All Stories

  1. Moving towards a systems-based classification of innate immune-mediated diseases

    Article • Nature Reviews Rheumatology, February 2020, Springer Science + Business Media

    Professor Michael McDermott

  2. ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in cystic fibrosis

    Article • eLife, September 2019, eLife

    Professor Michael McDermott

  3. Tumour necrosis factor signalling in health and disease

    Article • F1000Research, January 2019, Faculty of 1000, Ltd.

    Professor Michael McDermott, Michael McDermott

  4. Cellular stress, with activation of unfolded protein response (UPR) and microRNA, in disease.

    Article • Current Immunology Reviews, June 2018, Bentham Science Publishers

    Michael McDermott , Professor Michael McDermott

  5. Corticosteroid transdermal delivery significantly improves arthritis pain and functional disability

    Article • Drug Delivery and Translational Research, December 2016, Springer Science + Business Media

    Andrea Malagoli, Professor Michael McDermott

  6. Protection against lupus-like inflammatory disease is in the LAP of non-canonical autophagy

    Article • Annals of Translational Medicine, December 2016, AME Publishing Company

    Professor Michael McDermott

  7. The burgeoning field of innate immune-mediated disease and autoinflammation

    Article • The Journal of Pathology, November 2016, Wiley

    Professor Michael McDermott

  8. Autoinflammatory diseases: update on classification diagnosis and management

    Article • Journal of Clinical Pathology, September 2016, BMJ

    Professor Michael McDermott

  9. Faculty of 1000 evaluation for In vivo imaging of inflammasome activation reveals a subcapsular macrophage burst response that mobilizes innate and adaptive immunity.

    Article • January 2016, Faculty of 1000, Ltd.

    Professor Michael McDermott

  10. Faculty of 1000 evaluation for Mitochondrial Ca2+-dependent NLRP3 activation exacerbates the Pseudomonas aeruginosa-driven inflammatory response in cystic fibrosis.

    Article • October 2015, Faculty of 1000, Ltd.

    Professor Michael McDermott

  11. Protein misfolding and dysregulated protein homeostasis in autoinflammatory diseases and beyond

    Article • Seminars in Immunopathology, May 2015, Springer Science + Business Media

    Professor Michael McDermott

  12. Clinical genetics in 2014: New monogenic diseases span the immunological disease continuum

    Article • Nature Reviews Rheumatology, December 2014, Nature

    Professor Michael McDermott

  13. TNF and TNF-receptors: From mediators of cell death and inflammation to therapeutic giants – past, present and future

    Article • Cytokine & Growth Factor Reviews, August 2014, Elsevier

    Professor Michael McDermott

  14. TLR dependent XBP-1 activation induces an autocrine loop in rheumatoid arthritis synoviocytes

    Article • Journal of Autoimmunity, May 2014, Elsevier

    Professor Michael McDermott

  15. IL-17A RNA Aptamer: Possible Therapeutic Potential in Some Cells, More than We Bargained for in Others?

    Article • Journal of Investigative Dermatology, March 2014, Elsevier

    Professor Michael McDermott

  16. First Report of Circulating MicroRNAs in Tumour Necrosis Factor Receptor-Associated Periodic Syndrome (TRAPS)

    Article • PLoS ONE, September 2013, PLOS

    Luca Cantarini, Professor Michael McDermott

  17. Evidence of NLRP3-inflammasome activation in rheumatoid arthritis (RA); genetic variants within the NLRP3-inflammasome complex in relation to susceptibility to RA and response to anti-TNF treatment

    Article • Annals of the Rheumatic Diseases, May 2013, BMJ

    Professor Michael McDermott

  18. Identification of a new exon 2-skipped TNFR1 transcript: regulation by three functional polymorphisms of the TNFR-associated periodic syndrome (TRAPS) gene

    Article • Annals of the Rheumatic Diseases, March 2013, BMJ

    Professor Michael McDermott

  19. OR10-002 - A novel TNFR1 transcript of TRAPS gene

    Article • Pediatric Rheumatology, January 2013, Springer Science + Business Media

    Professor Michael McDermott

  20. OR10-004 - Circulating micrornas in TRAPS

    Article • Pediatric Rheumatology, January 2013, Springer Science + Business Media

