All Stories

  1. highly potential new drug candidates against TB

    Article • Medicinal Research Reviews, June 2017, Wiley

    Professor Rahul Jain, Dr vajinder Kumar

  2. Synthesis of CNS active thyrotropin-releasing hormone (TRH)-like peptides: Biological evaluation and effect on cognitive impairment induced by cerebral ischemia in mice

    Article • Bioorganic & Medicinal Chemistry, September 2015, Elsevier

    Professor Rahul Jain

  3. ChemInform Abstract: Room Temperature N-Arylation of Amino Acids and Peptides Using Copper(I) and β-Diketone.

    Article • ChemInform, July 2015, Wiley

    Professor Rahul Jain

  4. Synthesis, biological evaluation and 3D QSAR study of 2,4-disubstituted quinolines as anti-tuberculosis agents

    Article • European Journal of Medicinal Chemistry, March 2015, Elsevier

    Professor Rahul Jain

  5. Antiplasmodial activity of short peptide-based compounds

    Article • RSC Advances, January 2015, Royal Society of Chemistry

    Professor Rahul Jain

  6. Room temperature N-arylation of amino acids and peptides using copper(i) and β-diketone

    Article • Organic & Biomolecular Chemistry, January 2015, Royal Society of Chemistry

    Professor Rahul Jain

  7. Discovery of a low affinity thyrotropin-releasing hormone (TRH)-like peptide that exhibits potent inhibition of scopolamine-induced memory impairment in mice

    Article • RSC Advances, January 2015, Royal Society of Chemistry

    Professor Rahul Jain

  8. Metal-free synthesis of N-fused heterocyclic iodides via C–H functionalization mediated by tert-butylhydroperoxide

    Article • Chemical Communications, January 2015, Royal Society of Chemistry

    Professor Rahul Jain

  9. ChemInform Abstract: Regiocontrolled Palladium-Catalyzed and Copper-Mediated C-H Bond Functionalization of Protected L-Histidine.

    Article • ChemInform, October 2014, Wiley

    Professor Rahul Jain

  10. Synthesis, biological evaluation and 3D-QSAR study of hydrazide, semicarbazide and thiosemicarbazide derivatives of 4-(adamantan-1-yl)quinoline as anti-tuberculosis agents

    Article • European Journal of Medicinal Chemistry, October 2014, Elsevier

    Professor Rahul Jain

  11. Intestinal transport of TRH analogs through PepT1: the role ofin silicoandin vitromodeling

    Article • Journal of Molecular Recognition, August 2014, Wiley

    Professor Rahul Jain, abhay sangamwar

  12. Synthetically modified l-histidine-rich peptidomimetics exhibit potent activity against Cryptococcus neoformans

    Article • Bioorganic & Medicinal Chemistry Letters, July 2014, Elsevier

    Professor Rahul Jain

  13. Discovery of Short Peptides Exhibiting High Potency against Cryptococcus neoformans

    Article • ACS Medicinal Chemistry Letters, April 2014, American Chemical Society (ACS)

    Professor Rahul Jain

  14. ChemInform Abstract: Palladium-Catalyzed Regioselective C-5 Arylation of Protected L-Histidine: Microwave-Assisted C-H Activation Adjacent to Donor Arm.

    Article • ChemInform, March 2014, Wiley

    Professor Rahul Jain

  15. Solvent-free peptide synthesis assisted by microwave irradiation: environmentally benign synthesis of bioactive peptides

    Article • RSC Advances, January 2014, Royal Society of Chemistry

    Professor Rahul Jain

  16. Synthesis and antimicrobial activities of His(2-aryl)-Arg and Trp-His(2-aryl) classes of dipeptidomimetics

    Article • MedChemComm, January 2014, Royal Society of Chemistry

    Professor Rahul Jain

  17. Regiocontrolled palladium-catalyzed and copper-mediated C–H bond functionalization of protectedl-histidine

    Article • Organic & Biomolecular Chemistry, January 2014, Royal Society of Chemistry

