All Stories

  1. The biomedical challenge associated with the Artemis space program

    Article • Acta Astronautica, November 2023, Elsevier

    Prof Mariano Bizzarri

  2. Synchronization between Attractors: Genomic Mechanism of Cell-Fate Change

    Article • International Journal of Molecular Sciences, July 2023, MDPI AG

    Prof Mariano Bizzarri

  3. ERK Signaling Pathway Is Constitutively Active in NT2D1 Non-Seminoma Cells and Its Inhibition Impairs Basal and HGF-Activated Cell Proliferation

    Article • Biomedicines, July 2023, MDPI AG

    Prof Mariano Bizzarri

  4. A Critical Perspective on the Supplementation of Akkermansia muciniphila: Benefits and Harms

    Article • Life, May 2023, MDPI AG

    Prof. Antonio Simone Laganà, Prof Mariano Bizzarri

  5. Impact of Oocyte Extract Supplement on Quality of Life after Hepatectomy for Liver Tumours: A Prospective, Multicentre, Double-Blind Randomized Clinical Trial

    Article • Cancers, May 2023, MDPI AG

    Prof Mariano Bizzarri

  6. Effects of Simulated Microgravity In Vitro on Human Metaphase II Oocytes: An Electron Microscopy-Based Study

    Article • Cells, May 2023, MDPI AG

    Prof Mariano Bizzarri

  7. Is Cancer Reversible? Rethinking Carcinogenesis Models—A New Epistemological Tool

    Article • Biomolecules, April 2023, MDPI AG

    Prof Mariano Bizzarri

  8. Myo-Inositol Reverses TGF-β1-Induced EMT in MCF-10A Non-Tumorigenic Breast Cells

    Article • Cancers, April 2023, MDPI AG

    Prof Mariano Bizzarri

  9. Myo-Inositol and D-Chiro-Inositol as Modulators of Ovary Steroidogenesis: A Narrative Review

    Article • Nutrients, April 2023, MDPI AG

    Prof Mariano Bizzarri

  10. The Role of Inositols in the Hyperandrogenic Phenotypes of PCOS: A Re-Reading of Larner’s Results

    Article • International Journal of Molecular Sciences, March 2023, MDPI AG

    Prof Mariano Bizzarri

  11. Role of SIRT3 in Microgravity Response: A New Player in Muscle Tissue Recovery

    Article • Cells, February 2023, MDPI AG

    Prof Mariano Bizzarri

  12. Space Biomedicine: A Unique Opportunity to Rethink the Relationships between Physics and Biology

    Article • Biomedicines, October 2022, MDPI AG

    Prof Mariano Bizzarri

  13. Positive Effects of α-Lactalbumin in the Management of Symptoms of Polycystic Ovary Syndrome

    Article • Nutrients, August 2022, MDPI AG

    Prof Mariano Bizzarri

  14. Allethrin Promotes Apoptosis and Autophagy Associated with the Oxidative Stress-Related PI3K/AKT/mTOR Signaling Pathway in Developing Rat Ovaries

    Article • International Journal of Molecular Sciences, June 2022, MDPI AG

    Prof Mariano Bizzarri

  15. Inositols in the ovaries: activities and potential therapeutic applications

    Article • Expert Opinion on Drug Metabolism & Toxicology, May 2022, Taylor & Francis

    Prof. Antonio Simone Laganà, Prof Mariano Bizzarri

  16. Paradoxical Behavior of Oncogenes Undermines the Somatic Mutation Theory

    Article • Biomolecules, April 2022, MDPI AG

    Prof Mariano Bizzarri

  17. Microgravity Modifies the Phenotype of Fibroblast and Promotes Remodeling of the Fibroblast–Keratinocyte Interaction in a 3D Co-Culture Model

