All Stories

  1. Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche’s Endocannabinoid System Projects

    Article • CHIMIA International Journal for Chemistry, August 2024, Swiss Chemical Society

    Dr Rainer E Martin

  2. RG7774 (Vicasinabin), an orally bioavailable cannabinoid receptor 2 (CB2R) agonist, decreases retinal vascular permeability, leukocyte adhesion, and ocular inflammation in animal models

    Article • Frontiers in Pharmacology, July 2024, Frontiers

    Dr Rainer E Martin

  3. Simple User-Friendly Reaction Format

    Article • May 2024, American Chemical Society (ACS)

    Dr Rainer E Martin

  4. sp3‐Rich Heterocycle Synthesis on DNA: Application to DNA‐Encoded Library Production

    Article • Angewandte Chemie, February 2024, Wiley

    Dr Rainer E Martin

  5. sp3‐Rich Heterocycle Synthesis on DNA: Application to DNA‐Encoded Library Production

    Article • Angewandte Chemie, February 2024, Wiley

    Dr Rainer E Martin

  6. Geometric deep learning-guided Suzuki reaction conditions assessment for applications in medicinal chemistry

    Article • RSC Medicinal Chemistry, January 2024, Royal Society of Chemistry

    Dr Rainer E Martin

  7. Enabling late-stage drug diversification by high-throughput experimentation with geometric deep learning

    Article • Nature Chemistry, November 2023, Springer Science + Business Media

    Dr Rainer E Martin

  8. Identifying opportunities for late-stage C-H alkylation with high-throughput experimentation and in silico reaction screening

    Article • Communications Chemistry, November 2023, Springer Science + Business Media

    Dr Rainer E Martin

  9. Investigations into mRNA Lipid Nanoparticles Shelf-Life Stability under Nonfrozen Conditions

    Article • Molecular Pharmaceutics, November 2023, American Chemical Society (ACS)

    Dr Rainer E Martin

  10. Development and Demonstration of a High-Volume Manufacturing Process for a Key Intermediate of Dalcetrapib: Investigations on the Alkylation of Carboxylic Acids, Esters, and Nitriles

    Article • Organic Process Research & Development, November 2023, American Chemical Society (ACS)

    Dr Rainer E Martin

  11. Diligent Design Enables Antibody-ASO Conjugates with Optimal Pharmacokinetic Properties

    Article • Bioconjugate Chemistry, November 2023, American Chemical Society (ACS)

    Dr Rainer E Martin

  12. Rapid 18F‐ and 19F‐Difluoromethylation via Desulfurative Fluorination of Transient N‐, O‐, and C‐Linked Dithioles

    Article • Chemistry - A European Journal, November 2022, Wiley

    Dr Rainer E Martin

  13. Late-stage Functionalization and its Impact on Modern Drug Discovery

    Article • CHIMIA International Journal for Chemistry, March 2022, Swiss Chemical Society

    Dr Rainer E Martin

  14. Antagonizing somatostatin receptor subtype 2 and 5 reduces blood glucose in a gut- and GLP-1R-dependent manner

    Article • JCI Insight, January 2021, American Society for Clinical Investigation

    Dr Rainer E Martin

  15. Quaternary Ammonium Trifluoromethoxide Salts as Stable Sources of Nucleophilic OCF3

    Article • Organic Letters, February 2020, American Chemical Society (ACS)

    Dr Rainer E Martin

  16. Paracrine crosstalk between intestinal L- and D-cells controls secretion of glucagon-like peptide-1 in mice

    Article • AJP Endocrinology and Metabolism, December 2019, American Physiological Society

    Dr Rainer E Martin

  17. Modulation of Pharmacologically Relevant Properties of Piperidine Derivatives by Functional Groups in an Equatorial or Axial β‐Position to the Amino Group

