All Stories

  1. DHA status influences effects of B-vitamin supplementation on cognitive ageing: a post-hoc analysis of the B-proof trial

    Article • European Journal of Nutrition, June 2022, Springer Science + Business Media

    Professor Renger Witkamp

  2. Prevalence of Micronutrient Deficiencies and Relationship with Clinical and Patient-Related Outcomes in Pulmonary Hypertension Types I and IV

    Article • Nutrients, November 2021, MDPI AG

    Professor Renger Witkamp

  3. Effects of Nutrients on Platelet Function: A Modifiable Link between Metabolic Syndrome and Neurodegeneration?

    Article • Biomolecules, October 2021, MDPI AG

    Professor Renger Witkamp

  4. Nutrition to Optimise Human Health—How to Obtain Physiological Substantiation?

    Article • Nutrients, June 2021, MDPI AG

    Professor Renger Witkamp

  5. Positive effects of folic acid supplementation on cognitive aging are dependent on ω-3 fatty acid status: a post hoc analysis of the FACIT trial

    Article • American Journal of Clinical Nutrition, April 2021, Elsevier

    Professor Renger Witkamp

  6. Levels of Inflammation Markers Are Associated with the Risk of Recurrence and All-Cause Mortality in Patients with Colorectal Cancer

    Article • Cancer Epidemiology Biomarkers & Prevention, March 2021, American Association for Cancer Research (AACR)

    Professor Renger Witkamp

  7. A 2 Week Cross-over Intervention with a Low Carbohydrate, High Fat Diet Compared to a High Carbohydrate Diet Attenuates Exercise-Induced Cortisol Response, but Not the Reduction of Exercise Capacity, in Recreational Athletes

    Article • Nutrients, January 2021, MDPI AG

    Professor Renger Witkamp

  8. Inflammation Is a Mediating Factor in the Association between Lifestyle and Fatigue in Colorectal Cancer Patients

    Article • Cancers, December 2020, MDPI AG

    Professor Renger Witkamp

  9. Chemotherapy and vitamin D supplement use are determinants of serum 25-hydroxyvitamin D levels during the first six months after colorectal cancer diagnosis

    Article • The Journal of Steroid Biochemistry and Molecular Biology, May 2020, Elsevier

    Professor Renger Witkamp

  10. Modulating Tumor-Associated Macrophage Polarization by Synthetic and Natural PPARγ Ligands as a Potential Target in Breast Cancer

    Article • Cells, January 2020, MDPI AG

    Professor Renger Witkamp

  11. Drug use is associated with lower plasma magnesium levels in geriatric outpatients; possible clinical relevance

    Article • Clinical Nutrition, December 2019, Elsevier

    Professor Renger Witkamp

  12. Novel COX-2 products of n-3 polyunsaturated fatty acid-ethanolamine-conjugates identified in RAW264.7 macrophages

    Article • Journal of Lipid Research, November 2019, Elsevier

    Professor Renger Witkamp

  13. A Diet Rich in Fish Oil and Leucine Ameliorates Hypercalcemia in Tumour-Induced Cachectic Mice

    Article • International Journal of Molecular Sciences, October 2019, MDPI AG

    Dr. Ir. Ardy van Helvoort, Professor Renger Witkamp

  14. The role of n-3 PUFA-derived fatty acid derivatives and their oxygenated metabolites in the modulation of inflammation

    Article • Prostaglandins & Other Lipid Mediators, October 2019, Elsevier

    Professor Renger Witkamp

  15. N-Eicosapentaenoyl Dopamine, A Conjugate of Dopamine and Eicosapentaenoic Acid (EPA), Exerts Anti-inflammatory Properties in Mouse and Human Macrophages

    Article • Nutrients, September 2019, MDPI AG

    Professor Renger Witkamp

  16. Anti-inflammatory nutrition with high protein attenuates cardiac and skeletal muscle alterations in a pulmonary arterial hypertension model

    Article • Scientific Reports, July 2019, Springer Science + Business Media

    Professor Renger Witkamp

  17. The Effect of Calcium Buffering and Calcium Sensor Type on the Sensitivity of an Array-Based Bitter Receptor Screening Assay

    Article • Chemical Senses, July 2019, Oxford University Press (OUP)

    Professor Renger Witkamp

  18. Feeding mitochondria: Potential role of nutritional components to improve critical illness convalescence

    Article • Clinical Nutrition, June 2019, Elsevier

    Professor Renger Witkamp

  19. Ionized and Total Magnesium Levels Change during Repeated Exercise in Older Adults

    Article • The journal of nutrition health & aging, May 2019, Springer Science + Business Media

    Professor Renger Witkamp

  20. Identification of hydroxytyrosyl oleate, a derivative of hydroxytyrosol with anti-inflammatory properties, in olive oil by-products

    Article • Food Chemistry, May 2019, Elsevier

    Professor Renger Witkamp

  21. Capsaicin Analogues Derived from n-3 Polyunsaturated Fatty Acids (PUFAs) Reduce Inflammatory Activity of Macrophages and Stimulate Insulin Secretion by β-Cells In Vitro

    Article • Nutrients, April 2019, MDPI AG

    Professor Renger Witkamp

  22. Mitochondrial dynamics in cancer-induced cachexia

    Article • Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, December 2018, Elsevier

    Professor Renger Witkamp

  23. Let thy food be thy medicine….when possible

    Article • European Journal of Pharmacology, October 2018, Elsevier

    Professor Renger Witkamp

  24. Release of Major Peanut Allergens from Their Matrix under Various pH and Simulated Saliva Conditions—Ara h2 and Ara h6 Are Readily Bio-Accessible

