All Stories

  1. Self-assembled proteomimetic (SAP) with antibody-like binding from short PNA–peptide conjugates
  2. Identification of immunodominant linear epitopes from SARS-CoV-2 patient plasma
  3. PNA-encoded chemical libraries
  4. Identifizierung von niedermolekularen kovalenten Bromodomäne-Bindern aus einer DNA-kodierten Bibliothek
  5. Identification of Covalent Bromodomain Binders through DNA Display of Small Molecules
  6. DNA display of fragment pairs as a tool for the discovery of novel biologically active small molecules
  7. In cellulo protein labelling with Ru-conjugate for luminescence imaging and bioorthogonal photocatalysis
  8. PNA-Encoded Synthesis (PES) of a 10 000-Member Hetero-Glycoconjugate Library and Microarray Analysis of Diverse Lectins
  9. A LecA Ligand Identified from a Galactoside-Conjugate Array Inhibits Host Cell Invasion byPseudomonas aeruginosa
  10. A LecA Ligand Identified from a Galactoside-Conjugate Array Inhibits Host Cell Invasion byPseudomonas aeruginosa
  11. Synthesis of sesquiterpene-inspired derivatives designed for covalent binding and their inhibition of the NF-κB pathway
  12. Nucleic Acid-tagged Peptides: Encoding Libraries and Controlling Dimerization and Conformation
  13. Rapid miRNA Imaging in Cells Using Fluorogenic Templated Staudinger Reaction Between PNA-Based Probes
  14. Assembly of PNA-Tagged Small Molecules, Peptides, and Carbohydrates onto DNA Templates: Programming the Combinatorial Pairing and Inter-ligand Distance
  15. Picture Perfect: DNA-Templated Photoaffinity Labeling
  16. Following the Lead from Nature: Divergent Pathways in Natural Product Synthesis and Diversity-Oriented Synthesis (Eur. J. Org. Chem. 20/2013)
  17. Reactions Templated by Nucleic Acids: More Ways to Translate Oligonucleotide-Based Instructions into Emerging Function
  18. Corrigendum: Expanding the Scope of PNA-Encoded Synthesis (PES): Mtt-Protected PNA Fully Orthogonal to Fmoc Chemistry and a Broad Array of Robust Diversity-Generating Reactions
  19. Nucleic Acid-programmed Assemblies: Translating Instruction into Function in Chemical Biology
  20. Following the Lead from Nature: Divergent Pathways in Natural Product Synthesis and Diversity-Oriented Synthesis
  21. Detection of miRNA in Live Cells by Using Templated RuII-Catalyzed Unmasking of a Fluorophore
  22. DNA as a Platform to Program Assemblies with Emerging Functions in Chemical Biology
  23. Self-Assembled Antibody Multimers through Peptide Nucleic Acid Conjugation
  24. Selective affinity-based probe for oncogenic kinases suitable for live cell imaging
  25. Solid phase synthesis of glycopeptides using Shoda's activation of unprotected carbohydrates
  26. Photoreductive Uncaging of Fluorophore in Response to Protein Oligomers by Templated Reaction in Vitro and in Cellulo
  27. Expanding the Scope of PNA-Encoded Synthesis (PES): Mtt-Protected PNA Fully Orthogonal to Fmoc Chemistry and a Broad Array of Robust Diversity-Generating Reactions
  28. DNA display of PNA-tagged ligands
  29. Asymmetric Synthesis of Pochonin E and F, Revision of Their Proposed Structure, and Their Conversion to Potent Hsp90 Inhibitors
  30. Diversity-Oriented Synthesis of Diverse Polycyclic Scaffolds Inspired by the Logic of Sesquiterpene Lactones Biosynthesis
  31. Diversity-Oriented Synthesis of Diverse Polycyclic Scaffolds Inspired by the Logic of Sesquiterpene Lactones Biosynthesis
  32. Nucleic Acid Templated Uncaging of Fluorophores Using Ru-Catalyzed Photoreduction with Visible Light
