All Stories

  1. DNA fragment conformations in adducts with Kiteplatin

    Article • Dalton Transactions, January 2015, Royal Society of Chemistry

    Dr Nicola Margiotta

  2. Computational evidence for structural consequences of kiteplatin damage on DNA

    Article • JBIC Journal of Biological Inorganic Chemistry, November 2014, Springer Science + Business Media

    Dr Nicola Margiotta

  3. Monofunctional Platinum(II) Complexes with Potent Tumor Cell Growth Inhibitory Activity: The Effect of a Hydrogen-Bond Donor/Acceptor N-Heterocyclic Ligand

    Article • ChemMedChem, May 2014, Wiley

    Dr Nicola Margiotta

  4. Synthesis, Characterization, and in Vitro Evaluation of a New TSPO-Selective Bifunctional Chelate Ligand

    Article • ACS Medicinal Chemistry Letters, April 2014, American Chemical Society (ACS)

    Dr Nicola Margiotta

  5. Reactivity of kiteplatin with S-donor biomolecules and nucleotides

    Article • Dalton Transactions, January 2014, Royal Society of Chemistry

    Dr Nicola Margiotta

  6. Synthesis, characterization, and in vitro evaluation of new coordination complexes of platinum(ii) and rhenium(i) with a ligand targeting the translocator protein (TSPO)

    Article • Dalton Transactions, January 2014, Royal Society of Chemistry

    Dr Nicola Margiotta

  7. Synthesis, Characterization, and Binding to the Translocator Protein (18 kDa, TSPO) of a New Rhenium Complex as a Model of Radiopharmaceutical Agents

    Article • Zeitschrift für anorganische und allgemeine Chemie, June 2013, Wiley

    Dr Nicola Margiotta

  8. NMR Investigation of the Spontaneous Thermal- and/or Photoinduced Reduction of trans Dihydroxido Pt(IV) Derivatives

    Article • Inorganic Chemistry, February 2013, American Chemical Society (ACS)

    Dr Nicola Margiotta

  9. A model radiopharmaceutical agent targeted to translocator protein 18 kDa (TSPO)

    Article • Dalton Transactions, January 2013, Royal Society of Chemistry

    Dr Nicola Margiotta

  10. Silica xerogels and hydroxyapatite nanocrystals for the local delivery of platinum–bisphosphonate complexes in the treatment of bone tumors: A mini-review

    Article • Journal of Inorganic Biochemistry, December 2012, Elsevier

    Dr Nicola Margiotta

  11. Metallo-drugs in the treatment of malignant pleural mesothelioma

    Article • Inorganica Chimica Acta, December 2012, Elsevier

    Dr Nicola Margiotta

  12. Thermodynamic and Mechanistic Insights into Translesion DNA Synthesis Catalyzed by Y-Family DNA Polymerase Across a Bulky Double-Base Lesion of an Antitumor Platinum Drug

    Article • Chemistry - A European Journal, October 2012, Wiley

    Dr Nicola Margiotta

  13. Revisiting [PtCl2(cis-1,4-DACH)]: An Underestimated Antitumor Drug with Potential Application to the Treatment of Oxaliplatin-Refractory Colorectal Cancer

    Article • Journal of Medicinal Chemistry, August 2012, American Chemical Society (ACS)

    Dr Nicola Margiotta

  14. Dinuclear Pt(ii)-bisphosphonate complexes: a scaffold for multinuclear or different oxidation state platinum drugs

    Article • Dalton Transactions, January 2012, Royal Society of Chemistry

    Dr Nicola Margiotta

  15. Nanocrystalline carbonate-apatites: role of Ca/P ratio on the upload and release of anticancer platinum bisphosphonates

    Article • Nanoscale, January 2012, Royal Society of Chemistry

    Dr Nicola Margiotta

  16. Platinum–bisphosphonate complexes have proven to be inactive chemotherapeutics targeted for malignant mesothelioma because of inappropriate hydrolysis

