All Stories

  1. Conformational studies of pathogenic expanded polyglutamine protein deposits from Huntington’s disease

    Article • Experimental Biology and Medicine, June 2019, SAGE Publications

    Dr Patrick C A van der Wel

  2. Surface-Binding to Cardiolipin Nanodomains Triggers Cytochrome c Pro-apoptotic Peroxidase Activity via Localized Dynamics

    Article • Structure, March 2019, Elsevier

    Dr Patrick C A van der Wel

  3. Structural Fingerprinting of Protein Aggregates by Dynamic Nuclear Polarization-Enhanced Solid-State NMR at Natural Isotopic Abundance

    Article • Journal of the American Chemical Society, October 2018, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  4. Hidden motions and motion-induced invisibility: Dynamics-based spectral editing in solid-state NMR

    Article • April 2018, Elsevier

    Dr Patrick C A van der Wel

  5. New applications of solid-state NMR in structural biology

    Article • Emerging Topics in Life Sciences, February 2018, Portland Press Ltd.

    Dr Patrick C A van der Wel

  6. Methionine oxidized apolipoprotein A‐I at the crossroads of HDL biogenesis and amyloid formation

    Article • The FASEB Journal, January 2018, Wiley

    Dr Patrick C A van der Wel

  7. Energetics Underlying Twist Polymorphisms in Amyloid Fibrils

    Article • The Journal of Physical Chemistry B, January 2018, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  8. Fibril polymorphism affects immobilized non-amyloid flanking domains of huntingtin exon1 rather than its polyglutamine core

    Article • Nature Communications, May 2017, Springer Science + Business Media

    Dr Patrick C A van der Wel

  9. Cataract-associated P23T γD-crystallin retains a native-like fold in amorphous-looking aggregates formed at physiological pH

    Article • Nature Communications, May 2017, Springer Science + Business Media

    Dr Patrick C A van der Wel

  10. On the use of ultracentrifugal devices for routine sample preparation in biomolecular magic-angle-spinning NMR

    Article • Journal of Biomolecular NMR, February 2017, Springer Science + Business Media

    Dr Patrick C A van der Wel

  11. Backbone Engineering within a Latent β-Hairpin Structure to Design Inhibitors of Polyglutamine Amyloid Formation

    Article • January 2017, Elsevier

    Dr Patrick C A van der Wel

  12. MAS 1 H NMR Probes Freezing Point Depression of Water and Liquid-Gel Phase Transitions in Liposomes

    Article • November 2016, Elsevier

    Dr Patrick C A van der Wel

  13. Peptide-Directed Assembly of Single-Helical Gold Nanoparticle Superstructures Exhibiting Intense Chiroptical Activity

    Article • Journal of the American Chemical Society, October 2016, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  14. Huntingtin exon 1 fibrils feature an interdigitated β-hairpin–based polyglutamine core

    Article • Proceedings of the National Academy of Sciences, February 2016, Proceedings of the National Academy of Sciences

    Dr Patrick C A van der Wel

  15. Structural Changes and Proapoptotic Peroxidase Activity of Cardiolipin-Bound Mitochondrial Cytochrome c

    Article • November 2015, Elsevier

    Dr Patrick C A van der Wel

  16. Polyglutamine Amyloid Core Boundaries and Flanking Domain Dynamics in Huntingtin Fragment Fibrils Determined by Solid-State Nuclear Magnetic Resonance

    Article • Biochemistry, October 2014, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  17. Lipid Dynamics and Protein-Lipid Interactions in Integral Membrane Proteins: Insights from Solid-State NMR

    Article • March 2014, Wiley

    Dr Patrick C A van der Wel

  18. How Amyloid Precursor Protein Protects Itself from Cleavage

    Article • March 2014, Elsevier

    Dr Patrick C A van der Wel

  19. d-Polyglutamine Amyloid Recruits l-Polyglutamine Monomers and Kills Cells

    Article • Journal of Molecular Biology, February 2014, Elsevier

    Dr Patrick C A van der Wel

  20. Spinning-rate encoded chemical shift correlations from rotational resonance solid-state NMR experiments

    Article • May 2013, Elsevier

    Dr Patrick C A van der Wel

  21. β-Hairpin-Mediated Nucleation of Polyglutamine Amyloid Formation

    Article • Journal of Molecular Biology, April 2013, Elsevier

    Dr Patrick C A van der Wel

  22. Serine Phosphorylation Suppresses Huntingtin Amyloid Accumulation by Altering Protein Aggregation Properties

    Article • Journal of Molecular Biology, November 2012, Elsevier

    Dr Patrick C A van der Wel

  23. In support of the BMRB

    Article • Nature Structural & Molecular Biology, September 2012, Springer Science + Business Media

    Dr Patrick C A van der Wel, Dr. Alexandre M.J.J. Bonvin, Professor Michele Vendruscolo

  24. Domain swapping and amyloid fibril conformation

    Article • Prion, July 2012, Taylor & Francis

    Dr Patrick C A van der Wel

  25. Lipid Dynamics and Protein–Lipid Interactions in 2D Crystals Formed with the β-Barrel Integral Membrane Protein VDAC1

    Article • Journal of the American Chemical Society, March 2012, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  26. Structural Characterization of the Caveolin Scaffolding Domain in Association with Cholesterol-Rich Membranes

    Article • Biochemistry, December 2011, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  27. Structural Complexity of a Composite Amyloid Fibril