    Article • ChemBioChem, October 2019, Wiley

    Dr Rainer E Martin

  18. A Convenient Synthesis of Difluoroalkyl Ethers from Thionoesters using Silver(I) Fluoride

    Article • Chemistry - A European Journal, September 2019, Wiley

    Josiah Newton, Dr Rainer E Martin

  19. Electrostatic Effects Accelerate Decatungstate-Catalyzed C–H Fluorination Using [18F]- and [19F]NFSI in Small Molecules and Peptide Mimics

    Article • ACS Catalysis, August 2019, American Chemical Society (ACS)

    Dr Rainer E Martin

  20. 18F-Branched-Chain Amino Acids: Structure–Activity Relationships and PET Imaging Potential

    Article • Journal of Nuclear Medicine, January 2019, Society of Nuclear Medicine

    Dr Rainer E Martin

  21. Site-Selective, Late-Stage C−H 18 F-Fluorination on Unprotected Peptides for Positron Emission Tomography Imaging

    Article • Angewandte Chemie, September 2018, Wiley

    Dr Rainer E Martin

  22. Site-Selective, Late-Stage C−H 18 F-Fluorination on Unprotected Peptides for Positron Emission Tomography Imaging

    Article • Angewandte Chemie, September 2018, Wiley

    Dr Rainer E Martin

  23. A carbohydrate-derived trifunctional scaffold for medicinal chemistry library synthesis

    Article • Mediterranean Journal of Chemistry, September 2018, Mediterranean Journal of Chemistry

    Dr Rainer E Martin

  24. 2H-1,2,3-Triazole-Based Dipeptidyl Nitriles: Potent, Selective, and Trypanocidal Rhodesain Inhibitors by Structure-Based Design

    Article • Journal of Medicinal Chemistry, March 2018, American Chemical Society (ACS)

    Dr Rainer E Martin

  25. Direct heterobenzylic fluorination, difluorination and trifluoromethylthiolation with dibenzenesulfonamide derivatives

    Article • Chemical Science, January 2018, Royal Society of Chemistry

    Dr Rainer E Martin, Josiah Newton

  26. Synthesis of acyl fluorides via photocatalytic fluorination of aldehydic C–H bonds

    Article • Chemical Communications, January 2018, Royal Society of Chemistry

    Dr Rainer E Martin

  27. A carbohydrate-derived trifunctional scaffold for DNA-encoded libraries

    Article • Tetrahedron Asymmetry, June 2017, Elsevier

    Dr Rainer E Martin

  28. Prospective Evaluation of Free Energy Calculations for the Prioritization of Cathepsin L Inhibitors

    Article • Journal of Medicinal Chemistry, March 2017, American Chemical Society (ACS)

    Dr Rainer E Martin

  29. 18F-Fluorination of Unactivated C–H Bonds in Branched Aliphatic Amino Acids: Direct Synthesis of Oncological Positron Emission Tomography Imaging Agents

    Article • Journal of the American Chemical Society, March 2017, American Chemical Society (ACS)

    Dr Rainer E Martin

  30. Intramolecular Inverse Electron-Demand [4 + 2] Cycloadditions of Ynamides with Pyrimidines: Scope and Density Functional Theory Insights

    Article • The Journal of Organic Chemistry, January 2017, American Chemical Society (ACS)

    Dr Rainer E Martin

  31. A Convenient Late-Stage Fluorination of Pyridylic C−H Bonds with N -Fluorobenzenesulfonimide

    Article • Angewandte Chemie, October 2016, Wiley

    Dr Rainer E Martin

  32. Going with the flow

    Article • Science, March 2016, American Association for the Advancement of Science

    Dr Rainer E Martin

  33. Inverse Electron-Demand [4 + 2]-Cycloadditions of Ynamides: Access to Novel Pyridine Scaffolds

    Article • Organic Letters, March 2016, American Chemical Society (ACS)

    Dr Rainer E Martin

  34. Synthesis of annulated pyridines as inhibitors of aldosterone synthase (CYP11B2)

    Article • Organic & Biomolecular Chemistry, January 2016, Royal Society of Chemistry

    Dr Rainer E Martin

  35. Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys

    Article • Journal of Medicinal Chemistry, October 2015, American Chemical Society (ACS)