    Article • International Journal of Molecular Sciences, February 2022, MDPI AG

    Prof Mariano Bizzarri

  18. Tumor reversion and embryo morphogenetic factors

    Article • Seminars in Cancer Biology, February 2022, Elsevier

    Prof Mariano Bizzarri

  19. Evaluation of menstrual irregularities after COVID-19 vaccination: Results of the MECOVAC survey

    Article • Open Medicine, January 2022, De Gruyter

    Prof. Antonio Simone Laganà, Prof Mariano Bizzarri

  20. Inositols: From Established Knowledge to Novel Approaches

    Article • International Journal of Molecular Sciences, September 2021, MDPI AG

    Prof. Antonio Simone Laganà, Prof Mariano Bizzarri

  21. Critical transition across the Waddington landscape as an interpretative model

    Article • Physics of Life Reviews, September 2021, Elsevier

    Prof Mariano Bizzarri

  22. Analytical Performance of COVID-19 Detection Methods (RT-PCR): Scientific and Societal Concerns

    Article • Life, July 2021, MDPI AG

    Prof Mariano Bizzarri

  23. An innovative approach to polycystic ovary syndrome

    Article • Journal of Obstetrics and Gynaecology, June 2021, Taylor & Francis

    Prof. Antonio Simone Laganà, Prof Mariano Bizzarri

  24. Survival Pathways Are Differently Affected by Microgravity in Normal and Cancerous Breast Cells

    Article • International Journal of Molecular Sciences, January 2021, MDPI AG

    Prof Mariano Bizzarri

  25. Microgravity Induces Transient EMT in Human Keratinocytes by Early Down-Regulation of E-Cadherin and Cell-Adhesion Remodeling

    Article • Applied Sciences, December 2020, MDPI AG

    Prof Mariano Bizzarri

  26. The PI3K/AKT Pathway Is Activated by HGF in NT2D1 Non-Seminoma Cells and Has a Role in the Modulation of Their Malignant Behavior

    Article • International Journal of Molecular Sciences, November 2020, MDPI AG

    Prof Mariano Bizzarri

  27. Altered Ovarian Inositol Ratios May Account for Pathological Steroidogenesis in PCOS

    Article • International Journal of Molecular Sciences, September 2020, MDPI AG

    Prof. Antonio Simone Laganà, Prof Mariano Bizzarri

  28. The Key Role of IP6K: A Novel Target for Anticancer Treatments?

    Article • Molecules, September 2020, MDPI AG

    Prof Mariano Bizzarri

  29. Complexity in Biological Organization: Deconstruction (and Subsequent Restating) of Key Concepts

    Article • Entropy, August 2020, MDPI AG

    Prof Mariano Bizzarri

  30. “Constraining” the probability toward a specified attractor

    Article • Physics of Life Reviews, July 2020, Elsevier

    Prof Mariano Bizzarri

  31. Antioxidant Strategy to Prevent Simulated Microgravity-Induced Effects on Bone Osteoblasts

    Article • International Journal of Molecular Sciences, May 2020, MDPI AG

    Prof Mariano Bizzarri

  32. Rediscovery of natural compounds acting via multitarget recognition and noncanonical pharmacodynamical actions

    Article • Drug Discovery Today, May 2020, Elsevier

    Prof Mariano Bizzarri

  33. Constraints Shape Cell Function and Morphology by Canalizing the Developmental Path along the Waddington's Landscape

    Article • BioEssays, April 2020, Wiley

    Prof Mariano Bizzarri

  34. Redifferentiation therapeutic strategies in cancer

    Article • Drug Discovery Today, April 2020, Elsevier

    Prof Mariano Bizzarri

  35. Putative Receptors for Gravity Sensing in Mammalian Cells: The Effects of Microgravity

    Article • Applied Sciences, March 2020, MDPI AG

    Prof Mariano Bizzarri

  36. Experts’ opinion on Inositols in treating polycystic ovary syndrome and non-insulin dependent diabetes mellitus: a further help for human reproduction and beyond

    Article • Expert Opinion on Drug Metabolism & Toxicology, March 2020, Taylor & Francis