  33. Discovery of an entropically-driven small molecule streptavidin binder from nucleic acid-encoded libraries
  34. Synthesis of deguelin–biotin conjugates and investigation into deguelin’s interactions
  35. Nucleic Acid-Templated Energy Transfer Leading to a Photorelease Reaction and its Application to a System Displaying a Nonlinear Response
  36. Polyubiquitination of Transforming Growth Factor   (TGF )-associated Kinase 1 Mediates Nuclear Factor- B Activation in Response to Different Inflammatory Stimuli
  37. Cysteine Mapping in Conformationally Distinct Kinase Nucleotide Binding Sites: Application to the Design of Selective Covalent Inhibitors
  38. Selection of a synthetic glycan oligomer from a library of DNA-templated fragments against DC-SIGN and inhibition of HIV gp120 binding to dendritic cells
  39. DNA-templated release of functional molecules with an azide-reduction-triggered immolative linker
  40. Rapid fluorescence imaging of miRNAs in human cells using templated Staudinger reaction
  41. DNA-templated combinatorial assembly of small molecule fragments amenable to selection/amplification cycles
  42. The Molecular Chaperone Hsp90α Is Required for Meiotic Progression of Spermatocytes beyond Pachytene in the Mouse
  43. Combinatorial Self-Assembly of Glycan Fragments into Microarrays
  44. Substrate screening identifies a novel target sequence for the proteasomal activity regulated by ionizing radiation
  45. Concise Modular Asymmetric Synthesis of Deguelin, Tephrosin and Investigation into Their Mode of Action
  46. ChemInform Abstract: A Versatile Method for Parallel Synthesis
  47. ChemInform Abstract: Synthesis of Epothilones A and B in Solid and Solution Phase.
  48. The Novel Hsp90 Inhibitor NXD30001 Induces Tumor Regression in a Genetically Engineered Mouse Model of Glioblastoma Multiforme
  49. ChemInform Abstract: Synthesis of the Macrocyclic Core of Sanglifehrin A.
  50. ChemInform Abstract: Total Synthesis and Chemical Biology of the Sarcodictyins
  51. Autoactivation of Transforming Growth Factor  -activated Kinase 1 Is a Sequential Bimolecular Process
  52. ChemInform Abstract: The Art and Science of Total Synthesis and the Dawn of the Twenty-First Century
  53. Metathesis Reactions in Solid-Phase Organic Synthesis
  54. ChemInform Abstract: Synthesis and Biological Evaluation of Vancomycin Dimers with Potent Activity Against Vancomycin-Resistant Bacteria: Target-Accelerated Combinatorial Synthesis.
  55. ChemInform Abstract: Solid- and Solution-Phase Synthesis of Vancomycin and Vancomycin Analogues with Activity Against Vancomycin-Resistant Bacteria.
  56. Cover Picture: Molecular Editing of Kinase-Targeting Resorcylic Acid Lactones (RAL): Fluoroenone RAL (ChemMedChem 5/2010)
  57. Molecular Editing of Kinase-Targeting Resorcylic Acid Lactones (RAL): Fluoroenone RAL
  58. Ligand dimerization programmed by hybridization to study multimeric ligand–receptor interactions
  59. Clickable peptide nucleic acids (cPNA) with tunable affinity
  60. Substrate screening identifies a novel target sequence for the proteasomal activity regulated by ionizing radiation
  61. ChemInform Abstract: High-Throughput Synthesis of Natural Products
  62. Selection of bead-displayed, PNA-encoded chemicals
  63. Inhibition of HSP90 with Pochoximes: SAR and Structure-Based Insights
  64. Cover Picture: Divergent Syntheses of Resorcylic Acid Lactones: L-783277, LL-Z1640-2, and Hypothemycin / Synthesis of a Resorcylic Acid Lactone (RAL) Library Using Fluorous-Mixture Synthesis and Profile of its Selectivity Against a Panel of Kinases (Chem.
