terpene Synthases in the Liverwort Marchantia polymorpha
  58. Extreme promiscuity of a bacterial and a plant diterpene synthase enables combinatorial biosynthesis
  59. Investigating inducible short-chain alcohol dehydrogenases/reductases clarifies rice oryzalexin biosynthesis
  60. Analysis of the Genome Sequence of the Medicinal Plant Salvia miltiorrhiza
  61. Product Rearrangement from Altering a Single Residue in the Ricesyn-Copalyl Diphosphate Synthase
  62. Probing the promiscuity of ent -kaurene oxidases via combinatorial biosynthesis
  63. Characterization of CYP71Z18 indicates a role in maize zealexin biosynthesis
  64. Cytochrome P450 promiscuity leads to a bifurcating biosynthetic pathway for tanshinones
  65. A Tandem Array of ent -Kaurene Synthases in Maize with Roles in Gibberellin and More Specialized Metabolism
  66. Blocking Deprotonation with Retention of Aromaticity in a Plant ent -Copalyl Diphosphate Synthase Leads to Product Rearrangement
  67. Functional divergence of diterpene syntheses in the medicinal plant Salvia miltiorrhiza Bunge
  68. Full‐length transcriptome sequences and splice variants obtained by a combination of sequencing platforms applied to different root tissues of S alvia miltiorrhiza and tanshinone biosynt...
  69. Investigation of the Chemical Interface in the Soybean–Aphid and Rice–Bacteria Interactions Using MALDI-Mass Spectrometry Imaging
  70. Biosynthesis of the Diterpenoid Lycosantalonol via Nerylneryl Diphosphate in Solanum lycopersicum
  71. Optimization of recombinant expression enables discovery of novel cytochrome P450 activity in rice diterpenoid biosynthesis
  72. Efficient heterocyclisation by (di)terpene synthases
  73. The Application of Synthetic Biology to Elucidation of Plant Mono-, Sesqui-, and Diterpenoid Metabolism
  74. Investigation of terpene diversification across multiple sequenced plant genomes
  75. Biosynthesis of Lycosantalonol, acis-Prenyl Derived Diterpenoid
  76. Anent-kaurene-derived diterpenoid virulence factor fromXanthomonas oryzaepv. oryzicola
  77. Characterization of an Orphan Diterpenoid Biosynthetic Operon fromSalinispora arenicola
  78. Biochemical characterization of the castor bean ent-kaurene synthase(-like) family supports quantum chemical view of diterpene cyclization
  79. Novel Product Chemistry from Mechanistic Analysis ofent-Copalyl Diphosphate Synthases from Plant Hormone Biosynthesis
  80. To Gibberellins and Beyond! Surveying the Evolution of (Di)Terpenoid Metabolism
  81. Biosynthesis, elicitation and roles of monocot terpenoid phytoalexins
  82. 1.55Å-resolution structure of ent-copalyl diphosphate synthase and exploration of general acid function by site-directed mutagenesis
  83. Combining metabolomics and transcriptomics to characterize tanshinone biosynthesis in Salvia miltiorrhiza
  84. Functional Conservation of the Capacity for ent-Kaurene Biosynthesis and an Associated Operon in Certain Rhizobia
  85. Picking sides: distinct roles for CYP76M6 and CYP76M8 in rice oryzalexin biosynthesis
  86. CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts
  87. The Role of Momilactones in Rice Allelopathy
  88. Characterization of CYP76AH4 clarifies phenolic diterpenoid biosynthesis in the Lamiaceae
  89. A Single Residue Change Leads to a Hydroxylated Product from the Class II Diterpene Cyclization Catalyzed by Abietadiene Synthase
  90. Functional characterization of wheat copalyl diphosphate synthases sheds light on the early evolution of labdane-related diterpenoid metabolism in the cereals
  91. Functional characterization of wheat ent-kaurene(-like) synthases indicates continuing evolution of labdane-related diterpenoid metabolism in the cereals
  92. Effect of Isotopically Sensitive Branching on Product Distribution for Pentalenene Synthase: Support for a Mechanism Predicted by Quantum Chemistry
  93. CYP701A8: A Rice ent-Kaurene Oxidase Paralog Diverted to More Specialized Diterpenoid Metabolism
  94. Insights into Diterpene Cyclization from Structure of Bifunctional Abietadiene Synthase from Abies grandis
  95. Characterization of CYP76M5-8 Indicates Metabolic Plasticity within a Plant Biosynthetic Gene Cluster
  96. Isotuberculosinol: the unusual case of an immunomodulatory diterpenoid from Mycobacterium tuberculosis
  97. Terpenoid synthase structures: a so far incomplete view of complex catalysis
  98. Gibberellin Phytohormone Metabolism
  99. Functional characterization and evolution of the isotuberculosinol operon in Mycobacterium tuberculosis and related Mycobacteria
  100. Genetic evidence for natural product-mediated plant-plant allelopathy in rice (Oryza sativa)
  101. Domain loss has independently occurred multiple times in plant terpene synthase evolution
  102. Parsing a multifunctional biosynthetic gene cluster from rice: Biochemical characterization of CYP71Z6 & 7
  103. A Novel Labda-7,13E-dien-15-ol-Producing Bifunctional Diterpene Synthase from Selaginella moellendorffii
  104. Structure and mechanism of the diterpene cyclase ent-copalyl diphosphate synthase
  105. Evident and latent plasticity across the rice diterpene synthase family with potential implications for the evolution of diterpenoid metabolism in the cereals