    Article • Nutrients, September 2018, MDPI AG

    Professor Renger Witkamp

  25. Plasma citrulline concentration, a marker for intestinal functionality, reflects exercise intensity in healthy young men

    Article • Clinical Nutrition, September 2018, Elsevier

    Dr. Ir. Ardy van Helvoort, Professor Renger Witkamp

  26. Changes in iron metabolism during prolonged repeated walking exercise in middle-aged men and women

    Article • European Journal of Applied Physiology and Occupational Physiology, August 2018, Springer Science + Business Media

    Professor Renger Witkamp

  27. In Vitro Anti-Inflammatory and Radical Scavenging Properties of Chinotto (Citrus myrtifolia Raf.) Essential Oils

    Article • Nutrients, June 2018, MDPI AG

    Professor Renger Witkamp

  28. Increasing quality of life in pulmonary arterial hypertension: is there a role for nutrition?

    Article • Heart Failure Reviews, June 2018, Springer Science + Business Media

    Professor Renger Witkamp

  29. Associations of hyperosmolar medications administered via nasogastric or nasoduodenal tubes and feeding adequacy, food intolerance and gastrointestinal complications amongst critically ill patients: A retrospective study

    Article • Clinical Nutrition ESPEN, June 2018, Elsevier

    Professor Renger Witkamp

  30. Calcium Imaging of GPCR Activation Using Arrays of Reverse Transfected HEK293 Cells in a Microfluidic System

    Article • Sensors, February 2018, MDPI AG

    Professor Renger Witkamp

  31. The role of fatty acids and their endocannabinoid-like derivatives in the molecular regulation of appetite

    Article • Molecular Aspects of Medicine, January 2018, Elsevier

    Professor Renger Witkamp

  32. Docosahexaenoyl serotonin emerges as most potent inhibitor of IL-17 and CCL-20 released by blood mononuclear cells from a series of N -acyl serotonins identified in human intestinal tissue

    Article • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, September 2017, Elsevier

    Professor Renger Witkamp

  33. The role of hypothalamic inflammation, the hypothalamic–pituitary–adrenal axis and serotonin in the cancer anorexia–cachexia syndrome

    Article • Current Opinion in Clinical Nutrition & Metabolic Care, September 2017, Wolters Kluwer Health

    Professor Renger Witkamp

  34. Public health relevance of drug–nutrition interactions

    Article • Zeitschrift für Ernährungswissenschaft, July 2017, Springer Science + Business Media

    Professor Renger Witkamp

  35. Beta-blocker use and fall risk in older individuals: Original results from two studies with meta-analysis

    Article • British Journal of Clinical Pharmacology, July 2017, Wiley

    Professor Renger Witkamp

  36. Decrease in Ionized and Total Magnesium Blood Concentrations in Endurance Athletes Following an Exercise Bout Restores within Hours—Potential Consequences for Monitoring and Supplementation

    Article • International Journal of Sport Nutrition and Exercise Metabolism, June 2017, Human Kinetics

    Professor Renger Witkamp

  37. Optimal nutrition and the ever-changing dietary landscape: a conference report

    Article • Zeitschrift für Ernährungswissenschaft, May 2017, Springer Science + Business Media

    Professor Renger Witkamp

  38. Fish oil LC-PUFAs do not affect blood coagulation parameters and bleeding manifestations: Analysis of 8 clinical studies with selected patient groups on omega-3-enriched medical nutrition

    Article • Clinical Nutrition, March 2017, Elsevier

    Professor Renger Witkamp , Dr. Ir. Ardy van Helvoort

  39. Micronutrient Intakes in 553 Dutch Elite and Sub-Elite Athletes: Prevalence of Low and High Intakes in Users and Non-Users of Nutritional Supplements

    Article • Nutrients, February 2017, MDPI AG

    Professor Renger Witkamp

  40. Macronutrient Intakes in 553 Dutch Elite and Sub-Elite Endurance, Team, and Strength Athletes: Does Intake Differ between Sport Disciplines?

    Article • Nutrients, February 2017, MDPI AG

    Professor Renger Witkamp

  41. Nutritional Supplement Use by Dutch Elite and Sub-Elite Athletes: Does Receiving Dietary Counseling Make a Difference?

    Article • International Journal of Sport Nutrition and Exercise Metabolism, February 2017, Human Kinetics

    Professor Renger Witkamp

  42. Endurance Exercise Increases Intestinal Uptake of the Peanut Allergen Ara h 6 after Peanut Consumption in Humans

    Article • Nutrients, January 2017, MDPI AG

    Professor Renger Witkamp

  43. CYP2C9 Genotypes Modify Benzodiazepine-Related Fall Risk: Original Results From Three Studies With Meta-Analysis

    Article • Journal of the American Medical Directors Association, January 2017, Elsevier

    Professor Renger Witkamp

  44. Detection of peanut allergen in human blood after consumption of peanuts is skewed by endogenous immunoglobulins

    Article • Journal of Immunological Methods, January 2017, Elsevier

    Professor Renger Witkamp

  45. Explorative Placebo-Controlled Double-Blind Intervention Study with Low Doses of Inhaled Δ9-Tetrahydrocannabinol and Cannabidiol Reveals No Effect on Sweet Taste Intensity Perception and Liking in Humans

