All Stories

  1. Decoding Drug Metabolism: How Machine Learning is Revolutionizing Drug Development

    Article • Current Drug Metabolism, November 2022, Bentham Science Publishers

    Professor Parames C Sil, KRISHNENDU SINHA

  2. Can We Use mTOR Inhibitors for COVID-19 Therapy?

    Article • Combinatorial Chemistry & High Throughput Screening, September 2022, Bentham Science Publishers

    Prof. Maciej Banach, Prof. MA Kamal, Professor Parames C Sil, Maryam Khayatkashani

  3. Mangiferin: A xanthonoid with multipotent anti-inflammatory potential

    Article • BioFactors, May 2016, Wiley

    Professor Parames C Sil

  4. Attenuative role of mangiferin in oxidative stress-mediated liver dysfunction in arsenic-intoxicated murines

    Article • BioFactors, March 2016, Wiley

    Professor Parames C Sil

  5. Cytochrome P450s: Mechanisms and Biological Implications in Drug Metabolism and its Interaction with Oxidative Stress

    Article • Current Drug Metabolism, January 2015, Bentham Science Publishers

    Professor Parames C Sil

  6. Genistein: A Phytoestrogen with Multifaceted Therapeutic Properties

    Article • Mini-Reviews in Medicinal Chemistry, October 2014, Bentham Science Publishers

    Professor Parames C Sil

  7. Iron oxide nanoparticles mediated cytotoxicity via PI3K/AKT pathway: Role of quercetin

    Article • Food and Chemical Toxicology, September 2014, Elsevier

    Professor Parames C Sil

  8. Taurine attenuates nano-copper-induced oxidative hepatic damage via mitochondria-dependent and NF-κB/TNF-α-mediated pathway

    Article • Toxicology Research, July 2014, Oxford University Press (OUP)

    Professor Parames C Sil

  9. Cadmium (Cd2+) exposure differentially elicits both cell proliferation and cell death related responses in SK-RC-45

    Article • Toxicology in Vitro, March 2014, Elsevier

    Professor Parames C Sil

  10. Amelioration of Aspirin Induced Oxidative Impairment and Apoptotic Cell Death by a Novel Antioxidant Protein Molecule Isolated from the Herb Phyllanthus niruri

    Article • PLoS ONE, February 2014, PLOS

    Professor Parames C Sil

  11. The Protective Role of Taurine in Cardiac Oxidative Stress under Diabetic Conditions

    Article • January 2014, Elsevier

    Professor Parames C Sil

  12. Nanotoxicity: Oxidative Stress Mediated Toxicity of Metal and Metal Oxide Nanoparticles

    Article • Journal of Nanoscience and Nanotechnology, January 2014, American Scientific Publishers

    Professor Parames C Sil

  13. An update on oxidative stress-mediated organ pathophysiology

    Article • Food and Chemical Toxicology, December 2013, Elsevier

    Professor Parames C Sil

  14. Effect of Kombucha, a fermented black tea in attenuating oxidative stress mediated tissue damage in alloxan induced diabetic rats

    Article • Food and Chemical Toxicology, October 2013, Elsevier

    Professor Parames C Sil

  15. Arjunolic acid: A new multifunctional therapeutic promise of alternative medicine

    Article • Biochimie, June 2013, Elsevier

    Professor Parames C Sil

  16. Role of Sulfur Containing Amino Acids as an Adjuvant Therapy in the Prevention of Diabetes and its Associated Complications

    Article • Current Diabetes Reviews, April 2013, Bentham Science Publishers

    Professor Parames C Sil

  17. Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis

    Article • Archives of Toxicology, March 2013, Springer Science + Business Media

    Professor Parames C Sil

  18. The prophylactic role ofd-saccharic acid-1,4-lactone against hyperglycemia-induced hepatic apoptosis via inhibition of both extrinsic and intrinsic pathways in diabetic rats

    Article • Food & Function, January 2013, Royal Society of Chemistry

    Professor Parames C Sil

  19. Taurine ameliorate alloxan induced oxidative stress and intrinsic apoptotic pathway in the hepatic tissue of diabetic rats

    Article • Food and Chemical Toxicology, January 2013, Elsevier

    Professor Parames C Sil

  20. Iron induces hepatocytes death via MAPK activation and mitochondria-dependent apoptotic pathway: Beneficial role of glycine

    Article • Free Radical Research, August 2012, Taylor & Francis

    Professor Parames C Sil

  21. A 43 kD protein from the leaves of the herb Cajanus indicus L. modulates doxorubicin induced nephrotoxicity via MAPKs and both mitochondria dependent and independent pathways

