All Stories

  1. Differing Effects of Parathyroid Hormone, Alendronate, and Odanacatib on Bone Formation and on the Mineralization Process in Intracortical and Endocortical Bone of Ovariectomized Rabbits

    Article • Calcified Tissue International, July 2018, Springer Science + Business Media

    Natalie A Sims

  2. IL-6 trans -signalling mediates trabecular, but not cortical, bone loss after ovariectomy

    Article • Bone, July 2018, Elsevier

    Natalie A Sims

  3. Osteoblasts Are Rapidly Ablated by Virus-Induced Systemic Inflammation following Lymphocytic Choriomeningitis Virus or Pneumonia Virus of Mice Infection in Mice

    Article • The Journal of Immunology, December 2017, The American Association of Immunologists

    Natalie A Sims

  4. Anabolic action of parathyroid hormone (PTH) does not compromise bone matrix mineral composition or maturation

    Article • Bone, December 2016, Elsevier

    Natalie A Sims

  5. Cell-specific paracrine actions of IL-6 family cytokines from bone, marrow and muscle that control bone formation and resorption

    Article • The International Journal of Biochemistry & Cell Biology, October 2016, Elsevier

    Natalie A Sims

  6. Response to “Letter to the Editor: On osteocyte density in the human body”

    Article • Bone, July 2016, Elsevier

    Natalie A Sims

  7. VPS35: Two Ways to Recycle the Parathyroid Hormone Receptor (PTH1R) in Osteoblasts

    Article • EBioMedicine, July 2016, Elsevier

    Natalie A Sims

  8. Coupling: The Influences of Immune and Bone Cells

    Article • January 2016, Elsevier

    Natalie A Sims

  9. Glycoprotein130 (Gp130)/interleukin-6 (IL-6) signalling in osteoclasts promotes bone formation in periosteal and trabecular bone

    Article • Bone, December 2015, Elsevier

    Natalie A Sims

  10. Loss of G s α in the Postnatal Skeleton Leads to Low Bone Mass and a Blunted Response to Anabolic Parathyroid Hormone Therapy

    Article • Journal of Biological Chemistry, November 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Natalie A Sims

  11. Is RANKL inhibition both anti-resorptive and anabolic in rheumatoid arthritis?

    Article • Arthritis Research & Therapy, November 2015, Springer Science + Business Media

    Natalie A Sims

  12. Correction for Chen et al., Bindarit, an Inhibitor of Monocyte Chemotactic Protein Synthesis, Protects against Bone Loss Induced by Chikungunya Virus Infection

    Article • Journal of Virology, November 2015, ASM Journals

    Natalie A Sims

  13. EphrinB2 Signalling in Osteoblast Differentiation, Bone Formation and Endochondral Ossification

    Article • Current Molecular Biology Reports, October 2015, Springer Science + Business Media

    Natalie A Sims

  14. Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP) signalling and their roles in development, adulthood, cancer and degenerative disorders

    Article • Cytokine & Growth Factor Reviews, October 2015, Elsevier

    Natalie A Sims

  15. Quantifying the osteocyte network in the human skeleton

    Article • Bone, June 2015, Elsevier

    Natalie A Sims

  16. RARγ is a negative regulator of osteoclastogenesis

    Article • The Journal of Steroid Biochemistry and Molecular Biology, June 2015, Elsevier

    Natalie A Sims

  17. The DNA Helicase Recql4 Is Required for Normal Osteoblast Expansion and Osteosarcoma Formation

    Article • PLoS Genetics, April 2015, PLOS

    Natalie A Sims

  18. Coupling Signals between the Osteoclast and Osteoblast: How are Messages Transmitted between These Temporary Visitors to the Bone Surface?

    Article • Frontiers in Endocrinology, March 2015, Frontiers

    Natalie A Sims

  19. Isolation and gene expression of haematopoietic-cell-free preparations of highly purified murine osteocytes

    Article • Bone, March 2015, Elsevier

    Natalie A Sims

  20. Calcitonin Physiology, Saved by a Lysophospholipid

    Article • Journal of Bone and Mineral Research, January 2015, Wiley

    Natalie A Sims

  21. RANKL/OPG; Critical role in bone physiology

    Article • Reviews in Endocrine and Metabolic Disorders, January 2015, Springer Science + Business Media

    Natalie A Sims

  22. Arthritogenic alphaviruses: new insights into arthritis and bone pathology

    Article • Trends in Microbiology, January 2015, Elsevier

    Natalie A Sims

  23. Embedded in bone, but looking beyond: osteocalcin, epigenetics and ectopic bone formation (ASBMR 2014)

    Article • IBMS BoneKEy, November 2014, Nature

    Natalie A Sims

  24. Regulation of cortical and trabecular bone mass by communication between osteoblasts, osteocytes and osteoclasts

    Article • Archives of Biochemistry and Biophysics, November 2014, Elsevier

    Natalie A Sims

  25. Bindarit, an Inhibitor of Monocyte Chemotactic Protein Synthesis, Protects against Bone Loss Induced by Chikungunya Virus Infection

