All Stories

  1. Towards an early clinical diagnosis of sporadic CJD VV2 (ataxic type)

    Article • Journal of Neurology Neurosurgery & Psychiatry, July 2017, BMJ

    Maurizio Pocchiari, Professor Piero Parchi

  2. Prion Strain Characterization of a Novel Subtype of Creutzfeldt-Jakob Disease

    Article • Journal of Virology, March 2017, ASM Journals

    Maurizio Pocchiari

  3. Prion-specific and surrogate CSF biomarkers in Creutzfeldt-Jakob disease: diagnostic accuracy in relation to molecular subtypes and analysis of neuropathological correlates of p-tau and Aβ42 levels

    Article • Acta Neuropathologica, February 2017, Springer Science + Business Media

    Maurizio Pocchiari, Professor Piero Parchi, Samir Abu-Rumeileh

  4. Diagnosis of Human Prion Disease Using Real-Time Quaking-Induced Conversion Testing of Olfactory Mucosa and Cerebrospinal Fluid Samples

    Article • JAMA Neurology, February 2017, American Medical Association (AMA)

    Maurizio Pocchiari

  5. Detection and Diagnosis of Prion Diseases Using RT-QuIC: An Update

    Article • January 2017, Springer Science + Business Media

    Maurizio Pocchiari

  6. Patient with rapidly evolving neurological disease with neuropathological lesions of Creutzfeldt-Jakob disease, Lewy body dementia, chronic subcortical vascular encephalopathy and meningothelial meningioma

    Article • Neuropathology, September 2016, Wiley

    Maurizio Pocchiari, Professor Piero Parchi

  7. Erratum: Advanced tests for early and accurate diagnosis of Creutzfeldt–Jakob disease

    Article • Nature Reviews Neurology, June 2016, Springer Science + Business Media

    Maurizio Pocchiari

  8. Cerebrospinal fluid real-time quaking-induced conversion is a robust and reliable test for sporadic creutzfeldt-jakob disease: An international study

    Article • Annals of Neurology, June 2016, Wiley

    Maurizio Pocchiari, Professor Piero Parchi

  9. Advanced tests for early and accurate diagnosis of Creutzfeldt–Jakob disease

    Article • Nature Reviews Neurology, May 2016, Springer Science + Business Media

    Maurizio Pocchiari

  10. Revisiting the Heidenhain Variant of Creutzfeldt-Jakob Disease: Evidence for Prion Type Variability Influencing Clinical Course and Laboratory Findings

    Article • Journal of Alzheimer s Disease, December 2015, IOS Press

    Professor Piero Parchi, Maurizio Pocchiari

  11. Detection of exosomal prions in blood by immunochemistry techniques

    Article • Journal of General Virology, July 2015, Society for General Microbiology

    Maurizio Pocchiari

  12. A Genome Wide Association Study Links Glutamate Receptor Pathway to Sporadic Creutzfeldt-Jakob Disease Risk

    Article • PLoS ONE, April 2015, PLOS

    Maurizio Pocchiari, Prof. Herbert Budka

  13. Rethinking of doxycycline therapy in Creutzfeldt-Jakob disease

    Article • Journal of Neurology Neurosurgery & Psychiatry, January 2015, BMJ

    Maurizio Pocchiari

  14. Synthetic Scrapie Infectivity: Interaction between Recombinant PrP and Scrapie Brain-Derived RNA

    Article • Virulence, January 2015, Taylor & Francis

    Maurizio Pocchiari

  15. Creutzfeldt–Jakob disease masked by head trauma and features of Wilson's disease

    Article • International Journal of Neuroscience, January 2015, Taylor & Francis

    Maurizio Pocchiari, Professor Piero Parchi

  16. The future for treating Creutzfeldt–Jakob disease

    Article • Expert Opinion on Orphan Drugs, December 2014, Informa Healthcare

    Maurizio Pocchiari

  17. Mutant PrPCJD prevails over wild-type PrPCJD in the brain of V210I and R208H genetic Creutzfeldt–Jakob disease patients

    Article • Biochemical and Biophysical Research Communications, November 2014, Elsevier