    Article • Cannabis and Cannabinoid Research, January 2017, Mary Ann Liebert Inc

    Professor Renger Witkamp

  46. Drug-Nutrition Interactions in Older People

    Article • January 2017, Elsevier

    Professor Renger Witkamp

  47. Adaptation of exercise-induced stress in well-trained healthy young men

    Article • Experimental Physiology, December 2016, Wiley

    Professor Renger Witkamp

  48. N-Docosahexaenoyl Dopamine, an Endocannabinoid-like Conjugate of Dopamine and the n-3 Fatty Acid Docosahexaenoic Acid, Attenuates Lipopolysaccharide-Induced Activation of Microglia and Macrophages via COX-2

    Article • ACS Chemical Neuroscience, December 2016, American Chemical Society (ACS)

    Professor Renger Witkamp

  49. Molecule formed in gut from n-3 fatty acid DHA and serotonin may be beneficial in attenuating IBD

    Article • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, December 2016, Elsevier

    Professor Renger Witkamp

  50. Moderate alcohol consumption after a mental stressor attenuates the endocrine stress response

    Article • Alcohol, December 2016, Elsevier

    Professor Renger Witkamp

  51. The Noncaloric Sweetener Rebaudioside A Stimulates Glucagon-Like Peptide 1 Release and Increases Enteroendocrine Cell Numbers in 2-Dimensional Mouse Organoids Derived from Different Locations of the Intestine

    Article • Journal of Nutrition, October 2016, American Society for Nutrition

    Professor Renger Witkamp

  52. The effect of endurance exercise on intestinal integrity in well-trained healthy men

    Article • Physiological Reports, October 2016, Wiley

    Professor Renger Witkamp

  53. Fatty acids, endocannabinoids and inflammation

    Article • European Journal of Pharmacology, August 2016, Elsevier

    Professor Renger Witkamp

  54. Self-Reported Use and Reasons among the General Population for Using Sports Nutrition Products and Dietary Supplements

    Article • Sports, June 2016, MDPI AG

    Professor Renger Witkamp

  55. Nutrient-induced glucagon like peptide-1 release is modulated by serotonin

    Article • The Journal of Nutritional Biochemistry, June 2016, Elsevier

    Professor Renger Witkamp

  56. Increased hypothalamic serotonin turnover in inflammation-induced anorexia

    Article • BMC Neuroscience, May 2016, Springer Science + Business Media

    Professor Renger Witkamp

  57. Hypothalamic inflammation and food intake regulation during chronic illness

    Article • Peptides, March 2016, Elsevier

    Professor Renger Witkamp

  58. Vitamin D deficiency as adverse drug reaction? A cross-sectional study in Dutch geriatric outpatients

    Article • European Journal of Clinical Pharmacology, February 2016, Springer Science + Business Media

    Professor Renger Witkamp

  59. Analysis of Omega-3 Fatty Acid Derived N-Acylethanolamines in Biological Matrices

    Article • January 2016, Springer Science + Business Media

    Professor Renger Witkamp

  60. Intraileal casein infusion increases plasma concentrations of amino acids in humans: A randomized cross over trial

    Article • Clinical Nutrition, January 2016, Elsevier

    Professor Renger Witkamp

  61. The effects of a meal with moderate alcohol consumption on mood and autonomic nervous system balance

    Article • Psychoneuroendocrinology, November 2015, Elsevier

    Professor Renger Witkamp

  62. Validation of web-based, multiple 24-h recalls combined with nutritional supplement intake questionnaires against nitrogen excretions to determine protein intake in Dutch elite athletes

    Article • British Journal Of Nutrition, October 2015, Cambridge University Press

    Professor Renger Witkamp

  63. Vitamin D, Inflammation, and Colorectal Cancer Progression: A Review of Mechanistic Studies and Future Directions for Epidemiological Studies

    Article • Cancer Epidemiology Biomarkers & Prevention, September 2015, American Association for Cancer Research (AACR)

    Professor Renger Witkamp

  64. Nutrient Intake by Ultramarathon Runners: Can They Meet Recommendations?

    Article • International Journal of Sport Nutrition and Exercise Metabolism, August 2015, Human Kinetics

    Professor Renger Witkamp

  65. Moderate alcohol consumption stimulates food intake and food reward of savoury foods

    Article • Appetite, June 2015, Elsevier

    Professor Renger Witkamp

  66. Effects of Mood Inductions by Meal Ambiance and Moderate Alcohol Consumption on Endocannabinoids and N-Acylethanolamines in Humans: A Randomized Crossover Trial

    Article • PLoS ONE, May 2015, PLOS

    Professor Renger Witkamp

  67. Behavioural changes are a major contributing factor in the reduction of sarcopenia in caloric-restricted ageing mice

    Article • Journal of Cachexia Sarcopenia and Muscle, April 2015, Wiley

    Professor Renger Witkamp

  68. Differences in food intake of tumour-bearing cachectic mice are associated with hypothalamic serotonin signalling

    Article • Journal of Cachexia Sarcopenia and Muscle, March 2015, Wiley

    Professor Renger Witkamp

  69. Cholecystokinin regulates satiation independently of the abdominal vagal nerve in a pig model of total subdiaphragmatic vagotomy

    Article • Physiology & Behavior, February 2015, Elsevier

    Professor Renger Witkamp

  70. Tolerability and Safety of Souvenaid in Patients with Mild Alzheimer's Disease: Results of Multi-Center, 24-Week, Open-Label Extension Study

    Article • Journal of Alzheimer s Disease, January 2015, IOS Press

    Professor Renger Witkamp

  71. Omega-3 Polyunsaturated N-Acylethanolamines: A Link Between Diet and Cellular Biology

    Article • January 2015, Elsevier

    Professor Renger Witkamp

  72. Contributors

    Article • January 2015, Elsevier

    Professor Renger Witkamp

  73. Medication-Related Fall Incidents in an Older, Ambulant Population: The B-PROOF Study

    Article • Drugs & Aging, November 2014, Springer Science + Business Media

    Professor Renger Witkamp

  74. Inhibition of COX-2-mediated eicosanoid production plays a major role in the anti-inflammatory effects of the endocannabinoidN-docosahexaenoylethanolamine (DHEA) in macrophages

