All Stories

  1. Tau-mediated coupling between Pol III synthesis and DnaB helicase unwinding helps maintain genomic stability
  2. Dysregulated DnaB unwinding induces replisome decoupling and daughter strand gaps that are countered by RecA polymerization
  3. Gas-phase stability and thermodynamics of ligand-bound, binary complexes of chloramphenicol acetyltransferase reveal negative cooperativity
  4. Dysregulated DnaB unwinding induces replisome decoupling and daughter strand gaps that are countered by RecA polymerization
  5. Activity, substrate preference and structure of the HsMCM8/9 helicase
  6. A multi-functional role for the MCM8/9 helicase complex in maintaining fork integrity during replication stress
  7. In vivo fluorescent TUNEL detection of single stranded DNA gaps and breaks induced by dnaB helicase mutants in Escherichia coli
  8. A novel multi-functional role for the MCM8/9 helicase complex in maintaining fork integrity during replication stress
  9. Targeted chromosomal Escherichia coli:dnaB exterior surface residues regulate DNA helicase behavior to maintain genomic stability and organismal fitness
  10. Division of Chemical Toxicology Program at the American Chemical Society National Meeting: Celebrating 25 Years!
  11. A Unifying Framework for Understanding Biological Structures and Functions Across Levels of Biological Organization
  12. Targeted chromosomal Escherichia coli:dnaB exterior surface residues regulate DNA helicase behavior to maintain genomic stability and organismal fitness
  13. Motifs of the C-terminal domain of MCM9 direct localization to sites of mitomycin-C damage for RAD51 recruitment
  14. A hand-off of DNA between archaeal polymerases allows high-fidelity replication to resume at a discrete intermediate three bases past 8-oxoguanine
  15. Motifs of the C-terminal Domain of MCM9 Direct Localization to Sites of Mitomycin-C Damage for RAD51 Recruitment
  16. A hand-off of DNA between archaeal polymerases allows high-fidelity replication to resume at a discrete intermediate three bases past 8-oxoguanine
  17. Amidst multiple binding orientations on fork DNA, Saccharolobus MCM helicase proceeds N-first for unwinding
  18. Fine-tuning of the replisome: Mcm10 regulates fork progression and regression
  19. The MCM8/9 complex: A recent recruit to the roster of helicases involved in genome maintenance
  20. Contacts and context that regulate DNA helicase unwinding and replisome progression
  21. Control of Hexamerization, Assembly, and Excluded Strand Specificity for the Sulfolobus solfataricus MCM Helicase
  22. Bacterial DnaB helicase interacts with the excluded strand to regulate unwinding
  23. Coordination and Substitution of DNA Polymerases in Response to Genomic Obstacles
  24. Mechanistic insights into how CMG helicase facilitates replication past DNA roadblocks
  25. Biochemical Characterization of the Human Mitochondrial Replicative Twinkle Helicase
  26. DNA Interactions Probed by H/D Exchange FT-ICR Mass Spectrometry Confirm External Binding Sites on the MCM Helicase
  27. The excluded DNA strand is SEW important for hexameric helicase unwinding
  28. Structural Mechanisms of Hexameric Helicase Loading, Assembly, and Unwinding
  29. Crystal Structure of a Transcribing RNA Polymerase II Complex Reveals a Complete Transcription Bubble
  30. Exome sequencing reveals MCM8 mutation underlies ovarian failure and chromosomal instability
  31. MCM9 Mutations Are Associated with Ovarian Failure, Short Stature, and Chromosomal Instability
  32. Corrigendum to “Identification, quantification, and evolutionary analysis of a novel isoform of MCM9” [Gene 519 (2013) 41–49]
  33. Structure of a Highly Conserved Domain of Rock1 Required for Shroom-Mediated Regulation of Cell Morphology
  34. Assembly and Distributive Action of an Archaeal DNA Polymerase Holoenzyme
  35. A clamp-like biohybrid catalyst for DNA oxidation
  36. Novel Interaction of the Bacterial-Like DnaG Primase with the MCM Helicase in Archaea
  37. Identification, quantification, and evolutionary analysis of a novel isoform of MCM9
  38. Biochemistry: Molecular hurdles cleared with ease
  39. Differential Temperature-Dependent Multimeric Assemblies of Replication and Repair Polymerases on DNA Increase Processivity
  40. Structure of Shroom domain 2 reveals a three-segmented coiled-coil required for dimerization, Rock binding, and apical constriction
  41. Kinetics and Fidelity of Polymerization by DNA Polymerase III from Sulfolobus solfataricus
  42. Strand Annealing and Terminal Transferase Activities of a B-family DNA Polymerase
  43. Steric exclusion and wrapping of the excluded DNA strand occurs along discrete external binding paths during MCM helicase unwinding
  44. Characterization of a Functional DnaG-Type Primase in Archaea: Implications for a Dual-Primase System
  45. A trimeric DNA polymerase complex increases the native replication processivity
  46. MCM Forked Substrate Specificity Involves Dynamic Interaction with the 5'-Tail
  47. Correction
  48. Organization of the archaeal MCM complex on DNA and implications for the helicase mechanism
  49. Identification and Mapping of Protein−Protein Interactions by a Combination of Cross-Linking, Cleavage, and Proteomics
  50. Architecture of the bacteriophage T4 primosome: Electron microscopy studies of helicase (gp41) and primase (gp61)
  51. Assembly of the bacteriophage T4 primosome: Single-molecule and ensemble studies
  52. On the Solution Structure of the T4 Sliding Clamp (gp45) †
  53. 'Screw-cap' clamp loader proteins that thread
  54. Molecular biology: The loader of the rings
  55. The dynamic processivity of the T4 DNA polymerase during replication
  56. The Application of a Minicircle Substrate in the Study of the Coordinated T4 DNA Replication
  57. Dissociative Properties of the Proteins within the Bacteriophage T4 Replisome
  58. Examination of the Role of the Clamp-loader and ATP Hydrolysis in the Formation of the Bacteriophage T4 Polymerase Holoenzyme
  59. Protein-Protein Interactions in the Bacteriophage T4 Replisome: THE LEADING STRAND HOLOENZYME IS PHYSICALLY LINKED TO THE LAGGING STRAND HOLOENZYME AND THE PRIMOSOME
  60. Intricacies in ATP-Dependent Clamp Loading
  61. Dynamic protein interactions in the bacteriophage T4 replisome
  62. Building a Replisome Solution Structure by Elucidation of Protein-Protein Interactions in the Bacteriophage T4 DNA Polymerase Holoenzyme
  63. Creating a dynamic picture of the sliding clamp during T4 DNA polymerase holoenzyme assembly by using fluorescence resonance energy transfer
  64. Faculty of 1000 evaluation for A Major Role of DNA Polymerase δ in Replication of Both the Leading and Lagging DNA Strands.
  65. Faculty of 1000 evaluation for CMG helicase and DNA polymerase ε form a functional 15-subunit holoenzyme for eukaryotic leading-strand DNA replication.
  66. Faculty of 1000 evaluation for Dynamic look at DNA unwinding by a replicative helicase.
  67. Faculty of 1000 evaluation for Structures of human primase reveal design of nucleotide elongation site and mode of Pol α tethering.
  68. Faculty of 1000 evaluation for Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair.
  69. Faculty of 1000 evaluation for The Bacterial DnaC Helicase Loader Is a DnaB Ring Breaker.