All Stories

  1. Identification of new probe substrates for human CYP20A1

    Article • Biological Chemistry, February 2020, De Gruyter

    Professor Matthias Bureik

  2. Plasma membrane localization of CYP4Z1 and CYP19A1 and the detection of anti-CYP19A1 autoantibodies in humans

    Article • International Immunopharmacology, August 2019, Elsevier

    Professor Matthias Bureik

  3. Functional characterization and mechanistic modeling of the human cytochrome P450 enzyme CYP4A22

    Article • FEBS Letters, July 2019, Wiley

    Professor Matthias Bureik

  4. Functional expression and activity screening of all human cytochrome P450 enzymes in fission yeast

    Article • FEBS Letters, May 2019, Wiley

    Professor Matthias Bureik, Shishir Sharma

  5. A comprehensive overview of common polymorphic variants that cause missense mutations in human CYPs and UGTs

    Article • Biomedicine & Pharmacotherapy, March 2019, Elsevier

    Professor Matthias Bureik

  6. Conversion of chenodeoxycholic acid to cholic acid by human CYP8B1

    Article • Biological Chemistry, December 2018, De Gruyter

    Professor Matthias Bureik

  7. Combined chemical and biotechnological production of 20βOH-NorDHCMT, a long-term metabolite of Oral-Turinabol (DHCMT)

    Article • Journal of Inorganic Biochemistry, June 2018, Elsevier

    Professor Matthias Bureik

  8. A common polymorphic variant of UGT1A5 displays increased activity due to optimized cofactor binding

    Article • FEBS Letters, April 2018, Wiley

    Professor Matthias Bureik

  9. Efficient substrate screening and inhibitor testing of human CYP4Z1 using permeabilized recombinant fission yeast

    Article • Biochemical Pharmacology, December 2017, Elsevier

    Professor Matthias Bureik

  10. Bystander signaling via oxidative metabolism

    Article • OncoTargets and Therapy, August 2017, Dove Medical Press

    Dr. Nasir NJ Jalal, Humaira Sawal, Professor Matthias Bureik

  11. CYP4Z1 – A Human Cytochrome P450 Enzyme that Might Hold the Key to Curing Breast Cancer

    Article • Current Pharmaceutical Design, May 2017, Bentham Science Publishers

    Professor Matthias Bureik

  12. Biomarker Autoantibodies detected in breast cancer patients.

    Article • Cellular and Molecular Immunology, April 2017, Springer Science + Business Media

    Dr. Nasir NJ Jalal, Professor Matthias Bureik

  13. Comparison of cytochrome P450 expression in four different human osteoblast models

    Article • Biological Chemistry, January 2017, De Gruyter

    Professor Matthias Bureik

  14. Comparative Proteome Analysis inSchizosaccharomyces pombeIdentifies Metabolic Targets to Improve Protein Production and Secretion

    Article • Molecular & Cellular Proteomics, July 2016, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Matthias Bureik

  15. Selective oxidation of UDP-glucose to UDP-glucuronic acid using permeabilized Schizosaccharomyces pombe expressing human UDP-glucose 6-dehydrogenase

    Article • Biotechnology Letters, November 2015, Springer Science + Business Media

    Professor Matthias Bureik

  16. Overcoming the metabolic burden of protein secretion in Schizosaccharomyces pombe – A quantitative approach using 13C-based metabolic flux analysis

    Article • Metabolic Engineering, January 2014, Elsevier

    Professor Matthias Bureik

  17. Coexpression of CPR from Various Origins Enhances Biotransformation Activity of Human CYPs in S. pombe

    Article • Applied Biochemistry and Biotechnology, June 2013, Springer Science + Business Media

    Professor Matthias Bureik

  18. Unexpected contribution of cytochrome P450 enzymes CYP11B2 and CYP21, as well as CYP3A4 in xenobiotic androgen elimination – Insights from metandienone metabolism

    Article • Toxicology Letters, September 2012, Elsevier

    Professor Matthias Bureik

  19. Engineering of Human CYP3A Enzymes by Combination of Activating Polymorphic Variants

    Article • Applied Biochemistry and Biotechnology, August 2012, Springer Science + Business Media

    Professor Matthias Bureik

  20. Production and NMR analysis of the human ibuprofen metabolite 3-hydroxyibuprofen

    Article • Journal of Biotechnology, February 2012, Elsevier

    Professor Matthias Bureik

  21. S-Glucuronidation of 7-mercapto-4-methylcoumarin by human UDP glycosyltransferases in genetically engineered fission yeast cells

    Article • Biological Chemistry, September 2011, De Gruyter

    Professor Matthias Bureik

  22. Production of Ibuprofen Acyl Glucosides by Human UGT2B7

    Article • Drug Metabolism and Disposition, August 2011, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Matthias Bureik