    Article • British Journal of Pharmacology, September 2014, Wiley

    Professor Renger Witkamp

  75. Cross-Species Comparison of Genes Related to Nutrient Sensing Mechanisms Expressed along the Intestine

    Article • PLoS ONE, September 2014, PLOS

    Professor Renger Witkamp

  76. Steviol Glycoside Rebaudioside A Induces Glucagon-like Peptide-1 and Peptide YY Release in a Porcine ex Vivo Intestinal Model

    Article • Journal of Agricultural and Food Chemistry, August 2014, American Chemical Society (ACS)

    Professor Renger Witkamp

  77. Associations Between Medication Use and Homocysteine Levels in an Older Population, and Potential Mediation by Vitamin B12 and Folate: Data from the B-PROOF Study

    Article • Drugs & Aging, July 2014, Springer Science + Business Media

    Professor Renger Witkamp

  78. The endocannabinoid system and appetite: relevance for food reward

    Article • Nutrition Research Reviews, June 2014, Cambridge University Press

    Professor Renger Witkamp

  79. The endocannabinoid system

    Article • Current Opinion in Clinical Nutrition & Metabolic Care, March 2014, Wolters Kluwer Health

    Professor Renger Witkamp

  80. The Biphasic Effects of Moderate Alcohol Consumption with a Meal on Ambiance-Induced Mood and Autonomic Nervous System Balance: A Randomized Crossover Trial

    Article • PLoS ONE, January 2014, PLOS

    Professor Renger Witkamp

  81. The Association Between Drugs Frequently Used by the Elderly and Vitamin D Blood Levels: A Review of Observational and Experimental Studies

    Article • Drugs & Aging, January 2014, Springer Science + Business Media

    Professor Renger Witkamp

  82. Palmitoylethanolamide (PEA)—‘Promiscuous’ anti-inflammatory and analgesic molecule at the interface between nutrition and pharma

    Article • PharmaNutrition, January 2014, Elsevier

    jan keppel hesselink, Mr David Jos Kopsky, Professor Renger Witkamp

  83. The Endocannabinoid System: A Dynamic Signalling System at the Crossroads Between Metabolism and Disease

    Article • January 2014, Springer Science + Business Media

    Professor Renger Witkamp

  84. Hypothalamic food intake regulation in a cancer-cachectic mouse model

    Article • Journal of Cachexia Sarcopenia and Muscle, November 2013, Wiley

    Professor Renger Witkamp

  85. Comparative analyses of seeds of wild fruits of Rubus and Sambucus species from Southern Italy: Fatty acid composition of the oil, total phenolic content, antioxidant and anti-inflammatory properties of the methanolic extracts

    Article • Food Chemistry, October 2013, Elsevier

    Professor Renger Witkamp

  86. Review article: the role of gastrointestinal hormones in the treatment of delayed gastric emptying in critically ill patients

    Article • Alimentary Pharmacology & Therapeutics, July 2013, Wiley

    Professor Renger Witkamp

  87. N-acyl amines of docosahexaenoic acid and othern-3 polyunsatured fatty acids - from fishy endocannabinoids to potential leads

    Article • British Journal of Pharmacology, May 2013, Wiley

    Professor Renger Witkamp

  88. The Immunomodulatory Nutritional Intervention NR100157 Reduced CD4+ T-Cell Decline and Immune Activation: A 1-Year Multicenter Randomized Controlled Double-Blind Trial in HIV-Infected Persons Not Receiving Antiretroviral Therapy (The BITE Study)

    Article • Clinical Infectious Diseases, March 2013, Oxford University Press (OUP)

    Jan Knol, Professor Renger Witkamp

  89. Measurement of Palmitoylethanolamide and Other N-Acylethanolamines During Physiological and Pathological Conditions

    Article • CNS & Neurological Disorders - Drug Targets, March 2013, Bentham Science Publishers

    Professor Renger Witkamp

  90. Liquid chromatography–tandem mass spectrometry analysis of free and esterified fatty acid N-acyl ethanolamines in plasma and blood cells

    Article • Analytical Biochemistry, March 2013, Elsevier

    Professor Renger Witkamp

  91. Palmitoylethanolamide: A Natural Body-Own Anti-Inflammatory Agent, Effective and Safe against Influenza and Common Cold

    Article • International Journal of Inflammation, January 2013, Hindawi Publishing Corporation

    jan keppel hesselink, Professor Renger Witkamp

  92. Vitamin D: do we get enough?

    Article • Osteoporosis International, December 2012, Springer Science + Business Media

    Professor Renger Witkamp

  93. Effects of Long- and Short-Chain Fatty Acids on the Release of Gastrointestinal Hormones using an ex Vivo Porcine Intestinal Tissue Model

    Article • Journal of Agricultural and Food Chemistry, August 2012, American Chemical Society (ACS)

    Dr Trudy Voortman, Professor Renger Witkamp

  94. Time-dependent effect of in vivo inflammation on eicosanoid and endocannabinoid levels in plasma, liver, ileum and adipose tissue in C57BL/6 mice fed a fish-oil diet

    Article • International Immunopharmacology, June 2012, Elsevier

    Professor Renger Witkamp

  95. Fish oil and inflammatory status alter the n-3 to n-6 balance of the endocannabinoid and oxylipin metabolomes in mouse plasma and tissues

