Contact

All Stories

  1. Adeno-Associated virus 8 delivers an immunomodulatory peptide to mouse liver more efficiently than to rat liver

    Article • PLoS ONE, April 2023, PLOS

    Dr michael william Pennington

  2. A bioengineered probiotic for the oral delivery of a peptide Kv1.3 channel blocker to treat rheumatoid arthritis

    Article • Proceedings of the National Academy of Sciences, January 2023, Proceedings of the National Academy of Sciences

    Dr michael william Pennington

  3. A Conjugate between Lqh-8/6, a Natural Peptide Analogue of Chlorotoxin, and Doxorubicin Efficiently Induces Glioma Cell Death

    Article • Biomedicines, October 2022, MDPI AG

    Dr michael william Pennington

  4. A bioengineered probiotic for the oral delivery of a peptide Kv1.3 channel blocker to treat rheumatoid arthritis

    Article • July 2022, Cold Spring Harbor Laboratory Press

    Dr michael william Pennington

  5. Comprehensive engineering of the tarantula venom peptide huwentoxin-IV to inhibit the human voltage-gated sodium channel hNav1.7

    Article • Journal of Biological Chemistry, January 2020, Elsevier

    Dr michael william Pennington

  6. Comprehensive engineering of the tarantula venom peptide huwentoxin-IV to inhibit the human voltage-gated sodium channel hNav17

    Article • Journal of Biological Chemistry, December 2019, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr michael william Pennington

  7. The molecular evolution of feathers with direct evidence from fossils

    Article • Proceedings of the National Academy of Sciences, January 2019, Proceedings of the National Academy of Sciences

    Dr michael william Pennington

  8. Synthesis, folding, structure and activity of a predicted peptide from the sea anemone Oulactis sp. with an ShKT fold

    Article • Toxicon, August 2018, Elsevier

    Dr michael william Pennington, Professor Gyorgy Panyi

  9. Peptide therapeutics from venom: Current status and potential

    Article • Bioorganic & Medicinal Chemistry, June 2018, Elsevier

    Dr michael william Pennington

  10. Structure, synthesis and potassium channel blocking activity of a new sea anemone peptide

    Article • Peptide Science, May 2018, Wiley

    Dr michael william Pennington

  11. Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer’s disease

    Article • Molecular Neurodegeneration, May 2018, Springer Science + Business Media

    Dr michael william Pennington

  12. Corrigendum to “Structure, folding and stability of a minimal homologue from Anemonia sulcata of the sea anemone potassium channel blocker ShK” [Peptides 99 (2018) 169–178]

    Article • Peptides, March 2018, Elsevier

    Dr michael william Pennington

  13. Targeting KCa1.1 Channels with a Scorpion Venom Peptide for the Therapy of Rat Models of Rheumatoid Arthritis

    Article • Journal of Pharmacology and Experimental Therapeutics, February 2018, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr michael william Pennington

  14. Structure, folding and stability of a minimal homologue from Anemonia sulcata of the sea anemone potassium channel blocker ShK

    Article • Peptides, January 2018, Elsevier

    Dr michael william Pennington

  15. Enantioselective synthesis of Fmoc- -3-(2-benzothienyl)alanine (2-BtAla) via diastereoselective alkylation of a glycine equivalent

    Article • Tetrahedron Letters, November 2017, Elsevier

    Dr michael william Pennington

  16. Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog

    Article • Clinical Immunology, July 2017, Elsevier

    Dr michael william Pennington

  17. A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation

    Article • Journal of Neuroinflammation, June 2017, Springer Science + Business Media

    Dr michael william Pennington

  18. Distribution and kinetics of the Kv1.3-blocking peptide HsTX1[R14A] in experimental rats

    Article • Scientific Reports, June 2017, Springer Science + Business Media

    Dr michael william Pennington

  19. Reinvestigation of the biological activity of d-allo-ShK protein

    Article • Journal of Biological Chemistry, June 2017, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr michael william Pennington