    Professor Rahul Jain

  18. Palladium-Catalyzed Regioselective C-5 Arylation of Protected l -Histidine: Microwave-Assisted C–H Activation Adjacent to Donor Arm

    Article • The Journal of Organic Chemistry, November 2013, American Chemical Society (ACS)

    Professor Rahul Jain

  19. Microwave-assisted solution phase peptide synthesis in neat water

    Article • RSC Advances, January 2013, Royal Society of Chemistry

    Professor Rahul Jain

  20. Rapid microwave-assisted solution-phase peptide synthesis

    Article • Tetrahedron Letters, December 2012, Elsevier

    Professor Rahul Jain

  21. Mechanistic Insights into PEPT1-Mediated Transport of a Novel Antiepileptic, NP-647

    Article • Molecular Pharmaceutics, September 2012, American Chemical Society (ACS)

    Professor Rahul Jain

  22. Regiospecific Direct C-H Arylation at the 2-Position of l-Histidine Using Arylboronic Acids

    Article • Synlett, June 2012, Thieme Publishing Group

    Professor Rahul Jain

  23. Amino acid, dipeptide and pseudodipeptide conjugates of ring-substituted 8-aminoquinolines: Synthesis and evaluation of anti-infective, β-haematin inhibition and cytotoxic activities

    Article • European Journal of Medicinal Chemistry, June 2012, Elsevier

    Professor Rahul Jain

  24. Recent Advances in New Structural Classes of Anti-Tuberculosis Agents

    Article • March 2012, Bentham Science Publishers

    Professor Rahul Jain

  25. Convenient syntheses of bulky group containing imidazolium ionic liquids

    Article • Journal of Heterocyclic Chemistry, December 2011, Wiley

    Professor Rahul Jain

  26. Facile Syntheses of Histamine- and Imidazole-4-propionic Acid–Derived Room-Temperature Ionic Liquids

    Article • Synthetic Communications, December 2011, Taylor & Francis

    Professor Rahul Jain

  27. Protective effects of l-pGlu-(2-propyl)-l-His-l-ProNH2, a newer thyrotropin releasing hormone analog in in vitro and in vivo models of cerebral ischemia

    Article • Peptides, June 2011, Elsevier

    Professor Rahul Jain

  28. NP-647, a novel TRH analogue: Investigating physicochemical parameters critical for its oral and parenteral delivery

    Article • International Journal of Pharmaceutics, March 2011, Elsevier

    Professor Rahul Jain

  29. Synthesis, Receptor Binding, and CNS Pharmacological Studies of New Thyrotropin-Releasing Hormone (TRH) Analogues

    Article • ChemMedChem, February 2011, Wiley

    Professor Rahul Jain

  30. Extended side chain analogues of 8-aminoquinolines: Synthesis and evaluation of antiprotozoal, antimicrobial, β-hematin inhibition, and cytotoxic activities

    Article • MedChemComm, January 2011, Royal Society of Chemistry

    Professor Rahul Jain

  31. Evidence of the formation of direct covalent adducts of primaquine, 2-tert-butylprimaquine (NP-96) and monohydroxy metabolite of NP-96 with glutathione and N-acetylcysteine

    Article • Journal of Chromatography B, January 2011, Elsevier

    Professor Rahul Jain

  32. Synthesis, antiprotozoal, antimicrobial, β-hematin inhibition, cytotoxicity and methemoglobin (MetHb) formation activities of bis(8-aminoquinolines)

    Article • Bioorganic & Medicinal Chemistry, January 2011, Elsevier

    Professor Rahul Jain

  33. ChemInform Abstract: Quinolines and Structurally Related Heterocycles as Antimalarials

    Article • ChemInform, September 2010, Wiley

    Professor Rahul Jain

  34. CNS safety pharmacology of newer TRH Analog-L-pGlu-(1-benzyl)-L-His-LProNH2

    Article • Journal of Pharmacological and Toxicological Methods, September 2010, Elsevier