    Article • Biochimie, June 2012, Elsevier

    Professor Parames C Sil

  22. Arjunolic acid: beneficial role in type 1 diabetes and its associated organ pathophysiology

    Article • Free Radical Research, May 2012, Taylor & Francis

    Professor Parames C Sil

  23. Doxorubicin-induced neurotoxicity is attenuated by a 43-kD protein from the leaves ofCajanus indicusL. via NF-κB and mitochondria dependent pathways

    Article • Free Radical Research, April 2012, Taylor & Francis

    Professor Parames C Sil

  24. Tertiary butyl hydroperoxide induced oxidative damage in mice erythrocytes: Protection by taurine

    Article • Pathophysiology, April 2012, Elsevier

    Professor Parames C Sil

  25. Traditional extract of Pithecellobium dulce fruits protects mice against CCl4 induced renal oxidative impairments and necrotic cell death

    Article • Pathophysiology, April 2012, Elsevier

    Professor Parames C Sil

  26. Taurine protects murine hepatocytes against oxidative stress-induced apoptosis by tert-butyl hydroperoxide via PI3K/Akt and mitochondrial-dependent pathways

    Article • Food Chemistry, April 2012, Elsevier

    Professor Parames C Sil

  27. Mangiferin exerts hepatoprotective activity against D-galactosamine induced acute toxicity and oxidative/nitrosative stress via Nrf2–NFκB pathways

    Article • Toxicology and Applied Pharmacology, April 2012, Elsevier

    Professor Parames C Sil

  28. Impaired redox signaling and mitochondrial uncoupling contributes vascular inflammation and cardiac dysfunction in type 1 diabetes: Protective role of arjunolic acid

    Article • Biochimie, March 2012, Elsevier

    Professor Parames C Sil

  29. Taurine ameliorates alloxan-induced diabetic renal injury, oxidative stress-related signaling pathways and apoptosis in rats

    Article • Amino Acids, February 2012, Springer Science + Business Media

    Professor Parames C Sil

  30. Protective role of D-saccharic acid-1,4-lactone in alloxan induced oxidative stress in the spleen tissue of diabetic rats is mediated by suppressing mitochondria dependent apoptotic pathway

    Article • Free Radical Research, January 2012, Taylor & Francis

    Professor Parames C Sil

  31. D(+) galactosamine induced oxidative and nitrosative stress-mediated renal damage in rats via NF-κB and inducible nitric oxide synthase (iNOS) pathways is ameliorated by a polyphenol xanthone, mangiferin

    Article • Free Radical Research, January 2012, Taylor & Francis

    Professor Parames C Sil

  32. Mechanism of the protective action of taurine in toxin and drug induced organ pathophysiology and diabetic complications: a review

    Article • Food & Function, January 2012, Royal Society of Chemistry

    Professor Parames C Sil

  33. Taurine exerts hypoglycemic effect in alloxan-induced diabetic rats, improves insulin-mediated glucose transport signaling pathway in heart and ameliorates cardiac oxidative stress and apoptosis

    Article • Toxicology and Applied Pharmacology, January 2012, Elsevier

    Professor Parames C Sil

  34. Nano-copper induces oxidative stress and apoptosis in kidney via both extrinsic and intrinsic pathways

    Article • Toxicology, December 2011, Elsevier

    Professor Parames C Sil

  35. d-saccharic acid-1,4-lactone ameliorates alloxan-induced diabetes mellitus and oxidative stress in rats through inhibiting pancreatic beta-cells from apoptosis via mitochondrial dependent pathway

    Article • Toxicology and Applied Pharmacology, December 2011, Elsevier

    Professor Parames C Sil

  36. Cajanus indicus leaf protein: Beneficial role in experimental organ pathophysiology. A review

    Article • Pathophysiology, September 2011, Elsevier

    Professor Parames C Sil

  37. The protective role of arjunolic acid against doxorubicin induced intracellular ROS dependent JNK-p38 and p53-mediated cardiac apoptosis

    Article • Biomaterials, July 2011, Elsevier

    Professor Parames C Sil

  38. Hepatoprotective properties of kombucha tea against TBHP-induced oxidative stress via suppression of mitochondria dependent apoptosis

    Article • Pathophysiology, June 2011, Elsevier

    Professor Parames C Sil

  39. Involvement of both intrinsic and extrinsic pathways in hepatoprotection of arjunolic acid against cadmium induced acute damage in vitro

    Article • Toxicology, May 2011, Elsevier

    Professor Parames C Sil

  40. Prophylactic role of D‐saccharic acid‐1,4‐lactone in tertiary butyl hydroperoxide induced cytotoxicity and cell death of murine hepatocytes via mitochondria‐dependent pathways