    Prof. Antonio Simone Laganà, Prof Mariano Bizzarri

  37. Hyperoxia Alters Ultrastructure and Induces Apoptosis in Leukemia Cell Lines

    Article • Biomolecules, February 2020, MDPI AG

    Prof Mariano Bizzarri

  38. Phenotypic transitions enacted by simulated microgravity do not alter coherence in gene transcription profile

    Article • npj Microgravity, November 2019, Springer Science + Business Media

    Prof Mariano Bizzarri

  39. Physiological Responses of Jurkat Lymphocytes to Simulated Microgravity Conditions

    Article • International Journal of Molecular Sciences, April 2019, MDPI AG

    Prof Mariano Bizzarri

  40. Inositols in Insulin Signaling and Glucose Metabolism

    Article • International Journal of Endocrinology, November 2018, Hindawi Publishing Corporation

    Prof Mariano Bizzarri

  41. Myo-inositol and D-chiro-inositol (40:1) reverse histological and functional features of polycystic ovary syndrome in a mouse model

    Article • Journal of Cellular Physiology, October 2018, Wiley

    Prof Mariano Bizzarri

  42. Physical constraints in cell fate specification. A case in point: Microgravity and phenotypes differentiation

    Article • Progress in Biophysics and Molecular Biology, May 2018, Elsevier

    Prof Mariano Bizzarri

  43. Modulation of both Insulin Resistance and Cancer Growth by Inositol

    Article • Current Pharmaceutical Design, January 2018, Bentham Science Publishers

    Prof Mariano Bizzarri

  44. Nicotine increases colon cancer cell migration and invasion through epithelial to mesenchymal transition (EMT): COX-2 involvement

    Article • Journal of Cellular Physiology, January 2018, Wiley

    Prof Mariano Bizzarri

  45. Gravity Constraints Drive Biological Systems Toward Specific Organization Patterns

    Article • BioEssays, November 2017, Wiley

    Prof Mariano Bizzarri

  46. A Gas Sensor Device for Oxygen and Carbon Dioxide Detection

    Article • August 2017, MDPI AG

    Prof Mariano Bizzarri

  47. Melatonin, mitochondria, and the cancer cell

    Article • Cellular and Molecular Life Sciences, August 2017, Springer Science + Business Media

    Prof Mariano Bizzarri

  48. Tumor Reversion: Mesenchymal-Epithelial Transition as a Critical Step in Managing the Tumor-Microenvironment Cross-Talk

    Article • Current Pharmaceutical Design, June 2017, Bentham Science Publishers

    Prof Mariano Bizzarri

  49. Physiological role and clinical utility of inositols in polycystic ovary syndrome

    Article • Best Practice & Research Clinical Obstetrics & Gynaecology, November 2016, Elsevier

    Prof Mariano Bizzarri

  50. A Randomized Pilot Study of Inositol in Association with Betaine and Boswellia in the Management of Mastalgia and Benign Breast Lump in Premenopausal Women

    Article • Breast Cancer Basic and Clinical Research, April 2016, SAGE Publications

    Professor Abdel Halim Harrath, Prof Mariano Bizzarri, Prof. FRANCESCO TARTAGLIA

  51. Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate

    Article • International Journal of Endocrinology, January 2016, Hindawi Publishing Corporation

    Prof Mariano Bizzarri

  52. Myo-Inositol Safety in Pregnancy: From Preimplantation Development to Newborn Animals

    Article • International Journal of Endocrinology, January 2016, Hindawi Publishing Corporation

    Prof Mariano Bizzarri

  53. Multiwalled carbon nanotube buckypaper induces cell cycle arrest and apoptosis in human leukemia cell lines through modulation of AKT and MAPK signaling pathways

    Article • Toxicology in Vitro, October 2015, Elsevier

    Prof Mariano Bizzarri

  54. Nuclear redox imbalance affects circadian oscillation in HaCaT keratinocytes

    Article • The International Journal of Biochemistry & Cell Biology, August 2015, Elsevier

    Prof Mariano Bizzarri

  55. Results from the International Consensus Conference on myo-inositol and D-chiro-inositol in Obstetrics and Gynecology – assisted reproduction technology