    Article • Metabolomics, April 2012, Springer Science + Business Media

    Professor Renger Witkamp

  96. Lipidomics Reveals Multiple Pathway Effects of a Multi-Components Preparation on Lipid Biochemistry in ApoE*3Leiden.CETP Mice

    Article • PLoS ONE, January 2012, PLOS

    Professor Renger Witkamp

  97. Moderate alcohol consumption alters both leucocyte gene expression profiles and circulating proteins related to immune response and lipid metabolism in men

    Article • British Journal Of Nutrition, December 2011, Cambridge University Press

    Dr Michel M. Joosten, Professor Renger Witkamp

  98. A standardised approach towards PROving the efficacy of foods and food constituents for health CLAIMs (PROCLAIM): providing guidance

    Article • British Journal Of Nutrition, November 2011, Cambridge University Press

    Professor Renger Witkamp

  99. Presence, formation and putative biological activities of N-acyl serotonins, a novel class of fatty-acid derived mediators, in the intestinal tract

    Article • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, October 2011, Elsevier

    Dr Trudy Voortman, Professor Renger Witkamp

  100. 26th Hohenheim Consensus Conference, September 11, 2010 Scientific substantiation of health claims: Evidence-based nutrition

    Article • Nutrition, October 2011, Elsevier

    Professor Renger Witkamp

  101. Alterations in total and high–molecular-weight adiponectin after 3 weeks of moderate alcohol consumption in premenopausal women

    Article • Metabolism, August 2011, Elsevier

    Dr Michel M. Joosten, Professor Renger Witkamp

  102. Bovine Colostrum Supplementation’s Lack of Effect on Immune Variables during Short-Term Intense Exercise in Well-Trained Athletes

    Article • International Journal of Sport Nutrition and Exercise Metabolism, April 2011, Human Kinetics

    Professor Renger Witkamp

  103. The ethanolamide metabolite of DHA, docosahexaenoylethanolamine, shows immunomodulating effects in mouse peritoneal and RAW264.7 macrophages: evidence for a new link between fish oil and inflammation

    Article • British Journal Of Nutrition, February 2011, Cambridge University Press

    Professor Renger Witkamp

  104. Pharma–nutrition interface: The gap is narrowing

    Article • European Journal of Pharmacology, January 2011, Elsevier

    Professor Renger Witkamp

  105. Voeding en geneesmiddelen

    Article • January 2011, Springer Science + Business Media

    Professor Renger Witkamp

  106. Current and Future Drug Targets in Weight Management

    Article • Pharmaceutical Research, December 2010, Springer Science + Business Media

    Professor Renger Witkamp

  107. Docosahexaenoic acid and eicosapentaenoic acid are converted by 3T3-L1 adipocytes to N-acyl ethanolamines with anti-inflammatory properties

    Article • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, October 2010, Elsevier

    Professor Renger Witkamp

  108. Short-term oral exposure to white wine transiently lowers serum free fatty acids

    Article • Appetite, August 2010, Elsevier

    Dr Michel M. Joosten, Professor Renger Witkamp

  109. The role of epoxidation and electrophile-responsive element-regulated gene transcription in the potentially beneficial and harmful effects of the coffee components cafestol and kahweol☆

    Article • The Journal of Nutritional Biochemistry, August 2010, Elsevier

    Professor Renger Witkamp

  110. Use of Animal Models of Disease in the Preclinical Safety Evaluation of Biopharmaceuticals

    Article • March 2010, Wiley

    Professor Renger Witkamp

  111. ChemInform Abstract: Selective Synthesis of Unsaturated N-Acylethanolamines by Lipase-Catalyzed N-Acylation of Ethanolamine with Unsaturated Fatty Acids.

    Article • ChemInform, February 2010, Wiley

    Professor Renger Witkamp

  112. Absorption, Distribution, and Biliary Excretion of Cafestol, a Potent Cholesterol-Elevating Compound in Unfiltered Coffees, in Mice

    Article • Drug Metabolism and Disposition, January 2010, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Renger Witkamp

  113. Plasma anandamide and other N-acylethanolamines are correlated with their corresponding free fatty acid levels under both fasting and non-fasting conditions in women

    Article • Nutrition & Metabolism, January 2010, Springer Science + Business Media

    Dr Michel M. Joosten, Professor Renger Witkamp

  114. Biologically Active Compounds in Food Products and Their Effects on Obesity and Diabetes

    Article • January 2010, Elsevier

    Professor Renger Witkamp

  115. Selective Synthesis of Unsaturated N-Acylethanolamines by Lipase- Catalyzed N-Acylation of Ethanolamine with Unsaturated Fatty Acids

    Article • Letters in Organic Chemistry, September 2009, Bentham Science Publishers

    Professor Renger Witkamp

  116. Xanthohumol from Hop (Humulus lupulus L.) Is an Efficient Inhibitor of Monocyte Chemoattractant Protein-1 and Tumor Necrosis Factor-α Release in LPS-Stimulated RAW 264.7 Mouse Macrophages and U937 Human Monocytes

    Article • Journal of Agricultural and Food Chemistry, August 2009, American Chemical Society (ACS)

    Professor Renger Witkamp

  117. Development and validation of a quantitative method for the determination of 12 endocannabinoids and related compounds in human plasma using liquid chromatography–tandem mass spectrometry