  20. The Single Disulfide-Directed β-Hairpin Fold. Dynamics, Stability, and Engineering

    Article • Biochemistry, May 2017, American Chemical Society (ACS)

    Dr michael william Pennington

  21. KCa1.1 channels regulate β 1 -integrin function and cell adhesion in rheumatoid arthritis fibroblast-like synoviocytes

    Article • The FASEB Journal, April 2017, Federation of American Societies For Experimental Biology (FASEB)

    Dr michael william Pennington

  22. Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor

    Article • Scientific Reports, January 2017, Springer Science + Business Media

    Dr michael william Pennington

  23. Enabling Noninvasive Systemic Delivery of the Kv1.3-Blocking Peptide HsTX1[R14A] via the Buccal Mucosa

    Article • Journal of Pharmaceutical Sciences, July 2016, Elsevier

    Dr michael william Pennington

  24. Pulmonary Delivery of the Kv1.3-Blocking Peptide HsTX1[R14A] for the Treatment of Autoimmune Diseases

    Article • Journal of Pharmaceutical Sciences, February 2016, Elsevier

    Dr michael william Pennington

  25. N-terminally extended analogues of the K+channel toxin fromStichodactyla helianthusas potent and selective blockers of the voltage-gated potassium channel Kv1.3

    Article • FEBS Journal, April 2015, Wiley

    Dr michael william Pennington

  26. Buccal mucosal delivery of a potent peptide leads to therapeutically-relevant plasma concentrations for the treatment of autoimmune diseases

    Article • Journal of Controlled Release, February 2015, Elsevier

    Dr michael william Pennington

  27. Development of Highly Selective Kv1.3-Blocking Peptides Based on the Sea Anemone Peptide ShK

    Article • Marine Drugs, January 2015, MDPI AG

    Dr michael william Pennington

  28. FITC-Conjugated Cyclic RGD Peptides as Fluorescent Probes for Staining Integrin αvβ3/αvβ5 in Tumor Tissues

    Article • Bioconjugate Chemistry, October 2014, American Chemical Society (ACS)

    Dr michael william Pennington

  29. Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases

    Article • The FASEB Journal, June 2014, Federation of American Societies For Experimental Biology (FASEB)

    Dr michael william Pennington

  30. A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases

    Article • Scientific Reports, March 2014, Springer Science + Business Media

    Dr michael william Pennington

  31. Blocking KV1.3 Channels Inhibits Th2 Lymphocyte Function and Treats a Rat Model of Asthma

    Article • Journal of Biological Chemistry, March 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr michael william Pennington

  32. Total Synthesis of Human Hepcidin through Regioselective Disulfide-Bond Formation by using the Safety-Catch Cysteine Protecting Group 4,4′-Dimethylsulfinylbenzhydryl

    Article • Angewandte Chemie International Edition, February 2014, Wiley

    Dr michael william Pennington

  33. Blockade of Kv1.3 channels ameliorates radiation-induced brain injury

    Article • Neuro-Oncology, December 2013, Oxford University Press (OUP)

    Dr michael william Pennington

  34. A Potent and Selective Peptide Blocker of the Kv1.3 Channel: Prediction from Free-Energy Simulations and Experimental Confirmation

    Article • PLoS ONE, November 2013, PLOS

    Dr michael william Pennington

  35. Blocking KCa3.1 Channels Increases Tumor Cell Killing by a Subpopulation of Human Natural Killer Lymphocytes

    Article • PLoS ONE, October 2013, PLOS

    Dr michael william Pennington

  36. 99mTc-Galacto-RGD2: A Novel 99mTc-Labeled Cyclic RGD Peptide Dimer Useful for Tumor Imaging

    Article • Molecular Pharmaceutics, August 2013, American Chemical Society (ACS)

    Dr michael william Pennington

  37. A C-terminally amidated analogue of ShK is a potent and selective blocker of the voltage-gated potassium channel Kv1.3