    Professor Rahul Jain

  35. Quinolines and structurally related heterocycles as antimalarials

    Article • European Journal of Medicinal Chemistry, August 2010, Elsevier

    Professor Rahul Jain

  36. Structure based design of novel inhibitors for histidinol dehydrogenase from Geotrichum candidum

    Article • Bioorganic & Medicinal Chemistry Letters, July 2010, Elsevier

    Professor Rahul Jain

  37. Development and validation of a sensitive and selective UHPLC–MS/MS method for quantitation of an investigational anti-malarial compound, 2-tert-butylprimaquine (NP-96) in rat plasma, and its application in a preclinical pharmacokinetic study

    Article • Journal of Pharmaceutical and Biomedical Analysis, July 2010, Elsevier

    Professor Rahul Jain

  38. ChemInform Abstract: Regiospecific Synthesis of 2,3-Disubstituted-L-histidines and Histamines.

    Article • ChemInform, May 2010, Wiley

    Professor Rahul Jain

  39. ChemInform Abstract: Convenient N-Protection of L-Pyroglutamic Acid Esters.

    Article • ChemInform, May 2010, Wiley

    Professor Rahul Jain

  40. ChemInform Abstract: Synthesis and Biology of New Thyrotropin-Releasing Hormone (TRH) Analogues.

    Article • ChemInform, May 2010, Wiley

    Professor Rahul Jain

  41. ChemInform Abstract: Antimalarial Activities of Ring-Substituted Bioimidazoles.

    Article • ChemInform, May 2010, Wiley

    Professor Rahul Jain

  42. New Antimicrobial Hexapeptides: Synthesis, Antimicrobial Activities, Cytotoxicity, and Mechanistic Studies

    Article • ChemMedChem, January 2010, Wiley

    Professor Rahul Jain

  43. 2-tert-butyl-primaquine exhibit potent blood schizontocidal antimalarial activity via inhibition of heme crystallization

    Article • Malaria Journal, January 2010, Springer Science + Business Media

    Professor Rahul Jain

  44. Atorvastatin Calcium

    Article • January 2010, Elsevier

    Professor Rahul Jain

  45. Discovery of Trp-His and His-Arg Analogues as New Structural Classes of Short Antimicrobial Peptides

    Article • Journal of Medicinal Chemistry, December 2009, American Chemical Society (ACS)

    Professor Rahul Jain

  46. Neuropharmacological profile of l-pGlu-(1-benzyl)-l-His-l-ProNH2, a newer thyrotropin-releasing hormone analog: Effects on seizure models, sodium current, cerebral blood flow and behavioral parameters

    Article • Epilepsy Research, December 2009, Elsevier

    Professor Rahul Jain

  47. Antimalarials from nature

    Article • Bioorganic & Medicinal Chemistry, May 2009, Elsevier

    Professor Rahul Jain

  48. Synthesis, anti-tuberculosis activity and 3D-QSAR study of amino acid conjugates of 4-(adamantan-1-yl) group containing quinolines

    Article • European Journal of Medicinal Chemistry, May 2009, Elsevier

    Professor Rahul Jain

  49. ChemInform Abstract: Facile Synthesis of N-α-Boc-1,2-Dialkyl-L-histidines (VI): Utility in the Synthesis of Thyrotropin-Releasing Hormone (TRH) Analogues (VII) and Evaluation of the CNS Activity.

    Article • ChemInform, April 2009, Wiley

    Professor Rahul Jain

  50. Fexofenadine Hydrochloride

    Article • January 2009, Elsevier

    Professor Rahul Jain

  51. Antiepileptic potential and behavioral profile of l-pGlu-(2-propyl)–l-His–l-ProNH2, a newer thyrotropin-releasing hormone analog

    Article • Epilepsy & Behavior, January 2009, Elsevier

    Professor Rahul Jain

  52. Chemistry and Biology of Thyrotropin-Releasing Hormone (TRH) and its Analogs

    Article • Current Medicinal Chemistry, November 2008, Bentham Science Publishers

    Professor Rahul Jain

  53. Facile synthesis ofN-α-boc-1,2-dialkyl-l-histidines: Utility in the synthesis of thyrotropin-releasing hormone (trh) analogs and evaluation of the cns activity

