All Stories

  1. Resident mesenchymal vascular progenitors modulate adaptive angiogenesis and pulmonary remodeling via regulation of canonical Wnt signaling

    Article • The FASEB Journal, June 2020, Wiley

    Patrick Geraghty

  2. Should we worry about children's exposure to third-hand by-products generated from electronic nicotine delivery systems?

    Article • ERJ Open Research, April 2020, European Respiratory Society (ERS)

    Patrick Geraghty

  3. Protein Phosphatase 2A Reduces Cigarette Smoke–induced Cathepsin S and Loss of Lung Function

    Article • American Journal of Respiratory and Critical Care Medicine, July 2019, American Thoracic Society

    Patrick Geraghty

  4. Cigarette smoke exposure reduces leukemia inhibitory factor levels during respiratory syncytial viral infection

    Article • International Journal of Chronic Obstructive Pulmonary Disease, June 2019, Dove Medical Press

    Patrick Geraghty

  5. Cystic fibrosis disease severity correlates with plasma levels of desmosine and isodesmosine, biomarkers of elastin degradation

    Article • ERJ Open Research, April 2019, European Respiratory Society (ERS)

    Patrick Geraghty, Associate Professor Cormac McCarthy

  6. Smoke inhalation activates a cancer related gene that impacts on COPD

    Article • American Journal of Respiratory Cell and Molecular Biology, December 2018, American Thoracic Society

    Patrick Geraghty

  7. Phospholipid transfer protein and alpha-1 antitrypsin regulate Hck kinase activity during neutrophil degranulation

    Article • Scientific Reports, October 2018, Springer Science + Business Media

    Patrick Geraghty

  8. Fibroblast growth factor 23 and Klotho contribute to airway inflammation

    Article • European Respiratory Journal, May 2018, European Respiratory Society (ERS)

    Patrick Geraghty

  9. Klotho Inhibits Interleukin-8 Secretion from Cystic Fibrosis Airway Epithelia

    Article • Scientific Reports, October 2017, Springer Science + Business Media

    Patrick Geraghty

  10. Neutrophil Membrane Cholesterol Content is a Key Factor in Cystic Fibrosis Lung Disease

    Article • EBioMedicine, September 2017, Elsevier

    Patrick Geraghty

  11. HIV infection model of chronic obstructive pulmonary disease in mice

    Article • AJP Lung Cellular and Molecular Physiology, April 2017, American Physiological Society

    Patrick Geraghty

  12. Chronic electronic cigarette exposure in mice induces features of COPD in a nicotine-dependent manner

    Article • Thorax, August 2016, BMJ

    Patrick Geraghty

  13. TLR9 expression is required for the development of cigarette smoke-induced emphysema in mice

    Article • AJP Lung Cellular and Molecular Physiology, July 2016, American Physiological Society

    Patrick Geraghty

  14. Cigarette smoke inhibits ROCK2 activation in T cells and modulates IL-22 production

    Article • Molecular Immunology, March 2016, Elsevier

    Patrick Geraghty

  15. Mesenchymal Tumorigenesis Driven by TSC2 Haploinsufficiency Requires HMGA2 and Is Independent of mTOR Pathway Activation

    Article • Cancer Research, February 2016, American Association for Cancer Research (AACR)

    Patrick Geraghty

  16. Protein tyrosine phosphatase 1B negatively regulates S100A9-mediated lung damage during respiratory syncytial virus exacerbations

    Article • Mucosal Immunology, January 2016, Springer Science + Business Media

    Patrick Geraghty

  17. Glutathione Peroxidase-1 Suppresses the Unfolded Protein Response upon Cigarette Smoke Exposure

    Article • Mediators of Inflammation, January 2016, Hindawi Publishing Corporation

    Patrick Geraghty

  18. Matrix Metalloproteinase 9 Exerts Antiviral Activity against Respiratory Syncytial Virus

    Article • PLoS ONE, August 2015, PLOS

    Patrick Geraghty

  19. Integrative Analysis of DNA Methylation and Gene Expression Data Identifies EPAS1 as a Key Regulator of COPD

    Article • PLoS Genetics, January 2015, PLOS

    Dr CHARLES A POWELL, Patrick Geraghty

  20. α1-Antitrypsin Activates Protein Phosphatase 2A to Counter Lung Inflammatory Responses

    Article • American Journal of Respiratory and Critical Care Medicine, December 2014, American Thoracic Society

    Patrick Geraghty

  21. Leukemia inhibitory factor protects the lung during respiratory syncytial viral infection

    Article • BMC Immunology, October 2014, Springer Science + Business Media

    Patrick Geraghty

  22. Type-I interferons induce lung protease responses following respiratory syncytial virus infection via RIG-I-like receptors