    Article • Journal of Virology, October 2014, ASM Journals

    Natalie A Sims, Suresh Mahalingam

  26. gp130 in late osteoblasts and osteocytes is required for PTH-induced osteoblast differentiation

    Article • Journal of Endocrinology, September 2014, Bioscientifica

    Natalie A Sims

  27. Oncostatin M acting via OSMR, augments the actions of IL-1 and TNF in synovial fibroblasts

    Article • Cytokine, August 2014, Elsevier

    Natalie A Sims

  28. Myokines (muscle-derived cytokines and chemokines) including ciliary neurotrophic factor (CNTF) inhibit osteoblast differentiation

    Article • Bone, July 2014, Elsevier

    Natalie A Sims

  29. The Primary Function of gp130 Signaling in Osteoblasts Is To Maintain Bone Formation and Strength, Rather Than Promote Osteoclast Formation

    Article • Journal of Bone and Mineral Research, May 2014, Wiley

    Natalie A Sims

  30. Osteoimmunology: oncostatin M as a pleiotropic regulator of bone formation and resorption in health and disease

    Article • BoneKEy Reports, May 2014, Portico

    Natalie A Sims

  31. Decline in calcitonin receptor expression in osteocytes with age

    Article • February 2014, Bioscientifica

    Natalie A Sims

  32. Implications of Osteoblast-Osteoclast Interactions in the Management of Osteoporosis by Antiresorptive Agents Denosumab and Odanacatib

    Article • Current Osteoporosis Reports, January 2014, Springer Science + Business Media

    Natalie A Sims

  33. Coupling the activities of bone formation and resorption: a multitude of signals within the basic multicellular unit

    Article • BoneKEy Reports, January 2014, Nature

    Natalie A Sims

  34. Erratum to: Cell–Cell Signaling: Broadening Our View of the Basic Multicellular Unit

    Article • Calcified Tissue International, December 2013, Springer Science + Business Media

    Natalie A Sims

  35. New insights into osteocyte and osteoblast biology: support of osteoclast formation, PTH action and the role of Wnt16 (ASBMR 2013)

    Article • IBMS BoneKEy, December 2013, Nature

    Natalie A Sims

  36. Cell–Cell Signaling: Broadening Our View of the Basic Multicellular Unit

    Article • Calcified Tissue International, July 2013, Springer Science + Business Media

    Natalie A Sims

  37. Talking among Ourselves: Paracrine Control of Bone Formation within the Osteoblast Lineage

    Article • Calcified Tissue International, May 2013, Springer Science + Business Media

    Natalie A Sims

  38. LactatingCtcgrpNulls Lose Twice the Normal Bone Mineral Content due to Fewer Osteoblasts and More Osteoclasts, Whereas Bone Mass Is Fully Restored After Weaning in Association With Up-Regulation of Wnt Signaling and Other Novel Genes

    Article • Endocrinology, April 2013, Endocrine Society

    Natalie A Sims

  39. EphB4 enhances the process of endochondral ossification and inhibits remodeling during bone fracture repair

    Article • Journal of Bone and Mineral Research, March 2013, Wiley

    Natalie A Sims, Kate Vandyke

  40. EphrinB2/EphB4 inhibition in the osteoblast lineage modifies the anabolic response to parathyroid hormone

    Article • Journal of Bone and Mineral Research, March 2013, Wiley

    Natalie A Sims

  41. Erratum to: Ciliary Neurotrophic Factor Inhibits Bone Formation and Plays a Sex-Specific Role in Bone Growth and Remodeling

    Article • Calcified Tissue International, March 2013, Springer Science + Business Media

    Natalie A Sims

  42. Integrating Endocrine and Paracrine Influences on Bone

    Article • January 2013, Elsevier

    Natalie A Sims

  43. Basic Principles of Bone Cell Biology

    Article • January 2013, Elsevier

    Natalie A Sims

  44. Prospective Histomorphometric and DXA Evaluation of Bone Remodeling in Imatinib-Treated CML Patients: Evidence for Site-Specific Skeletal Effects

    Article • The Journal of Clinical Endocrinology & Metabolism, January 2013, Endocrine Society

    Natalie A Sims, Kate Vandyke, Seiji Fukumoto

  45. Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance

    Article • Cell Metabolism, June 2012, Elsevier

    Natalie A Sims

  46. Strain-Dependent Differences in Bone Development, Myeloid Hyperplasia, Morbidity and Mortality in Ptpn2-Deficient Mice

