All Stories

  1. Mechanistic insights on the antibacterial action of the kyotorphin peptide derivatives revealed by in vitro studies and Galleria mellonella proteomic analysis

    Article • Microbial Pathogenesis, April 2024, Elsevier

    Dr Montserrat Heras

  2. Evaluation of the Anti-biofilm Efficacy of Kyotorphin Derivatives and Biosafety Assessment: In Vitro and In Vivo Investigations Targeting Bacterial and Fungal Pathogens

    Article • International Journal of Peptide Research and Therapeutics, March 2024, Springer Science + Business Media

    Dr Montserrat Heras

  3. TUTORING PROGRAM FOR FIRST-YEAR UNIVERSITY STUDENTS: AN ESSENTIAL APPROACH TO REDUCE DROPOUT RATES

    Article • March 2023, IATED Academy, S.L.

    Dr Montserrat Heras

  4. Design, synthesis, and evaluation of Bothrops venom serine protease peptidic inhibitors

    Article • Journal of Venomous Animals and Toxins including Tropical Diseases, January 2021, FapUNIFESP (SciELO)

    Dr Montserrat Heras

  5. The Neuroprotective Action of Amidated-Kyotorphin on Amyloid β Peptide-Induced Alzheimer’s Disease Pathophysiology

    Article • Frontiers in Pharmacology, July 2020, Frontiers

    Margarida Martins, Dr Montserrat Heras

  6. Antifungal and anti-biofilm activity of designed derivatives from kyotorphin

    Article • Fungal Biology, May 2020, Elsevier

    Miguel Castanho, Dr Montserrat Heras

  7. Neuropeptide Kyotorphin Impacts on Lipopolysaccharide-Induced Glucocorticoid-Mediated Inflammatory Response. A Molecular Link to Nociception, Neuroprotection, and Anti-Inflammatory Action

    Article • ACS Chemical Neuroscience, May 2017, American Chemical Society (ACS)

    Miguel Castanho, Dr Montserrat Heras

  8. Quantitative analysis of molecular partition towards lipid membranes using surface plasmon resonance

    Article • Scientific Reports, March 2017, Nature

    Miguel Castanho, Dr Montserrat Heras

  9. Endothelium-Mediated Action of Analogues of the Endogenous Neuropeptide Kyotorphin (Tyrosil-Arginine): Mechanistic Insights from Permeation and Effects on Microcirculation

    Article • ACS Chemical Neuroscience, June 2016, American Chemical Society (ACS)

    Miguel Castanho, Dr Montserrat Heras

  10. Amidated and Ibuprofen-Conjugated Kyotorphins Promote Neuronal Rescue and Memory Recovery in Cerebral Hypoperfusion Dementia Model

    Article • Frontiers in Aging Neuroscience, January 2016, Frontiers

    Miguel Castanho, Dr Montserrat Heras

  11. Improvement of the pharmacological properties of amidated kyotorphin by means of iodination

    Article • MedChemComm, January 2016, Royal Society of Chemistry

    Miguel Castanho, Dr Montserrat Heras

  12. The anti-inflammatory action of the analgesic kyotorphin neuropeptide derivatives: insights of a lipid-mediated mechanism

    Article • Amino Acids, September 2015, Springer Science + Business Media

    Miguel Castanho, Dr Montserrat Heras

  13. Synthesis of new unnatural Nα-Fmoc pyrimidin-4-one amino acids: use of the p-benzyloxybenzyloxy group as a pyrimidinone masking group

    Article • Organic & Biomolecular Chemistry, January 2015, Royal Society of Chemistry

    Dr Montserrat Heras

  14. Correlation between membrane translocation and analgesic efficacy in kyotorphin derivatives

    Article • Biopolymers, January 2015, Wiley

    Miguel Castanho, Dr Montserrat Heras

  15. DEPBT as Coupling Reagent To Avoid Racemization in a Solution-Phase Synthesis of a Kyotorphin Derivative

    Article • Synthesis, April 2014, Thieme Publishing Group

    Dr Montserrat Heras

  16. Lyngbouilloside and Related Macrolides from Marine Cyanobacteria

    Article • Natural Product Communications, July 2013, SAGE Publications

    Dr Montserrat Heras

  17. Side-effects of analgesic kyotorphin derivatives: advantages over clinical opioid drugs

    Article • Amino Acids, March 2013, Springer Science + Business Media

    Miguel Castanho, Dr Montserrat Heras

  18. Antimicrobial properties of analgesic kyotorphin peptides unraveled through atomic force microscopy

    Article • Biochemical and Biophysical Research Communications, April 2012, Elsevier