    Article • FEBS Letters, October 2012, Wiley

    Dr michael william Pennington

  38. Expression and isotopic labelling of the potassium channel blocker ShK toxin as a thioredoxin fusion protein in bacteria

    Article • Toxicon, October 2012, Elsevier

    Dr michael william Pennington

  39. Durable Pharmacological Responses from the Peptide ShK-186, a Specific Kv1.3 Channel Inhibitor That Suppresses T Cell Mediators of Autoimmune Disease

    Article • Journal of Pharmacology and Experimental Therapeutics, May 2012, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr michael william Pennington

  40. Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases

    Article • Toxicon, March 2012, Elsevier

    Dr michael william Pennington

  41. Analogs of the Sea Anemone Potassium Channel Blocker ShK for the Treatment of Autoimmune Diseases

    Article • Inflammation & Allergy - Drug Targets, October 2011, Bentham Science Publishers

    Dr michael william Pennington

  42. Potassium Channel Modulation by a Toxin Domain in Matrix Metalloprotease 23

    Article • Journal of Biological Chemistry, December 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr michael william Pennington

  43. Kv1.3 potassium channels as a therapeutic target in multiple sclerosis

    Article • Expert Opinion on Therapeutic Targets, June 2009, Informa Healthcare

    Dr michael william Pennington

  44. Chemical synthesis and characterization of ShK toxin: a potent potassium channel inhibitor from a sea anemone

    Article • International journal of peptide & protein research, January 2009, Wiley

    Dr michael william Pennington

  45. Synthesis of the cardiac inotropic polypeptide anthopleurin-A

    Article • International journal of peptide & protein research, January 2009, Wiley

    Dr michael william Pennington

  46. Chemical synthesis of a neurotoxic polypeptide from the sea anemone Stichodactyla helianthus+

    Article • International journal of peptide & protein research, January 2009, Wiley

    Dr michael william Pennington

  47. Engineering a Stable and Selective Peptide Blocker of the Kv1.3 Channel in T Lymphocytes

    Article • Molecular Pharmacology, January 2009, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr michael william Pennington

  48. Efficient Synthesis of Protected L-Phosphonophenylalanine (Ppa) Derivatives Suitable for Solid Phase Synthesis

    Article • January 2009, Springer Science + Business Media

    Dr michael william Pennington

  49. Imaging of Effector Memory T Cells during a Delayed-Type Hypersensitivity Reaction and Suppression by Kv1.3 Channel Block

    Article • Immunity, October 2008, Elsevier

    Dr michael william Pennington

  50. The D-Diastereomer of ShK Toxin Selectively Blocks Voltage-gated K+Channels and Inhibits T Lymphocyte Proliferation

    Article • Journal of Biological Chemistry, November 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr michael william Pennington

  51. Characterization of the Functional Properties of the Voltage-Gated Potassium Channel Kv1.3 in Human CD4+ T Lymphocytes

    Article • The Journal of Immunology, September 2007, The American Association of Immunologists

    Dr michael william Pennington

  52. Efficient synthesis of protected l-phosphonophenylalanine (Ppa) derivatives suitable for solid phase peptide synthesis

    Article • Tetrahedron Letters, June 2007, Elsevier

    Dr michael william Pennington

  53. Targeted tyrosine iodination in a multi-tyrosine vasopressin analog

    Article • Journal of Peptide Science, January 2007, Wiley

    Dr michael william Pennington

  54. Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases

    Article • Proceedings of the National Academy of Sciences, November 2006, Proceedings of the National Academy of Sciences

    Dr michael william Pennington

  55. Potassium channels Kv1.3 and Kv1.5 are expressed on blood-derived dendritic cells in the central nervous system

    Article • Annals of Neurology, July 2006, Wiley

    Dr michael william Pennington

  56. A short practical synthesis of 2′-deoxymugineic acid

    Article • Tetrahedron Letters, February 2005, Elsevier

    Dr michael william Pennington

  57. Targeting Effector Memory T Cells with a Selective Peptide Inhibitor of Kv1.3 Channels for Therapy of Autoimmune Diseases