  106. Magnesium depletion triggers production of an immune modulating diterpenoid in Mycobacterium tuberculosis
  107. Rv0989c encodes a novel (E)-geranyl diphosphate synthase facilitating decaprenyl diphosphate biosynthesis inMycobacterium tuberculosis
  108. Electrostatic effects on (di)terpene synthase product outcome
  109. CYP99A3: functional identification of a diterpene oxidase from the momilactone biosynthetic gene cluster in rice
  110. Characterization of the kaurene oxidase CYP701A3, a multifunctional cytochrome P450 from gibberellin biosynthesis
  111. Diterpenoid biopolymers: New directions for renewable materials engineering
  112. Edaxadiene: A New Bioactive Diterpene fromMycobacterium tuberculosis
  113. Synthesis of (±)-Nosyberkol (Isotuberculosinol, Revised Structure of Edaxadiene) and (±)-Tuberculosinol
  114. A Single Residue Switch for Mg2+-dependent Inhibition Characterizes Plant Class II Diterpene Cyclases from Primary and Secondary Metabolism
  115. Diterpene cyclases and the nature of the isoprene fold
  116. Two rings in them all: The labdane-related diterpenoids
  117. Edaxadiene: A New Bioactive Diterpene fromMycobacterium tuberculosis
  118. A Functional Genomics Approach to Tanshinone Biosynthesis Provides Stereochemical Insights
  119. CYP76M7 Is an ent-Cassadiene C11 -Hydroxylase Defining a Second Multifunctional Diterpenoid Biosynthetic Gene Cluster in Rice
  120. Increasing diterpene yield with a modular metabolic engineering system in E. coli: comparison of MEV and MEP isoprenoid precursor pathway engineering
  121. Characterization and Inhibition of a Class II Diterpene Cyclase from Mycobacterium tuberculosis: IMPLICATIONS FOR TUBERCULOSIS
  122. Investigating the conservation pattern of a putative second terpene synthase divalent metal binding motif in plants
  123. Gibberellin biosynthesis in bacteria: Separateent-copalyl diphosphate andent-kaurene synthases inBradyrhizobium japonicum
  124. Increasing Complexity of a Diterpene Synthase Reaction with a Single Residue Switch
  125. A Single Residue Switch Converts Abietadiene Synthase into a Pimaradiene Specific Cyclase
  126. 16-Aza- ent -beyerane and 16-Aza- ent -trachylobane:  Potent Mechanism-Based Inhibitors of Recombinant ent -Kaurene Synthase from Arabidopsis thaliana
  127. Probing the Role of the DXDD Motif in Class II Diterpene Cyclases
  128. A Modular Approach for Facile Biosynthesis of Labdane-Related Diterpenes
  129. Following evolution's lead to a single residue switch for diterpene synthase product outcome
  130. Synergistic Substrate Inhibition of ent-Copalyl Diphosphate Synthase: A Potential Feed-Forward Inhibition Mechanism Limiting Gibberellin Metabolism
  131. Functional characterization of the rice kaurene synthase-like gene family
  132. Uncovering the complex metabolic network underlying diterpenoid phytoalexin biosynthesis in rice and other cereal crop plants
  133. An unexpected diterpene cyclase from rice: Functional identification of a stemodene synthase
  134. The Maize An2 Gene is Induced by Fusarium Attack and Encodes an ent-Copalyl Diphosphate Synthase
  135. Rice Contains Two Disparate ent-Copalyl Diphosphate Synthases with Distinct Metabolic Functions
  136. Functional identification of ricesyn-copalyl diphosphate synthase and its role in initiating biosynthesis of diterpenoid phytoalexin/allelopathic natural products
  137. Identification of Syn-Pimara-7,15-Diene Synthase Reveals Functional Clustering of Terpene Synthases Involved in Rice Phytoalexin/Allelochemical Biosynthesis
  138. Alternative termination chemistries utilized by monoterpene cyclases: chimeric analysis of bornyl diphosphate, 1,8-cineole, and sabinene synthases
  139. Monoterpene biosynthesis pathway construction in Escherichia coli
  140. Bifunctional Abietadiene Synthase:  Mutual Structural Dependence of the Active Sites for Protonation-Initiated and Ionization-Initiated Cyclizations†
  141. Mechanism of Abietadiene Synthase Catalysis:  Stereochemistry and Stabilization of the Cryptic Pimarenyl Carbocation Intermediates
  142. Abietadiene Synthase Catalysis:  Conserved Residues Involved in Protonation-Initiated Cyclization of Geranylgeranyl Diphosphate to (+)-Copalyl Diphosphate†
  143. Abietadiene synthase catalysis: Mutational analysis of a prenyl diphosphate ionization-initiated cyclization and rearrangement
  144. The solution structure of the viral binding domain of Tva, the cellular receptor for subgroup A avian leukosis and sarcoma virus1
  145. Bifunctional Abietadiene Synthase:  Free Diffusive Transfer of the (+)-Copalyl Diphosphate Intermediate between Two Distinct Active Sites
  146. Abietadiene Synthase from Grand Fir (Abies grandis):  Characterization and Mechanism of Action of the “Pseudomature” Recombinant Enzyme†
  147. α-Lytic Protease Precursor:  Characterization of a Structured Folding Intermediate †
  148. Pro Region C-Terminus:Protease Active Site Interactions Are Critical in Catalyzing the Folding of α-Lytic Protease †
  149. Activation of a Retroviral Membrane Fusion Protein: Soluble Receptor-induced Liposome Binding of the ALSV Envelope Glycoprotein