    Article • Mucosal Immunology, July 2014, Springer Science + Business Media

    Patrick Geraghty

  23. Cigarette Smoke Activates the Proto-Oncogene c-Src to Promote Airway Inflammation and Lung Tissue Destruction

    Article • American Journal of Respiratory Cell and Molecular Biology, March 2014, American Thoracic Society

    Patrick Geraghty

  24. Respiratory Syncytial Virus Infections Enhance Cigarette Smoke Induced COPD in Mice

    Article • PLoS ONE, February 2014, PLOS

    Patrick Geraghty

  25. Cathepsin G degradation of phospholipid transfer protein (PLTP) augments pulmonary inflammation

    Article • The FASEB Journal, February 2014, Federation of American Societies For Experimental Biology (FASEB)

    Patrick Geraghty

  26. The Glutathione Peroxidase 1–Protein Tyrosine Phosphatase 1B–Protein Phosphatase 2A Axis. A Key Determinant of Airway Inflammation and Alveolar Destruction

    Article • American Journal of Respiratory Cell and Molecular Biology, November 2013, American Thoracic Society

    Patrick Geraghty

  27. Protein Transfection of Mouse Lung

    Article • Journal of Visualized Experiments, May 2013, MyJove Corporation

    Patrick Geraghty

  28. Increased Matrix Metalloproteinase (MMPs) Levels Do Not Predict Disease Severity or Progression in Emphysema

    Article • PLoS ONE, February 2013, PLOS

    Patrick Geraghty

  29. STAT3 modulates cigarette smoke-induced inflammation and protease expression

    Article • Frontiers in Physiology, January 2013, Frontiers

    Patrick Geraghty

  30. Intracellular Secretory Leukoprotease Inhibitor Modulates Inositol 1,4,5-Triphosphate Generation and Exerts an Anti-Inflammatory Effect on Neutrophils of Individuals with Cystic Fibrosis and Chronic Obstructive Pulmonary Disease

    Article • BioMed Research International, January 2013, Hindawi Publishing Corporation

    Patrick Geraghty

  31. A Comparison of the Inflammatory and Proteolytic Effects of Dung Biomass and Cigarette Smoke Exposure in the Lung

    Article • PLoS ONE, December 2012, PLOS

    Patrick Geraghty

  32. Protein Phosphatase 2A Regulates Innate Immune and Proteolytic Responses to Cigarette Smoke Exposure in the Lung

    Article • Toxicological Sciences, January 2012, Oxford University Press (OUP)

    Patrick Geraghty

  33. TLR4 Protein Contributes to Cigarette Smoke-induced Matrix Metalloproteinase-1 (MMP-1) Expression in Chronic Obstructive Pulmonary Disease

    Article • Journal of Biological Chemistry, July 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Patrick Geraghty

  34. Induction of the unfolded protein response by cigarette smoke is primarily an activating transcription factor 4-C/EBP homologous protein mediated process

    Article • International Journal of Chronic Obstructive Pulmonary Disease, June 2011, Taylor & Francis

    Patrick Geraghty

  35. Activation of the Epidermal Growth Factor Receptor (EGFR) by a Novel Metalloprotease Pathway

    Article • Journal of Biological Chemistry, September 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Patrick Geraghty

  36. Alpha-1-antitrypsin aerosolised augmentation abrogates neutrophil elastase-induced expression of cathepsin B and matrix metalloprotease 2 in vivo and in vitro

    Article • Thorax, July 2008, BMJ

    Patrick Geraghty

  37. Secretory Leucocyte Protease Inhibitor Inhibits Interferon-γ-induced Cathepsin S Expression

    Article • Journal of Biological Chemistry, September 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Patrick Geraghty

  38. Neutrophil Elastase Up-Regulates Cathepsin B and Matrix Metalloprotease-2 Expression

    Article • The Journal of Immunology, April 2007, The American Association of Immunologists

    Patrick Geraghty

  39. Antimicrobial proteins and polypeptides in pulmonary innate defence

    Article • February 2006, Springer Science + Business Media

    Patrick Geraghty

  40. Disruption of mitochondrial function in Candida albicans leads to reduced cellular ergosterol levels and elevated growth in the presence of amphotericin B

    Article • Archives of Microbiology, March 2003, Springer Science + Business Media

    Patrick Geraghty

  41. Erythromycin, an inhibitor of mitoribosomal protein biosynthesis, alters the amphotericin B susceptibility ofCandida albicans

    Article • Journal of Pharmacy and Pharmacology, February 2003, Wiley

    Patrick Geraghty