    Article • Journal of Heterocyclic Chemistry, November 2008, Wiley

    Professor Rahul Jain

  54. Selectivity-based QSAR approach for screening and evaluation of TRH analogs for TRH-R1 and TRH-R2 receptors subtypes

    Article • Journal of Molecular Graphics and Modelling, October 2008, Elsevier

    Professor Rahul Jain

  55. Target-Specific Anti-Fungal Discovery by TargetingGeotrichum candidumHistidinol Dehydrogenase: A Hybrid Approach

    Article • Chemical Biology & Drug Design, September 2008, Wiley

    Professor Rahul Jain

  56. ChemInform Abstract: Synthesis and Antituberculosis Activity of 2,4-Disubstituted Quinolines.

    Article • ChemInform, April 2008, Wiley

    Professor Rahul Jain

  57. ChemInform Abstract: Facile Regiospecific Syntheses of N-α,N-1(τ)-Dialkyl-L-histidines.

    Article • ChemInform, March 2008, Wiley

    Professor Rahul Jain, Dr Surendra Kumar Nayak

  58. Minimum requirements of hydrophobic and hydrophilic features in cationic peptide antibiotics (CPAs): pharmacophore generation and validation with cationic steroid antibiotics (CSAs)

    Article • Journal of Molecular Modeling, February 2008, Springer Science + Business Media

    Professor Rahul Jain

  59. A highly significant scheme to modify amino acids for novel bioactive peptides.

    Article • Journal of Heterocyclic Chemistry, November 2007, Wiley

    Professor Rahul Jain, Dr Surendra Kumar Nayak

  60. Synthesis and Evaluation of N-Acetyl-L-tyrosine Based Compounds as PPARα Selective Activators.

    Article • ChemInform, August 2007, Wiley

    Professor Rahul Jain

  61. Unprecedented 1,1′-Carbonyldiimidazole-Mediated Amidation of Unprotected α-Amino Acids in Water.

    Article • ChemInform, July 2007, Wiley

    Professor Rahul Jain

  62. Recent Advances in Antimalarial Drug Development

    Article • ChemInform, May 2007, Wiley

    Professor Rahul Jain

  63. Synthesis and evaluation of N-acetyl-l-tyrosine based compounds as PPARα selective activators

    Article • European Journal of Medicinal Chemistry, April 2007, Elsevier

    Professor Rahul Jain

  64. Unprecedented 1,1′-Carbonyldiimidazole-Mediated Amidation of ­Unprotected α-Amino Acids in Water

    Article • Synlett, February 2007, Thieme Publishing Group

    Professor Rahul Jain

  65. Synthesis, anti-tuberculosis activity, and 3D-QSAR study of 4-(adamantan-1-yl)-2-substituted quinolines

    Article • Bioorganic & Medicinal Chemistry, January 2007, Elsevier

    Professor Rahul Jain

  66. Synthesis, antimalarial, antileishmanial, antimicrobial, cytotoxicity, and methemoglobin (MetHB) formation activities of new 8-quinolinamines

    Article • Bioorganic & Medicinal Chemistry, January 2007, Elsevier

    Professor Rahul Jain

  67. Modifications of the pyroglutamic acid and histidine residues in thyrotropin-releasing hormone (TRH) yield analogs with selectivity for TRH receptor type 2 over type 1

    Article • Bioorganic & Medicinal Chemistry, January 2007, Elsevier

    Professor Rahul Jain

  68. Synthesis, anti-tuberculosis activity, and 3D-QSAR study of ring-substituted-2/4-quinolinecarbaldehyde derivatives

    Article • Bioorganic & Medicinal Chemistry, November 2006, Elsevier

    Professor Rahul Jain

  69. Synthesis, receptor binding, and activation studies of N(1)-alkyl-l-histidine containing thyrotropin-releasing hormone (TRH) analogues

    Article • Bioorganic & Medicinal Chemistry, September 2006, Elsevier

    Professor Rahul Jain

  70. Thyrotropin-Releasing Hormone (TRH) Analogues That Exhibit Selectivity to TRH Receptor Subtype 2.

    Article • Journal of Medicinal Chemistry, August 2006, American Chemical Society (ACS)