    Article • Journal of Chromatography B, May 2009, Elsevier

    Professor Renger Witkamp

  118. Contributor contact details

    Article • January 2009, Elsevier

    Professor Renger Witkamp

  119. Commentary: “A systems view on the future of medicine: Inspiration from Chinese medicine?”

    Article • Journal of Ethnopharmacology, January 2009, Elsevier

    Professor Renger Witkamp

  120. Herbal products: Marketing strategies and legislation

    Article • International Journal of Green Pharmacy, January 2009, BRNSS Publication Hub

    Professor Renger Witkamp

  121. Food–Drug Interactions in Older People

    Article • January 2009, Elsevier

    Professor Renger Witkamp

  122. Unheated Cannabis sativa extracts and its major compound THC-acid have potential immuno-modulating properties not mediated by CB1 and CB2 receptor coupled pathways

    Article • International Immunopharmacology, April 2006, Elsevier

    Professor Renger Witkamp

  123. Beta-adrenergic receptor agonists induce the release of granulocyte chemotactic protein-2, oncostatin M, and vascular endothelial growth factor from macrophages

    Article • International Immunopharmacology, January 2006, Elsevier

    Professor Renger Witkamp

  124. In Search of Secreted Protein Biomarkers for the Anti-inflammatory Effect of β 2 -Adrenergic Receptor Agonists:  Application of DIGE Technology in Combination with Multivariate and Univariate Data Analysis Tools

    Article • Journal of Proteome Research, December 2005, American Chemical Society (ACS)

    Professor Renger Witkamp

  125. Inhibitory effects of the beta2-adrenergic receptor agonist zilpaterol on the LPS-induced production of TNF-alpha in vitro and in vivo

    Article • Journal of Veterinary Pharmacology and Therapeutics, December 2005, Wiley

    Professor Renger Witkamp

  126. Genomics and systems biology - how relevant are the developments to veterinary pharmacology, toxicology and therapeutics?

    Article • Journal of Veterinary Pharmacology and Therapeutics, June 2005, Wiley

    Professor Renger Witkamp

  127. Metabolomics in the context of systems biology: bridging traditional Chinese medicine and molecular pharmacology

    Article • Phytotherapy Research, January 2005, Wiley

    Professor Renger Witkamp

  128. Characterization of anti-inflammatory compounds using transcriptomics, proteomics, and metabolomics in combination with multivariate data analysis

    Article • International Immunopharmacology, November 2004, Elsevier

    Professor Renger Witkamp

  129. Multi-detector computed tomography and 3-dimensional imaging in a multi-vendor picture archiving and communications systems (PACS) environment1

    Article • Academic Radiology, June 2004, Elsevier

    Professor Renger Witkamp

  130. A combination of proteomics, principal component analysis and transcriptomics is a powerful tool for the identification of biomarkers for macrophage maturation in the U937 cell line

    Article • PROTEOMICS, April 2004, Wiley

    Professor Renger Witkamp

  131. Endotoxin-induced liver damage in rats is minimized by � 2 -adrenoceptor stimulation

    Article • Inflammation Research, February 2004, Springer Science + Business Media

    Professor Renger Witkamp

  132. TRANSFER OF POLYCHLORINATED BIPHENYLS AND CHLORINATED PESTICIDES FROM MOTHER TO PUP IN RELATION TO CYTOCHROME P450 ENZYME ACTIVITIES IN HARP SEALS (PHOCA GROENLANDICA) FROM THE GULF OF ST. LAWRENCE, CANADA

    Article • Environmental Toxicology and Chemistry, January 2002, Wiley

    Professor Renger Witkamp

  133. Transfer of polychlorinated biphenyls and chlorinated pesticides from mother to pup in relation to cytochrome P450 enzyme activities in harp seals (Phoca groenlandica) from the Gulf of St. Lawrence, Canada

    Article • Environmental Toxicology and Chemistry, January 2002, Wiley

    Professor Renger Witkamp

  134. Development of an Androgen Reporter Gene Assay (AR-LUX) Utilizing a Human Cell Line with an Endogenously Regulated Androgen Receptor

    Article • Analytical Biochemistry, November 2001, Elsevier

    Professor Renger Witkamp

  135. Differential effects of pentoxifylline on the hepatic inflammatory response in porcine liver cell cultures

    Article • Biochemical Pharmacology, May 2001, Elsevier

    Professor Renger Witkamp

  136. Direct cell-to-cell contact between Kupffer cells and hepatocytes augments endotoxin-induced hepatic injury

    Article • AJP Gastrointestinal and Liver Physiology, April 2001, American Physiological Society

    Professor Renger Witkamp

  137. The preparation, solubilisation and binding characteristics of a β2-adrenoceptor isolated from transfected Chinese hamster cells

    Article • The Analyst, January 2001, Royal Society of Chemistry

    Professor Renger Witkamp

  138. Stereoselectivity at the β 2 -adrenoceptor on macrophages is a major determinant of the anti-inflammatory effects of β 2 -agonists

    Article • Naunyn-Schmiedeberg s Archives of Pharmacology, July 2000, Springer Science + Business Media

    Professor Renger Witkamp

  139. Chlorinated pesticide concentrations, with an emphasis on polychlorinated camphenes (toxaphenes), in relation to cytochrome P450 enzyme activities in harp seals (Phoca groenlandica) from the Barents Sea

    Article • Environmental Toxicology and Chemistry, June 2000, Wiley

    Professor Renger Witkamp

  140. Cocultures of porcine hepatocytes and kupffer cells as an improvedin vitromodel for the study of hepatotoxic compounds