    Article • Journal of Biochemical and Molecular Toxicology, April 2011, Wiley

    Professor Parames C Sil

  41. Taurine protects rat testes against doxorubicin-induced oxidative stress as well as p53, Fas and caspase 12-mediated apoptosis

    Article • Amino Acids, April 2011, Springer Science + Business Media

    Professor Parames C Sil

  42. Structure, photophysics, electrochemistry, DFT calculation, and in-vitro antioxidant activity of coumarin Schiff base complexes of Group 6 metal carbonyls

    Article • Journal of Inorganic Biochemistry, April 2011, Elsevier

    Professor Parames C Sil

  43. Taurine suppresses doxorubicin-triggered oxidative stress and cardiac apoptosis in rat via up-regulation of PI3-K/Akt and inhibition of p53, p38-JNK

    Article • Biochemical Pharmacology, April 2011, Elsevier

    Professor Parames C Sil

  44. Protective role of a coumarin-derived schiff base scaffold against tertiary butyl hydroperoxide (TBHP)-induced oxidative impairment and cell death via MAPKs, NF-κB and mitochondria-dependent pathways

    Article • Free Radical Research, March 2011, Taylor & Francis

    Professor Parames C Sil

  45. Modulation of mercury-induced mitochondria-dependent apoptosis by glycine in hepatocytes

    Article • Amino Acids, March 2011, Springer Science + Business Media

    Professor Parames C Sil

  46. RETRACTED ARTICLE: Contribution of nano-copper particles to in vivo liver dysfunction and cellular damage: Role of IκBα/NF-κB, MAPKs and mitochondrial signal

    Article • Nanotoxicology, February 2011, Taylor & Francis

    Professor Parames C Sil

  47. Phytomedicinal Role of Pithecellobium dulce against CCl4‐mediated Hepatic Oxidative Impairments and Necrotic Cell Death

    Article • Evidence-based Complementary and Alternative Medicine, January 2011, Wiley

    Professor Parames C Sil

  48. Hepatotoxicity of di-(2-ethylhexyl)phthalate is attributed to calcium aggravation, ROS-mediated mitochondrial depolarization, and ERK/NF-κB pathway activation

    Article • Free Radical Biology and Medicine, December 2010, Elsevier

    Professor Parames C Sil

  49. Protective effect of the fruits of Terminalia arjuna against cadmium-induced oxidant stress and hepatic cell injury via MAPK activation and mitochondria dependent pathway

    Article • Food Chemistry, December 2010, Elsevier

    Professor Parames C Sil

  50. Protective Role of Taurine against Arsenic-Induced Mitochondria-Dependent Hepatic Apoptosis via the Inhibition of PKCδ-JNK Pathway

    Article • PLoS ONE, September 2010, PLOS

    Professor Parames C Sil

  51. Prevention of tertiary butyl hydroperoxide induced oxidative impairment and cell death by a novel antioxidant protein molecule isolated from the herb, Phyllanthus niruri

    Article • Toxicology in Vitro, September 2010, Elsevier

    Professor Parames C Sil

  52. Contribution of type 1 diabetes to rat liver dysfunction and cellular damage via activation of NOS, PARP, IκBα/NF-κB, MAPKs, and mitochondria-dependent pathways: Prophylactic role of arjunolic acid

    Article • Free Radical Biology and Medicine, June 2010, Elsevier

    Professor Parames C Sil

  53. Streptozotocin induced activation of oxidative stress responsive splenic cell signaling pathways: Protective role of arjunolic acid

    Article • Toxicology and Applied Pharmacology, April 2010, Elsevier

    Professor Parames C Sil

  54. Arjunolic acid, a triterpenoid saponin, prevents acetaminophen (APAP)-induced liver and hepatocyte injury via the inhibition of APAP bioactivation and JNK-mediated mitochondrial protection

    Article • Free Radical Biology and Medicine, February 2010, Elsevier

    Professor Parames C Sil

  55. Taurine protects acetaminophen-induced oxidative damage in mice kidney through APAP urinary excretion and CYP2E1 inactivation

    Article • Toxicology, February 2010, Elsevier

    Professor Parames C Sil

  56. Acetaminophen induced renal injury via oxidative stress and TNF-α production: Therapeutic potential of arjunolic acid

    Article • Toxicology, January 2010, Elsevier

    Professor Parames C Sil

  57. Acetaminophen induced acute liver failure via oxidative stress and JNK activation: Protective role of taurine by the suppression of cytochrome P450 2E1