    Professor Rahul Jain

  71. Current Advances in Antifungal Targets and Drug Development

    Article • Current Medicinal Chemistry, May 2006, Bentham Science Publishers

    Professor Rahul Jain

  72. Current Status of Target-Based Antimycobacterial Natural Products

    Article • Anti-Infective Agents in Medicinal Chemistry, April 2006, Bentham Science Publishers

    Professor Rahul Jain

  73. 3D-QSAR study of ring-substituted quinoline class of anti-tuberculosis agents

    Article • Bioorganic & Medicinal Chemistry, February 2006, Elsevier

    Professor Rahul Jain

  74. Recent advances in antimalarial drug development

    Article • Medicinal Research Reviews, January 2006, Wiley

    Professor Rahul Jain

  75. Thyrotropin-Releasing Hormone (TRH) Analogues That Exhibit Selectivity to TRH Receptor Subtype 2

    Article • Journal of Medicinal Chemistry, September 2005, American Chemical Society (ACS)

    Professor Rahul Jain

  76. Recent Advances in New Structural Classes of Anti-Tuberculosis Agents

    Article • Current Medicinal Chemistry, August 2005, Bentham Science Publishers

    Professor Rahul Jain

  77. Synthesis, antimalarial, antileishmanial, and antimicrobial activities of some 8-quinolinamine analogues

    Article • Bioorganic & Medicinal Chemistry, July 2005, Elsevier

    Professor Rahul Jain

  78. Advancements in the Anti-Diabetes Chemotherapeutics Based on Amino Acids, Peptides, and Peptidomimetics

    Article • Mini-Reviews in Medicinal Chemistry, May 2005, Bentham Science Publishers

    Professor Rahul Jain

  79. Ring-Substituted Imidazoles as a New Class of anti-Tuberculosis Agents.

    Article • ChemInform, January 2005, Wiley

    Professor Rahul Jain

  80. Facile One-Step Synthesis of N-α-Boc-1-alkyl-L-histidines.

    Article • ChemInform, December 2004, Wiley

    Professor Rahul Jain

  81. Ring-substituted quinolines. Part 2: Synthesis and antimycobacterial activities of ring-substituted quinolinecarbohydrazide and ring-substituted quinolinecarboxamide analogues

    Article • Bioorganic & Medicinal Chemistry, December 2004, Elsevier

    Professor Rahul Jain

  82. Facile one-step synthesis of N-α-Boc-1-alkyl-l-histidines

    Article • Tetrahedron Letters, September 2004, Elsevier

    Professor Rahul Jain

  83. Ring-substituted imidazoles as a new class of anti-tuberculosis agents

    Article • European Journal of Medicinal Chemistry, September 2004, Elsevier

    Professor Rahul Jain

  84. Synthesis and antimycobacterial activities of ring-substituted quinolinecarboxylic acid/ester analogues. Part 1

    Article • Bioorganic & Medicinal Chemistry, August 2004, Elsevier

    Professor Rahul Jain

  85. Ring-substituted quinolines as potential anti-tuberculosis agents

    Article • Bioorganic & Medicinal Chemistry, May 2004, Elsevier

    Professor Rahul Jain

  86. Synthesis and blood-schizontocidal antimalarial activities of 2-substituted/2,5-disubstituted-8-quinolinamines and some of their amino acid conjugates

    Article • Bioorganic & Medicinal Chemistry, March 2004, Elsevier

    Professor Rahul Jain

  87. 8-Quinolinamines conjugated with amino acids are exhibiting potent blood-schizontocidal antimalarial activities

    Article • Bioorganic & Medicinal Chemistry, January 2004, Elsevier

    Professor Rahul Jain

  88. Discovery of a Bulky 2- tert -Butyl Group Containing Primaquine Analogue That Exhibits Potent Blood-Schizontocidal Antimalarial Activities and Complete Elimination of Methemoglobin Toxicity