    Professor Michael McDermott

  21. PW02-013 - The role of IL6 and LPS in pathogenesis of TRAPS

    Article • Pediatric Rheumatology, January 2013, Springer Science + Business Media

    Professor Michael McDermott

  22. Differential effects of infliximab on absolute circulating blood leucocyte counts of innate immune cells in early and late rheumatoid arthritis patients

    Article • Clinical & Experimental Immunology, September 2012, Wiley

    Professor Michael McDermott

  23. Autoinflammatory syndromes and cellular responses to stress: pathophysiology, diagnosis and new treatment perspectives

    Article • Best Practice & Research Clinical Rheumatology, August 2012, Elsevier

    Professor Michael McDermott

  24. Involvement of X-box binding protein 1 and reactive oxygen species pathways in the pathogenesis of tumour necrosis factor receptor-associated periodic syndrome

    Article • Annals of the Rheumatic Diseases, June 2012, BMJ

    Luca Cantarini, Professor Michael McDermott

  25. Histone deacetylases are dysregulated in rheumatoid arthritis and a novel histone deacetylase 3-selective inhibitor reduces interleukin-6 production by peripheral blood mononuclear cells from rheumatoid arthritis patients

    Article • Arthritis & Rheumatism, January 2012, Wiley

    Professor Michael McDermott

  26. Familial Mediterranean fever and related periodic fever syndromes/autoinflammatory diseases

    Article • Current Opinion in Rheumatology, January 2012, Wolters Kluwer Health

    Professor Michael McDermott

  27. Anti-TNF Treatment in Rheumatoid Arthritis

    Article • Current Pharmaceutical Design, October 2011, Bentham Science Publishers

    Professor Michael McDermott

  28. Is caspase 1 central to activation of interleukin-1?

    Article • Joint Bone Spine, July 2011, Elsevier

    Professor Michael McDermott

  29. Failure of sustained response to etanercept and refractoriness to anakinra in patients with T50M TNF-receptor-associated periodic syndrome

    Article • Annals of the Rheumatic Diseases, March 2011, BMJ

    Professor Michael McDermott

  30. The role of the NLRP3 inflammasome in gout

    Article • Journal of Inflammation Research, March 2011, Taylor & Francis

    Michael McDermott , Professor Michael McDermott

  31. Inflammasomes and autoimmunity

    Article • Trends in Molecular Medicine, February 2011, Elsevier

    Professor Michael McDermott

  32. Differential cytokine secretion results from p65 and c-Rel NF-κB subunit signaling in peripheral blood mononuclear cells of TNF receptor-associated periodic syndrome patients

    Article • Cellular Immunology, January 2011, Elsevier

    Professor Michael McDermott

  33. Canakinumab: a human anti-IL-1β monoclonal antibody for the treatment of cryopyrin-associated periodic syndromes

    Article • Expert Review of Clinical Immunology, November 2010, Taylor & Francis

    Professor Michael McDermott

  34. Lessons from Anti-TNF Biologics: Infliximab Failure in a TRAPS Family with the T50M Mutation in TNFRSF1A

    Article • October 2010, Springer Science + Business Media

    Professor Michael McDermott

  35. Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients

    Article • Annals of the Rheumatic Diseases, August 2010, BMJ

    Professor Michael McDermott

  36. Vitamin D3 down-regulates intracellular Toll-like receptor 9 expression and Toll-like receptor 9-induced IL-6 production in human monocytes

    Article • Rheumatology, April 2010, Oxford University Press (OUP)

    Professor Michael McDermott

  37. The NLRP3 inflammasome, a target for therapy in diverse disease states

    Article • European Journal of Immunology, March 2010, Wiley

    Professor Michael McDermott

  38. Periodic fever syndrome and autoinflammatory diseases

    Article • F1000 Medicine Reports, January 2010, Faculty of 1000, Ltd.

