All Stories

  1. The role of PAF in immunopathology: From immediate hypersensitivity reactions to fungal defense

    Article • BioFactors, September 2022, Wiley

    Mariano Sanchez Crespo

  2. Fungal Patterns Induce Cytokine Expression through Fluxes of Metabolic Intermediates That Support Glycolysis and Oxidative Phosphorylation

    Article • The Journal of Immunology, June 2022, The American Association of Immunologists

    Mariano Sanchez Crespo

  3. Interferons Are Pro-Inflammatory Cytokines in Sheared-Stressed Human Aortic Valve Endothelial Cells

    Article • International Journal of Molecular Sciences, September 2021, MDPI AG

    Mariano Sanchez Crespo

  4. Clinically used JAK inhibitor blunts dsRNA‐induced inflammation and calcification in aortic valve interstitial cells

    Article • FEBS Journal, June 2021, Wiley

    Mariano Sanchez Crespo

  5. IRE1α–XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain

    Article • Science, July 2019, American Association for the Advancement of Science

    Mariano Sanchez Crespo

  6. Tricarboxylic Acid Cycle Activity and Remodeling of Glycerophosphocholine Lipids Support Cytokine Induction in Response to Fungal Patterns

    Article • Cell Reports, April 2019, Elsevier

    Mariano Sanchez Crespo

  7. Polymorphisms in Receptors Involved in Opsonic and Nonopsonic Phagocytosis, and Correlation with Risk of Infection in Oncohematology Patients

    Article • Infection and Immunity, October 2018, ASM Journals

    Mariano Crespo, Mariano Sanchez Crespo

  8. Calcification Induced by Type I Interferon in Human Aortic Valve Interstitial Cells Is Larger in Males and Blunted by a Janus Kinase Inhibitor

    Article • Arteriosclerosis Thrombosis and Vascular Biology, September 2018, Wolters Kluwer Health

    Mariano Sanchez Crespo

  9. Toll-Like Receptors, Inflammation, and Calcific Aortic Valve Disease

    Article • Frontiers in Physiology, March 2018, Frontiers

    Mariano Sanchez Crespo

  10. Endoplasmic Reticulum Stress Sensor IRE1α Enhances IL-23 Expression by Human Dendritic Cells

    Article • Frontiers in Immunology, June 2017, Frontiers

    Mariano Sanchez Crespo

  11. Fungal pattern receptors down-regulate the inflammatory response by a cross-inhibitory mechanism independent of interleukin-10 production

    Article • Immunology, November 2016, Wiley

    Mariano Crespo, Mariano Sanchez Crespo

  12. Pharmacological inhibition of eicosanoids and platelet-activating factor signaling impairs zymosan-induced release of IL-23 by dendritic cells

    Article • Biochemical Pharmacology, February 2016, Elsevier

    Mariano Sanchez Crespo

  13. Synergy between Sphingosine 1-Phosphate and Lipopolysaccharide Signaling Promotes an Inflammatory, Angiogenic and Osteogenic Response in Human Aortic Valve Interstitial Cells

    Article • PLoS ONE, October 2014, PLOS

    Mariano Sanchez Crespo

  14. Proline‐serine‐threonine phosphatase interacting protein 1 inhibition of T‐cell receptor signaling depends on its SH3 domain

    Article • FEBS Journal, August 2014, Wiley

    Mariano Sanchez Crespo

  15. The Unfolded Protein Response and the Phosphorylations of Activating Transcription Factor 2 in the trans-Activation of il23a Promoter Produced by β-Glucans