    Article • Journal of Medicinal Chemistry, January 2004, American Chemical Society (ACS)

    Professor Rahul Jain

  89. Trityl-Directed Regiospecific Synthesis of 2,3-Disubstituted Bioimidazoles.

    Article • ChemInform, December 2003, Wiley

    Professor Rahul Jain

  90. 8-Quinolinamines and Their pro prodrug conjugates as potent blood-Schizontocidal antimalarial agents

    Article • Bioorganic & Medicinal Chemistry, October 2003, Elsevier

    Professor Rahul Jain

  91. Substituted 4-Methylquinolines as a New Class of anti-Tuberculosis Agents.

    Article • ChemInform, July 2003, Wiley

    Professor Rahul Jain

  92. Substituted 4-methylquinolines as a new class of anti-tuberculosis agents

    Article • Bioorganic & Medicinal Chemistry Letters, March 2003, Elsevier

    Professor Rahul Jain

  93. Trityl-Directed Regiospecific Synthesis of 2,3-Disubstituted Bioimidazoles

    Article • Synthetic Communications, January 2003, Taylor & Francis

    Professor Rahul Jain

  94. Antimalarial activities of ring-substituted bioimidazoles

    Article • Bioorganic & Medicinal Chemistry Letters, July 2002, Elsevier

    Professor Rahul Jain

  95. Synthesis and biology of new thyrotropin-Releasing hormone (TRH) analogues

    Article • Bioorganic & Medicinal Chemistry, January 2002, Elsevier

    Professor Rahul Jain

  96. CONVENIENT N-PROTECTION OF L-PYROGLUTAMIC ACID ESTERS

    Article • Organic Preparations and Procedures International, August 2001, Taylor & Francis

    Professor Rahul Jain

  97. Regiospecific Synthesis of 2,3-Disubstituted-l-Histidines and Histamines

    Article • Bioorganic & Medicinal Chemistry Letters, May 2001, Elsevier

    Professor Rahul Jain

  98. Highly Potent Cyclic Disulfide Antagonists of Somatostatin

    Article • Journal of Medicinal Chemistry, June 1999, American Chemical Society (ACS)

    Professor Rahul Jain

  99. Synthesis of ring-halogenated histidines and histamines

    Article • Tetrahedron, March 1998, Elsevier

    Professor Rahul Jain

  100. Potent Antagonists of Somatostatin:  Synthesis and Biology

    Article • Journal of Medicinal Chemistry, March 1998, American Chemical Society (ACS)

    Professor Rahul Jain

  101. Role of the Extracellular Loops of the Thyrotropin-Releasing Hormone Receptor:  Evidence for an Initial Interaction with Thyrotropin-Releasing Hormone †

    Article • Biochemistry, December 1997, American Chemical Society (ACS)

    Professor Rahul Jain

  102. Synthesis of novel ring-substituted histidines and histamines

    Article • Tetrahedron, March 1997, Elsevier

    Professor Rahul Jain

  103. Regiospecific alkylation of histidine and histamine at C-2

    Article • Tetrahedron, February 1997, Elsevier

    Professor Rahul Jain

  104. Regiospecific alkylation of histidine and histamine at N-1 (τ)

    Article • Tetrahedron, April 1996, Elsevier

    Professor Rahul Jain

  105. Survey of Nonxanthine Derivatives as Adenosine Receptor Ligands

    Article • Nucleosides and Nucleotides, January 1996, Taylor & Francis

    Professor Rahul Jain

  106. Lactam acetals : Part XXIV reaction with activated haloalkyl compounds with and without zinc

    Article • Tetrahedron Letters, May 1994, Elsevier

    Professor Rahul Jain

  107. A novel synthesis of di(1-methylazacycloalkeno)[2,3-b:2′,3′-d]pyridines through annulation on lactam acetals

    Article • Tetrahedron Letters, January 1990, Elsevier

    Professor Rahul Jain

  108. Somatostatin receptor antagonists based on a mixed neuromedin B antagonist/somatostatin agonist

    Article • Springer Science + Business Media

    Professor Rahul Jain