    Professor Michael McDermott

  39. Imaging evidence for persistent subclinical fasciitis and arthritis in tumour necrosis factor receptor-associated periodic syndrome (TRAPS) between febrile attacks

    Article • Annals of the Rheumatic Diseases, November 2009, BMJ

    Professor Michael McDermott

  40. Inflammation: Canakinumab for the cryopyrin-associated periodic syndromes

    Article • Nature Reviews Rheumatology, October 2009, Nature

    Professor Michael McDermott

  41. p38MAPK: stress responses from molecular mechanisms to therapeutics

    Article • Trends in Molecular Medicine, August 2009, Elsevier

    Professor Michael McDermott

  42. Proteolytic Activation of the Cytotoxic Phenotype during Human NK Cell Development

    Article • The Journal of Immunology, July 2009, The American Association of Immunologists

    Professor Michael McDermott

  43. Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

    Article • Nature Genetics, June 2009, Springer Science + Business Media

    Dr Marwan Shinawi, Professor Lieven Lagae, Professor Michael McDermott

  44. An Integrated Classification of Pediatric Inflammatory Diseases, Based on the Concepts of Autoinflammation and the Immunological Disease Continuum

    Article • Pediatric Research, May 2009, Nature

    Professor Michael McDermott

  45. Proinflammatory action of the antiinflammatory drug infliximab in tumor necrosis factor receptor-associated periodic syndrome

    Article • Arthritis & Rheumatism, February 2009, Wiley

    Professor Michael McDermott

  46. Rilonacept in the treatment of chronic inflammatory disorders

    Article • January 2009, Prous Science

    Professor Michael McDermott

  47. Tumor Necrosis Factor Receptor-Associated Periodic Syndrome (TRAPS) or Familial Hibernian Fever

    Article • JCR Journal of Clinical Rheumatology, December 2008, Wolters Kluwer Health

    Professor Michael McDermott

  48. Rilonacept in cryopyrin-associated periodic syndromes: the beginning of longer-acting interleukin-1 antagonism

    Article • Nature Clinical Practice Rheumatology, November 2008, Nature

    Professor Michael McDermott

  49. Long term management of patients with cryopyrin-associated periodic syndromes (CAPS): focus on rilonacept (IL-1 Trap)

    Article • Biologics Targets & Therapy, October 2008, Dove Medical Press

    Professor Michael McDermott

  50. Fifth International Congress on Familial Mediterranean Fever and Systemic Autoinflammatory Diseases

    Article • Expert Review of Clinical Immunology, July 2008, Taylor & Francis

    Professor Michael McDermott

  51. Successful treatment of resistant pseudogout with anakinra

    Article • Arthritis & Rheumatism, January 2008, Wiley

    Professor Michael McDermott

  52. Primer: inflammasomes and interleukin 1β in inflammatory disorders

    Article • Nature Clinical Practice Rheumatology, January 2008, Nature

    Professor Michael McDermott

  53. NOD-like receptors and inflammation

    Article • Arthritis Research & Therapy, January 2008, Springer Science + Business Media

    Professor Michael McDermott

  54. A novel TNFRSF1A splice mutation associated with increased nuclear factor  appaB (NF- B) transcription factor activation in patients with tumour necrosis factor receptor associated periodic syndrome (TRAPS)

    Article • Annals of the Rheumatic Diseases, December 2007, BMJ

    Professor Michael McDermott

  55. Management of treatment resistant inflammation of acute on chronic tophaceous gout with anakinra

    Article • Annals of the Rheumatic Diseases, December 2007, BMJ

    Professor Michael McDermott

  56. The NLR network and the immunological disease continuum of adaptive and innate immune-mediated inflammation against self

    Article • Seminars in Immunopathology, September 2007, Springer Science + Business Media

    Professor Michael McDermott

  57. From inflammasomes to fevers, crystals and hypertension: how basic research explains inflammatory diseases

    Article • Trends in Molecular Medicine, September 2007, Elsevier

    Professor Michael McDermott

  58. Abnormal tumor necrosis factor receptor I cell surface expression and NF-κB activation in tumor necrosis factor receptor–associated periodic syndrome

    Article • Arthritis & Rheumatism, January 2007, Wiley

    Professor Michael McDermott

  59. A Proposed Classification of the Immunological Diseases

    Article • PLoS Medicine, August 2006, PLOS

    Professor Michael McDermott

  60. Hereditary auto-inflammatory disorders and biologics

    Article • Springer Seminars in Immunopathology, May 2006, Springer Science + Business Media