  23. Biotechnological Production of 20-alpha-Dihydrodydrogesterone at Pilot Scale

    Article • Applied Biochemistry and Biotechnology, April 2011, Springer Science + Business Media

    Professor Matthias Bureik

  24. Whole-cell biotransformation assay for investigation of the human drug metabolizing enzyme CYP3A7

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, January 2011, Elsevier

    Professor Matthias Bureik

  25. S-Glucuronidation of 7-mercapto-4-methylcoumarin by human UDP glycosyltransferases in genetically engineered fission yeast cells

    Article • Biological Chemistry, January 2011, De Gruyter

    Professor Matthias Bureik

  26. Convenient Gram-Scale Metabolite Synthesis by Engineered Fission Yeast Strains Expressing Functional Human P450 Systems

    Article • Applied Biochemistry and Biotechnology, October 2010, Springer Science + Business Media

    Professor Matthias Bureik

  27. Human 20α-hydroxysteroid dehydrogenase (AKR1C1)-dependent biotransformation with recombinant fission yeast Schizosaccharomyces pombe

    Article • Journal of Biotechnology, October 2010, Elsevier

    Professor Matthias Bureik

  28. Expression and Secretion of a CB4-1 scFv–GFP Fusion Protein by Fission Yeast

    Article • Applied Biochemistry and Biotechnology, July 2010, Springer Science + Business Media

    Professor Matthias Bureik

  29. Production of human phase 1 and 2 metabolites by whole-cell biotransformation with recombinant microbes

    Article • Bioanalysis, July 2010, Future Science

    Professor Matthias Bureik

  30. Challenges of steroid biotransformation with human cytochrome P450 monooxygenase CYP21 using resting cells of recombinant Schizosaccharomyces pombe

    Article • Journal of Biotechnology, April 2010, Elsevier

    Professor Matthias Bureik

  31. CYP21-catalyzed production of the long-term urinary metandienone metabolite 17β-hydroxymethyl-17α-methyl-18-norandrosta-1,4,13-trien-3-one: a contribution to the fight against doping

    Article • Biological Chemistry, January 2010, De Gruyter

    Professor Matthias Bureik

  32. Glucuronide Production by Whole-Cell Biotransformation Using Genetically Engineered Fission Yeast Schizosaccharomyces pombe

    Article • Drug Metabolism and Disposition, December 2009, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Matthias Bureik

  33. Biotechnological synthesis of drug metabolites using human cytochrome P450 isozymes heterologously expressed in fission yeast

    Article • Bioanalysis, July 2009, Future Science

    Professor Matthias Bureik

  34. Biotechnological Synthesis of the Designer Drug Metabolite 4'-Hydroxymethyl- -pyrrolidinohexanophenone in Fission Yeast Heterologously Expressing Human Cytochrome P450 2D6--A Versatile Alternative to Multistep Chemical Synthesis

    Article • Journal of Analytical Toxicology, May 2009, Oxford University Press (OUP)

    Professor Matthias Bureik

  35. Use of fission yeast heterologously expressing human cytochrome P450 2B6 in biotechnological synthesis of the designer drug metabolite N-(1-phenylcyclohexyl)-2-hydroxyethanamine

    Article • Forensic Science International, January 2009, Elsevier

    Professor Matthias Bureik

  36. Human CYP4Z1 catalyzes the in-chain hydroxylation of lauric acid and myristic acid

    Article • Biological Chemistry, December 2008, De Gruyter

    Professor Helge B Bode, Professor Matthias Bureik

  37. Coexpression of redox partners increases the hydrocortisone (cortisol) production efficiency in CYP11B1 expressing fission yeast Schizosaccharomyces pombe

    Article • Journal of Biotechnology, February 2008, Elsevier

    Professor Matthias Bureik

  38. ROS production by adrenodoxin does not cause apoptosis in fission yeast

    Article • APOPTOSIS, September 2007, Springer Science + Business Media

    Professor Matthias Bureik

  39. Biotechnological synthesis of drug metabolites using human cytochrome P450 2D6 heterologously expressed in fission yeast exemplified for the designer drug metabolite 4′-hydroxymethyl-α-pyrrolidinobutyrophenone

    Article • Biochemical Pharmacology, August 2007, Elsevier

    Professor Matthias Bureik

  40. A fission yeast-based test system for the determination of IC50values of anti-prostate tumor drugs acting on CYP21

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, January 2006, Taylor & Francis

    Professor Matthias Bureik

  41. Increased TCA cycle activity and reduced oxygen consumption during cytochrome P450-dependent biotransformation in fission yeast