  65. Divergent Syntheses of Resorcylic Acid Lactones: L-783277, LL-Z1640-2, and Hypothemycin
  66. Synthesis of a Resorcylic Acid Lactone (RAL) Library Using Fluorous-Mixture Synthesis and Profile of its Selectivity Against a Panel of Kinases
  67. DNA-Templated Homo- and Heterodimerization of Peptide Nucleic Acid Encoded Oligosaccharides that Mimick the Carbohydrate Epitope of HIV
  68. DNA-Templated Homo- and Heterodimerization of Peptide Nucleic Acid Encoded Oligosaccharides that Mimick the Carbohydrate Epitope of HIV
  69. The HSP90 binding mode of a radicicol-like E-oxime determined by docking, binding free energy estimations, and NMR 15N chemical shifts
  70. Synthesis of pochoxime prodrugs as potent HSP90 inhibitors
  71. Imaging of mRNA in Live Cells Using Nucleic Acid-Templated Reduction of Azidorhodamine Probes
  72. Self-Assembly of PNA-Encoded Peptides into Microarrays
  73. Resorcylic acid lactones: A pluripotent scaffold with therapeutic potential
  74. Divergent Synthesis of a Pochonin Library Targeting HSP90 and In Vivo Efficacy of an Identified Inhibitor
  75. Divergent Synthesis of a Pochonin Library Targeting HSP90 and In Vivo Efficacy of an Identified Inhibitor
  76. Nucleic acid encoding to program self-assembly in chemical biology
  77. Diversity-oriented synthesis of novel polycyclic scaffolds using polymer-bound reagents
  78. A Highly Efficient Azide-Based Protecting Group for Amines and Alcohols.
  79. Modular Synthesis of Radicicol A and Related Resorcylic Acid Lactones, Potent Kinase Inhibitors
  80. Modular Synthesis of Radicicol A and Related Resorcylic Acid Lactones, Potent Kinase Inhibitors
  81. Azidomethyl Carbamate and Carbonate: Cleavage with Polymeric Phosphine
  82. IPy2BF4-Mediated Glycosylation and Glycosyl Fluoride Formation.
  83. Chemical Biology: From Small Molecules to Systems Biology and Drug Design. Edited by Stuart L. Schreiber, Tarun Kapoor, and Günther Wess.
  84. Expanding the scope of PNA-encoded libraries: divergent synthesis of libraries targeting cysteine, serine and metallo-proteases as well as tyrosine phosphatases
  85. A Highly Efficient Azide-Based Protecting Group for Amines and Alcohols
  86. Chemistry and Biology of Resorcylic Acid Lactones
  87. IPy2BF4-Mediated Glycosylation and Glycosyl Fluoride Formation
  88. Chemistry and biology of resorcylic acid lactones
  89. Fluorescence-based detection of single nucleotide permutation in DNA via catalytically templated reaction
  90. Diversity-Oriented Synthesis of Pochonins and Biological Evaluation against a Panel of Kinases
  91. Methods in Molecular Medicine 114: Microarrays in Clinical Diagnostics. Edited by Thomas O. Joos and Paolo Fortina.
  92. Self-Assembled Small-Molecule Microarrays for Protease Screening and Profiling
  93. Modular Asymmetric Synthesis of Aigialomycin D, a Kinase-Inhibitory Scaffold
  94. Modular Asymmetric Synthesis of Aigialomycin D, a Kinase-Inhibitory Scaffold
  95. Concise Synthesis of Pochonin A, and HSP90 Inhibitor.
  96. Microarray-based functional protein profiling using peptide nucleic acid-encoded libraries
  97. PNA Encoding (PNA=peptide nucleic acid): From Solution-Based Libraries to Organized Microarrays
  98. Concise Synthesis of Pochonin A, an HSP90 Inhibitor
  99. Solution- and Solid-Phase Synthesis of Radicicol (Monorden) and Pochonin C
  100. Design, Synthesis, and Biological Evaluation of HSP90 Inhibitors Based on Conformational Analysis of Radicicol and Its Analogues