    Article • Molecular Pharmacology, January 2005, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr michael william Pennington

  58. Potassium Channel Blockade by the Sea Anemone Toxin ShK for the Treatment of Multiple Sclerosis and Other Autoimmune Diseases

    Article • Current Medicinal Chemistry, December 2004, Bentham Science Publishers

    Dr michael william Pennington

  59. Bass Hepcidin Synthesis, Solution Structure, Antimicrobial Activities and Synergism, and in Vivo Hepatic Response to Bacterial Infections

    Article • Journal of Biological Chemistry, November 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr michael william Pennington

  60. K+ Channel Expression during B Cell Differentiation: Implications for Immunomodulation and Autoimmunity

    Article • The Journal of Immunology, July 2004, The American Association of Immunologists

    Dr michael william Pennington

  61. Efficient Asymmetric Synthesis of (S)- and (R)-N-Fmoc-S-Trityl-α-methylcysteine Using Camphorsultam as a Chiral Auxiliary

    Article • The Journal of Organic Chemistry, June 2004, American Chemical Society (ACS)

    Dr michael william Pennington

  62. K+ channels as targets for specific immunomodulation

    Article • Trends in Pharmacological Sciences, May 2004, Elsevier

    Dr michael william Pennington

  63. Rational design and synthesis of selective BACE-1 inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, February 2004, Elsevier

    Dr michael william Pennington

  64. The voltage-gated Kv1.3 K+ channel in effector memory T cells as new target for MS

    Article • Journal of Clinical Investigation, July 2003, American Society for Clinical Investigation

    Dr michael william Pennington

  65. The Caspase-like Sites of Proteasomes, Their Substrate Specificity, New Inhibitors and Substrates, and Allosteric Interactions with the Trypsin-like Sites

    Article • Journal of Biological Chemistry, June 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr michael william Pennington

  66. The voltage-gated Kv1.3 K+ channel in effector memory T cells as new target for MS

    Article • Journal of Clinical Investigation, June 2003, American Society for Clinical Investigation

    Dr michael william Pennington

  67. An efficient asymmetric synthesis of Fmoc-l-cyclopentylglycine via diastereoselective alkylation of glycine enolate equivalent

    Article • Tetrahedron Letters, March 2003, Elsevier

    Dr michael william Pennington

  68. A Novel Fluorescent Toxin to Detect and Investigate Kv1.3 Channel Up-regulation in Chronically Activated T Lymphocytes

    Article • Journal of Biological Chemistry, January 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr michael william Pennington

  69. Mutating a Critical Lysine in ShK Toxin Alters Its Binding Configuration in the Pore−Vestibule Region of the Voltage-Gated Potassium Channel, Kv1.3†

    Article • Biochemistry, October 2002, American Chemical Society (ACS)

    Dr michael william Pennington

  70. Addition ofo-aminobenzoic acid during Fmoc solid phase synthesis of a fluorogenic substrate containing 3-nitrotyrosine

    Article • July 2002, Springer Science + Business Media

    Dr michael william Pennington

  71. Designed Peptide Analogues of the Potassium Channel Blocker ShK Toxin †

    Article • Biochemistry, December 2001, American Chemical Society (ACS)

    Dr michael william Pennington

  72. Selective blockade of T lymphocyte K+channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis

    Article • Proceedings of the National Academy of Sciences, November 2001, Proceedings of the National Academy of Sciences

    Dr michael william Pennington

  73. Potassium channels in T lymphocytes: toxins to therapeutic immunosuppressants

    Article • Toxicon, September 2001, Elsevier

    Dr michael william Pennington

  74. Structure-guided Transformation of Charybdotoxin Yields an Analog That Selectively Targets Ca2+-activated over Voltage-gated K+ Channels