    Dr Rainer E Martin

  36. Direct photocatalytic fluorination of benzylic C–H bonds with N-fluorobenzenesulfonimide

    Article • Chemical Communications, January 2015, Royal Society of Chemistry

    Dr Rainer E Martin

  37. A Convenient Photocatalytic Fluorination of Unactivated CH Bonds

    Article • Angewandte Chemie, March 2014, Wiley

    Dr Rainer E Martin

  38. Inside Cover: Seamless Integration of Dose-Response Screening and Flow Chemistry: Efficient Generation of Structure-Activity Relationship Data of β-Secretase (BACE1) Inhibitors (Angew. Chem. Int. Ed. 6/2014)

    Article • Angewandte Chemie, January 2014, Wiley

    Dr Rainer E Martin

  39. Seamless Integration of Dose-Response Screening and Flow Chemistry: Efficient Generation of Structure-Activity Relationship Data of β-Secretase (BACE1) Inhibitors

    Article • Angewandte Chemie, January 2014, Wiley

    Dr Rainer E Martin

  40. Converting oxazoles into imidazoles: new opportunities for diversity-oriented synthesis

    Article • Chemical Communications, January 2014, Royal Society of Chemistry

    Dr Rainer E Martin

  41. Flow synthesis of annulated 5-aryl-substituted pyridines by tandem intramolecular inverse-electron-demand hetero-/retro-Diels–Alder reaction

    Article • Tetrahedron Letters, December 2013, Elsevier

    Dr Rainer E Martin

  42. Discovery and optimisation of 1-hydroxyimino-3,3-diphenylpropanes, a new class of orally active GPBAR1 (TGR5) agonists

    Article • Bioorganic & Medicinal Chemistry Letters, August 2013, Elsevier

    Dr Rainer E Martin

  43. The Kondrat’eva Reaction in Flow: Direct Access to Annulated Pyridines

    Article • Organic Letters, June 2013, American Chemical Society (ACS)

    Dr Rainer E Martin

  44. Cover Picture: 2-Phenoxy-nicotinamides are Potent Agonists at the Bile Acid Receptor GPBAR1 (TGR5) (ChemMedChem 4/2013)

    Article • ChemMedChem, March 2013, Wiley

    Dr Rainer E Martin

  45. Photocatalytic Synthesis of Allylic Trifluoromethyl Substituted Styrene Derivatives in Batch and Flow

    Article • Organic Letters, March 2013, American Chemical Society (ACS)

    Dr Rainer E Martin

  46. 2-Phenoxy-nicotinamides are Potent Agonists at the Bile Acid Receptor GPBAR1 (TGR5)

    Article • ChemMedChem, December 2012, Wiley

    Dr Rainer E Martin

  47. Evaluation of a flow-photochemistry platform for the synthesis of compact modules

    Article • Tetrahedron Letters, March 2012, Elsevier

    Dr Rainer E Martin

  48. Scale-Up of Flow-Assisted Synthesis of C2-Symmetric Chiral PyBox Ligands

    Article • Synthesis, January 2012, Thieme Publishing Group

    Dr Rainer E Martin

  49. Synthesis of Annulated Pyridines by Intramolecular Inverse-Electron-Demand Hetero-Diels-Alder Reaction under Superheated Continuous Flow Conditions

    Article • European Journal of Organic Chemistry, November 2011, Wiley

    Dr Rainer E Martin

  50. Neighborhood-Preserving Visualization of Adaptive Structure-Activity Landscapes: Application to Drug Discovery

    Article • Angewandte Chemie, October 2011, Wiley

    Dr Rainer E Martin

  51. G Protein-Coupled Receptor Transmembrane Binding Pockets and their Applications in GPCR Research and Drug Discovery: A Survey

    Article • Current Topics in Medicinal Chemistry, August 2011, Bentham Science Publishers

    Dr Rainer E Martin

  52. Synthesis of a Drug-Like Focused Library of Trisubstituted Pyrrolidines Using Integrated Flow Chemistry and Batch Methods