    Article • Journal of the American Chemical Society, September 2011, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  28. Amyloid-like Fibrils from a Domain-swapping Protein Feature a Parallel, in-Register Conformation without Native-like Interactions

    Article • Journal of Biological Chemistry, June 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Patrick C A van der Wel

  29. The Aggregation-Enhancing Huntingtin N-Terminus Is Helical in Amyloid Fibrils

    Article • Journal of the American Chemical Society, March 2011, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  30. Structural Characterization of GNNQQNY Amyloid Fibrils by Magic Angle Spinning NMR

    Article • Biochemistry, November 2010, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  31. Time Averaging of NMR Chemical Shifts in the MLF Peptide in the Solid State

    Article • Journal of the American Chemical Society, May 2010, American Chemical Society (ACS)

    Professor Michele Vendruscolo, Dr Patrick C A van der Wel

  32. Dynamic nuclear polarization-enhanced solid-state NMR spectroscopy of GNNQQNY nanocrystals and amyloid fibrils

    Article • Physical Chemistry Chemical Physics, January 2010, Royal Society of Chemistry

    Dr Patrick C A van der Wel

  33. High-resolution solid-state NMR structure of Alanyl-Prolyl-Glycine

    Article • September 2009, Elsevier

    Dr Patrick C A van der Wel

  34. Targeted13C-13C Distance Measurements in a Microcrystalline Protein via J-Decoupled Rotational Resonance Width Measurements

    Article • ChemPhysChem, July 2009, Wiley

    Dr Patrick C A van der Wel

  35. Cryogenic sample exchange NMR probe for magic angle spinning dynamic nuclear polarization

    Article • June 2009, Elsevier

    Dr Patrick C A van der Wel

  36. Observation of a Low-Temperature, Dynamically Driven Structural Transition in a Polypeptide by Solid-State NMR Spectroscopy

    Article • Journal of the American Chemical Society, January 2009, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  37. High-Field Dynamic Nuclear Polarization for Solid and Solution Biological NMR

    Article • Applied Magnetic Resonance, August 2008, Springer Science + Business Media

    Dr Patrick C A van der Wel

  38. Dynamic nuclear polarization at high magnetic fields

    Article • The Journal of Chemical Physics, February 2008, American Institute of Physics

    Dr Patrick C A van der Wel

  39. Helical Distortion in Tryptophan- and Lysine-Anchored Membrane-Spanning α-Helices as a Function of Hydrophobic Mismatch: A Solid-State Deuterium NMR Investigation Using the Geometric Analysis of Labeled Alanines Method

    Article • January 2008, Elsevier

    Dr Patrick C A van der Wel

  40. Peptide Influences on Lipids

    Article • September 2007, Wiley

    Dr Patrick C A van der Wel

  41. Orientation and Motion of Tryptophan Interfacial Anchors in Membrane-Spanning Peptides†

    Article • Biochemistry, June 2007, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  42. Solid-State NMR Study of Amyloid Nanocrystals and Fibrils Formed by the Peptide GNNQQNY from Yeast Prion Protein Sup35p

    Article • Journal of the American Chemical Society, April 2007, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  43. Dynamic Nuclear Polarization of Amyloidogenic Peptide Nanocrystals:  GNNQQNY, a Core Segment of the Yeast Prion Protein Sup35p

    Article • Journal of the American Chemical Society, August 2006, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  44. Multipole-multimode Floquet theory of rotational resonance width experiments: C13–C13 distance measurements in uniformly labeled solids

    Article • The Journal of Chemical Physics, June 2006, American Institute of Physics

    Dr Patrick C A van der Wel

  45. Importance of Tensor Asymmetry for the Analysis of2H NMR Spectra from Deuterated Aromatic Rings

    Article • Journal of the American Chemical Society, December 2005, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  46. Complexes obtained by electrophilic attack on a dinitrogen-derived terminal molybdenum nitride: electronic structure analysis by solid state CP/MAS 15N NMR in combination with DFT calculations

    Article • Polyhedron, November 2004, Elsevier

    Dr Patrick C A van der Wel

  47. Tilt Angles of Transmembrane Model Peptides in Oriented and Non-Oriented Lipid Bilayers as Determined by 2 H Solid-State NMR

    Article • June 2004, Elsevier

    Dr Patrick C A van der Wel

  48. Combined Experimental/Theoretical Refinement of Indole Ring Geometry Using Deuterium Magnetic Resonance and ab Initio Calculations

    Article • Journal of the American Chemical Society, October 2003, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  49. Hydrophobic Mismatch between Helices and Lipid Bilayers

    Article • January 2003, Elsevier

    Dr Patrick C A van der Wel

  50. Lipid Dependence of Membrane Anchoring Properties and Snorkeling Behavior of Aromatic and Charged Residues in Transmembrane Peptides†

    Article • Biochemistry, June 2002, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  51. Optimized aminolysis conditions for cleavage of N-protected hydrophobic peptides from solid-phase resins

    Article • Journal of Peptide Research, June 2001, Wiley

    Dr Patrick C A van der Wel

  52. Tryptophan-Anchored Transmembrane Peptides Promote Formation of Nonlamellar Phases in Phosphatidylethanolamine Model Membranes in a Mismatch-Dependent Manner†

    Article • Biochemistry, March 2000, American Chemical Society (ACS)

    Dr Patrick C A van der Wel

  53. Modulation of membrane structure and function by hydrophobic mismatch between proteins and lipids

    Article • Pure and Applied Chemistry, January 1998, De Gruyter

    Dr Patrick C A van der Wel