All Stories

  1. Resolving polymorphs and radiation-driven effects in microcrystals using fixed-target serial synchrotron crystallography

    Article • Acta Crystallographica Section D Structural Biology, November 2018, International Union of Crystallography

    Dr Michael A Hough

  2. From crystal to structure with CCP4

    Article • Acta Crystallographica Section D Structural Biology, February 2018, International Union of Crystallography

    Dr Michael A Hough

  3. Photoreduction and validation of haem–ligand intermediate states in protein crystals byin situsingle-crystal spectroscopy and diffraction

    Article • IUCrJ, April 2017, International Union of Crystallography

    Dr Michael A Hough

  4. Crystal structure of non symbiotic plant hemoglobin AHb3 (GLB3) from Arabidopsis thaliana

    Article • May 2014, Protein Data Bank, Rutgers University

    Dr Michael A Hough

  5. Structural and mechanistic insights into an extracytoplasmic copper trafficking pathway in Streptomyces lividans

    Article • Biochemical Journal, May 2014, Portland Press Ltd.

    Dr Michael A Hough

  6. The structure of a class 3 nonsymbiotic plant haemoglobin fromArabidopsis thalianareveals a novel N-terminal helical extension

    Article • Acta Crystallographica Section D Biological Crystallography, April 2014, International Union of Crystallography

    Dr Michael A Hough

  7. Fingerprinting crystal structures with Raman spectroscopy

    Article • Acta Crystallographica Section D Biological Crystallography, April 2014, International Union of Crystallography

    Dr Michael A Hough, Dr Florian Sven Nico Dworkowski, Dr Svetlana Antonyuk

  8. The benefit of the European User Community from transnational access to national radiation facilities

    Article • Journal of Synchrotron Radiation, April 2014, International Union of Crystallography

    Dr Michael A Hough, Ullrich Pietsch, Dr. Matej Jergel

  9. Crystal structure of the C90A mutant of the Sco copper chaperone protein from Streptomyces lividans

    Article • March 2014, Protein Data Bank, Rutgers University

    Dr Michael A Hough

  10. The crystal structure of a Cu(I) metallochaperone from Streptomyces lividans

    Article • January 2014, Protein Data Bank, Rutgers University

    Dr Michael A Hough

  11. The crystal structure of a Cu(I) metallochaperone from Streptomyces lividans in its apo form

    Article • January 2014, Protein Data Bank, Rutgers University

    Dr Michael A Hough

  12. NO Binding to the Proapoptotic Cytochrome c–Cardiolipin Complex

    Article • January 2014, Elsevier

    Dr Michael A Hough

  13. The hydrogen-peroxide-induced radical behaviour in human cytochrome c –phospholipid complexes: implications for the enhanced pro-apoptotic activity of the G41S mutant

    Article • Biochemical Journal, December 2013, Portland Press Ltd.

    Dr Michael A Hough

  14. Structure of recombinant human cytochrome c

    Article • October 2013, Protein Data Bank, Rutgers University

    Dr Michael A Hough

  15. Structure of the Y46F mutant of human cytochrome c

    Article • October 2013, Protein Data Bank, Rutgers University

    Dr Michael A Hough

  16. Structural Evidence for a Copper-Bound Carbonate Intermediate in the Peroxidase and Dismutase Activities of Superoxide Dismutase

    Article • PLoS ONE, September 2012, PLOS

    Dr Michael A Hough, Dr Svetlana Antonyuk

  17. Response to Copper Stress in Streptomyces lividans Extends beyond Genes under Direct Control of a Copper-sensitive Operon Repressor Protein (CsoR)

    Article • Journal of Biological Chemistry, March 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Michael A Hough

  18. Challenges of sulfur SAD phasing as a routine method in macromolecular crystallography

    Article • Journal of Synchrotron Radiation, November 2011, International Union of Crystallography

    Dr Michael A Hough

  19. Proton-Coupled Electron Transfer in the Catalytic Cycle of Alcaligenes xylosoxidans Copper-Dependent Nitrite Reductase

    Article • Biochemistry, April 2011, American Chemical Society (ACS)

    Dr Michael A Hough, Dr Svetlana Antonyuk

  20. Distal-to-Proximal NO Conversion in Hemoproteins: The Role of the Proximal Pocket

    Article • Journal of Molecular Biology, January 2011, Elsevier

    Dr Michael A Hough, Dr Svetlana Antonyuk

  21. Demonstration of Proton-coupled Electron Transfer in the Copper-containing Nitrite Reductases

    Article • Journal of Biological Chemistry, July 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Michael A Hough

  22. Structure of the N90S mutant of nitrite reductase from Alcaligenes xylosoxidans

    Article • December 2008, Protein Data Bank, Rutgers University

    Dr Michael A Hough

  23. Crystal structure of the Cu metallated H254F mutant of Alcaligenes xylosoxidans Cu nitrite reductase

    Article • December 2008, Protein Data Bank, Rutgers University

    Dr Michael A Hough

  24. Identification of the Proton Channel to the Active Site Type 2 Cu Center of Nitrite Reductase: Structural and Enzymatic Properties of the His254Phe and Asn90Ser Mutants,