    Article • Free Radical Research, January 2010, Taylor & Francis

    Professor Parames C Sil

  58. Induction of necrosis in cadmium-induced hepatic oxidative stress and its prevention by the prophylactic properties of taurine

    Article • Journal of Trace Elements in Medicine and Biology, November 2009, Elsevier

    Professor Parames C Sil

  59. Taurine prevents arsenic-induced cardiac oxidative stress and apoptotic damage: Role of NF-κB, p38 and JNK MAPK pathway

    Article • Toxicology and Applied Pharmacology, October 2009, Elsevier

    Professor Parames C Sil

  60. Prophylactic role of arjunolic acid in response to streptozotocin mediated diabetic renal injury: Activation of polyol pathway and oxidative stress responsive signaling cascades

    Article • Chemico-Biological Interactions, October 2009, Elsevier

    Professor Parames C Sil

  61. Taurine protects rat testes against NaAsO2-induced oxidative stress and apoptosis via mitochondrial dependent and independent pathways

    Article • Toxicology Letters, June 2009, Elsevier

    Professor Parames C Sil

  62. Purification and characterisation of a novel antioxidant protein molecule from Phyllanthus niruri

    Article • Food Chemistry, June 2009, Elsevier

    Professor Parames C Sil

  63. Arsenic-induced oxidative cerebral disorders: Protection by taurine

    Article • Drug and Chemical Toxicology, April 2009, Taylor & Francis

    Professor Parames C Sil

  64. Protective role of arjunolic acid in response to streptozotocin-induced type-I diabetes via the mitochondrial dependent and independent pathways

    Article • Toxicology, March 2009, Elsevier

    Professor Parames C Sil

  65. Protection of acetaminophen induced mitochondrial dysfunctions and hepatic necrosis via Akt-NF-κB pathway: Role of a novel plant protein

    Article • Chemico-Biological Interactions, January 2009, Elsevier

    Professor Parames C Sil

  66. Cytoprotective effect of arjunolic acid in response to sodium fluoride mediated oxidative stress and cell death via necrotic pathway

    Article • Toxicology in Vitro, December 2008, Elsevier

    Professor Parames C Sil

  67. Terminalia arjuna Protects Mouse Hearts Against Sodium Fluoride-Induced Oxidative Stress

    Article • Journal of Medicinal Food, December 2008, Mary Ann Liebert Inc

    Professor Parames C Sil

  68. Cadmium induced testicular pathophysiology: Prophylactic role of taurine

    Article • Reproductive Toxicology, November 2008, Elsevier

    Professor Parames C Sil

  69. Arjunolic acid attenuates arsenic-induced nephrotoxicity

    Article • Pathophysiology, October 2008, Elsevier

    Professor Parames C Sil

  70. Taurine provides antioxidant defense against NaF-induced cytotoxicity in murine hepatocytes

    Article • Pathophysiology, October 2008, Elsevier

    Professor Parames C Sil

  71. Amelioration of cadmium-induced cardiac impairment by taurine

    Article • Chemico-Biological Interactions, July 2008, Elsevier

    Professor Parames C Sil

  72. Cadmium‐induced neurological disorders: prophylactic role of taurine

    Article • Journal of Applied Toxicology, June 2008, Wiley

    Professor Parames C Sil

  73. RETRACTED ARTICLE: Taurine plays a beneficial role against cadmium-induced oxidative renal dysfunction

    Article • Amino Acids, April 2008, Springer Science + Business Media

    Professor Parames C Sil

  74. Protection of arsenic-induced testicular oxidative stress by arjunolic acid

    Article • Redox Report, April 2008, Taylor & Francis

    Professor Parames C Sil

  75. Protective effect of arjunolic acid against arsenic‐induced oxidative stress in mouse brain

    Article • Journal of Biochemical and Molecular Toxicology, February 2008, Wiley

    Professor Parames C Sil

  76. Arsenic-induced oxidative myocardial injury: protective role of arjunolic acid

    Article • Archives of Toxicology, January 2008, Springer Science + Business Media

    Professor Parames C Sil

  77. A Protein from Cajanus indicus Spreng Protects Liver and Kidney against Mercuric Chloride-Induced Oxidative Stress

    Article • Biological and Pharmaceutical Bulletin, January 2008, Pharmaceutical Society of Japan