    Article • Journal of Biological Chemistry, August 2014, Elsevier

    Mariano Sanchez Crespo

  16. The Response of Human Macrophages to β-Glucans Depends on the Inflammatory Milieu

    Article • PLoS ONE, April 2013, PLOS

    Mariano Sanchez Crespo

  17. The Autoimmunity Risk Variant LYP-W620 Cooperates with CSK in the Regulation of TCR Signaling

    Article • PLoS ONE, January 2013, PLOS

    Mariano Sanchez Crespo

  18. Sirtuin 1 Is a Key Regulator of the Interleukin-12 p70/Interleukin-23 Balance in Human Dendritic Cells

    Article • Journal of Biological Chemistry, October 2012, Elsevier

    Mariano Sanchez Crespo

  19. Viral and bacterial patterns induce TLR-mediated sustained inflammation and calcification in aortic valve interstitial cells

    Article • International Journal of Cardiology, June 2012, Elsevier

    Mariano Sanchez Crespo

  20. Apoptotic cells enhance IL-10 and reduce IL-23 production in human dendritic cells treated with zymosan

    Article • Molecular Immunology, October 2011, Elsevier

    Mariano Sanchez Crespo

  21. Notch- and Transducin-like Enhancer of Split (TLE)-dependent Histone Deacetylation Explain Interleukin 12 (IL-12) p70 Inhibition by Zymosan

    Article • Journal of Biological Chemistry, May 2011, Elsevier

    Mariano Sanchez Crespo

  22. Eicosanoids in the Innate Immune Response: TLR and Non-TLR Routes

    Article • Mediators of Inflammation, January 2010, Hindawi Publishing Corporation

    Mariano Sanchez Crespo

  23. Characterization of New Substrates Targeted By Yersinia Tyrosine Phosphatase YopH

    Article • PLoS ONE, February 2009, PLOS

    Mariano Sanchez Crespo

  24. KCTD5, a putative substrate adaptor for cullin3 ubiquitin ligases

    Article • FEBS Journal, June 2008, Wiley

    Mariano Sanchez Crespo

  25. Estudio de la expresión de interleucina-8 en el tejido pulmonar durante la isquemia-reperfusión

    Article • Archivos de Bronconeumología, October 2007, Elsevier

    Mariano Sanchez Crespo

  26. Mannan and peptidoglycan induce COX‐2 protein in human PMN via the mammalian target of rapamycin

    Article • European Journal of Immunology, August 2007, Wiley

    Mariano Sanchez Crespo

  27. Interleukin-8 Expression in Lung Tissue During Ischemia-Reperfusion

    Article • Archivos de Bronconeumología (English Edition), January 2007, Elsevier

    Mariano Sanchez Crespo

  28. Muscarinic Acetylcholine Receptor Enhances Phosphatidylcholine Hydrolysis via Phospholipase D in Bovine Chromaffin Cells in Culture

    Article • Journal of Neurochemistry, October 2006, Wiley

    Mariano Sanchez Crespo

  29. Immune Complex Processing: A Phagocytosis-Based Mechanism with Proinflammatory Potential

    Article • Transfusion Medicine and Hemotherapy, January 2005, Karger Publishers

    Mariano Sanchez Crespo

  30. Blood and endothelium in immune complex-mediated tissue injury

    Article • Trends in Pharmacological Sciences, October 2004, Elsevier

    Mariano Sanchez Crespo

  31. Biological effects of group IIA secreted phosholipase A2

    Article • FEBS Letters, September 2002, Wiley

    Mariano Sanchez Crespo

  32. FcγR receptors activate MAP kinase and up-regulate the cyclooxygenase pathway without increasing arachidonic acid release in monocytic cells

    Article • European Journal of Immunology, February 2002, Wiley

    Mariano Sanchez Crespo

  33. Signaling Mechanisms Involved in the Activation of Arachidonic Acid Metabolism in Human Astrocytoma Cells by Tumor Necrosis Factor-α

    Article • Journal of Neurochemistry, January 2002, Wiley

    Mariano Sanchez Crespo

  34. Lysophosphatidic Acid Inhibits Ca2+ Signaling in Response to Epidermal Growth Factor Receptor Stimulation in Human Astrocytoma Cells by a Mechanism Involving Phospholipase Cγ and a Gαi Protein