    Article • Gynecological Endocrinology, June 2015, Taylor & Francis

    Prof Mariano Bizzarri

  56. Microgravity influences circadian clock oscillation in human keratinocytes

    Article • FEBS Open Bio, January 2015, Wiley

    Prof Mariano Bizzarri

  57. How Microgravity Affects the Biology of Living Systems

    Article • BioMed Research International, January 2015, Hindawi Publishing Corporation

    Prof Mariano Bizzarri

  58. Quercetin Affects Hsp70/IRE1αMediated Protection from Death Induced by Endoplasmic Reticulum Stress

    Article • Oxidative Medicine and Cellular Longevity, January 2015, Hindawi Publishing Corporation

    Prof Mariano Bizzarri

  59. Feasibility of teleoperations with multi-fingered robotic hand for safe extravehicular manipulations

    Article • Aerospace Science and Technology, December 2014, Elsevier

    Prof Mariano Bizzarri

  60. The multisensory integrated modules for training

    Article • October 2014, Institute of Electrical & Electronics Engineers (IEEE)

    Prof Mariano Bizzarri

  61. Peroxiredoxin 2 nuclear levels are regulated by circadian clock synchronization in human keratinocytes

    Article • The International Journal of Biochemistry & Cell Biology, August 2014, Elsevier

    Prof Mariano Bizzarri

  62. Soft gel capsules improve melatonin’s bioavailability in humans

    Article • Expert Opinion on Drug Metabolism & Toxicology, July 2014, Taylor & Francis

    Prof Mariano Bizzarri

  63. The rationale of the myo-inositol and D-chiro-inositol combined treatment for polycystic ovary syndrome

    Article • The Journal of Clinical Pharmacology, July 2014, Wiley

    Prof Mariano Bizzarri

  64. Melatonin down-regulates MDM2 gene expression and enhances p53 acetylation in MCF-7 cells

    Article • Journal of Pineal Research, July 2014, Wiley

    Prof Mariano Bizzarri

  65. Fractal analysis of shape changes in murine osteoblasts cultured under simulated microgravity

    Article • RENDICONTI LINCEI, February 2014, Springer Science + Business Media

    Prof Mariano Bizzarri

  66. Reprogramming Cancer Cells in Endocrine-Related Tumors: Open Issues

    Article • Current Medicinal Chemistry, February 2014, Bentham Science Publishers

    Prof Mariano Bizzarri

  67. Bridging hypoxia, inflammation and estrogen receptors in thyroid cancer progression

    Article • Biomedicine & Pharmacotherapy, February 2014, Elsevier

    Prof Mariano Bizzarri

  68. Gravity sensing by cells: mechanisms and theoretical grounds

    Article • RENDICONTI LINCEI, January 2014, Springer Science + Business Media

    Prof Mariano Bizzarri

  69. Innovative IAQ Organic Sensor

    Article • Procedia Engineering, January 2014, Elsevier

    Prof Mariano Bizzarri

  70. Lung Cancer Stem Cell Lose Their Stemness Default State after Exposure to Microgravity

    Article • BioMed Research International, January 2014, Hindawi Publishing Corporation

    Prof Mariano Bizzarri

  71. Phenotypic Switch Induced by Simulated Microgravity on MDA-MB-231 Breast Cancer Cells

    Article • BioMed Research International, January 2014, Hindawi Publishing Corporation

    Prof Mariano Bizzarri

  72. Tumor and the Microenvironment: A Chance to Reframe the Paradigm of Carcinogenesis?

    Article • BioMed Research International, January 2014, Hindawi Publishing Corporation