    Maurizio Pocchiari, Professor Piero Parchi

  18. A Test for Creutzfeldt–Jakob Disease Using Nasal Brushings

    Article • New England Journal of Medicine, August 2014, New England Journal of Medicine (NEJM/MMS)

    Maurizio Pocchiari

  19. Doxycycline in Creutzfeldt-Jakob disease: a phase 2, randomised, double-blind, placebo-controlled trial

    Article • The Lancet Neurology, February 2014, Elsevier

    Maurizio Pocchiari

  20. Gerstmann-Sträussler-Scheinker Syndrome with Variable Phenotype in a New Kindred withPRNP-P102L Mutation

    Article • Brain Pathology, September 2013, Wiley

    Maurizio Pocchiari

  21. Subtype-Specific Synaptic Proteome Alterations in Sporadic Creutzfeldt-Jakob Disease

    Article • Journal of Alzheimer s Disease, August 2013, IOS Press

    Maurizio Pocchiari

  22. Assessment of prion reduction filters in decreasing infectivity of ultracentrifuged 263K scrapie-infected brain homogenates in “spiked” human blood and red blood cells

    Article • Transfusion, August 2013, Wiley

    Maurizio Pocchiari

  23. Age at Death of Creutzfeldt-Jakob Disease in Subsequent Family Generation Carrying the E200K Mutation of the Prion Protein Gene

    Article • PLoS ONE, April 2013, PLOS

    Maurizio Pocchiari

  24. Identification of Misfolded Proteins in Body Fluids for the Diagnosis of Prion Diseases

    Article • International Journal of Cell Biology, January 2013, Hindawi Publishing Corporation

    Maurizio Pocchiari

  25. Sporadic Creutzfeldt-Jakob disease subtype-specific alterations of the brain proteome: Impact on Rab3a recycling

    Article • PROTEOMICS, December 2012, Wiley

    Maurizio Pocchiari

  26. Role of proteomics in understanding prion infection

    Article • Expert Review of Proteomics, December 2012, Taylor & Francis

    Maurizio Pocchiari

  27. Cerebrospinal fluid biomarker supported diagnosis of Creutzfeldt–Jakob disease and rapid dementias: a longitudinal multicentre study over 10 years

    Article • Brain, September 2012, Oxford University Press (OUP)

    Maurizio Pocchiari

  28. Increased levels of acute-phase inflammatory proteins in plasma of patients with sporadic CJD

    Article • Neurology, August 2012, Wolters Kluwer Health

    Maurizio Pocchiari

  29. Editorial. The CNCCS, a benchmark Italian consortium for bioeconomy and an opportunity for the Istituto Superiore di Sanità

    Article • Annali dell Istituto Superiore di Sanità, June 2012, Istituto Superiore di Sanita

    Maurizio Pocchiari

  30. Iatrogenic Creutzfeldt-Jakob Disease, Final Assessment

    Article • Emerging Infectious Diseases, June 2012, Centers for Disease Control and Prevention (CDC)

    Maurizio Pocchiari

  31. Chronic wasting disease and atypical forms of bovine spongiform encephalopathy and scrapie are not transmissible to mice expressing wild-type levels of human prion protein

    Article • Journal of General Virology, April 2012, Society for General Microbiology

    Maurizio Pocchiari

  32. Assessing Prion Infectivity of Human Urine in Sporadic Creutzfeldt-Jakob Disease

    Article • Emerging Infectious Diseases, January 2012, Centers for Disease Control and Prevention (CDC)

    Maurizio Pocchiari

  33. Sensitivity to Biases of Case-Control Studies on Medical Procedures, Particularly Surgery and Blood Transfusion, and Risk of Creutzfeldt-Jakob Disease

    Article • Neuroepidemiology, January 2012, Karger Publishers

    Maurizio Pocchiari

  34. Sublethal Doses of β-Amyloid Peptide Abrogate DNA-dependent Protein Kinase Activity

    Article • Journal of Biological Chemistry, December 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Maurizio Pocchiari

  35. Comparison of nanofiltration efficacy in reducing infectivity of centrifuged versus ultracentrifuged 263K scrapie-infected brain homogenates in “spiked” albumin solutions