    Article • Biochemistry, November 2008, American Chemical Society (ACS)

    Dr Michael A Hough

  25. On-line optical and X-ray spectroscopies with crystallography: an integrated approach for determining metalloprotein structures in functionally well defined states

    Article • Journal of Synchrotron Radiation, July 2008, International Union of Crystallography

    Dr Michael A Hough

  26. Crystallography with Online Optical and X-ray Absorption Spectroscopies Demonstrates an Ordered Mechanism in Copper Nitrite Reductase

    Article • Journal of Molecular Biology, April 2008, Elsevier

    Dr Michael A Hough, Dr Svetlana Antonyuk

  27. The structure of the Met144Leu mutant of copper nitrite reductase from Alcaligenes xylosoxidans provides the first glimpse of a protein–protein complex with azurin II

    Article • JBIC Journal of Biological Inorganic Chemistry, May 2007, Springer Science + Business Media

    Professor Gary Sawers, Dr Michael A Hough

  28. Variable Metallation of Human Superoxide Dismutase: Atomic Resolution Crystal Structures of Cu–Zn, Zn–Zn and As-isolated Wild-type Enzymes

    Article • Journal of Molecular Biology, March 2006, Elsevier

    Dr Michael A Hough, Dr Svetlana Antonyuk

  29. Atomic Resolution Crystal Structures, EXAFS, and Quantum Chemical Studies of Rusticyanin and Its Two Mutants Provide Insight into Its Unusual Properties,

    Article • Biochemistry, February 2006, American Chemical Society (ACS)

    Dr Michael A Hough, Dr Mahesh Sundararajan

  30. Active site structures and the redox properties of blue copper proteins: atomic resolution structure of azurin II and electronic structure calculations of azurin, plastocyanin and stellacyanin

    Article • Dalton Transactions, January 2006, Royal Society of Chemistry

    Dr Michael A Hough, Dr Mahesh Sundararajan

  31. High Resolution Structural Studies of Mutants Provide Insights into Catalysis and Electron Transfer Processes in Copper Nitrite Reductase

    Article • Journal of Molecular Biology, July 2005, Elsevier

    Professor Gary Sawers, Dr Michael A Hough, Dr Svetlana Antonyuk

  32. Structural consequences of the familial amyotrophic lateral sclerosis SOD1 mutant His46Arg

    Article • Protein Science, May 2005, Wiley

    Dr Michael A Hough, Dr Svetlana Antonyuk

  33. Insights into Redox Partner Interactions and Substrate Binding in Nitrite Reductase from Alcaligenes xylosoxidans: Crystal Structures of the Trp138His and His313Gln Mutants,

    Article • Biochemistry, December 2004, American Chemical Society (ACS)

    Professor Gary Sawers, Dr Michael A Hough, Dr Svetlana Antonyuk

  34. Dimer destabilization in superoxide dismutase may result in disease-causing properties: Structures of motor neuron disease mutants

    Article • Proceedings of the National Academy of Sciences, March 2004, Proceedings of the National Academy of Sciences

    Dr Michael A Hough, Dr Svetlana Antonyuk

  35. Structure of Fully Reduced Bovine Copper Zinc Superoxide Dismutase at 1.15 Å

    Article • Structure, August 2003, Elsevier

    Dr Michael A Hough

  36. The Structure of Holo and Metal-deficient Wild-type Human Cu, Zn Superoxide Dismutase and its Relevance to Familial Amyotrophic Lateral Sclerosis

    Article • Journal of Molecular Biology, May 2003, Elsevier

    Dr Michael A Hough, Dr Svetlana Antonyuk

  37. High resolution structures of wild type and apo human CuZn superoxide dismutase and its fals-related mutants

    Article • Acta Crystallographica Section A Foundations of Crystallography, August 2002, International Union of Crystallography

    Dr Michael A Hough

  38. Crystal Structures of the Met148Leu and Ser86Asp Mutants of Rusticyanin from Thiobacillus ferrooxidans: Insights into the Structural Relationship with the Cupredoxins and the Multi Copper Proteins

    Article • Journal of Molecular Biology, July 2002, Elsevier

    Dr Michael A Hough, Dr Svetlana Antonyuk

  39. Structure of the M148Q mutant of rusticyanin at 1.5 Å: a model for the copper site of stellacyanin

    Article • Acta Crystallographica Section D Biological Crystallography, March 2001, International Union of Crystallography

    Dr Michael A Hough

  40. Conformational variability of the Cu site in one subunit of bovine CuZn superoxide dismutase: the importance of mobility in the Glu119-Leu142 loop region for catalytic function

    Article • Journal of Molecular Biology, November 2000, Elsevier

    Dr Michael A Hough

  41. Implementation of cluster analysis forab initiophasing using the molecular envelope from solution X-ray scattering

    Article • Acta Crystallographica Section D Biological Crystallography, August 2000, International Union of Crystallography

    Dr Michael A Hough

  42. Crystallographic structures of bovine copper-zinc superoxide dismutase reveal asymmetry in two subunits: functionally important three and five coordinate copper sites captured in the same crystal

    Article • Journal of Molecular Biology, April 1999, Elsevier

    Dr Michael A Hough