    Prof Mariano Bizzarri

  73. Microenvironment Promotes Tumor Cell Reprogramming in Human Breast Cancer Cell Lines

    Article • PLoS ONE, December 2013, PLOS

    Prof Mariano Bizzarri

  74. Design and Test of a Biosensor-Based Multisensorial System: A Proof of Concept Study

    Article • Sensors, December 2013, MDPI AG

    Prof Mariano Bizzarri

  75. Nicotine increases survival in human colon cancer cells treated with chemotherapeutic drugs

    Article • Toxicology in Vitro, December 2013, Elsevier

    Prof Mariano Bizzarri

  76. TCam-2 Seminoma Cells Exposed to Egg-Derived Microenvironment Modify Their Shape, Adhesive Pattern and Migratory Behaviour: A Molecular and Morphometric Analysis

    Article • PLoS ONE, October 2013, PLOS

    Prof Mariano Bizzarri

  77. Shape in migration

    Article • Cell Adhesion & Migration, September 2013, Taylor & Francis

    Prof Mariano Bizzarri

  78. Molecular mechanisms of the pro-apoptotic actions of melatonin in cancer: a review

    Article • Expert Opinion on Therapeutic Targets, September 2013, Informa Healthcare

    Prof Mariano Bizzarri

  79. Effect of a recombinant manganese superoxide dismutase on prevention of contrast-induced acute kidney injury

    Article • Clinical and Experimental Nephrology, June 2013, Springer Science + Business Media

    Prof Mariano Bizzarri

  80. Grape seed extract suppresses MDA-MB231 breast cancer cell migration and invasion

    Article • Zeitschrift für Ernährungswissenschaft, June 2013, Springer Science + Business Media

    Prof Mariano Bizzarri

  81. Theoretical aspects of Systems Biology

    Article • Progress in Biophysics and Molecular Biology, May 2013, Elsevier

    Prof Mariano Bizzarri

  82. Grape seed extract triggers apoptosis in Caco-2 human colon cancer cells through reactive oxygen species and calcium increase: extracellular signal-regulated kinase involvement

    Article • British Journal Of Nutrition, February 2013, Cambridge University Press

    Prof Mariano Bizzarri

  83. Nicotine stimulates proliferation and inhibits apoptosis in colon cancer cell lines through activation of survival pathways

    Article • Journal of Surgical Research, November 2012, Elsevier

    Prof Mariano Bizzarri

  84. Multiwalled carbon nanotubes-induced cytotoxic effects on human breast adenocarcinoma cell line

    Article • October 2012, Institute of Electrical & Electronics Engineers (IEEE)

    Prof Mariano Bizzarri

  85. Molecular mechanisms of melatonin’s inhibitory actions on breast cancers

    Article • Cellular and Molecular Life Sciences, September 2012, Springer Science + Business Media

    Prof Mariano Bizzarri

  86. Quantitative shape analysis of chemoresistant colon cancer cells: Correlation between morphotype and phenotype

    Article • Experimental Cell Research, April 2012, Elsevier

    Prof Mariano Bizzarri

  87. A new approach for the preparation of hydrophilic poly(L -lactide) porous scaffold for tissue engineering by using lamellar single crystals

    Article • Polymer International, March 2012, Wiley

    Professor Andrea Martinelli, Prof Mariano Bizzarri

  88. Antiproliferative and Apoptotic Effects Triggered by Grape Seed Extract (GSE) versus Epigallocatechin and Procyanidins on Colon Cancer Cell Lines

    Article • International Journal of Molecular Sciences, January 2012, MDPI AG

    Prof Mariano Bizzarri

  89. Systems Biology Approach to Metabolomics in Cancer Studies

    Article • January 2012, Springer Science + Business Media

    Prof Mariano Bizzarri

  90. Metabolism and cell shape in cancer: A fractal analysis

    Article • The International Journal of Biochemistry & Cell Biology, July 2011, Elsevier

    Prof Mariano Bizzarri

  91. Fractal analysis in a systems biology approach to cancer

    Article • Seminars in Cancer Biology, June 2011, Elsevier

    Prof Mariano Bizzarri

  92. Representing Cancer Cell Trajectories in a Phase-Space Diagram: Switching Cellular States by Biological Phase Transitions