    Professor Michael McDermott

  61. Hearing improvement in a patient with variant Muckle-Wells syndrome in response to interleukin 1 receptor antagonism

    Article • Annals of the Rheumatic Diseases, April 2006, BMJ

    Professor Michael McDermott

  62. Tumor necrosis factor receptor I from patients with tumor necrosis factor receptor-associated periodic syndrome interacts with wild-type tumor necrosis factor receptor I and induces ligand-independent NF-κB activation

    Article • Arthritis & Rheumatism, January 2005, Wiley

    Professor Michael McDermott

  63. TNF and TNFR polymorphisms in severe sepsis and septic shock: a prospective multicentre study

    Article • Genes and Immunity, November 2004, Nature

    Professor Michael McDermott

  64. The EIF2AK3 gene region and type I diabetes in subjects from South India

    Article • Genes and Immunity, October 2004, Nature

    Professor Michael McDermott

  65. Tumour necrosis factor receptor associated periodic syndrome (TRAPS) with central nervous system involvement

    Article • Annals of the Rheumatic Diseases, October 2004, BMJ

    Professor Michael McDermott

  66. A common pathway in periodic fever syndromes

    Article • Trends in Immunology, September 2004, Elsevier

    Professor Michael McDermott

  67. Allelic variants in genes associated with hereditary periodic fever syndromes as susceptibility factors for reactive systemic AA amyloidosis

    Article • Genes and Immunity, April 2004, Nature

    Professor Michael McDermott

  68. The major histocompatibility complex origin

    Article • Immunological Reviews, April 2004, Wiley

    Professor Michael McDermott

  69. NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder

    Article • Immunity, March 2004, Elsevier

    Professor Michael McDermott

  70. Periodic fever due to a novel TNFRSF1A mutation in a heterozygous Chinese carrier of MEFV E148Q

    Article • Rheumatology, January 2004, Oxford University Press (OUP)

    Professor Michael McDermott

  71. Response to anakinra in a de novo case of neonatal-onset multisystem inflammatory disease

    Article • Arthritis & Rheumatism, January 2004, Wiley

    Professor Michael McDermott

  72. Spectrum of clinical features in Muckle-Wells syndrome and response to anakinra

    Article • Arthritis & Rheumatism, January 2004, Wiley

    Professor Michael McDermott

  73. Heterogeneity among patients with tumor necrosis factor receptor-associated periodic syndrome phenotypes

    Article • Arthritis & Rheumatism, September 2003, Wiley

    Professor Michael McDermott

  74. Interleukin-1–Receptor Antagonist in the Muckle–Wells Syndrome

    Article • New England Journal of Medicine, June 2003, New England Journal of Medicine (NEJM/MMS)

    Professor Michael McDermott

  75. Genetic clues to understanding periodic fevers, and possible therapies

    Article • Trends in Molecular Medicine, December 2002, Elsevier

    Professor Michael McDermott

  76. Hyper IgD syndrome (HIDS) associated with in vitro evidence of defective monocyte TNFRSF1A shedding and partial response to TNF receptor blockade with etanercept

    Article • Clinical & Experimental Immunology, December 2002, Wiley

    Professor Michael McDermott, Sander Houten

  77. The autoinflammatory syndromes

    Article • Current Opinion in Allergy and Clinical Immunology, December 2002, Wolters Kluwer Health

    Professor Michael McDermott

  78. SPINK1 Is a Susceptibility Gene for Fibrocalculous Pancreatic Diabetes in Subjects from the Indian Subcontinent

    Article • The American Journal of Human Genetics, October 2002, Elsevier

    Professor Michael McDermott

  79. Association of mutations in theNALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis

    Article • Arthritis & Rheumatism, September 2002, Wiley

    Professor Michael McDermott

  80. Cytokine gene polymorphism in human disease: on-line databases, Supplement 2

    Article • Genes and Immunity, September 2002, Nature

    Professor Michael McDermott

  81. Genetics of type 1 diabetes mellitus

    Article • Genes and Immunity, July 2002, Nature

    Professor Michael McDermott

  82. Vitamin D Receptor (VDR) mRNA and VDR Protein Levels in Relation to Vitamin D Status, Insulin Secretory Capacity, and VDR Genotype in Bangladeshi Asians