    Article • Veterinary Quarterly, January 2000, Taylor & Francis

    Professor Renger Witkamp

  141. Cytochromes and cytokines: Changes in drug disposition in animals during an acute phase response: A mini‐review

    Article • Veterinary Quarterly, January 2000, Taylor & Francis

    Professor Renger Witkamp

  142. Suppression of the acute inflammatory response of porcine alveolar‐ and liver macrophages

    Article • Veterinary Quarterly, January 2000, Taylor & Francis

    Professor Renger Witkamp

  143. The β-adrenoceptor agonist clenbuterol is a potent inhibitor of the LPS-induced production of TNF-α and IL-6 in vitro and in vivo

    Article • Inflammation Research, September 1999, Springer Science + Business Media

    Professor Renger Witkamp

  144. Cytochrome P450-mediated enzyme activities and polychlorinated biphenyl accumulation in harp seal (Phoca groenlandica)

    Article • Marine Environmental Research, July 1999, Elsevier

    Professor Renger Witkamp

  145. 17α-Ethyl-5β-estrane-3α,17β-diol, a biological marker for the abuse of norethandrolone and ethylestrenol in slaughter cattle

    Article • Journal of Chromatography B Biomedical Sciences and Applications, May 1999, Elsevier

    Professor Peter Adriaensens, Professor Renger Witkamp

  146. In vitro complex formation and inhibition of hepatic cytochrome P450 activity by different macrolides and tiamulin in goats and cattle

    Article • Research in Veterinary Science, January 1999, Elsevier

    Professor Renger Witkamp

  147. Participation of β-Adrenergic Receptors on Macrophages in Modulation of LPS-Induced Cytokine Release

    Article • Journal of Receptors and Signal Transduction, January 1999, Taylor & Francis

    Professor Renger Witkamp

  148. Characterization of cytochrome P450 isoenzymes in primary cultures of pig hepatocytes

    Article • Toxicology in Vitro, December 1998, Elsevier

    Professor Renger Witkamp

  149. Phase I and phase II enzyme activities in Ringed seals (Phoca hispida): characterization of hepatic cytochrome P450 by activity patterns, inhibition studies, mRNA analyses, and western blotting

    Article • Aquatic Toxicology, December 1998, Elsevier

    Professor Renger Witkamp

  150. Dose and time dependency of cytochrome P4501A induction in liver and kidney of B(a)P exposed Arctic charr (Salvelinus alpinus)

    Article • Marine Environmental Research, July 1998, Elsevier

    Professor Renger Witkamp

  151. Congener specific PCB and polychlorinated camphene (toxaphene) levels in Svalbard ringed seals (Phoca hispida) in relation to sex, age, condition and cytochrome P450 enzyme activity

    Article • The Science of The Total Environment, May 1998, Elsevier

    Professor Renger Witkamp

  152. Identification of some important metabolites of boldenone in urine and feces of cattle by gas chromatography-mass spectrometry†

    Article • The Analyst, January 1998, Royal Society of Chemistry

    Professor Dirk JM Vanderzande, Professor Renger Witkamp

  153. Multi-laboratory study of the analysis and kinetics of stanozolol and its metabolites in treated calves†

    Article • The Analyst, January 1998, Royal Society of Chemistry

    Professor Renger Witkamp

  154. Comparison of conventional immunoassays and the oestrogen radioreceptor assay for screening for the presence of oestrogenic anabolic compounds in urine samples†

    Article • The Analyst, January 1998, Royal Society of Chemistry

    Professor Renger Witkamp

  155. In vitro liver models are important tools to monitor the abuse of anabolic steroids in cattle†

    Article • The Analyst, January 1998, Royal Society of Chemistry

    Professor Renger Witkamp

  156. The effect of sulfaphenazole and sulfadoxine on tolbutamide disposition in dwarf goats (Caprus hircus aegagrus)

    Article • Research in Veterinary Science, November 1997, Elsevier

    Professor Renger Witkamp

  157. Isolation of a bovine full length cytochrome P450 (CYP3A) cDNA sequence and its functional expression in V79 cells

    Article • Environmental Toxicology and Pharmacology, February 1997, Elsevier

    Professor Renger Witkamp

  158. Differential inhibitory effects of phenytoin, diclofenac, phenylbutazone and a series of sulfonam ides on hepatic cytochrom e P4502C activityin vitro, and correlation with som e m olecular descriptors in the dwarf goat (Caprus hircus aegagrus).

    Article • Xenobiotica, January 1997, Taylor & Francis

    Professor Renger Witkamp

  159. Differential effect of pentoxifylline on lipopolysaccharide-induced downregulation of cytochrome p450

    Article • Biochemical Pharmacology, October 1996, Elsevier

    Professor Renger Witkamp

  160. A lipopolysaccharide-induced acute phase response in the pig is associated with a decrease in hepatic cytochrome P450-mediated drug metabolism

    Article • Journal of Veterinary Pharmacology and Therapeutics, October 1996, Wiley

    Professor Renger Witkamp

  161. Time-dependent induction of two distinct hepatic cytochrome P4501A catalytic activities at low temperatures in Arctic charr (Salvelinus alpinus) after oral exposure to benzo(a)pyrene

    Article • Aquatic Toxicology, June 1996, Elsevier

    Professor Renger Witkamp

  162. Cytochrome P4502E in vivo and in vitro in the dwarf goat: effects of enzyme induction and the applicability of chlorzoxazone as marker substrate

    Article • Journal of Veterinary Pharmacology and Therapeutics, June 1996, Wiley

    Professor Renger Witkamp

  163. Suppression of Cytochrome P450- and UDP Glucuronosyl Transferase-Dependent Enzyme Activities by Proinflammatory Cytokines and Possible Role of Nitric Oxide in Primary Cultures of Pig Hepatocytes