    Professor Parames C Sil

  78. Taurine, a conditionally essential amino acid, ameliorates arsenic-induced cytotoxicity in murine hepatocytes

    Article • Toxicology in Vitro, December 2007, Elsevier

    Professor Parames C Sil

  79. Arjunolic acid, a triterpenoid saponin, ameliorates arsenic-induced cyto-toxicity in hepatocytes

    Article • Chemico-Biological Interactions, December 2007, Elsevier

    Professor Parames C Sil

  80. Hepatocytes are protected by herb Phyllanthus niruri protein isolate against thioacetamide toxicity

    Article • Pathophysiology, October 2007, Elsevier

    Professor Parames C Sil

  81. Phytomedicinal activity of Terminalia arjuna against carbon tetrachloride induced cardiac oxidative stress

    Article • Pathophysiology, October 2007, Elsevier

    Professor Parames C Sil

  82. Protection of Arsenic‐Induced Hepatic Disorder by Arjunolic Acid

    Article • Basic & Clinical Pharmacology & Toxicology, September 2007, Wiley

    Professor Parames C Sil

  83. A 43kD protein from the herb, Cajanus indicus L., protects against fluoride induced oxidative stress in mice erythrocytes

    Article • Pathophysiology, May 2007, Elsevier

    Professor Parames C Sil

  84. Protein isolate from the herb, Phyllanthus niruri L. (Euphorbiaceae), plays hepatoprotective role against carbon tetrachloride induced liver damage via its antioxidant properties

    Article • Food and Chemical Toxicology, May 2007, Elsevier

    Professor Parames C Sil

  85. Amelioration of galactosamine-induced nephrotoxicity by a protein isolated from the leaves of the herb, Cajanus indicus L

    Article • BMC Complementary and Alternative Medicine, April 2007, Springer Science + Business Media

    Professor Parames C Sil

  86. Galactosamine‐induced hepatotoxic effect and hepatoprotective role of a protein isolated from the herb Cajanus indicus L in vivo

    Article • Journal of Biochemical and Molecular Toxicology, March 2007, Wiley

    Professor Parames C Sil

  87. Protective role ofPhyllanthus niruri against nimesulide induced hepatic damage

    Article • Indian Journal of Clinical Biochemistry, March 2007, Springer Science + Business Media

    Professor Parames C Sil

  88. Aqueous extract of the bark of Terminalia arjuna plays a protective role against sodium-fluoride-induced hepatic and renal oxidative stress

    Article • Journal of Natural Medicines, February 2007, Springer Science + Business Media

    Professor Parames C Sil

  89. Attenuation of cadmium chloride induced cytotoxicity in murine hepatocytes by a protein isolated from the leaves of the herb Cajanus indicus L.

    Article • Archives of Toxicology, January 2007, Springer Science + Business Media

    Professor Parames C Sil

  90. Protein Isolate from the HerbPhyllanthus niruriModulates Carbon Tetrachloride-Induced Cytotoxicity in Hepatocytes

    Article • Toxicology Mechanisms and Methods, January 2007, Taylor & Francis

    Professor Parames C Sil

  91. Attenuation of Acetaminophen-Induced Hepatotoxicity In Vivo and In Vitro by a 43-kD Protein Isolated from the HerbCajanus indicusL

    Article • Toxicology Mechanisms and Methods, January 2007, Taylor & Francis

    Professor Parames C Sil

  92. Purification and Characterization of a 43 kD Hepatoprotective Protein from the Herb Cajanus indicus L.

    Article • The Protein Journal, September 2006, Springer Science + Business Media

    Professor Parames C Sil

  93. A 43kDa protein from the herb Cajanus indicus L. protects thioacetamide induced cytotoxicity in hepatocytes

    Article • Toxicology in Vitro, August 2006, Elsevier

    Professor Parames C Sil

  94. The protein fraction of Phyllanthus niruri plays a protective role against acetaminophen induced hepatic disorder via its antioxidant properties

    Article • Phytotherapy Research, May 2006, Wiley

    Professor Parames C Sil

  95. Herbal (Phyllanthus niruri) protein isolate protects liver from nimesulide induced oxidative stress

    Article • Pathophysiology, May 2006, Elsevier

    Professor Parames C Sil

  96. A 43-kDa Protein from the Leaves of the HerbCajanus indicusL. Modulates Chloroform Induced HepatotoxicityIn Vitro

    Article • Drug and Chemical Toxicology, January 2006, Taylor & Francis

    Professor Parames C Sil

  97. Characterization and functional significance of myotrophin: A gene with multiple transcripts

    Article • Gene, June 2005, Elsevier

    Professor Parames C Sil

  98. Regulation of myotrophin gene by pressure overload and stretch

    Article • Molecular and Cellular Biochemistry, July 2004, Springer Science + Business Media

    Professor Parames C Sil