    Article • ACS Combinatorial Science, May 2011, American Chemical Society (ACS)

    Dr Rainer E Martin

  53. Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties

    Article • Bioorganic & Medicinal Chemistry Letters, February 2011, Elsevier

    Dr Rainer E Martin

  54. Discovery of novel and orally active FXR agonists for the potential treatment of dyslipidemia & diabetes

    Article • Bioorganic & Medicinal Chemistry Letters, January 2011, Elsevier

    Dr Rainer E Martin

  55. Piperidinyl-nicotinamides as potent and selective somatostatin receptor subtype 5 antagonists

    Article • Bioorganic & Medicinal Chemistry Letters, August 2010, Elsevier

    Dr Rainer E Martin

  56. Novel, non-peptidic somatostatin receptor subtype 5 antagonists improve glucose tolerance in rodents

    Article • Regulatory Peptides, January 2010, Elsevier

    Dr Rainer E Martin

  57. Benzoxazole piperidines as selective and potent somatostatin receptor subtype 5 antagonists

    Article • Bioorganic & Medicinal Chemistry Letters, November 2009, Elsevier

    Dr Rainer E Martin

  58. Identification of an N-oxide pyridine GW4064 analog as a potent FXR agonist

    Article • Bioorganic & Medicinal Chemistry Letters, May 2009, Elsevier

    Dr Rainer E Martin

  59. Synthesis of Light-Emitting Conjugated Polymers for Applications in Electroluminescent Devices

    Article • Chemical Reviews, March 2009, American Chemical Society (ACS)

    Dr Rainer E Martin

  60. Discovery of the First Nonpeptidic, Small-Molecule, Highly Selective Somatostatin Receptor Subtype 5 Antagonists: A Chemogenomics Approach

    Article • Journal of Medicinal Chemistry, December 2007, American Chemical Society (ACS)

    Dr Rainer E Martin

  61. From Astemizole to a Novel Hit Series of Small-Molecule Somatostatin 5 Receptor Antagonists via GPCR Affinity Profiling

    Article • Journal of Medicinal Chemistry, December 2007, American Chemical Society (ACS)

    Dr Rainer E Martin

  62. Predicting and Tuning Physicochemical Properties in Lead Optimization: Amine Basicities

    Article • ChemMedChem, August 2007, Wiley

    Anja Hoffmann-Röder, Dr Rainer E Martin

  63. Remote Modulation of Amine Basicity by a Phenylsulfone and a Phenylthio Group

    Article • ChemMedChem, March 2007, Wiley

    Dr Rainer E Martin

  64. Cyclopropanation of 3,4-dihydro-1 H-benzo[e][1,4]diazepine-2,5-diones

    Article • Tetrahedron Letters, November 2005, Elsevier

    Dr Rainer E Martin

  65. Joint Meeting on Medicinal Chemistry in Vienna

    Article • Angewandte Chemie, August 2005, Wiley

    Dr Rainer E Martin

  66. Ligand identification for G-protein-coupled receptors: a lead generation perspective

    Article • Current Opinion in Chemical Biology, June 2004, Elsevier

    Dr Rainer E Martin

  67. Preparation of 5-amino-6-oxo-1,6-dihydro[1,2,4]triazine-3-carboxylic acid derivatives and synthesis of compound libraries thereof

    Article • Tetrahedron Letters, March 2004, Elsevier

    Dr Rainer E Martin

  68. μSR in polymers

    Article • Physica B Condensed Matter, February 2003, Elsevier

    Dr Rainer E Martin

  69. Muon-spin relaxation study of anisotropic charge carrier motion in polyphenylene vinylene-based polymers

    Article • Journal of Physics Condensed Matter, October 2002, Institute of Physics Publishing