  101. Modular Asymmetric Synthesis of Pochonin C (I).
  102. Development of a Functionalized Xenon Biosensor
  103. PNA-Encoded Protease Substrate Microarrays
  104. Activity Profile of Dust Mite Allergen Extract Using Substrate Libraries and Functional Proteomic Microarrays
  105. Synthesis of a PNA-encoded cysteine protease inhibitor library
  106. Modular Asymmetric Synthesis of Pochonin C
  107. Applications of laser-polarized 129xe to biomolecular assays
  108. Azidopeptide Nucleic Acid. An Alternative Strategy for Solid-Phase Peptide Nucleic Acid (PNA) Synthesis
  109. Profiling protein function with small molecule microarrays
  110. From Split-Pool Libraries to Spatially Addressable Microarrays and Its Application to Functional Proteomic Profiling
  111. Solid- and Solution-Phase Synthesis of Vancomycin and Vancomycin Analogues with Activity against Vancomycin-Resistant Bacteria
  112. Synthesis and Biological Evaluation of Vancomycin Dimers with Potent Activity against Vancomycin-Resistant Bacteria: Target-Accelerated Combinatorial Synthesis
  113. Cover Picture
  114. Cover Picture
  115. A New Photolabile Linker for the Photoactivation of Carboxyl Groups
  116. Target-Accelerated Combinatorial Synthesis and Discovery of Highly Potent Antibiotics Effective Against Vancomycin-Resistant Bacteria
  117. Target-Accelerated Combinatorial Synthesis and Discovery of Highly Potent Antibiotics Effective Against Vancomycin-Resistant Bacteria
  118. Total Synthesis of 16-Desmethylepothilone B, Epothilone B10, Epothilone F, and Related Side Chain Modified Epothilone B Analogues
  119. New Selenium-Based Safety-Catch Linkers: Solid-Phase Semisynthesis of Vancomycin
  120. New Selenium-Based Safety-Catch Linkers: Solid-Phase Semisynthesis of Vancomycin
  121. The Art and Science of Total Synthesis at the Dawn of the Twenty-First Century
  122. The Art and Science of Total Synthesis at the Dawn of the Twenty-First Century
  123. Total Synthesis of Vancomycin—Part 4: Attachment of the Sugar Moieties and Completion of the Synthesis
  124. Total Synthesis of Vancomycin
  125. Totalsynthese von Vancomycin
  126. Synthesis of the macrocyclic core of sanglifehrin A
  127. Total Synthesis and Chemical Biology of the Sarcodictyins.
  128. Solid-Phase Synthesis of Macrocyclic Systems by a Cyclorelease Strategy: Application of the Stille Coupling to a Synthesis of (S)-Zearalenone
  129. The Art and Science of Organic and Natural Products Synthesis
  130. Solid and Solution Phase Synthesis and Biological Evaluation of Combinatorial Sarcodictyin Libraries
  131. Solid-Phase Synthesis of Oligosaccharides: Construction of a Dodecasaccharide
  132. Solid-Phase Synthesis of Oligosaccharides: Construction of a Dodecasaccharide
  133. Solid Phase Synthesis of Macrocycles by an Intramolecular Ketophosphonate Reaction. Synthesis of a ( dl )-Muscone Library
  134. Polymer-supported selenium reagents for organic synthesis
  135. Gezielt entworfene Epothilone: kombinatorische Synthese, Induktion der Tubulin-Polymerisation und cytotoxische Wirkung gegen taxolresistente Tumorzellen
  136. Synthesis of epothilones A and B in solid and solution phase
  137. A General and Highly Efficient Solid Phase Synthesis of Oligosaccharides. Total Synthesis of a Heptasaccharide Phytoalexin Elicitor (HPE)
  138. Multiple simultaneous synthesis of phenolic libraries
  139. Chemical Technologies: Probing Biology with Small Molecules