    Article • PLoS ONE, May 2012, PLOS

    Natalie A Sims

  47. Sustained RANKL response to parathyroid hormone in oncostatin M receptor-deficient osteoblasts converts anabolic treatment to a catabolic effect in vivo

    Article • Journal of Bone and Mineral Research, March 2012, Wiley

    Natalie A Sims

  48. Intercellular Cross-Talk Among Bone Cells: New Factors and Pathways

    Article • Current Osteoporosis Reports, March 2012, Springer Science + Business Media

    Natalie A Sims

  49. Contrasting roles of leukemia inhibitory factor in murine bone development and remodeling involve region-specific changes in vascularization

    Article • Journal of Bone and Mineral Research, February 2012, Wiley

    Natalie A Sims

  50. Leukemia inhibitory factor: A paracrine mediator of bone metabolism

    Article • Growth Factors, February 2012, Taylor & Francis

    Natalie A Sims

  51. Regulation of Sclerostin Expression by Paracrine and Endocrine Factors

    Article • Clinical Reviews in Bone and Mineral Metabolism, November 2011, Springer Science + Business Media

    Natalie A Sims

  52. Dissociation of Bone Resorption and Bone Formation in Adult Mice with a Non-Functional V-ATPase in Osteoclasts Leads to Increased Bone Strength

    Article • PLoS ONE, November 2011, PLOS

    Natalie A Sims

  53. Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance

    Article • Cell Metabolism, November 2011, Elsevier

    Natalie A Sims

  54. Gsα enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice

    Article • Journal of Clinical Investigation, September 2011, American Society for Clinical Investigation

    Natalie A Sims

  55. Skeletal recovery after weaning does not require PTHrP

    Article • Journal of Bone and Mineral Research, May 2011, Wiley

    Natalie A Sims

  56. Vaginally Administered PEGylated LIF Antagonist Blocked Embryo Implantation and Eliminated Non-Target Effects on Bone in Mice

    Article • PLoS ONE, May 2011, PLOS

    Natalie A Sims

  57. EphB/ephrin-B interactions mediate human MSC attachment, migration and osteochondral differentiation

    Article • Bone, March 2011, Elsevier

    Natalie A Sims

  58. Interactions Among Osteoblasts, Osteoclasts, and Other Cells in Bone

    Article • January 2011, Elsevier

    Natalie A Sims

  59. Tissue Inhibitor of Metalloproteinase-3 (TIMP-3) Regulates Hematopoiesis and Bone Formation In Vivo

    Article • PLoS ONE, September 2010, PLOS

    Natalie A Sims

  60. EPHs and ephrins: Many pathways to regulate osteoblasts and osteoclasts

    Article • IBMS BoneKEy, September 2010, Nature

    Natalie A Sims

  61. The tyrosine kinase inhibitor dasatinib dysregulates bone remodeling through inhibition of osteoclasts in vivo

    Article • Journal of Bone and Mineral Research, March 2010, Wiley

    Natalie A Sims, Kate Vandyke

  62. Identifying epigenetic targets in osteosarcoma and differentiating osteoblasts

    Article • Bone, March 2010, Elsevier

    Natalie A Sims

  63. Lack of Sustained Response to Teriparatide in a Patient with Adult Hypophosphatasia

    Article • The Journal of Clinical Endocrinology & Metabolism, March 2010, Endocrine Society

    Natalie A Sims

  64. Ciliary Neurotrophic Factor Inhibits Bone Formation and Plays a Sex-Specific Role in Bone Growth and Remodeling

    Article • Calcified Tissue International, February 2010, Springer Science + Business Media

    Natalie A Sims

  65. Adverse effects of valproate on bone: Defining a model to investigate the pathophysiology

    Article • Epilepsia, February 2010, Wiley

    Natalie A Sims

  66. Building bone with a SOST-PTH partnership

    Article • Journal of Bone and Mineral Research, February 2010, Wiley

    Natalie A Sims

  67. Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice

    Article • Journal of Clinical Investigation, February 2010, American Society for Clinical Investigation

    Natalie A Sims

  68. How Cells Communicate in the Bone Remodelling Process

    Article • Journal of Korean Endocrine Society, January 2010, Korean Endocrine Society (KAMJE)

    Natalie A Sims

  69. Theoretical investigation of the role of the RANK–RANKL–OPG system in bone remodeling

    Article • Journal of Theoretical Biology, January 2010, Elsevier

    Natalie A Sims

  70. gp130 signaling in bone cell biology: Multiple roles revealed by analysis of genetically altered mice