    Dr Rainer E Martin

  70. Anodic and Cathodic Electrochemically Generated Chemiluminescence in Conjugated Polymers

    Article • Advanced Functional Materials, April 2002, Wiley

    Dr Rainer E Martin

  71. New family of polyfluorene copolymers for light-emitting devices

    Article • February 2002, SPIE

    Dr Rainer E Martin, Professor of Physics Franco Cacialli

  72. Multi-layer Polymer Light-emitting Diodes with 2,3-Dialkoxy-p-phenylene Vinylene and its Blends.

    Article • Journal of Photopolymer Science and Technology, January 2002, Technical Association of Photopolymers, Japan

    Dr Rainer E Martin

  73. White-light-continuum spectroscopy to determine third-order nonlinear optical properties

    Article • December 2001, SPIE

    Dr Rainer E Martin

  74. Versatile synthesis of various conjugated aromatic homo- and copolymers

    Article • Synthetic Metals, May 2001, Elsevier

    Dr Rainer E Martin, Professor of Physics Franco Cacialli

  75. Efficient electroluminescent poly(p-phenylene vinylene) copolymers for application in LEDs

    Article • Synthetic Metals, March 2001, Elsevier

    Dr Rainer E Martin, Professor of Physics Franco Cacialli

  76. Polymer and small molecule multi-layer light-emitting diodes

    Article • Synthetic Metals, March 2001, Elsevier

    Dr Rainer E Martin

  77. Electrochemiluminescence of conjugated polymer

    Article • Synthetic Metals, March 2001, Elsevier

    Dr Rainer E Martin

  78. Muon-spin relaxation study of charge carrier dynamics in the conducting polymer PPV

    Article • Synthetic Metals, March 2001, Elsevier

    Dr Rainer E Martin

  79. Ortho-Metallation as a key step for the synthesis of silyl substituted Poly(p-phenylenevinylene)s

    Article • Synthetic Metals, March 2001, Elsevier

    Dr Rainer E Martin

  80. Insulated Molecular Wires: Dendritic Encapsulation of Poly(triacetylene) Oligomers, Attempted Dendritic Stabilization of Novel Poly(pentaacetylene) Oligomers, and an Organometallic Approach to Dendritic Rods

    Article • Helvetica Chimica Acta, February 2001, Wiley

    Dr Rainer E Martin

  81. New routes to monomers and polymers for LEDs

    Article • February 2001, SPIE

    Dr Rainer E Martin, Professor of Physics Franco Cacialli

  82. Conjugated Oligomers and Polymers, Synthesis of

    Article • January 2001, Elsevier

    Dr Rainer E Martin

  83. Design of Luminescent Polymers for Leds

    Article • MRS Proceedings, January 2001, Springer Science + Business Media

    Dr Rainer E Martin

  84. Synthesis and Physical Investigation of Donor–Donor and Acceptor–Acceptor End-Functionalized Monodisperse Poly(triacetylene) Oligomers

    Article • Chemistry - A European Journal, December 2000, Wiley

    Dr Rainer E Martin

  85. Monodisperse Poly(triacetylene) Oligomers Extending from Monomer to Hexadecamer: Joint Experimental and Theoretical Investigation of Physical Properties

    Article • Chemistry - A European Journal, October 2000, Wiley

    Dr Rainer E Martin

  86. μSR of conducting and non-conducting polymers

    Article • Physica B Condensed Matter, August 2000, Elsevier

    Dr Rainer E Martin

  87. Synthesis of conjugated polymers for application in light-emitting diodes (PLEDs)

    Article • Comptes Rendus de l Académie des Sciences - Series IV - Physics-Astrophysics, May 2000, Elsevier