    Article • Journal of Neurochemistry, January 2002, Wiley

    Mariano Sanchez Crespo

  35. Brucella Lipopolysaccharides Induce Cyclooxygenase-2 Expression in Monocytic Cells

    Article • Biochemical and Biophysical Research Communications, November 2001, Elsevier

    Mariano Sanchez Crespo

  36. FcγRIIA exogenously expressed in HeLa cells activates the mitogen-activated protein kinase cascade by a mechanism dependent on the endogenous expression of the protein tyrosine kinaseSyk

    Article • European Journal of Immunology, May 2001, Wiley

    Mariano Sanchez Crespo

  37. Effect of 4‐trifluoromethyl derivatives of salicylate on nuclear factor κB‐dependent transcription in human astrocytoma cells

    Article • British Journal of Pharmacology, January 2001, Wiley

    Mariano Sanchez Crespo

  38. Cytosolic phospholipase A2 and the distinct transcriptional programs of astrocytoma cells

    Article • Trends in Neurosciences, June 2000, Elsevier

    Mariano Sanchez Crespo

  39. Secretory Phospholipase A2 Induces Phospholipase Cγ-1 Activation and Ca2+ Mobilization in the Human Astrocytoma Cell Line 1321N1 by a Mechanism Independent of Its Catalytic Activity

    Article • Biochemical and Biophysical Research Communications, June 1999, Elsevier

    Mariano Sanchez Crespo

  40. 4-trifluoromethyl derivatives of salicylate, triflusal and its main metabolite 2-hydroxy-4-trifluoromethylbenzoic acid, are potent inhibitors of nuclear factor κB activation

    Article • British Journal of Pharmacology, March 1999, Wiley

    Mariano Sanchez Crespo

  41. Immunoglobulin-E/Dinitrophenyl Complexes Induce Nitric Oxide Synthesis in Rat Peritoneal Macrophages by a Mechanism Involving CD23 and NF-κB Activation

    Article • Biochemical and Biophysical Research Communications, January 1998, Elsevier

    Mariano Sanchez Crespo

  42. Thrombin produces phosphorylation of cytosolic phospholipase A2 by a mitogen-activated protein kinase kinase-independent mechanism in the human astrocytoma cell line 1321N1

    Article • Biochemical Journal, November 1997, Portland Press Ltd.

    Mariano Sanchez Crespo

  43. Cytosolic phospholipase A2 is coupled to muscarinic receptors in the human astrocytoma cell line 1321N1: characterization of the transducing mechanism

    Article • Biochemical Journal, April 1997, Portland Press Ltd.

    Mariano Sanchez Crespo

  44. The expression of cytokine-induced neutrophil chemoattractants (CINC-1 and CINC-2) in rat peritoneal macrophages is triggered by Fcγ receptor activation: Study of the signaling mechanism

    Article • European Journal of Immunology, September 1996, Wiley

    Mariano Sanchez Crespo

  45. Lack of platelet-activating factor release on acute myocardial ischemia in the isolated interventricular septum of rabbit heart

    Article • European Journal of Pharmacology Environmental Toxicology and Pharmacology, May 1995, Elsevier

    Mariano Sanchez Crespo

  46. Platelet-activating factor: the effector of protein-rich plasma extravasation and nitric oxide synthase induction in rat immune complex peritonitis

    Article • British Journal of Pharmacology, February 1995, Wiley

    Lisardo Bosca, Mariano Sanchez Crespo

  47. Study of the effector mechanism involved in the production of haemorrhagic necrosis of the small intestine in rat passive anaphylaxis

    Article • British Journal of Pharmacology, August 1994, Wiley

    Mariano Sanchez Crespo

  48. Study of Some Mechanisms that may Contribute to the Presence of High Levels of Phospholipase A2 Activity in Plasma of Patients with Septicemia