    Article • Molecular and Cellular Endocrinology, October 2009, Elsevier

    Natalie A Sims

  71. What is the true nature of the osteoblastic hematopoietic stem cell niche?

    Article • Trends in Endocrinology and Metabolism, August 2009, Elsevier

    Natalie A Sims

  72. The Chemokine Cxcl1 Is a Novel Target Gene of Parathyroid Hormone (PTH)/PTH-Related Protein in Committed Osteoblasts

    Article • Endocrinology, May 2009, Endocrine Society

    Natalie A Sims

  73. Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice

    Article • Journal of Clinical Investigation, April 2009, American Society for Clinical Investigation

    Professor Alexander Dobrovic, Natalie A Sims

  74. Molecular Mechanisms in Coupling of Bone Formation to Resorption

    Article • Critical Reviews in Eukaryotic Gene Expression, January 2009, Begell House

    Natalie A Sims

  75. Cardiotrophin-1 Is an Osteoclast-Derived Stimulus of Bone Formation Required for Normal Bone Remodeling

    Article • Journal of Bone and Mineral Research, December 2008, Wiley

    Natalie A Sims

  76. Bone remodeling: Multiple cellular interactions required for coupling of bone formation and resorption

    Article • Seminars in Cell and Developmental Biology, October 2008, Elsevier

    Natalie A Sims

  77. Model structure and control of bone remodeling: A theoretical study

    Article • Bone, August 2008, Elsevier

    Natalie A Sims

  78. Intermittent Fugu parathyroid hormone 1 (1–34) is an anabolic bone agent in young male rats and osteopenic ovariectomized rats

    Article • Bone, June 2008, Elsevier

    Natalie A Sims

  79. EphrinB2 Regulation by PTH and PTHrP Revealed by Molecular Profiling in Differentiating Osteoblasts

    Article • Journal of Bone and Mineral Research, March 2008, Wiley

    Natalie A Sims

  80. 156 A Novel Mutation in the Nfkb2 Gene Generates an NFκB2 ‘Super Repressor’

    Article • Cytokine, July 2007, Elsevier

    Natalie A Sims

  81. Rb Regulates Interactions between Hematopoietic Stem Cells and Their Bone Marrow Microenvironment

    Article • Cell, June 2007, Elsevier

    Natalie A Sims

  82. Osteoclast inhibitory lectin (OCIL) inhibits osteoblast differentiation and function in vitro

    Article • Bone, February 2007, Elsevier

    Natalie A Sims

  83. Signaling in Bone

    Article • January 2006, Elsevier

    Natalie A Sims

  84. Interleukin-11 Receptor Signaling Is Required for Normal Bone Remodeling

    Article • Journal of Bone and Mineral Research, February 2005, Wiley

    Natalie A Sims

  85. Osteoclast-derived activity in the coupling of bone formation to resorption

    Article • Trends in Molecular Medicine, February 2005, Elsevier

    Natalie A Sims

  86. Interleukin-6 modulates production of T lymphocyte–derived cytokines in antigen-induced arthritis and drives inflammation-induced osteoclastogenesis

    Article • Arthritis & Rheumatism, January 2005, Wiley

    Natalie A Sims

  87. gp130-Mediated Signaling Is Necessary for Normal Osteoblastic Functionin Vivoandin Vitro

    Article • Endocrinology, March 2004, Endocrine Society

    Natalie A Sims

  88. Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways

    Article • Journal of Clinical Investigation, February 2004, American Society for Clinical Investigation

    Natalie A Sims

  89. Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways

    Article • Journal of Clinical Investigation, February 2004, American Society for Clinical Investigation

    Natalie A Sims

  90. Targeting osteoclasts with zoledronic acid prevents bone destruction in collagen-induced arthritis

    Article • Arthritis & Rheumatism, January 2004, Wiley

    Natalie A Sims

  91. A functional androgen receptor is not sufficient to allow estradiol to protect bone after gonadectomy in estradiol receptor–deficient mice

    Article • Journal of Clinical Investigation, May 2003, American Society for Clinical Investigation

    Natalie A Sims

  92. A functional androgen receptor is not sufficient to allow estradiol to protect bone after gonadectomy in estradiol receptor–deficient mice

    Article • Journal of Clinical Investigation, May 2003, American Society for Clinical Investigation

    Natalie A Sims

  93. An Ethyl-Nitrosourea-Induced Point Mutation in Phex Causes Exon Skipping, X-Linked Hypophosphatemia, and Rickets

    Article • American Journal Of Pathology, November 2002, Elsevier

    Natalie A Sims

  94. Bone homeostasis in growth hormone receptor–null mice is restored by IGF-I but independent of Stat5

    Article • Journal of Clinical Investigation, November 2000, American Society for Clinical Investigation

    Natalie A Sims

  95. Human and Murine Osteocalcin Gene Expression: Conserved Tissue Restricted Expression and Divergent Responses to 1,25-Dihydroxyvitamin D3in Vivo

    Article • Molecular Endocrinology, October 1997, Endocrine Society

    Natalie A Sims