    Article • Transfusion, November 2011, Wiley

    Maurizio Pocchiari

  36. In reply

    Article • Transfusion, August 2011, Wiley

    Maurizio Pocchiari

  37. The pathological prion protein forms ionic conductance in lipid bilayer

    Article • Neurochemistry International, August 2011, Elsevier

    Maurizio Pocchiari, Professor Tullio Florio

  38. Corrigendum

    Article • Brain, February 2011, Oxford University Press (OUP)

    Maurizio Pocchiari

  39. Transmission of sporadic Creutzfeldt-Jakob disease by blood transfusion: risk factor or possible biases

    Article • Transfusion, January 2011, Wiley

    Maurizio Pocchiari

  40. Management and prevention of human prion diseases

    Article • Current Neurology and Neuroscience Reports, October 2009, Springer Science + Business Media

    Maurizio Pocchiari

  41. Updated clinical diagnostic criteria for sporadic Creutzfeldt-Jakob disease

    Article • Brain, September 2009, Oxford University Press (OUP)

    Maurizio Pocchiari

  42. Clinical trials and methodological problems in prion diseases

    Article • The Lancet Neurology, September 2009, Elsevier

    Maurizio Pocchiari

  43. Incidence and spectrum of sporadic Creutzfeldt–Jakob disease variants with mixed phenotype and co-occurrence of PrPSc types: an updated classification

    Article • Acta Neuropathologica, August 2009, Springer Science + Business Media

    Maurizio Pocchiari, Professor Piero Parchi

  44. Proteomic profiling of PrP27-30-enriched preparations extracted from the brain of hamsters with experimental scrapie

    Article • PROTEOMICS, August 2009, Wiley

    Maurizio Pocchiari

  45. PrPTSE in muscle-associated lymphatic tissue during the preclinical stage of mice infected orally with bovine spongiform encephalopathy

    Article • Journal of General Virology, June 2009, Society for General Microbiology

    Maurizio Pocchiari

  46. Efficacy of phthalocyanine tetrasulfonate against mouse-adapted human prion strains

    Article • Archives of Virology, May 2009, Springer Science + Business Media

    Maurizio Pocchiari

  47. Prevalence of variant CJD in the UK

    Article • BMJ, May 2009, BMJ

    Maurizio Pocchiari

  48. Cerebrospinal fluid biomarkers in human genetic transmissible spongiform encephalopathies

    Article • Journal of Neurology, May 2009, Springer Science + Business Media

    Maurizio Pocchiari

  49. Oral pravastatin prolongs survival time of scrapie-infected mice

    Article • Journal of General Virology, March 2009, Society for General Microbiology

    Maurizio Pocchiari

  50. Genomic and post-genomic analyses of human prion diseases

    Article • Genome Medicine, January 2009, Springer Science + Business Media

    Maurizio Pocchiari

  51. Neuroinvasion of the 263K scrapie strain after intranasal administration occurs through olfactory-unrelated pathways

    Article • Acta Neuropathologica, December 2008, Springer Science + Business Media

    Maurizio Pocchiari

  52. A novel PSEN2 mutation associated with a peculiar phenotype

    Article • Neurology, April 2008, Wolters Kluwer Health

    Maurizio Pocchiari

  53. Survival in Alzheimer’s Disease Is Shorter in Women Carrying Heterozygosity at Codon 129 of the PRNP Gene and No APOE ε4 Allele

    Article • Dementia and Geriatric Cognitive Disorders, January 2008, Karger Publishers

    Maurizio Pocchiari

  54. Influence of timing on CSF tests value for Creutzfeldt-Jakob disease diagnosis

    Article • Journal of Neurology, March 2007, Springer Science + Business Media

    Maurizio Pocchiari

  55. Cyclooxygenase‐2, Prostaglandin E2, and Microglial Activation in Prion Diseases

    Article • January 2007, Elsevier

    Maurizio Pocchiari

  56. Recent Italian FFI Cases

    Article • Brain Pathology, April 2006, Wiley

    Maurizio Pocchiari

  57. Preparation of soluble infectious samples from scrapie-infected brain: a new tool to study the clearance of transmissible spongiform encephalopathy agents during plasma fractionation

    Article • Transfusion, April 2006, Wiley

    Maurizio Pocchiari

  58. Inactivation of transmissible spongiform encephalopathy agents in food products by ultra high pressure–temperature treatment