    Article • Yeast, January 2006, Wiley

    Professor Matthias Bureik

  42. A fluorimetric assay for cortisol

    Article • Analytical and Bioanalytical Chemistry, September 2005, Springer Science + Business Media

    Professor Matthias Bureik

  43. Vitamin D3 Metabolism in Human Glioblastoma Multiforme: Functionality of CYP27B1 Splice Variants, Metabolism of Calcidiol, and Effect of Calcitriol

    Article • Clinical Cancer Research, August 2005, American Association for Cancer Research (AACR)

    Professor Matthias Bureik

  44. Efficient conversion of 11-deoxycortisol to cortisol (hydrocortisone) by recombinant fission yeast

    Article • FEMS Yeast Research, April 2005, Oxford University Press (OUP)

    Professor Matthias Bureik

  45. The human mineralocorticoid receptor only partially differentiates between different ligands after expression in fission yeast

    Article • FEMS Yeast Research, April 2005, Oxford University Press (OUP)

    Professor Matthias Bureik

  46. Phosphorylation of Bovine Adrenodoxin by Protein Kinase CK2 Affects the Interaction with Its Redox Partner Cytochrome P450scc(CYP11A1)†

    Article • Biochemistry, March 2005, American Chemical Society (ACS)

    Professor Matthias Bureik

  47. Synthesis and Evaluation of Imidazolylmethylenetetrahydronaphthalenes and Imidazolylmethyleneindanes:  Potent Inhibitors of Aldosterone Synthase

    Article • Journal of Medicinal Chemistry, March 2005, American Chemical Society (ACS)

    Professor Matthias Bureik

  48. Adrenodoxin (Adx) and CYP11A1 (P450scc) induce apoptosis by the generation of reactive oxygen species in mitochondria

    Article • Biological Chemistry, January 2005, De Gruyter

    Professor Matthias Bureik

  49. Inhibition of aldosterone biosynthesis by staurosporine

    Article • Biological Chemistry, January 2005, De Gruyter

    Professor Matthias Bureik

  50. The adrenodoxin-like ferredoxin of Schizosaccharomyces pombe mitochondria

    Article • Journal of Inorganic Biochemistry, July 2004, Elsevier

    Professor Matthias Bureik

  51. Development of test systems for the discovery of selective human aldosterone synthase (CYP11B2) and 11β-hydroxylase (CYP11B1) inhibitors.

    Article • Molecular and Cellular Endocrinology, March 2004, Elsevier

    Professor Matthias Bureik

  52. The "Bringer" Strategy: A Very Fast and Highly Efficient Method for Construction of Mutant Libraries by Error-Prone Polymerase Chain Reaction of Ring-Closed Plasmids

    Article • Applied Biochemistry and Biotechnology, January 2004, Springer Science + Business Media

    Professor Matthias Bureik

  53. Production of steroid hormones by fission yeast cells expressing human mitochondrial cytochromes P450

    Article • September 2002, Elsevier

    Professor Matthias Bureik

  54. Development of a test system for inhibitors of human aldosterone synthase (CYP11B2): screening in fission yeast and evaluation of selectivity in V79 cells

    Article • The Journal of Steroid Biochemistry and Molecular Biology, June 2002, Elsevier

    Professor Matthias Bureik

  55. Functional Expression of Human Mitochondrial CYP11B2 in Fission Yeast and Identification of a New Internal Electron Transfer Protein, etp1†

    Article • Biochemistry, February 2002, American Chemical Society (ACS)

    Professor Matthias Bureik

  56. The Human Steroid Hydroxylases CYP11B1 and CYP11B2

    Article • Biological Chemistry, January 2002, De Gruyter

    Professor Matthias Bureik

  57. MODULATION OF STEROID HYDROXYLASE ACTIVITY IN STABLY TRANSFECTED V79MZH11B1 AND V79MZH11B2 CELLS BY PKC AND PKD INHIBITORS

    Article • Endocrine Research, January 2002, Taylor & Francis

    Professor Matthias Bureik

  58. An additional transcript of the cdc25C gene from A431 cells encodes a functional protein.

    Article • International Journal of Oncology, December 2000, Spandidos Publications

    Professor Matthias Bureik

  59. p53 antibodies: Call for quality

    Article • International Journal of Cancer, November 1997, Wiley

    Professor Matthias Bureik

  60. Human p53 Restores DNA Synthesis Control in Fission Yeast

    Article • Biological Chemistry, January 1997, De Gruyter

    Professor Matthias Bureik

  61. Steroid Hydroxylation: Microbial Steroid Biotransformations Using Cytochrome P450 Enzymes

    Article • Wiley

    Professor Matthias Bureik