    Article • April 2011, Wiley

    Prof Mariano Bizzarri

  93. A Systems Biology Approach to Cancer: Fractals, Attractors, and Nonlinear Dynamics

    Article • OMICS A Journal of Integrative Biology, March 2011, Mary Ann Liebert Inc

    Prof Mariano Bizzarri

  94. Rapid Resolution Liquid chromatography/High Resolution Tandem Mass Spectrometry to Characterize Metabolic Changes in Subjects Involved in MARS500 Project

    Article • Chromatographia, January 2011, Springer Science + Business Media

    Prof Mariano Bizzarri

  95. Melatonin and vitamin D3 synergistically down-regulate Akt and MDM2 leading to TGFβ-1-dependent growth inhibition of breast cancer cells

    Article • Journal of Pineal Research, November 2010, Wiley

    Prof Mariano Bizzarri

  96. Apoptosis-inducing factor and caspase-dependent apoptotic pathways triggered by different grape seed extracts on human colon cancer cell line Caco-2

    Article • British Journal Of Nutrition, June 2010, Cambridge University Press

    Prof Mariano Bizzarri

  97. Modulation of redox status and calcium handling by extremely low frequency electromagnetic fields in C2C12 muscle cells: A real-time, single-cell approach

    Article • Free Radical Biology and Medicine, February 2010, Elsevier

    MD Giovanna Mazzoleni, Prof Mariano Bizzarri

  98. Classification of prostatic diseases by means of multivariate analysis on in vivo proton MRSI and DCE-MRI data

    Article • NMR in Biomedicine, July 2009, Wiley

    Prof Mariano Bizzarri

  99. Evidence for a biphasic apoptotic pathway induced by melatonin in MCF-7 breast cancer cells

    Article • Journal of Pineal Research, March 2009, Wiley

    Prof Mariano Bizzarri

  100. A label-free method based on MALDI-TOF mass spectrometry for the absolute quantitation of troponin T in mouse cardiac tissue

    Article • Analytical and Bioanalytical Chemistry, April 2008, Springer Science + Business Media

    Prof Mariano Bizzarri

  101. Beyond the Oncogene Paradigm: Understanding Complexity in Cancerogenesis

    Article • Acta Biotheoretica, February 2008, Springer Science + Business Media

    Prof Mariano Bizzarri

  102. S-adenosylmethionine Inhibits Ubiquitin-Proteasome System In Vitro and on Rat Vascular Smooth Muscle Cells

    Article • Protein and Peptide Letters, January 2008, Bentham Science Publishers

    Prof Mariano Bizzarri

  103. NMR-based metabolic profiling of human hepatoma cells in relation to cell growth by culture media analysis

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, November 2006, Elsevier

    Prof Mariano Bizzarri

  104. Zebrafish embryo proteins induce apoptosis in human colon cancer cells (Caco2)

    Article • APOPTOSIS, June 2006, Springer Science + Business Media

    Prof Mariano Bizzarri

  105. EMBRYO EXTRACTS OPOTHERAPY REDUCES Alpha-FETOPROTEIN LEVELS IN hepatocellular carcinoma PATIENTS

    Article • Journal of Gastroenterology and Hepatology, September 2005, Wiley

    Prof Mariano Bizzarri

  106. NMR-based metabonomic study of transgenic maize

    Article • Phytochemistry, December 2004, Elsevier

    Prof Mariano Bizzarri

  107. Melatonin and vitamin D 3 increase TGF-β 1 release and induce growth inhibition in breast cancer cell cultures

    Article • Journal of Surgical Research, April 2003, Elsevier

    Prof Mariano Bizzarri

  108. Determination of serum total lipid and free N-acetylneuraminic acid in genitourinary malignancies by fluorimetric high performance liquid chromatography. Relevance of free N-acetylneuraminic acid as tumour marker

    Article • Clinica Chimica Acta, December 1995, Elsevier

    Prof Mariano Bizzarri

  109. Sensitive assay for melatonin in human serum by liquid chromatography

    Article • Analytica Chimica Acta, December 1995, Elsevier

    Prof Mariano Bizzarri