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, March 2006, Elsevier

    Maurizio Pocchiari

  59. Efficient Transmission and Characterization of Creutzfeldt–Jakob Disease Strains in Bank Voles

    Article • PLoS Pathogens, January 2006, PLOS

    Maurizio Pocchiari

  60. Pathological prion protein in muscles of hamsters and mice infected with rodent-adapted BSE or vCJD

    Article • Journal of General Virology, January 2006, Society for General Microbiology

    Maurizio Pocchiari

  61. Article • BMC Veterinary Research, January 2006, Springer Science + Business Media

    Maurizio Pocchiari

  62. KDEL-tagged anti-prion intrabodies impair PrP lysosomal degradation and inhibit scrapie infectivity

    Article • Biochemical and Biophysical Research Communications, December 2005, Elsevier

    Maurizio Pocchiari

  63. Genetic prion disease: the EUROCJD experience

    Article • Human Genetics, September 2005, Springer Science + Business Media

    Prof. Herbert Budka, Maurizio Pocchiari

  64. Migration of dendritic cells into the brain in a mouse model of prion disease

    Article • Journal of Neuroimmunology, August 2005, Elsevier

    Maurizio Pocchiari

  65. Mortality from Human Transmissible Spongiform Encephalopathies: A Record Linkage Study

    Article • Neuroepidemiology, January 2005, Karger Publishers

    Maurizio Pocchiari

  66. Pre-symptomatic detection of prions by cyclic amplification of protein misfolding

    Article • FEBS Letters, December 2004, Wiley

    Maurizio Pocchiari

  67. Trapping Prion Protein in the Endoplasmic Reticulum Impairs PrPCMaturation and Prevents PrPScAccumulation

    Article • Journal of Biological Chemistry, October 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Maurizio Pocchiari

  68. Predictors of survival in sporadic Creutzfeldt-Jakob disease and other human transmissible spongiform encephalopathies

    Article • Brain, September 2004, Oxford University Press (OUP)

    Prof. Herbert Budka, Maurizio Pocchiari

  69. Standards for the assay of Creutzfeldt-Jakob disease specimens

    Article • Journal of General Virology, June 2004, Society for General Microbiology

    Prof. Herbert Budka, Maurizio Pocchiari

  70. Prion (PrPres) Allotypes Profiling: New Perspectives from Mass Spectrometry

    Article • European Journal of Mass Spectrometry, June 2004, SAGE Publications

    Maurizio Pocchiari

  71. Regulation of intrinsic prion protein by growth factors and tnf-α: the role of intracellular reactive oxygen species

    Article • Free Radical Biology and Medicine, September 2003, Elsevier

    Maurizio Pocchiari

  72. Ultra-high-pressure inactivation of prion infectivity in processed meat: A practical method to prevent human infection

    Article • Proceedings of the National Academy of Sciences, May 2003, Proceedings of the National Academy of Sciences

    Maurizio Pocchiari

  73. Mortality trend from sporadic Creutzfeldt-Jakob disease (CJD) in Italy, 1993–2000

    Article • Journal of Clinical Epidemiology, May 2003, Elsevier

    Maurizio Pocchiari

  74. Detection of Pathologic Prion Protein in the Olfactory Epithelium in Sporadic Creutzfeldt–Jakob Disease

    Article • New England Journal of Medicine, February 2003, New England Journal of Medicine (NEJM/MMS)

    Maurizio Pocchiari

  75. Variant Creutzfeldt-Jakob disease in an Italian woman

    Article • The Lancet, September 2002, Elsevier

    Maurizio Pocchiari

  76. BSE and variant Creutzfeldt-Jakob disease: never say never

    Article • Acta Neuropathologica, June 2002, Springer Science + Business Media

    Prof. Herbert Budka, Maurizio Pocchiari

  77. Molecular diagnostics of transmissible spongiform encephalopathies

    Article • Trends in Molecular Medicine, June 2002, Elsevier

    Maurizio Pocchiari

  78. A role for complement in transmissible spongiform encephalopathies

    Article • Nature Medicine, April 2001, Springer Science + Business Media

    Maurizio Pocchiari

  79. Mutation of thePRNP gene at codon 211 in familial Creutzfeldt-Jakob disease

    Article • American Journal of Medical Genetics, January 2001, Wiley

    Maurizio Pocchiari

  80. WHO Consultation on Diagnostic Procedures for Transmissible Spongiform Encephalopathies: Need for Reference Reagents and Reference Panels