    Dr Rainer E Martin

  88. The copolymer route to new luminescent materials for LEDs

    Article • Macromolecular Symposia, April 2000, Wiley

    Dr Rainer E Martin, Professor of Physics Franco Cacialli

  89. Efficient blue–green light emitting poly(1,4-phenylene vinylene) copolymers

    Article • Chemical Communications, January 2000, Royal Society of Chemistry

    Dr Rainer E Martin, Professor of Physics Franco Cacialli

  90. Synthesis of New Building Blocks for Light Emitting Polymers

    Article • MRS Proceedings, January 2000, Cambridge University Press

    Dr Rainer E Martin

  91. Synthesis of New Building Blocks for Light Emitting Polymers

    Article • MRS Proceedings, January 2000, Cambridge University Press

    Dr Rainer E Martin

  92. Design and synthesis of conjugated materials for efficient optoelectronic devices

    Article • December 1999, SPIE

    Dr Rainer E Martin, Professor of Physics Franco Cacialli

  93. Scaling law for second-order hyperpolarizability in poly(triacetylene) molecular wires

    Article • Optics Letters, November 1999, Optical Society of America (OSA)

    Dr Rainer E Martin

  94. Modulation ofπ-Electron Conjugation in Oligo(triacetylene) Chromophores by Incorporation of a Central Spacer

    Article • Helvetica Chimica Acta, September 1999, Wiley

    Dr Rainer E Martin

  95. Linear Monodisperse π-Conjugated Oligomers: Model Compounds for Polymers and More

    Article • Angewandte Chemie, May 1999, Wiley

    Dr Rainer E Martin

  96. Monodisperse Poly(triacetylene) Rods: Synthesis of a 11.9 nm Long Molecular Wire and Direct Determination of the Effective Conjugation Length by UV/Vis and Raman Spectroscopies

    Article • Angewandte Chemie, March 1999, Wiley

    Dr Rainer E Martin

  97. PM3 geometry optimization and CNDO/S-CI computation of UV/Vis spectra of large organic structures: Program description and application to poly(triacetylene) hexamer and taxotere

    Article • Journal of Computational Chemistry, March 1999, Wiley

    Dr Rainer E Martin

  98. PM3 geometry optimization and CNDO/S-CI computation of UV/Vis spectra of large organic structures: Program description and application to poly(triacetylene) hexamer and taxotere

    Article • Journal of Computational Chemistry, March 1999, Wiley

    Dr Rainer E Martin

  99. Versatile Syntheses of Various Homo- and Copolymers of Poly(1,4-Arylene Vinylene)S

    Article • MRS Proceedings, January 1999, Cambridge University Press

    Dr Rainer E Martin

  100. Determination of End-to-End Distances in a Series of TEMPO Diradicals of up to 2.8 nm Length with a New Four-Pulse Double Electron Electron Resonance Experiment

    Article • Angewandte Chemie, November 1998, Wiley

    Dr Rainer E Martin

  101. Structure−Property Relationships in Third-Order Nonlinear Optical Chromophores

    Article • The Journal of Physical Chemistry B, June 1998, American Chemical Society (ACS)

    Dr Rainer E Martin

  102. Dendritic rods with a poly(triacetylene) backbone: insulated molecular wires

    Article • Chemical Communications, January 1998, Royal Society of Chemistry

    Dr Rainer E Martin

  103. Photochemical trans–cis isomerisation of donor/acceptor-substituted (E )-hex-3-ene-1,5-diynes (1,2-diethynylethenes, DEEs) and 3,4-diethynylhex-3-ene-1,5-diynes (tetraethynylethenes, TEEs)

    Article • Journal of the Chemical Society Perkin Transactions 2, January 1998, Royal Society of Chemistry

    Dr Rainer E Martin

  104. Poly(triacetylene) Oligomers: Synthesis, Characterization, and Estimation of the Effective Conjugation Length by Electrochemical, UV/Vis, and Nonlinear Optical Methods

    Article • Chemistry - A European Journal, September 1997, Wiley

    Dr Rainer E Martin

  105. Electronic Characteristics of Arylated Tetraethynylethenes:  A Cooperative Computational and Electrochemical Investigation

    Article • Journal of the American Chemical Society, March 1997, American Chemical Society (ACS)

    Dr Rainer E Martin

  106. Functionalized One and Two-Dimensionally Conjugated Molecules for Thrid Order Nonlinear Optics

    Article • Institute of Electrical & Electronics Engineers (IEEE)

    Dr Rainer E Martin