    Article • Journal of Inorganic Biochemistry, April 2011, Elsevier

    Dr Nicola Margiotta

  17. Cationic intermediates in oxidative addition reactions of Cl2 to [PtCl2(cis-1,4-DACH)]

    Article • Dalton Transactions, January 2011, Royal Society of Chemistry

    Dr Nicola Margiotta

  18. Platinum(II) Complexes with Bioactive Carrier Ligands Having High Affinity for the Translocator Protein

    Article • Journal of Medicinal Chemistry, June 2010, American Chemical Society (ACS)

    Dr Nicola Margiotta

  19. Cytotoxicity, cellular uptake, glutathione and DNA interactions of an antitumor large-ring PtII chelate complex incorporating the cis-1,4-diaminocyclohexane carrier ligand

    Article • Biochemical Pharmacology, February 2010, Elsevier

    Dr Nicola Margiotta

  20. Synthesis, characterization, and cytotoxicity of dinuclear platinum-bisphosphonate complexes to be used as prodrugs in the local treatment of bone tumours

    Article • Dalton Transactions, January 2009, Royal Society of Chemistry

    Dr Nicola Margiotta

  21. Smart delivery of antitumoral platinum complexes from biomimetic hydroxyapatite nanocrystals

    Article • Journal of Materials Chemistry, January 2009, Royal Society of Chemistry

    Dr Nicola Margiotta

  22. A new dinuclear platinum complex with a nitrogen-containing geminal bisphosphonate as potential anticancer compound specifically targeted to bone tissues

    Article • Journal of Inorganic Biochemistry, December 2008, Elsevier

    Dr Nicola Margiotta

  23. Conformer Distribution in (cis-1,4-DACH)bis(guanosine-5′-phosphate)platinum(II) Adducts: A Reliable Model for DNA Adducts of Antitumoral Cisplatin

    Article • Inorganic Chemistry, February 2008, American Chemical Society (ACS)

    Dr Nicola Margiotta

  24. Synthesis and Characterization of a Platinum(II) Complex Tethered to a Ligand of the Peripheral Benzodiazepine Receptor

    Article • Journal of Medicinal Chemistry, February 2007, American Chemical Society (ACS)

    Dr Nicola Margiotta

  25. Bisphosphonate complexation and calcium doping in silica xerogels as a combined strategy for local and controlled release of active platinum antitumor compounds

    Article • Dalton Transactions, January 2007, Royal Society of Chemistry

    Dr Nicola Margiotta

  26. Novel Therapeutic Agents for Bone Resorption. Part 1. Synthesis and Protonation Thermodynamics of Poly(amido-amine)s Containing Bis-phosphonate Residues

    Article • Biomacromolecules, November 2006, American Chemical Society (ACS)

    Dr Nicola Margiotta

  27. Sterically hindered complexes of platinum(II) with planar heterocyclic nitrogen donors. A novel complex with 1-methyl-cytosine has a spectrum of activity different from cisplatin and is able of overcoming acquired cisplatin resistance

    Article • Journal of Inorganic Biochemistry, November 2006, Elsevier

    Dr Nicola Margiotta, Professor Francesco Paolo Fanizzi

  28. Platinum-Based Antitumor Drugs Containing Enantiomerically Pure α-Trifluoromethyl Alanine as Ligand

    Article • Journal of Medicinal Chemistry, November 2005, American Chemical Society (ACS)

    Dr Nicola Margiotta

  29. Platinum Complexes with the Novel Ligand Diethyl [(Methylsulfinyl)‐methyl]phosphonate (SMP): Solid‐State Characterization of Potassium Trichloro(SMP)platinum( II ) which, in Solution, Gives Dichloro(SMP)‐platinum( ...