    Article • Biologicals, September 1999, Elsevier

    Maurizio Pocchiari

  81. Prion protein glycotype analysis in familial and sporadic Creutzfeldt-Jakob disease patients

    Article • Brain Research Bulletin, August 1999, Elsevier

    Maurizio Pocchiari

  82. Expression of wild-type and V210I mutant prion protein in human neuroblastoma cells

    Article • Neuroscience Letters, July 1999, Elsevier

    Maurizio Pocchiari

  83. Codon 129 prion protein genotype and sporadic Creutzfeldt-Jakob disease

    Article • The Lancet, May 1999, Elsevier

    Maurizio Pocchiari

  84. Ancestral Origins and Worldwide Distribution of the PRNP 200K Mutation Causing Familial Creutzfeldt-Jakob Disease

    Article • The American Journal of Human Genetics, April 1999, Elsevier

    Prof. Herbert Budka, Maurizio Pocchiari

  85. Diagnosis of Creutzfeldt-Jakob disease

    Article • BMJ, February 1999, BMJ

    Maurizio Pocchiari

  86. High incidence of Creutzfeldt-Jakob disease in rural Calabria, Italy

    Article • The Lancet, December 1998, Elsevier

    Maurizio Pocchiari

  87. Alpha1 antichymotrypsin signal peptide polymorphism in sporadic Creutzfeldt–Jakob disease

    Article • Neuroscience Letters, May 1997, Elsevier

    Maurizio Pocchiari

  88. Highly Infectious Purified Preparations of Disease-Specific Amyloid of Transmissible Spongiform Encephalopathies Are Not Devoid of Nucleic Acids of Viral Size

    Article • Intervirology, January 1997, Karger Publishers

    Maurizio Pocchiari

  89. A new variant of Creutzfeldt-Jakob disease in the UK

    Article • The Lancet, April 1996, Elsevier

    Maurizio Pocchiari

  90. Apolipoprotein E in sporadic and familial Creutzfeldt-Jakob disease

    Article • Neuroscience Letters, October 1995, Elsevier

    Maurizio Pocchiari

  91. Creutzfeldt-Jakob disease in Europe

    Article • The Lancet, September 1995, Elsevier

    Maurizio Pocchiari

  92. Tissue Handling in Suspected Creutzfeldt-Jakob Disease (CJD) and Other Human Spongiform Encephalopathies (Prion Diseases)

    Article • Brain Pathology, July 1995, Wiley

    Maurizio Pocchiari

  93. Polymorphisms of the Prion Protein gene in italian patients with Creutzfeldt-Jakob disease

    Article • Human Genetics, May 1995, Springer Science + Business Media

    Maurizio Pocchiari

  94. Proteinase-resistant protein in human neuroblastoma cells infected with brain material from Creutzfeldt-Jakob patient

    Article • The Lancet, March 1995, Elsevier

    Maurizio Pocchiari

  95. Polymorphisms of the prion protein gene in Italian patients with Creutzfeldt-Jakob disease

    Article • Human Genetics, October 1994, Springer Science + Business Media

    Maurizio Pocchiari

  96. Small virus-like structure in brains from cases of sporadic and familial Creutzfeldt-Jakob disease

    Article • The Lancet, October 1994, Elsevier

    Maurizio Pocchiari

  97. Detection of proteinase-resistant protein (PrP) in small brain tissue samples from Creutzfeldt-Jakob disease patients

    Article • Journal of the Neurological Sciences, July 1994, Elsevier

    Maurizio Pocchiari

  98. Progressive Dementia in a Young Patient with a Homozygous Deletion of the PrP Gene.

    Article • Annals of the New York Academy of Sciences, May 1994, Wiley

    Maurizio Pocchiari

  99. Incidence of Creutzfeldt-Jakob disease In Europe in 1993

    Article • The Lancet, April 1994, Elsevier

    Maurizio Pocchiari

  100. Characterisation of antisera raised against species-specific peptide sequences from scrapie-associated fibril protein and their application for post-mortem immunodiagnosis of spongiform encephalopathies