    Article • Toxicology and Applied Pharmacology, April 1996, Elsevier

    Professor Renger Witkamp

  164. Inhibition of tolbutamide 4-methylhydroxylation by a series of non-steroidal anti-inflammatory drugs in V79-NH cells expressing human cytochrome P4502C10

    Article • Xenobiotica, January 1996, Taylor & Francis

    Professor Renger Witkamp

  165. Gender differences in ethanol oxidation and cytochrome P4502E1 content and functions in hepatic microsomes from alcohol-preferring and non-preferring rats

    Article • Xenobiotica, January 1996, Taylor & Francis

    Professor Renger Witkamp

  166. In vitro and in vivo oxidative biotransformation in the West-African dwarf goat (Caprus hircus aegagrus): Substrate activities and effects of inducers

    Article • Xenobiotica, January 1996, Taylor & Francis

    Professor Renger Witkamp

  167. Tiamulin inhibits human CYP3A4 activity in an NIH/3T3 cell line stably expressing CYP3A4 cDNA

    Article • Biochemical Pharmacology, September 1995, Elsevier

    Professor Renger Witkamp

  168. Oral bioavailability of sulphonamides in ruminants: A comparison between sulphamethoxazole, sulphatroxazole, and sulphamerazine, using the dwarf goat as animal model

    Article • Veterinary Quarterly, September 1995, Taylor & Francis

    Professor Renger Witkamp

  169. Oral bioavailability and pharmacokinetics of baquiloprim in dwarf goats

    Article • Research in Veterinary Science, May 1995, Elsevier

    Professor Renger Witkamp

  170. Selective effects of a bacterial infection (Actinobacillus pleuropneumoniae) on the hepatic clearances of caffeine, antipyrine, paracetamol, and indocyanine green in the pig

    Article • Xenobiotica, January 1995, Taylor & Francis

    Professor Renger Witkamp

  171. Tiamulin selectively inhibits oxidative hepatic steroid and drug metabolism in vitro in the pig

    Article • Journal of Veterinary Pharmacology and Therapeutics, August 1994, Wiley

    Professor Renger Witkamp

  172. The Pig as a Model for Studying AH Receptor and Other PAH-Binding Proteins In Man

    Article • Biochemical and Biophysical Research Communications, April 1994, Elsevier

    Professor Renger Witkamp

  173. Oral bioavailability of sulphamethoxydiazine, sulphathiazole and sulphamoxole in dwarf goats

    Article • Veterinary Quarterly, March 1994, Taylor & Francis

    Professor Renger Witkamp

  174. Dose-dependent pharmacokinetic interaction between antipyrine and paracetamolin vivoandin vitrowhen administered as a cocktail in pig

    Article • Xenobiotica, January 1994, Taylor & Francis

    Professor Renger Witkamp

  175. Selective changes in oxidative xenobiotic metabolism in vivo and in vitro after parenteral administration of recombinant bovine somatotrophin to rats

    Article • Research in Veterinary Science, July 1993, Elsevier

    Professor Renger Witkamp

  176. Effect of gonadal hormones on the plasma clearance and metabolite formation of antipyrine in the dwarf goat

    Article • Journal of Veterinary Pharmacology and Therapeutics, June 1993, Wiley

    Professor Renger Witkamp

  177. Hormonal regulation of oxidative drug metabolism in the dwarf goat. The effect of sex and hormonal treatment on plasma disposition and metabolite formation of sulphadimidine

    Article • Journal of Veterinary Pharmacology and Therapeutics, March 1993, Wiley

    Professor Renger Witkamp

  178. The regulation of oxidative drug metabolism by growth hormone in the dwarf goat: differences from and similarities to the mechanisms in rats

    Article • Journal of Endocrinology, February 1993, Bioscientifica

    Professor Renger Witkamp

  179. Regioselective O-demethylation of scoparone (6,7-dimethoxycoumarin) to assess cytochrome P450 activities in vitro in rat. Effects of gonadal steroids and the involvement of constitutive P450 enzymes

    Article • Xenobiotica, January 1993, Taylor & Francis

    Professor Renger Witkamp

  180. Metabolism of antipyrine and sulphadimidine in dwarf goats: effects of the enzyme-inducing agents phenobarbital, troleandomycin and rifampicin

    Article • Xenobiotica, January 1992, Taylor & Francis

    Professor Renger Witkamp

  181. High-performance liquid chromatographic method for the routine determination of sulphadimidine, its hydroxy metabolites and N4-acetylsulphadimidine in body fluids and cell culture media

    Article • Journal of Chromatography B Biomedical Sciences and Applications, December 1991, Elsevier

    Professor Renger Witkamp

  182. Species- and sex-related differences in the plasma clearance and metabolite formation of antipyrine. A comparative study in four animal species: Cattle, goat, rat and rabbit

    Article • Xenobiotica, January 1991, Taylor & Francis

    Professor Renger Witkamp

  183. The influence of gender and gonadal hormones on the plasma clearance and metabolite formation of antipyrine in ruminants

    Article • European Journal of Pharmacology, July 1990, Elsevier

    Professor Renger Witkamp

  184. Has bovine somatotropin (BST) an effect upon drug disposition? Comparative studies in goats and cattle with sulphadimidine and antipyrine after parenteral administration of BST, zeranol and proligestone

    Article • Journal of Veterinary Pharmacology and Therapeutics, June 1989, Wiley

    Professor Renger Witkamp

  185. Use of Animal Models of Disease in the Preclinical Safety Evaluation of Biopharmaceuticals

    Article • Wiley

    Professor Renger Witkamp