    Miguel Castanho, Dr Montserrat Heras

  19. Total Synthesis of Nominal Lyngbouilloside Aglycon

    Article • Organic Letters, December 2011, American Chemical Society (ACS)

    Dr Montserrat Heras, Dr Stellios Arseniyadis

  20. Chemical Conjugation of the Neuropeptide Kyotorphin and Ibuprofen Enhances Brain Targeting and Analgesia

    Article • Molecular Pharmaceutics, October 2011, American Chemical Society (ACS)

    Miguel Castanho, Dr Montserrat Heras

  21. Inhibition of nociceptive responses after systemic administration of amidated kyotorphin

    Article • British Journal of Pharmacology, June 2011, Wiley

    Miguel Castanho, Dr Montserrat Heras

  22. Coupling reaction between electron-rich pyrimidinones and α-amino acids promoted by phosphonium salts

    Article • Organic & Biomolecular Chemistry, January 2011, Royal Society of Chemistry

    Dr Montserrat Heras

  23. Expedient Synthesis of a Stereoisomer of Acremolide B

    Article • The Journal of Organic Chemistry, November 2010, American Chemical Society (ACS)

    Dr Montserrat Heras, Dr Stellios Arseniyadis

  24. Two Concise Total Syntheses of (−)-Bitungolide F

    Article • Organic Letters, August 2010, American Chemical Society (ACS)

    Dr Montserrat Heras, Dr Stellios Arseniyadis

  25. A simple approach for the synthesis of new pyrimidinyl α-amino acids

    Article • Tetrahedron, January 2010, Elsevier

    Dr Montserrat Heras

  26. Synthesis of pyrimidinyl arylglycines through subsequent Mitsunobu and Petasis reactions

    Article • Tetrahedron, May 2008, Elsevier

    Dr Montserrat Heras

  27. A simple approach for the regioselective synthesis of imidazo[1,2-a]pyrimidiones and pyrimido[1,2-a]pyrimidinones

    Article • Tetrahedron, February 2006, Elsevier

    Dr Montserrat Heras, Anthony Linden

  28. A Hetero-Diels−Alder Approach to Phosphonothiashikimic Acid and New Thiaglycosides

    Article • European Journal of Organic Chemistry, January 2004, Wiley

    Dr Montserrat Heras

  29. Synthesis of Triazolo[1,5‐a]triazin‐7‐one Derivatives and Highly Functionalized [1,2,4]Triazoles

    Article • Helvetica Chimica Acta, September 2003, Wiley

    Dr Montserrat Heras, Anthony Linden

  30. Solution- and Solid-Phase Parallel Synthesis of 4-Alkoxy-Substituted Pyrimidines with High Molecular Diversity

    Article • Journal of Combinatorial Chemistry, February 2003, American Chemical Society (ACS)

    Dr Montserrat Heras

  31. Development of an Efficient and Straightforward Methodology Toward the Synthesis of Molecularly Diverse 2,6-Disubstituted 3,4-Dihydropyrimidin-4(3 H )-ones

    Article • Synthesis, January 2002, Thieme Publishing Group

    Dr Montserrat Heras

  32. Synthesis of Novel 2,3-Dihydroimidazo[2,1- b ][1,3]oxazoles Through Intramolecular Nucleophilic ipso -Substitution in 2-Alkylsulfonylimidazoles

    Article • Synthesis, January 2002, Thieme Publishing Group

    Dr Montserrat Heras

  33. Reaction of α-iminomethylene amino esters with mono- and bidentate nucleophiles: a straightforward route to 2-amino-1H-5-imidazolones

    Article • Tetrahedron, May 2001, Elsevier

    Dr Montserrat Heras, Anthony Linden

  34. First synthesis of a phosphonothiashikimic acid derivative

    Article • Chemical Communications, January 2001, Royal Society of Chemistry

    Dr Montserrat Heras

  35. Phosphonodithioformates as heterodienophiles: synthesis of (3,6-dihydro-2H-thiopyran-2-yl)phosphonates

    Article • Tetrahedron Letters, September 2000, Elsevier

    Dr Montserrat Heras

  36. A New Class of Fused Imidazoles by Intramolecular Nucleophilic ipso-Substitution in 2-Alkylsulfonylimidazoles: Synthesis of 2,3-Dihydroimidazo[2,1-b][1,3]oxazoles

    Article • Synthesis, September 1999, Thieme Publishing Group

    Dr Montserrat Heras