    Article • European Journal of Inorganic Chemistry, April 2005, Wiley

    Dr Nicola Margiotta

  30. Platinum(II) Complexes with Antitumoral/Antiviral Aromatic Heterocycles:  Effect of Glutathione upon in Vitro Cell Growth Inhibition

    Article • Journal of Medicinal Chemistry, April 2005, American Chemical Society (ACS)

    Dr Nicola Margiotta

  31. Synthesis and Characterization of Platinum( II ) Complexes of Diethyl [(Methylsulfinyl)methyl]phosphonate: Potential Drugs against Bone Tumors

    Article • European Journal of Inorganic Chemistry, August 2004, Wiley

    Dr Nicola Margiotta

  32. Antiviral properties and cytotoxic activity of platinum(II) complexes with 1,10-phenanthrolines and acyclovir or penciclovir

    Article • Journal of Inorganic Biochemistry, August 2004, Elsevier

    Dr Nicola Margiotta

  33. A Molecular Tool for Measuring the Electron‐Acceptor Ability of Ligands from Crystallographic Data

    Article • European Journal of Inorganic Chemistry, April 2004, Wiley

    Dr Nicola Margiotta, Professor Francesco Paolo Fanizzi

  34. Role of Metal Ions and Hydrogen Bond Acceptorsin the Tautomeric Equilibrium of Nitro‐9[(Alkylamino)Amino]‐Acridine Drugs

    Article • Bioinorganic Chemistry and Applications, January 2004, Wiley

    Dr Nicola Margiotta

  35. Influence of steric and electronic factors in the stabilization of five-coordinate ethylene complexes of platinum(II): X-ray crystal structure of [PtCl2(2,9-dimethyl-1,10-phenanthroline-5,6-dione)]

    Article • Inorganica Chimica Acta, January 2004, Elsevier

    Dr Nicola Margiotta

  36. Mono‐ and Bis‐Guanosine Adducts of Platinum Complexes with Carrier Ligands Having In‐Plane Steric Bulk: The Case of 1,10‐Phenanthroline and 2,9‐Dimethyl‐1,10‐phenanthroline

    Article • European Journal of Inorganic Chemistry, March 2003, Wiley

    Dr Nicola Margiotta, Professor Francesco Paolo Fanizzi

  37. Addition versus substitution in the reaction of diiodo(2,9-dimethyl-1,10-phenanthroline)platinum(II) with aromatic bases. X-ray crystal structures of the substitution products with 2-amino-pyridine and 1-methyl-cytosine

    Article • Inorganica Chimica Acta, November 2002, Elsevier

    Dr Nicola Margiotta, Professor Francesco Paolo Fanizzi

  38. Synthesis, Characterisation and Antiviral Activity of Platinum(II) Complexes with 1,10-Phenanthrolines and the Antiviral Agents Acyclovir and Penciclovir

    Article • European Journal of Inorganic Chemistry, May 2001, Wiley

    Dr Nicola Margiotta, Professor Francesco Paolo Fanizzi

  39. Structure and dynamics of a platinum(II) aminophosphine complex and its nucleobase adducts

    Article • Journal of the Chemical Society Dalton Transactions, January 2001, Royal Society of Chemistry

    Dr Nicola Margiotta

  40. Influence of Carrier Ligand NH Hydrogen Bonding to the O6 and Phosphate Group of Guanine Nucleotides in Platinum Complexes with a Single Guanine Ligand

    Article • Inorganic Chemistry, January 2000, American Chemical Society (ACS)

    Dr Nicola Margiotta, Professor Francesco Paolo Fanizzi

  41. Antitumor Trans Platinum DNA Adducts: NMR and HPLC Study of the Interaction Between a trans‐Pt Iminoether Complex and the Deoxy Decamer d(CCTCGCTCTC)·d(GAGAGCGAGG)

    Article • Metal-Based Drugs, January 2000, Wiley

    Dr Nicola Margiotta

  42. Strong, Rapid Binding of a Platinum Complex to Thymine and Uracil Under Physiological Conditions

    Article • Angewandte Chemie International Edition in English, June 1997, Wiley

    Dr Nicola Margiotta

  43. Starkes und schnelles Binden eines Platinkomplexes an Thymin und Uracil unter physiologischen Bedingungen

    Article • Angewandte Chemie, June 1997, Wiley

    Dr Nicola Margiotta