    Article • Journal of Biological Chemistry, January 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr michael william Pennington

  75. Role of Disulfide Bonds in the Structure and Potassium Channel Blocking Activity of ShK Toxin†

    Article • Biochemistry, November 1999, American Chemical Society (ACS)

    Dr michael william Pennington

  76. Structural Conservation of the Pores of Calcium-activated and Voltage-gated Potassium Channels Determined by a Sea Anemone Toxin

    Article • Journal of Biological Chemistry, July 1999, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr michael william Pennington

  77. Auto-inactivation by cleavage within the dimer interface of kaposi’s sarcoma-associated herpesvirus protease

    Article • Journal of Molecular Biology, June 1999, Elsevier

    Dr michael william Pennington

  78. Article • Perspectives in Drug Discovery and Design, January 1999, Springer Science + Business Media

    Dr michael william Pennington

  79. ShK-Dap22, a Potent Kv1.3-specific Immunosuppressive Polypeptide

    Article • Journal of Biological Chemistry, December 1998, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr michael william Pennington

  80. Ionisation behaviour and solution properties of the potassium-channel blocker ShK toxin

    Article • European Journal of Biochemistry, January 1998, Wiley

    Dr michael william Pennington

  81. Secondary structure of ShK toxin, a potassium-channel-blocking peptide

    Article • Letters in Peptide Science, May 1996, Springer Science + Business Media

    Dr michael william Pennington

  82. Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone

    Article • Nature Structural & Molecular Biology, April 1996, Springer Science + Business Media

    Dr michael william Pennington

  83. Identification of Three Separate Binding Sites on SHK Toxin, a Potent Inhibitor of Voltage-Dependent Potassium Channels in Human T-Lymphocytes and Rat Brain

    Article • Biochemical and Biophysical Research Communications, February 1996, Elsevier

    Dr michael william Pennington

  84. An Essential Binding Surface for ShK Toxin Interaction with Rat Brain Potassium Channels†

    Article • Biochemistry, January 1996, American Chemical Society (ACS)

    Dr michael william Pennington

  85. Mass spectral analysis of peptides containing nitrobenzyl moieties

    Article • Letters in Peptide Science, January 1996, Springer Science + Business Media

    Dr michael william Pennington

  86. Synthesis and structural characterisation of analogues of the potassium channel blocker charybdotoxin

    Article • Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, January 1996, Elsevier

    Dr michael william Pennington

  87. A Continuous Fluorescence-Based Assay of Human Cytomegalovirus Protease Using a Peptide Substrate

    Article • Analytical Biochemistry, May 1995, Elsevier

    Dr michael william Pennington

  88. Assignment of the three disulfide bonds in ShK toxin: A potent potassium channel inhibitor from the sea anemone Stichodactyla helianthus

    Article • Letters in Peptide Science, May 1995, Springer Science + Business Media

    Dr michael william Pennington

  89. A facile method to prepare C-terminal fluorescently labelled peptides by an Fmoc strategy

    Article • Letters in Peptide Science, December 1994, Springer Science + Business Media

    Dr michael william Pennington

  90. Three-dimensional Structure in Solution of the Calcium Channel Blocker ω-Conotoxin

    Article • Journal of Molecular Biology, November 1993, Elsevier

    Dr michael william Pennington

  91. Noncompetitive Inhibition of N-Methyl-D-Aspartate by Conantokin-G: Evidence for an Allosteric Interaction at Polyamine Sites

    Article • Journal of Neurochemistry, October 1992, Wiley

    Dr michael william Pennington

  92. Synthesis and characterization of a disulfide bond isomer of omega-conotoxin GVIA

    Article • Toxicon, July 1992, Elsevier

    Dr michael william Pennington

  93. Isolation, characterization, and amino acid sequence of a polypeptide neurotoxin occurring in the sea anemone Stichodactyla helianthus

    Article • Biochemistry, April 1989, American Chemical Society (ACS)

    Dr michael william Pennington