    Article • Diabetes, July 2002, American Diabetes Association

    Professor Michael McDermott

  83. A novel mutation in the third extracellular domain of the tumor necrosis factor receptor 1 in a Finnish family with autosomal-dominant recurrent fever

    Article • Arthritis & Rheumatism, April 2002, Wiley

    Professor Michael McDermott

  84. Genetic susceptibility to fibrocalculous pancreatic diabetes in Bangladeshi subjects: a family study

    Article • Genes and Immunity, February 2002, Nature

    Professor Michael McDermott

  85. An Israeli Arab patient with a de novoTNFRSF1A mutation causing tumor necrosis factor receptor-associated periodic syndrome

    Article • Arthritis & Rheumatism, January 2002, Wiley

    Professor Michael McDermott

  86. Hereditary periodic fever syndromes

    Article • The Netherlands Journal of Medicine, September 2001, Elsevier

    Professor Michael McDermott

  87. Cytokine gene polymorphism in human disease: on-line databases, Supplement 1

    Article • Genes and Immunity, April 2001, Nature

    Professor Michael McDermott

  88. Tumour necrosis factor 5′ promoter single nucleotide polymorphisms influence susceptibility to rheumatoid arthritis (RA) in immunogenetically defined multiplex RA families

    Article • Genes and Immunity, April 2001, Nature

    Professor Michael McDermott

  89. Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) in a Dutch family: evidence for a TNFRSF1A mutation with reduced penetrance

    Article • European Journal of Human Genetics, January 2001, Nature

    Professor Michael McDermott

  90. An autosomal dominant periodic fever associated with AA amyloidosis in a North Indian family maps to distal chromosome 1q

    Article • Arthritis & Rheumatism, September 2000, Wiley

    Professor Michael McDermott

  91. TNFRSF1A mutations and autoinflammatory syndromes

    Article • Current Opinion in Immunology, August 2000, Elsevier

    Professor Michael McDermott

  92. Family association studies of markers on chromosome 2q and Type 1 diabetes in subjects from South India

    Article • Diabetes/Metabolism Research and Reviews, January 2000, Wiley

    Professor Michael McDermott

  93. Pancreatitis in fibrocalculous pancreatic diabetes mellitus is not associated with common mutations in the trypsinogen gene

    Article • Diabetes/Metabolism Research and Reviews, January 2000, Wiley

    Professor Michael McDermott

  94. Cytokine gene polymorphism in human disease: on-line databases

    Article • Genes and Immunity, September 1999, Nature

    Professor Michael McDermott

  95. Germline Mutations in the Extracellular Domains of the 55 kDa TNF Receptor, TNFR1, Define a Family of Dominantly Inherited Autoinflammatory Syndromes

    Article • Cell, April 1999, Elsevier

    Professor Michael McDermott

  96. The MHC Big Bang

    Article • Immunological Reviews, February 1999, Wiley

    Professor Michael McDermott

  97. B30.2-like domain proteins: update and new insights into a rapidly expanding family of proteins

    Article • Molecular Biology and Evolution, December 1998, Oxford University Press (OUP)

    Professor Michael McDermott

  98. Linkage of Familial Hibernian Fever to Chromosome 12p13

    Article • The American Journal of Human Genetics, June 1998, Elsevier

    Professor Michael McDermott

  99. Exclusion of the familial Mediterranean fever locus as a susceptibility region for autosomal dominant familial Hibernian fever.

    Article • Journal of Medical Genetics, May 1998, BMJ

    Professor Michael McDermott

  100. Vitamin D receptor gene polymorphisms influence insulin secretion in Bangladeshi Asians

    Article • Diabetes, April 1998, American Diabetes Association

    Professor Michael McDermott

  101. Modelling the major histocompatibility complex susceptibility to RA using the MASC method

    Article • Genetic Epidemiology, January 1998, Wiley

    Professor Michael McDermott

  102. Allelic variation in the vitamin D receptor influences susceptibility to IDDM in Indian Asians

    Article • Diabetologia, July 1997, Springer Science + Business Media

    Professor Michael McDermott