    Article • January 1994, Springer Science + Business Media

    Mariano Sanchez Crespo

  49. Effect of immunological stimulation on the production of platelet-activating factor by rat peritoneal cells: its relevance to anaphylactic reactions

    Article • Immunopharmacology, July 1993, Elsevier

    Mariano Sanchez Crespo

  50. REPLY FROM M.C. GARCIA, M. G. LOPEZ, A. G. GARCIA, AND M. SANCHEZ CRESPO

    Article • Journal of Neurochemistry, May 1993, Wiley

    Mariano Sanchez Crespo

  51. The role of platelet-activating factor and peptidoleukotrienes in the vascular changes of rat passive anaphylaxis

    Article • British Journal of Pharmacology, January 1992, Wiley

    Mariano Sanchez Crespo

  52. Platelet-activating factor antagonists do not protect against the development of experimental autoimmune encephalomyelitis

    Article • Journal of Neuroimmunology, July 1991, Elsevier

    Mariano Sanchez Crespo

  53. Occupancy of platelet receptors for platelet-activating factor in patients with septicemia.

    Article • Journal of Clinical Investigation, May 1989, American Society for Clinical Investigation

    Mariano Sanchez Crespo

  54. Intracellular localization of platelet-activating factor synthesis in human neutrophils

    Article • Biochemical and Biophysical Research Communications, August 1988, Elsevier

    Mariano Sanchez Crespo

  55. Role of PAF-acether in the mediation of pathophysiological responses to aggregated immunoglobulins. Studies with the platelet-activating factor receptor antagonist BN 52021

    Article • International Journal of Immunopharmacology, January 1988, Elsevier

    Mariano Sanchez Crespo

  56. Platelet-Activating Factor: A Secretory Product from Phagocytes

    Article • January 1987, Springer Science + Business Media

    Mariano Sanchez Crespo

  57. Inhibition of the vascular actions of IgG aggregates by BN 52021, a highly specific antagonist of paf-acether

    Article • Immunopharmacology, October 1985, Elsevier

    Mariano Sanchez Crespo

  58. Modulation of lyso-platelet activating factor:acetyl-CoA acetyltransferase from rat splenic microsomes. The role of cyclic AMP-dependent protein kinase

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, June 1985, Elsevier

    Mariano Sanchez Crespo

  59. Modulation of lyso-platelet-activating factor:acetyl-CoA acetyltransferase from rat splenic microsomes. The role of calcium ions

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, June 1985, Elsevier

    Mariano Sanchez Crespo

  60. Synthesis of PAF-acether and blood volume changes in gram-negative sepsis

    Article • Immunopharmacology, February 1985, Elsevier

    Mariano Sanchez Crespo

  61. Platelet-activating factor: An effector substance of the vasopermeability changes induced by the infusion of immune aggregates in the mouse

    Article • Immunopharmacology, June 1983, Elsevier

    Mariano Sanchez Crespo

  62. Phospholipid turnover during phagocytosis in human polymorphonuclear leucocytes

    Article • Biochemical Journal, July 1982, Portland Press Ltd.

    Mariano Sanchez Crespo

  63. Vascular actions of synthetic PAF-acether (a synthetic platelet-activating factor) in the rat: Evidence for a platelet independent mechanism

    Article • Immunopharmacology, April 1982, Elsevier

    Mariano Sanchez Crespo

  64. Inhibition of phospholipid methyltransferase during zymosan induced secretion of platelet-activating factor in human polymorphonuclear leukocytes

    Article • Biochemical and Biophysical Research Communications, August 1981, Elsevier

    Mariano Sanchez Crespo

  65. Immunological Aspects of Renal Vascular Involvement

    Article • January 1981, Springer Science + Business Media

    Mariano Sanchez Crespo

  66. IN-VITRO BASOPHIL DEGRANULATION IN DRUG-SUSPECTED ACUTE RENAL FAILURE

    Article • The Lancet, October 1977, Elsevier

    Mariano Sanchez Crespo