    Article • Archives of Virology, March 1994, Springer Science + Business Media

    Maurizio Pocchiari

  101. Prions and related neurological diseases

    Article • Molecular Aspects of Medicine, January 1994, Elsevier

    Maurizio Pocchiari

  102. A new point mutation of the prion protein gene in Creutzfeldt-Jakob disease

    Article • Annals of Neurology, December 1993, Wiley

    Maurizio Pocchiari

  103. Creutzfeldt-Jakob disease after non-commercial dura mater graft

    Article • The Lancet, September 1992, Elsevier

    Maurizio Pocchiari

  104. Failure to Ameliorate Creutzfeldt-Jakob Disease with Amphotericin B Therapy

    Article • The Journal of Infectious Diseases, April 1992, Oxford University Press (OUP)

    Maurizio Pocchiari

  105. Creutzfeldt-jakob disease in Italy

    Article • European Journal of Epidemiology, November 1991, Springer Science + Business Media

    Maurizio Pocchiari

  106. Experimental drug treatment of scrapie: A pathogenetic basis for rationale therapeutics

    Article • European Journal of Epidemiology, September 1991, Springer Science + Business Media

    Maurizio Pocchiari

  107. Combination Ultrafiltration and 6 MUrea Treatment of Human Growth Hormone Effectively Minimizes Risk from Potential Creutzfeldt-Jakob Disease Virus Contamination

    Article • Hormone Research, January 1991, Karger Publishers

    Maurizio Pocchiari

  108. Amphotericin B: A Novel Class of Antiscrapie Drugs

    Article • The Journal of Infectious Diseases, November 1989, Oxford University Press (OUP)

    Maurizio Pocchiari

  109. THE NUCLEUS BASALIS OF MEYNERT IN PARKINSONISM–DEMENTIA OF GUAM: A MORPHOMETRIC STUDY

    Article • Neuropathology and Applied Neurobiology, June 1989, Wiley

    Maurizio Pocchiari

  110. Levels of infectivity in the blood throughout the incubation period of hamsters peripherally injected with scrapie

    Article • Archives of Virology, March 1989, Springer Science + Business Media

    Maurizio Pocchiari

  111. A retrospective study of Creutzfeldt-Jakob disease in Italy (1972?1986)

    Article • European Journal of Epidemiology, December 1988, Springer Science + Business Media

    Maurizio Pocchiari

  112. The scrapie agent and the prion hypothesis

    Article • Trends in Biochemical Sciences, August 1988, Elsevier

    Maurizio Pocchiari

  113. Can potential hazard of Creutzfeldt-Jakob disease infectivity be reduced in the production of human Growth Hormone?

    Article • Archives of Virology, March 1988, Springer Science + Business Media

    Maurizio Pocchiari

  114. Molecular forms of cholinesterases in CSF of Alzheimer's disease/senile dementia of Alzheimer type patients and matched neurological controls

    Article • Life Sciences, February 1986, Elsevier

    Maurizio Pocchiari

  115. Serotoninergic System in Scrapie-Infected Hamsters

    Article • Journal of Neurochemistry, March 1985, Wiley

    Maurizio Pocchiari

  116. Plasma levels of 13,14-dihydro-15-keto PGE2 after vaginal application of a new PGE2 film

    Article • Prostaglandins, February 1985, Elsevier

    Maurizio Pocchiari

  117. Isonicotinic hydrazide causes seizures in scrapie-infected hamstesr with shorter latency than in control animals: A possible GABAergic defect

    Article • Brain Research, February 1985, Elsevier

    Maurizio Pocchiari

  118. Choline acetyltransferase activity and [3H]quinuclidinylbenzilate binding in brains of scrapie-infected hamsters

    Article • Neuroscience Letters, September 1984, Elsevier

    Maurizio Pocchiari

  119. Ultrastructural studies in synaptic formations in dissociated fetal mouse brain cultures

    Article • Neuroscience Letters, December 1983, Elsevier

    Maurizio Pocchiari

  120. Peripheral neuropathy in the course of progressive systemic sclerosis: Light and ultrastructural study

    Article • The Italian Journal of Neurological Sciences, December 1982, Springer Science + Business Media

    Maurizio Pocchiari